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Select item 89224341.

Estrogen induced apoptosis in breast cancers is phenocopied by blocking dephosphorylation of eukaryotic initiation factor 2 alpha (eIF2α) protein.

Surojeet Sengupta, Catherine M Sevigny, Poulomi Bhattacharya, V Craig Jordan, Robert Clarke

Mol Cancer Res. Author manuscript; available in PMC 2022 Mar 15.

Published in final edited form as: Mol Cancer Res. 2019 Apr; 17(4): 918–928. Published online 2019 Jan 17. doi: 10.1158/1541-7786.MCR-18-0481

PMCID:: PMC8922434

Abstract Article PDF–2.8M

Select item 63291032.

Translational control mechanisms in cutaneous malignant melanoma: the role of eIF2α

Immacolata Maida, Paola Zanna, Stefania Guida, Anna Ferretta, Tiziana Cocco, Luigi Leonardo Palese, Paola Londei, Dario Benelli, Amalia Azzariti, Stefania Tommasi, Michele Guida, Giovanni Pellacani, Gabriella Guida

J Transl Med. 2019; 17: 20. Published online 2019 Jan 11. doi: 10.1186/s12967-019-1772-z

PMCID:: PMC6329103

Abstract Article PDF–1.5M

Select item 55241543.

Single amino acid substitution in LC-CDR1 induces Russell body phenotype that attenuates cellular protein synthesis through eIF2α phosphorylation and thereby downregulates IgG secretion despite operational secretory pathway traffic

Haruki Hasegawa, Ann Hsu, Christine E. Tinberg, Karen E. Siegler, Aaron A. Nazarian, Mei-Mei Tsai

MAbs. 2017 Jul; 9(5): 854–873. Published online 2017 Apr 5. doi: 10.1080/19420862.2017.1314875

PMCID:: PMC5524154

Abstract Article PDF–2.9M

Select item 53536354.

Phosphorylated eIF2α predicts disease-free survival in triple-negative breast cancer patients

Liang Guo, Yayun Chi, Jingyan Xue, Linxiaoxi Ma, Zhiming Shao, Jiong Wu

Sci Rep. 2017; 7: 44674. Published online 2017 Mar 15. doi: 10.1038/srep44674

PMCID:: PMC5353635

Abstract Article PDF–1.1M

Select item 53467465.

Increased phosphorylation of eIF2α in chronic myeloid leukemia cells stimulates secretion of matrix modifying enzymes

Paulina Podszywalow-Bartnicka, Anna Cmoch, Magdalena Wolczyk, Lukasz Bugajski, Marta Tkaczyk, Michal Dadlez, Margaret Nieborowska-Skorska, Antonis E. Koromilas, Tomasz Skorski, Katarzyna Piwocka

Oncotarget. 2016 Nov 29; 7(48): 79706–79721. Published online 2016 Oct 27. doi: 10.18632/oncotarget.12941

PMCID:: PMC5346746

Abstract Article PDF–4.1M

Select item 52954446.

Elevated eukaryotic elongation factor 2 expression is involved in proliferation and invasion of lung squamous cell carcinoma

Yang Song, Bing Sun, LiHong Hao, Jun Hu, Sha Du, Xin Zhou, LiYuan Zhang, Lu Liu, LinLin Gong, XinMing Chi, Qiang Liu, ShuJuan Shao

Oncotarget. 2016 Sep 6; 7(36): 58470–58482. Published online 2016 Aug 16. doi: 10.18632/oncotarget.11298

PMCID:: PMC5295444

Abstract Article PDF–4.0M

Select item 46360667.

EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition

Chiara Zucal, Vito G. D’Agostino, Antonio Casini, Barbara Mantelli, Natthakan Thongon, Debora Soncini, Irene Caffa, Michele Cea, Alberto Ballestrero, Alessandro Quattrone, Stefano Indraccolo, Alessio Nencioni, Alessandro Provenzani

BMC Cancer. 2015; 15: 855. Published online 2015 Nov 5. doi: 10.1186/s12885-015-1845-1

PMCID:: PMC4636066

Abstract Article PDF–2.0M

Select item 43659778.

Residues required for phosphorylation of translation initiation factor eIF2α under diverse stress conditions are divergent between yeast and human

Mithu Majumder, Daniel Mitchell, Sergei Merkulov, Jing Wu, Bo-Jhih Guan, Martin D. Snider, Dawid Krokowski, Vivien C. Yee, Maria Hatzoglou

Int J Biochem Cell Biol. Author manuscript; available in PMC 2016 Feb 1.

Published in final edited form as: Int J Biochem Cell Biol. 2015 Feb; 59: 135–141. Published online 2014 Dec 22. doi: 10.1016/j.biocel.2014.12.004

PMCID:: PMC4365977

Abstract Article PDF–1.2M

Select item 41761229.

6-Shogaol induces apoptosis in human leukemia cells through a process involving caspase-mediated cleavage of eIF2α

Qun Liu, Yong-Bo Peng, Ping Zhou, Lian-Wen Qi, Mu Zhang, Ning Gao, E-Hu Liu, Ping Li

Mol Cancer. 2013; 12: 135. Published online 2013 Nov 12. doi: 10.1186/1476-4598-12-135

PMCID:: PMC4176122

Abstract Article PDF–3.4M

Select item 372418710.

Eukaryotic initiation factor 2α phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism

Cynthia K. Hahn, Christopher H. Lowrey

Blood. 2013 Jul 25; 122(4): 477–485. Prepublished online 2013 May 20. doi: 10.1182/blood-2013-03-491043

PMCID:: PMC3724187

Abstract Article

Select item 316554611.

Inhibition of Nonsense-Mediated RNA Decay by the Tumor Microenvironment Promotes Tumorigenesis

Ding Wang, Jiri Zavadil, Leenus Martin, Fabio Parisi, Eugene Friedman, David Levy, Heather Harding, David Ron, Lawrence B. Gardner

Mol Cell Biol. 2011 Sep; 31(17): 3670–3680. doi: 10.1128/MCB.05704-11

PMCID:: PMC3165546

Abstract Article PDF–2.5M

Select item 313705412.

ICP34.5 Protein of Herpes Simplex Virus Facilitates the Initiation of Protein Translation by Bridging Eukaryotic Initiation Factor 2α (eIF2α) and Protein Phosphatase 1

Yapeng Li, Cuizhu Zhang, Xiangdong Chen, Jia Yu, Yu Wang, Yin Yang, Mingjuan Du, Huali Jin, Yijie Ma, Bin He, Youjia Cao

J Biol Chem. 2011 Jul 15; 286(28): 24785–24792. Published online 2011 May 26. doi: 10.1074/jbc.M111.232439

PMCID:: PMC3137054

Abstract Article PDF–1.7M

Select item 311933513.

Gene Expression and Integrated Stress Response in HepG2/C3A cells Cultured in Amino Acid Deficient Medium

Angelos K. Sikalidis, Jeong-In Lee, Martha H. Stipanuk

Amino Acids. Author manuscript; available in PMC 2012 Jun 1.

Published in final edited form as: Amino Acids. 2011 Jun; 41(1): 159–171. Published online 2010 Apr 2. doi: 10.1007/s00726-010-0571-x

PMCID:: PMC3119335

Abstract Article PDF–432K

Select item 311628014.

eIF2A mediates translation of hepatitis C viral mRNA under stress conditions

Joon Hyun Kim, Sung Mi Park, Ji Hoon Park, Sun Ju Keum, Sung Key Jang

EMBO J. 2011 Jun 15; 30(12): 2454–2464. Published online 2011 May 10. doi: 10.1038/emboj.2011.146

PMCID:: PMC3116280

Abstract Article PDF–690K

Select item 291127615.

Respiratory Syncytial Virus Limits α Subunit of Eukaryotic Translation Initiation Factor 2 (eIF2α) Phosphorylation to Maintain Translation and Viral Replication

Dayna J. Groskreutz, Ellen C. Babor, Martha M. Monick, Steven M. Varga, Gary W. Hunninghake

J Biol Chem. 2010 Jul 30; 285(31): 24023–24031. Published online 2010 Jun 2. doi: 10.1074/jbc.M109.077321

PMCID:: PMC2911276

Abstract Article PDF–2.3M

Select item 284858016.

eIF5A Promotes Translation Elongation, Polysome Disassembly and Stress Granule Assembly

Chi Ho Li, Takbum Ohn, Pavel Ivanov, Sarah Tisdale, Paul Anderson

PLoS One. 2010; 5(4): e9942. Published online 2010 Apr 1. doi: 10.1371/journal.pone.0009942

PMCID:: PMC2848580

Abstract Article PDF–1.3M

Select item 272665117.

Inhibition of eIF2α Dephosphorylation Maximizes Bortezomib Efficiency and Eliminates Quiescent Multiple Myeloma Cells Surviving Proteasome Inhibitor Therapy

Denis M. Schewe, Julio A. Aguirre-Ghiso

Cancer Res. Author manuscript; available in PMC 2010 Feb 15.

Published in final edited form as: Cancer Res. 2009 Feb 15; 69(4): 1545–1552. Published online 2009 Feb 3. doi: 10.1158/0008-5472.CAN-08-3858

PMCID:: PMC2726651

Abstract Article PDF–892K

Select item 216877318.

Adeno-Associated Viruses Can Induce Phosphorylation of eIF2α via PKR Activation, Which Can Be Overcome by Helper Adenovirus Type 5 Virus-Associated RNA

Ramnath Nayak, David J. Pintel

J Virol. 2007 Nov; 81(21): 11908–11916. Published online 2007 Aug 22. doi: 10.1128/JVI.01132-07

PMCID:: PMC2168773

Abstract Article PDF–334K

Select item 163534219.

Inhibition of Ribosome Recruitment Induces Stress Granule Formation Independently of Eukaryotic Initiation Factor 2α Phosphorylation

Rachid Mazroui, Rami Sukarieh, Marie-Eve Bordeleau, Randal J. Kaufman, Peter Northcote, Junichi Tanaka, Imed Gallouzi, Jerry Pelletier

Mol Biol Cell. 2006 Oct; 17(10): 4212–4219. doi: 10.1091/mbc.E06-04-0318

PMCID:: PMC1635342

Abstract Article PDF–989K

Select item 146421220.

Exercise rapidly increases eukaryotic elongation factor 2 phosphorylation in skeletal muscle of men

Adam J Rose, Christa Broholm, Kristian Kiillerich, Stephen G Finn, Christopher G Proud, Mark H Rider, Erik A Richter, Bente Kiens

J Physiol. 2005 Nov 15; 569(Pt 1): 223–228. Published online 2005 Oct 6. doi: 10.1113/jphysiol.2005.097154

PMCID:: PMC1464212

Abstract Article PDF–164K

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