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Select item 103300031.

Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction

In-Young Jung, Robert L. Bartoszek, Andrew J. Rech, Sierra M. Collins, Soon-Keat Ooi, Erik F. Williams, Caitlin R. Hopkins, Vivek Narayan, Naomi B. Haas, Noelle V. Frey, Elizabeth O. Hexner, Donald L. Siegel, Gabriela Plesa, David L. Porter, Adrian Cantu, John K. Everett, Sonia Guedan, Shelley L. Berger, Frederic D. Bushman, Friederike Herbst, Joseph A. Fraietta

Cancer Discov. Author manuscript; available in PMC 2024 Jan 7.

Published in final edited form as: Cancer Discov. 2023 Jul 7; 13(7): 1636–1655. doi: 10.1158/2159-8290.CD-22-1175

PMCID:: PMC10330003

Abstract Article PDF–3.8M

Select item 79633332.

Early growth response 2 (EGR2) is a novel regulator of the senescence programme

Eleanor J. Tyler, Ana Gutierrez del Arroyo, Bethany K. Hughes, Ryan Wallis, James C. Garbe, Martha R. Stampfer, Jim Koh, Robert Lowe, Michael P. Philpott, Cleo L. Bishop

Aging Cell. 2021 Mar; 20(3): e13318. Published online 2021 Feb 6. doi: 10.1111/acel.13318

PMCID:: PMC7963333

Abstract Article PDF–1.6M

Select item 79469033.

The epigenetic pioneer EGR2 initiates DNA demethylation in differentiating monocytes at both stable and transient binding sites

Karina Mendes, Sandra Schmidhofer, Julia Minderjahn, Dagmar Glatz, Claudia Kiesewetter, Johanna Raithel, Julia Wimmer, Claudia Gebhard, Michael Rehli

Nat Commun. 2021; 12: 1556. Published online 2021 Mar 10. doi: 10.1038/s41467-021-21661-y

PMCID:: PMC7946903

Abstract Article PDF–4.0M

Select item 58344694.

Early Growth Response Gene 2-Expressing CD4⁺LAG3⁺ Regulatory T Cells: The Therapeutic Potential for Treating Autoimmune Diseases

Tomohisa Okamura, Kazuhiko Yamamoto, Keishi Fujio

Front Immunol. 2018; 9: 340. Published online 2018 Feb 26. doi: 10.3389/fimmu.2018.00340

PMCID:: PMC5834469

Abstract Article PDF–390K

Select item 45910735.

Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite

Thomas G. P. Grünewald, Virginie Bernard, Pascale Gilardi-Hebenstreit, Virginie Raynal, Didier Surdez, Marie-Ming Aynaud, Olivier Mirabeau, Florencia Cidre-Aranaz, Franck Tirode, Sakina Zaidi, Gaëlle Perot, Anneliene H. Jonker, Carlo Lucchesi, Marie-Cécile Le Deley, Odile Oberlin, Perrine Marec-Bérard, Amélie S. Véron, Stephanie Reynaud, Eve Lapouble, Valentina Boeva, Thomas Rio Frio, Javier Alonso, Smita Bhatia, Gaëlle Pierron, Geraldine Cancel-Tassin, Olivier Cussenot, David G. Cox, Lindsay M. Morton, Mitchell J. Machiela, Stephen J. Chanock, Patrick Charnay, Olivier Delattre

Nat Genet. Author manuscript; available in PMC 2016 Sep 1.

Published in final edited form as: Nat Genet. 2015 Sep; 47(9): 1073–1078. Published online 2015 Jul 27. doi: 10.1038/ng.3363

PMCID:: PMC4591073

Abstract Article PDF–1.1M

Select item 38874186.

Early Growth Response-2 Signaling Mediates Immunomodulatory Effects of Human Multipotential Stromal Cells

Dominique J. Barbeau, Kiet Tran La, Duk Soo Kim, Svetoslava S. Kerpedjieva, Galina V. Shurin, Kenichi Tamama

Stem Cells Dev. 2014 Jan 15; 23(2): 155–166. Published online 2013 Sep 5. doi: 10.1089/scd.2013.0194

PMCID:: PMC3887418

Abstract Article PDF–677K

Select item 34467137.

IRES-dependent translation of egr2 is induced under inflammatory conditions

Daniela Rübsamen, Johanna S. Blees, Kathrin Schulz, Claudia Döring, Martin-Leo Hansmann, Heinrich Heide, Andreas Weigert, Tobias Schmid, Bernhard Brüne

RNA. 2012 Oct; 18(10): 1910–1920. doi: 10.1261/rna.033019.112

PMCID:: PMC3446713

Abstract Article PDF–452K

Select item 32968088.

Genetic association of the EGR2 gene with bipolar disorder in Korea

Se Hyun Kim, Joo Youn Song, Eun Jeong Joo, Kyu Young Lee, Soon Young Shin, Young Han Lee, Yong Min Ahn, Yong Sik Kim

Exp Mol Med. 2012 Feb 29; 44(2): 121–129. Published online 2011 Nov 16. doi: 10.3858/emm.2012.44.2.007

PMCID:: PMC3296808

Abstract Article PDF–1.0M

Select item 31432429.

Early growth response-2 expression in uterine leiomyoma cells: regulation and function

Ping Yin, Antonia Navarro, Feng Fang, Anna Xie, John S. Coon V., Carrie Richardson, Serdar E. Bulun

Fertil Steril. Author manuscript; available in PMC 2012 Aug 1.

Published in final edited form as: Fertil Steril. 2011 Aug; 96(2): 439–444. Published online 2011 Jun 24. doi: 10.1016/j.fertnstert.2011.05.062

PMCID:: PMC3143242

Abstract Article PDF–494K

Select item 254682310.

Toxoplasma gondii Rhoptry Discharge Correlates with Activation of the Early Growth Response 2 Host Cell Transcription Factor

Eric D. Phelps, Kristin R. Sweeney, Ira J. Blader

Infect Immun. 2008 Oct; 76(10): 4703–4712. Published online 2008 Aug 4. doi: 10.1128/IAI.01447-07

PMCID:: PMC2546823

Abstract Article PDF–952K

Select item 33076011.

The serum and TPA responsive promoter and intron-exon structure of EGR2, a human early growth response gene encoding a zinc finger protein.

V M Rangnekar, A C Aplin, V P Sukhatme

Nucleic Acids Res. 1990 May 11; 18(9): 2749–2757. doi: 10.1093/nar/18.9.2749

PMCID:: PMC330760

Summary Page Browse PDF–2.6M

Select item 1050034212.

The transcription factor EGR2 controls homing and pathogenicity of T_H17 cells in the central nervous system

Yuanyuan Gao, Yan Wang, Daniel Chauss, Alejandro V. Villarino, Verena M. Link, Hiroyuki Nagashima, Camille A. Spinner, Vishal N. Koparde, Nicolas Bouladoux, Michael S. Abers, Timothy J. Break, Laura B. Chopp, Jung-Hyun Park, Jinfang Zhu, David L. Wiest, Warren J. Leonard, Michail S. Lionakis, John J. O’Shea, Behdad Afzali, Yasmine Belkaid, Vanja Lazarevic

Nat Immunol. Author manuscript; available in PMC 2023 Sep 14.

Published in final edited form as: Nat Immunol. 2023 Aug; 24(8): 1331–1344. Published online 2023 Jul 13. doi: 10.1038/s41590-023-01553-7

PMCID:: PMC10500342

Abstract Article PDF–2.6M

Select item 880669513.

MicroRNA-17-5p inhibits thyroid cancer progression by suppressing Early growth response 2 (EGR2)

Xiang Geng, YangYang Sun, JinJin Fu, Liang Cao, Yuan Li

Bioengineered. 2021; 12(1): 2713–2722. Published online 2021 Jun 15. doi: 10.1080/21655979.2021.1935137

PMCID:: PMC8806695

Abstract Article PDF–3.4M

Select item 761221614.

The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair

Jack McCowan, Frédéric Fercoq, Phoebe M. Kirkwood, Wouter T’Jonck, Lizi M. Hegarty, Connar M. Mawer, Richard Cunningham, Ananda S. Mirchandani, Anna Hoy, Duncan C. Humphries, Gareth-Rhys Jones, Carsten G. Hansen, Nik Hirani, Stephen J. Jenkins, Sandrine Henri, Bernard Malissen, Sarah R. Walmsley, David H. Dockrell, Philippa T. K. Saunders, Leo M. Carlin, Calum C. Bain

Sci Immunol. Author manuscript; available in PMC 2022 Jan 13.

Published in final edited form as: Sci Immunol. 2021 Nov 19; 6(65): eabj2132. Published online 2021 Nov 19. doi: 10.1126/sciimmunol.abj2132