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Select item 74623511.

Multifunnel Energy Landscapes for Phosphorylated Translation Repressor 4E-BP2 and Its Mutants

Wei Kang, Fan Jiang, Yun-Dong Wu, David J. Wales

J Chem Theory Comput. 2020 Jan 14; 16(1): 800–810. Published online 2019 Nov 27. doi: 10.1021/acs.jctc.9b01042

PMCID:: PMC7462351

Abstract Article PDF–6.7M

Select item 110941362.

mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism

Tal Levy, Kai Voeltzke, Laura Hruby, Khawla Alasad, Zuelal Bas, Marteinn Snaebjörnsson, Ran Marciano, Katerina Scharov, Mélanie Planque, Kim Vriens, Stefan Christen, Cornelius M. Funk, Christina Hassiepen, Alisa Kahler, Beate Heider, Daniel Picard, Jonathan K. M. Lim, Anja Stefanski, Katja Bendrin, Andres Vargas-Toscano, Ulf D. Kahlert, Kai Stühler, Marc Remke, Moshe Elkabets, Thomas G. P. Grünewald, Andreas S. Reichert, Sarah-Maria Fendt, Almut Schulze, Guido Reifenberger, Barak Rotblat, Gabriel Leprivier

Nat Commun. 2024; 15: 4083. Published online 2024 May 14. doi: 10.1038/s41467-024-48386-y

PMCID:: PMC11094136

Abstract Article PDF–2.0M

Select item 106412273.

4EBP2-regulated protein translation has a critical role in high-fat diet–induced insulin resistance in hepatocytes

Xiao Han, Fei Yang, Zhengyi Zhang, Zhanwu Hou, Qiong Sun, Tian Su, Weiqiang Lv, Zhen Wang, Chao Yuan, Guanfei Zhang, Xin Pi, Jiangang Long, Huadong Liu

J Biol Chem. 2023 Nov; 299(11): 105315. Published online 2023 Oct 4. doi: 10.1016/j.jbc.2023.105315

PMCID:: PMC10641227

Abstract Article PDF–4.2M

Select item 64108044.

Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation

Brian Tsang, Jason Arsenault, Robert M. Vernon, Hong Lin, Nahum Sonenberg, Lu-Yang Wang, Alaji Bah, Julie D. Forman-Kay

Proc Natl Acad Sci U S A. 2019 Mar 5; 116(10): 4218–4227. Published online 2019 Feb 14. doi: 10.1073/pnas.1814385116

PMCID:: PMC6410804

Abstract Article PDF–1.3M

Select item 28852205.

Repair of Isoaspartate Formation Modulates the Interaction of Deamidated 4E-BP2 with mTORC1 in Brain

Michael Bidinosti, Yvan Martineau, Filipp Frank, Nahum Sonenberg

J Biol Chem. 2010 Jun 18; 285(25): 19402–19408. Published online 2010 Apr 27. doi: 10.1074/jbc.M110.120774

PMCID:: PMC2885220

Abstract Article PDF–607K

Select item 2307466.

The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins.

S Mader, H Lee, A Pause, N Sonenberg

Mol Cell Biol. 1995 Sep; 15(9): 4990–4997. doi: 10.1128/mcb.15.9.4990

PMCID:: PMC230746

Summary PDF–336K

Select item 1356127.

Caspase Cleavage of Initiation Factor 4E-Binding Protein 1 Yields a Dominant Inhibitor of Cap-Dependent Translation and Reveals a Novel Regulatory Motif

Andrew R. Tee, Christopher G. Proud

Mol Cell Biol. 2002 Mar; 22(6): 1674–1683. doi: 10.1128/MCB.22.6.1674-1683.2002

PMCID:: PMC135612

Abstract Article PDF–448K

Select item 190328.

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

Patrick E. Burnett, Roxanne K. Barrow, Noam A. Cohen, Solomon H. Snyder, David M. Sabatini

Proc Natl Acad Sci U S A. 1998 Feb 17; 95(4): 1432–1437. doi: 10.1073/pnas.95.4.1432

PMCID:: PMC19032

Abstract Article PDF–401K

Select item 69153279.

Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity

Stella Kouloulia, Erik I. Hallin, Konstanze Simbriger, Inês S. Amorim, Gilliard Lach, Theoklitos Amvrosiadis, Kleanthi Chalkiadaki, Agniete Kampaite, Vinh Tai Truong, Mehdi Hooshmandi, Seyed Mehdi Jafarnejad, Paul Skehel, Petri Kursula, Arkady Khoutorsky, Christos G. Gkogkas

Cell Rep. 2019 Dec 10; 29(11): 3620–3635.e7. Published online 2019 Dec 10. doi: 10.1016/j.celrep.2019.11.023

PMCID:: PMC6915327

Abstract Article

Select item 268138210.

The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response

R. Sukarieh, N. Sonenberg, J. Pelletier

Am J Physiol Cell Physiol. 2009 May; 296(5): C1207–C1217. Published online 2009 Feb 25. doi: 10.1152/ajpcell.00511.2008

PMCID:: PMC2681382

Abstract Article

Select item 286154711.

Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission

Michael Bidinosti, Israeli Ran, Maria R. Sanchez-Carbente, Yvan Martineau, Anne-Claude Gingras, Christos Gkogkas, Brian Raught, Clive Bramham, Wayne S. Sossin, Mauro Costa-Mattioli, Luc DesGroseillers, Jean-Claude Lacaille, Nahum Sonenberg

Mol Cell. Author manuscript; available in PMC 2010 Sep 26.

Published in final edited form as: Mol Cell. 2010 Mar 26; 37(6): 797–808. doi: 10.1016/j.molcel.2010.02.022

PMCID:: PMC2861547

Abstract Article PDF–2.4M

Select item 613866012.

rec-YnH enables simultaneous many-by-many detection of direct protein–protein and protein–RNA interactions

Jae-Seong Yang, Mireia Garriga-Canut, Nele Link, Carlo Carolis, Katrina Broadbent, Violeta Beltran-Sastre, Luis Serrano, Sebastian P. Maurer

Nat Commun. 2018; 9: 3747. Published online 2018 Sep 14. doi: 10.1038/s41467-018-06128-x

PMCID:: PMC6138660

Abstract Article PDF–1.9M

Select item 290029513.

Evaluation of Candidate Stromal Epithelial Cross-Talk Genes Identifies Association between Risk of Serous Ovarian Cancer and TERT, a Cancer Susceptibility “Hot-Spot”

Sharon E. Johnatty, Jonathan Beesley, Xiaoqing Chen, Stuart Macgregor, David L. Duffy, Amanda B. Spurdle, Anna deFazio, Natalie Gava, Penelope M. Webb, Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer), Mary Anne Rossing, Jennifer Anne Doherty, Marc T. Goodman, Galina Lurie, Pamela J. Thompson, Lynne R. Wilkens, Roberta B. Ness, Kirsten B. Moysich, Jenny Chang-Claude, Shan Wang-Gohrke, Daniel W. Cramer, Kathryn L. Terry, Susan E. Hankinson, Shelley S. Tworoger, Montserrat Garcia-Closas, Hannah Yang, Jolanta Lissowska, Stephen J. Chanock, Paul D. Pharoah, Honglin Song, Alice S. Whitemore, Celeste L. Pearce, Daniel O. Stram, Anna H. Wu, Malcolm C. Pike, Simon A. Gayther, Susan J. Ramus, Usha Menon, Aleksandra Gentry-Maharaj, Hoda Anton-Culver, Argyrios Ziogas, Estrid Hogdall, Susanne K. Kjaer, Claus Hogdall, Andrew Berchuck, Joellen M. Schildkraut, Edwin S. Iversen, Patricia G. Moorman, Catherine M. Phelan, Thomas A. Sellers, Julie M. Cunningham, Robert A. Vierkant, David N. Rider, Ellen L. Goode, Izhak Haviv, Georgia Chenevix-Trench, Ovarian Cancer Association Consortium

PLoS Genet. 2010 Jul; 6(7): e1001016. Published online 2010 Jul 8. doi: 10.1371/journal.pgen.1001016

PMCID:: PMC2900295

Abstract Article PDF–587K

Select item 379029214.

Bcl2-associated Athanogene 3 Interactome Analysis Reveals a New Role in Modulating Proteasome Activity

Ying Chen, Li-Na Yang, Li Cheng, Shun Tu, Shu-Juan Guo, Huang-Ying Le, Qian Xiong, Ran Mo, Chong-Yang Li, Jun-Seop Jeong, Lizhi Jiang, Seth Blackshaw, Li-Jun Bi, Heng Zhu, Sheng-Ce Tao, Feng Ge

Mol Cell Proteomics. 2013 Oct; 12(10): 2804–2819. Published online 2013 Jul 3. doi: 10.1074/mcp.M112.025882

PMCID:: PMC3790292

Abstract Article PDF–2.6M

Select item 399653715.

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism

Roser Corominas, Xinping Yang, Guan Ning Lin, Shuli Kang, Yun Shen, Lila Ghamsari, Martin Broly, Maria Rodriguez, Stanley Tam, Shelly A. Wanamaker, Changyu Fan, Song Yi, Murat Tasan, Irma Lemmens, Xingyan Kuang, Nan Zhao, Dheeraj Malhotra, Jacob J. Michaelson, Vladimir Vacic, Michael A. Calderwood, Frederick P. Roth, Jan Tavernier, Steve Horvath, Kourosh Salehi-Ashtiani, Dmitry Korkin, Jonathan Sebat, David E. Hill, Tong Hao, Marc Vidal, Lilia M. Iakoucheva

Nat Commun. 2014; 5: 3650. Published online 2014 Apr 11. doi: 10.1038/ncomms4650

Correction in:: Nat Commun. 2023; 14: 569.

PMCID:: PMC3996537

Abstract Article PDF–1.9M

Select item 138022516.

A Scan of Chromosome 10 Identifies a Novel Locus Showing Strong Association with Late-Onset Alzheimer Disease

Andrew Grupe, Yonghong Li, Charles Rowland, Petra Nowotny, Anthony L. Hinrichs, Scott Smemo, John S. K. Kauwe, Taylor J. Maxwell, Sara Cherny, Lisa Doil, Kristina Tacey, Ryan van Luchene, Amanda Myers, Fabienne Wavrant-De Vrièze, Mona Kaleem, Paul Hollingworth, Luke Jehu, Catherine Foy, Nicola Archer, Gillian Hamilton, Peter Holmans, Chris M. Morris, Joseph Catanese, John Sninsky, Thomas J. White, John Powell, John Hardy, Michael O’Donovan, Simon Lovestone, Lesley Jones, John C. Morris, Leon Thal, Michael Owen, Julie Williams, Alison Goate

Am J Hum Genet. 2006 Jan; 78(1): 78–88. Published online 2005 Nov 15. doi: 10.1086/498851

PMCID:: PMC1380225

Abstract Article PDF–329K

Select item 674264617.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Abstract Article PDF–1.2M

Select item 268304718.

Ubiquitin-mediated proteolysis of HuR by heat shock

Kotb Abdelmohsen, Subramanya Srikantan, Xiaoling Yang, Ashish Lal, Hyeon Ho Kim, Yuki Kuwano, Stefanie Galban, Kevin G Becker, Davida Kamara, Rafael de Cabo, Myriam Gorospe

EMBO J. 2009 May 6; 28(9): 1271–1282. Published online 2009 Mar 26. doi: 10.1038/emboj.2009.67

PMCID:: PMC2683047

Abstract Article PDF–1.4M

Select item 294516819.

Variation at the NFATC2 Locus Increases the Risk of Thiazolidinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study

Swneke D. Bailey, Changchun Xie, Ron Do, Alexandre Montpetit, Rafael Diaz, Viswanathan Mohan, Bernard Keavney, Salim Yusuf, Hertzel C. Gerstein, James C. Engert, Sonia Anand, on behalf of the DREAM investigators

Diabetes Care. 2010 Oct; 33(10): 2250–2253. Published online 2010 Jul 13. doi: 10.2337/dc10-0452

PMCID:: PMC2945168

Abstract Article PDF–153K

Select item 277583220.

Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip

Philippa J. Talmud, Fotios Drenos, Sonia Shah, Tina Shah, Jutta Palmen, Claudio Verzilli, Tom R. Gaunt, Jacky Pallas, Ruth Lovering, Kawah Li, Juan Pablo Casas, Reecha Sofat, Meena Kumari, Santiago Rodriguez, Toby Johnson, Stephen J. Newhouse, Anna Dominiczak, Nilesh J. Samani, Mark Caulfield, Peter Sever, Alice Stanton, Denis C. Shields, on behalf of the ASCOT investigators, Sandosh Padmanabhan, Olle Melander, Claire Hastie, Christian Delles, on behalf of the NORDIL investigators, Shah Ebrahim, Michael G. Marmot, George Davey Smith, Debbie A. Lawlor, Patricia B. Munroe, for the BRIGHT Consortium, Ian N. Day, Mika Kivimaki, John Whittaker, Steve E. Humphries, Aroon D. Hingorani

Am J Hum Genet. 2009 Nov 13; 85(5): 628–642. doi: 10.1016/j.ajhg.2009.10.014

PMCID:: PMC2775832

Abstract Article PDF–2.8M

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