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Select item 100033661.

SPRED2: A Novel Regulator of Epithelial-Mesenchymal Transition and Stemness in Hepatocellular Carcinoma Cells

Tong Gao, Xu Yang, Masayoshi Fujisawa, Toshiaki Ohara, Tianyi Wang, Nahoko Tomonobu, Masakiyo Sakaguchi, Teizo Yoshimura, Akihiro Matsukawa

Int J Mol Sci. 2023 Mar; 24(5): 4996. Published online 2023 Mar 5. doi: 10.3390/ijms24054996

PMCID:: PMC10003366

Abstract Article PDF–3.3M

Select item 77845652.

miR-19 Promotes Cell Proliferation, Invasion, Migration, and EMT by Inhibiting SPRED2-mediated Autophagy in Osteosarcoma Cells

Chuhai Xie, Shengyao Liu, Boyi Wu, Yu Zhao, Binwei Chen, Jianhong Guo, ShouHong Qiu, Yan-ming Cao

Cell Transplant. 2020 Jan-Dec; 29: 0963689720962460. Published online 2020 Oct 6. doi: 10.1177/0963689720962460

PMCID:: PMC7784565

Abstract Article PDF–2.8M

Select item 72516563.

Spred2 inhibits epithelial-mesenchymal transition of colorectal cancer cells by impairing ERK signaling

Hao Wang, Shuchen Liu, Fanxuan Kong, Fengjun Xiao, Yuxiang Li, Hua Wang, Shun Zhang, Dandan Huang, Lisheng Wang, Yuefeng Yang

Oncol Rep. 2020 Jul; 44(1): 174–185. Published online 2020 Apr 16. doi: 10.3892/or.2020.7586

PMCID:: PMC7251656

Abstract Article PDF–3.1M

Select item 43314234.

Spred2 Modulates the Erythroid Differentiation Induced by Imatinib in Chronic Myeloid Leukemia Cells

Yuefeng Yang, Xiaoyun Liu, Fengjun Xiao, Shuya Xue, Qinqin Xu, Yue Yin, Huiyan Sun, Jie Xu, Hengxiang Wang, Qunwei Zhang, Hua Wang, Lisheng Wang

PLoS One. 2015; 10(2): e0117573. Published online 2015 Feb 17. doi: 10.1371/journal.pone.0117573

PMCID:: PMC4331423

Abstract Article PDF–1.1M

Select item 111727225.

SPRED2 Is a Novel Regulator of Autophagy in Hepatocellular Carcinoma Cells and Normal Hepatocytes

Tianyi Wang, Tong Gao, Masayoshi Fujisawa, Toshiaki Ohara, Masakiyo Sakaguchi, Teizo Yoshimura, Akihiro Matsukawa

Int J Mol Sci. 2024 Jun; 25(11): 6269. Published online 2024 Jun 6. doi: 10.3390/ijms25116269

PMCID:: PMC11172722

Abstract Article PDF–3.2M

Select item 102485536.

The ribosomal S6 kinase 2 (RSK2)–SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling

Jocelyne Lopez, Daniel A. Bonsor, Matthew J. Sale, Anatoly Urisman, Jennifer L. Mehalko, Miranda Cabanski-Dunning, Pau Castel, Dhirendra K. Simanshu, Frank McCormick

J Biol Chem. 2023 Jun; 299(6): 104789. Published online 2023 May 5. doi: 10.1016/j.jbc.2023.104789

PMCID:: PMC10248553

Abstract Article PDF–3.1M

Select item 50419347.

Tumor suppressor Spred2 interaction with LC3 promotes autophagosome maturation and induces autophagy-dependent cell death

Ke Jiang, Min Liu, Guibin Lin, Beibei Mao, Wei Cheng, Han Liu, Jozsef Gal, Haining Zhu, Zengqiang Yuan, Wuguo Deng, Quentin Liu, Peng Gong, Xiaolin Bi, Songshu Meng

Oncotarget. 2016 May 3; 7(18): 25652–25667. Published online 2016 Mar 25. doi: 10.18632/oncotarget.8357

PMCID:: PMC5041934

Abstract Article PDF–12M

Select item 35935308.

Evidence for downregulation of the negative regulator SPRED2 in clinical prostate cancer

N Kachroo, T Valencia, A Y Warren, V J Gnanapragasam

Br J Cancer. 2013 Feb 19; 108(3): 597–601. Published online 2012 Nov 20. doi: 10.1038/bjc.2012.507

PMCID:: PMC3593530

Abstract Article PDF–316K

Select item 30430579.

Sprouty2 and Spred1-2 Proteins Inhibit the Activation of the ERK Pathway Elicited by Cyclopentenone Prostanoids

Carlota A. García-Domínguez, Natalia Martínez, Teresa Gragera, Andrea Pérez-Rodríguez, Diana Retana, Gonzalo León, Agustín Sánchez, José Luis Oliva, Dolores Pérez-Sala, José M. Rojas

PLoS One. 2011; 6(2): e16787. Published online 2011 Feb 22. doi: 10.1371/journal.pone.0016787

PMCID:: PMC3043057

Abstract Article PDF–571K

Select item 221330110.

Spred-2 Suppresses Aorta-Gonad-Mesonephros Hematopoiesis by Inhibiting MAP Kinase Activation

Ikuo Nobuhisa, Reiko Kato, Hirofumi Inoue, Makiko Takizawa, Keisuke Okita, Akihiko Yoshimura, Tetsuya Taga

J Exp Med. 2004 Mar 1; 199(5): 737–742. doi: 10.1084/jem.20030830

PMCID:: PMC2213301

Abstract Article PDF–313K

Select item 113895111.

Distinct requirements for the Sprouty domain for functional activity of Spred proteins

James A. J. King, Andrew F. L. Straffon, Giovanna M. D'Abaco, Carole L. C. Poon, Stacey T. T. I, Craig M. Smith, Michael Buchert, Niall M. Corcoran, Nathan E. Hall, Bernard A. Callus, Boris Sarcevic, Daniel Martin, Peter Lock, Christopher M. Hovens

Biochem J. 2005 Jun 1; 388(Pt 2): 445–454. Prepublished online 2005 Jan 31. Published online 2005 May 24. doi: 10.1042/BJ20041284

PMCID:: PMC1138951

Abstract Article PDF–615K

Select item 276883512.

Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling

Faraz K. Mardakheh, Mona Yekezare, Laura M. Machesky, John K. Heath

J Cell Biol. 2009 Oct 19; 187(2): 265–277. doi: 10.1083/jcb.200905118

PMCID:: PMC2768835

Abstract Article PDF–3.1M

Select item 859589913.

SPRED2 loss-of-function causes a recessive Noonan syndrome-like phenotype

Marialetizia Motta, Giulia Fasano, Sina Gredy, Julia Brinkmann, Adeline Alice Bonnard, Pelin Ozlem Simsek-Kiper, Elif Yilmaz Gulec, Leila Essaddam, Gulen Eda Utine, Ingrid Guarnetti Prandi, Martina Venditti, Francesca Pantaleoni, Francesca Clementina Radio, Andrea Ciolfi, Stefania Petrini, Federica Consoli, Cédric Vignal, Denis Hepbasli, Melanie Ullrich, Elke de Boer, Lisenka E.L.M. Vissers, Sami Gritli, Cesare Rossi, Alessandro De Luca, Saayda Ben Becher, Bruce D. Gelb, Bruno Dallapiccola, Antonella Lauri, Giovanni Chillemi, Kai Schuh, Hélène Cavé, Martin Zenker, Marco Tartaglia

Am J Hum Genet. 2021 Nov 4; 108(11): 2112–2129. Published online 2021 Oct 8. doi: 10.1016/j.ajhg.2021.09.007

PMCID:: PMC8595899

Abstract Article PDF–2.6M

Select item 444989014.

Cosuppression of Sprouty and Sprouty-Related Negative Regulators of FGF Signalling in Prostate Cancer: A Working Hypothesis

Stephen J. Assinder, Daniella Beniamen, Frank J. Lovicu

Biomed Res Int. 2015; 2015: 827462. Published online 2015 May 17. doi: 10.1155/2015/827462

PMCID:: PMC4449890

Abstract Article PDF–6.3M

Select item 297516115.

Direct Association of Sprouty-related Protein with an EVH1 Domain (SPRED) 1 or SPRED2 with DYRK1A Modifies Substrate/Kinase Interactions

Dan Li, Rebecca A. Jackson, Permeen Yusoff, Graeme R. Guy

J Biol Chem. 2010 Nov 12; 285(46): 35374–35385. Published online 2010 Aug 24. doi: 10.1074/jbc.M110.148445

PMCID:: PMC2975161

Abstract Article PDF–3.1M

Select item 304468516.

Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci

Alexandra Zhernakova, Eli A. Stahl, Gosia Trynka, Soumya Raychaudhuri, Eleanora A. Festen, Lude Franke, Harm-Jan Westra, Rudolf S. N. Fehrmann, Fina A. S. Kurreeman, Brian Thomson, Namrata Gupta, Jihane Romanos, Ross McManus, Anthony W. Ryan, Graham Turner, Elisabeth Brouwer, Marcel D. Posthumus, Elaine F. Remmers, Francesca Tucci, Rene Toes, Elvira Grandone, Maria Cristina Mazzilli, Anna Rybak, Bozena Cukrowska, Marieke J. H. Coenen, Timothy R. D. J. Radstake, Piet L. C. M. van Riel, Yonghong Li, Paul I. W. de Bakker, Peter K. Gregersen, Jane Worthington, Katherine A. Siminovitch, Lars Klareskog, Tom W. J. Huizinga, Cisca Wijmenga, Robert M. Plenge

PLoS Genet. 2011 Feb; 7(2): e1002004. Published online 2011 Feb 24. doi: 10.1371/journal.pgen.1002004

PMCID:: PMC3044685

Abstract Article PDF–421K

Select item 424384017.

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

Eli A. Stahl, Soumya Raychaudhuri, Elaine F. Remmers, Gang Xie, Stephen Eyre, Brian P. Thomson, Yonghong Li, Fina A. S. Kurreeman, Alexandra Zhernakova, Anne Hinks, Candace Guiducci, Robert Chen, Lars Alfredsson, Christopher I. Amos, Kristin G. Ardlie, BIRAC Consortium, Anne Barton, John Bowes, Elisabeth Brouwer, Noel P. Burtt, Joseph J. Catanese, Jonathan Coblyn, Marieke JH Coenen, Karen H. Costenbader, Lindsey A. Criswell, J. Bart A. Crusius, Jing Cui, Paul I.W. de Bakker, Phillip L. De Jager, Bo Ding, Paul Emery, Edward Flynn, Pille Harrison, Lynne J. Hocking, Tom W. J. Huizinga, Daniel L. Kastner, Xiayi Ke, Annette T. Lee, Xiangdong Liu, Paul Martin, Ann W. Morgan, Leonid Padyukov, Marcel D. Posthumus, Timothy RDJ Radstake, David M. Reid, Mark Seielstad, Michael F. Seldin, Nancy A. Shadick, Sophia Steer, Paul P. Tak, Wendy Thomson, Annette H. M. van der Helm-van Mil, Irene E. van der Horst-Bruinsma, C. Ellen van der Schoot, Piet LCM van Riel, Michael E. Weinblatt, Anthony G. Wilson, Gert Jan Wolbink, Paul Wordsworth, YEAR Consortium, Cisca Wijmenga, Elizabeth W. Karlson, Rene E. M. Toes, Niek de Vries, Ann B. Begovich, Jane Worthington, Katherine A. Siminovitch, Peter K. Gregersen, Lars Klareskog, Robert M. Plenge

Nat Genet. Author manuscript; available in PMC 2014 Nov 25.

Published in final edited form as: Nat Genet. 2010 Jun; 42(6): 508–514. Published online 2010 May 9. doi: 10.1038/ng.582

PMCID:: PMC4243840

Abstract Article PDF–748K

Select item 394409818.

Genetics of rheumatoid arthritis contributes to biology and drug discovery

Yukinori Okada, Di Wu, Gosia Trynka, Towfique Raj, Chikashi Terao, Katsunori Ikari, Yuta Kochi, Koichiro Ohmura, Akari Suzuki, Shinji Yoshida, Robert R. Graham, Arun Manoharan, Ward Ortmann, Tushar Bhangale, Joshua C. Denny, Robert J. Carroll, Anne E. Eyler, Jeffrey D. Greenberg, Joel M. Kremer, Dimitrios A. Pappas, Lei Jiang, Jian Yin, Lingying Ye, Ding-Feng Su, Jian Yang, Gang Xie, Ed Keystone, Harm-Jan Westra, Tõnu Esko, Andres Metspalu, Xuezhong Zhou, Namrata Gupta, Daniel Mirel, Eli A. Stahl, Dorothée Diogo, Jing Cui, Katherine Liao, Michael H. Guo, Keiko Myouzen, Takahisa Kawaguchi, Marieke J.H. Coenen, Piet L.C.M. van Riel, Mart A.F.J. van de Laar, Henk-Jan Guchelaar, Tom W.J. Huizinga, Philippe Dieudé, Xavier Mariette, S. Louis Bridges, Jr., Alexandra Zhernakova, Rene E.M. Toes, Paul P. Tak, Corinne Miceli-Richard, So-Young Bang, Hye-Soon Lee, Javier Martin, Miguel A. Gonzalez-Gay, Luis Rodriguez-Rodriguez, Solbritt Rantapää-Dahlqvist, Lisbeth Ärlestig, Hyon K. Choi, Yoichiro Kamatani, Pilar Galan, Mark Lathrop, the RACI consortium, the GARNET consortium, Steve Eyre, John Bowes, Anne Barton, Niek de Vries, Larry W. Moreland, Lindsey A. Criswell, Elizabeth W. Karlson, Atsuo Taniguchi, Ryo Yamada, Michiaki Kubo, Jun S. Liu, Sang-Cheol Bae, Jane Worthington, Leonid Padyukov, Lars Klareskog, Peter K. Gregersen, Soumya Raychaudhuri, Barbara E. Stranger, Philip L. De Jager, Lude Franke, Peter M. Visscher, Matthew A. Brown, Hisashi Yamanaka, Tsuneyo Mimori, Atsushi Takahashi, Huji Xu, Timothy W. Behrens, Katherine A. Siminovitch, Shigeki Momohara, Fumihiko Matsuda, Kazuhiko Yamamoto, Robert M. Plenge

Nature. Author manuscript; available in PMC 2014 Aug 20.

Published in final edited form as: Nature. 2014 Feb 20; 506(7488): 376–381. Published online 2013 Dec 25. doi: 10.1038/nature12873

PMCID:: PMC3944098

Abstract Article PDF–1.9M

Select item 328162819.

Cytoplasmic Metadherin (MTDH) Provides Survival Advantage under Conditions of Stress by Acting as RNA-binding Protein

Xiangbing Meng, Danlin Zhu, Shujie Yang, Xinjun Wang, Zhi Xiong, Yuping Zhang, Pavla Brachova, Kimberly K. Leslie

J Biol Chem. 2012 Feb 10; 287(7): 4485–4491. Published online 2011 Dec 23. doi: 10.1074/jbc.C111.291518

PMCID:: PMC3281628

Abstract Article PDF–2.0M

Select item 408237220.

The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease

Stefanie L. Butland, Shaun S. Sanders, Mandi E. Schmidt, Sean-Patrick Riechers, David T.S. Lin, Dale D.O. Martin, Kuljeet Vaid, Rona K. Graham, Roshni R. Singaraja, Erich E. Wanker, Elizabeth Conibear, Michael R. Hayden

Hum Mol Genet. 2014 Aug 1; 23(15): 4142–4160. Published online 2014 Apr 4. doi: 10.1093/hmg/ddu137

PMCID:: PMC4082372

Abstract Article PDF–1.7M

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