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Select item 97115281.

Unleashing a novel function of Endonuclease G in mitochondrial genome instability

Sumedha Dahal, Humaira Siddiqua, Shivangi Sharma, Ravi K Babu, Diksha Rathore, Sheetal Sharma, Sathees C Raghavan

eLife. 2022; 11: e69916. Published online 2022 Nov 17. doi: 10.7554/eLife.69916

PMCID:: PMC9711528

Abstract Article PDF–6.0M

Select item 86323132.

Autophagy restricts mitochondrial DNA damage-induced release of ENDOG (endonuclease G) to regulate genome stability

Tung Chao, Hsueh-Tzu Shih, Shih-Chin Hsu, Pei-Jer Chen, Yu-Shan Fan, Yung-Ming Jeng, Zhao-Qing Shen, Ting-Fen Tsai, Zee-Fen Chang

Autophagy. 2021; 17(11): 3444–3460. Published online 2021 Jan 19. doi: 10.1080/15548627.2021.1874209

PMCID:: PMC8632313

Abstract Article PDF–16M

Select item 59150743.

Endonuclease G promotes mitochondrial genome cleavage and replication

Rahel Stefanie Wiehe, Boris Gole, Laurent Chatre, Paul Walther, Enrico Calzia, Miria Ricchetti, Lisa Wiesmüller

Oncotarget. 2018 Apr 6; 9(26): 18309–18326. Published online 2018 Apr 6. doi: 10.18632/oncotarget.24822

Correction in:: Oncotarget. 2018 Jun 12; 9(45): 27908.

PMCID:: PMC5915074

Abstract Article PDF–5.3M

Select item 43088264.

Novel Cytoprotective Inhibitors for Apoptotic Endonuclease G

Dae Song Jang, Narsimha R. Penthala, Eugene O. Apostolov, Xiaoying Wang, Peter A. Crooks, Alexei G. Basnakian

DNA Cell Biol. 2015 Feb 1; 34(2): 92–100. doi: 10.1089/dna.2014.2530

PMCID:: PMC4308826

Abstract Article PDF–581K

Select item 26535145.

Mutagenesis identifies the critical amino acid residues of human endonuclease G involved in catalysis, magnesium coordination, and substrate specificity

Shih-Lu Wu, Chia-Cheng Li, Jaw-Chyun Chen, Yi-Jin Chen, Ching-Ting Lin, Tin-Yun Ho, Chien-Yun Hsiang

J Biomed Sci. 2009; 16(1): 6. Published online 2009 Jan 15. doi: 10.1186/1423-0127-16-6

PMCID:: PMC2653514

Abstract Article PDF–802K

Select item 18399476.

Endonuclease G promotes cell death of non-invasive human breast cancer cells

Alexei G. Basnakian, Eugene O. Apostolov, Xiaoyan Yin, Stanley O. Abiri, Anna G. Stewart, Amar B. Singh, Sudhir V. Shah

Exp Cell Res. Author manuscript; available in PMC 2007 Dec 10.

Published in final edited form as: Exp Cell Res. 2006 Dec 10; 312(20): 4139–4149. Published online 2006 Sep 20. doi: 10.1016/j.yexcr.2006.09.012

PMCID:: PMC1839947

Abstract Article PDF–990K

Select item 42459377.

Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination

Adam B. Robertson, Julia Robertson, Markus Fusser, Arne Klungland

Nucleic Acids Res. 2014 Dec 1; 42(21): 13280–13293. Published online 2014 Oct 29. doi: 10.1093/nar/gku1032

PMCID:: PMC4245937

Abstract Article PDF–546K

Select item 38449538.

Endonuclease G mediates α-synuclein cytotoxicity during Parkinson’s disease

Sabrina Büttner, Lukas Habernig, Filomena Broeskamp, Doris Ruli, F Nora Vögtle, Manolis Vlachos, Francesca Macchi, Victoria Küttner, Didac Carmona-Gutierrez, Tobias Eisenberg, Julia Ring, Maria Markaki, Asli Aras Taskin, Stefan Benke, Christoph Ruckenstuhl, Ralf Braun, Chris Van den Haute, Tine Bammens, Anke van der Perren, Kai-Uwe Fröhlich, Joris Winderickx, Guido Kroemer, Veerle Baekelandt, Nektarios Tavernarakis, Gabor G Kovacs, Jörn Dengjel, Chris Meisinger, Stephan J Sigrist, Frank Madeo

EMBO J. 2013 Nov 27; 32(23): 3041–3054. Published online 2013 Oct 15. doi: 10.1038/emboj.2013.228

PMCID:: PMC3844953

Abstract Article PDF–2.2M

Select item 38073749.

Mitochondrial Nucleases ENDOG and EXOG Participate in Mitochondrial DNA Depletion Initiated by Herpes Simplex Virus 1 UL12.5

Brett A. Duguay, James R. Smiley

J Virol. 2013 Nov; 87(21): 11787–11797. doi: 10.1128/JVI.02306-13

PMCID:: PMC3807374

Abstract Article PDF–3.2M

Select item 430928810.

Apoptotic death of striatal neurons induced by HIV-1 Tat and gp120: differential involvement of caspase-3 and endonuclease G

Indrapal N. Singh, Robin J. Goody, Celeste Dean, Nael M. Ahmad, Sarah E. Lutz, Pamela E. Knapp, Avindra Nath, Kurt F. Hauser

J Neurovirol. Author manuscript; available in PMC 2015 Jan 28.

Published in final edited form as: J Neurovirol. 2004 Jun; 10(3): 141–151. doi: 10.1080/13550280490441103

PMCID:: PMC4309288

Abstract Article PDF–3.1M

Select item 369854811.

CHIP has a protective role against oxidative stress-induced cell death through specific regulation of Endonuclease G

J S Lee, T W Seo, J H Yi, K S Shin, S J Yoo

Cell Death Dis. 2013 Jun; 4(6): e666. Published online 2013 Jun 13. doi: 10.1038/cddis.2013.181

PMCID:: PMC3698548

Abstract Article PDF–3.2M

Select item 781783312.

Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response

Wenjun Wang, Jianshuang Li, Junyang Tan, Miaomiao Wang, Jing Yang, Zhi-Min Zhang, Chuanzhou Li, Alexei G. Basnakian, Hong-Wen Tang, Norbert Perrimon, Qinghua Zhou

Nat Commun. 2021; 12: 476. Published online 2021 Jan 20. doi: 10.1038/s41467-020-20780-2

PMCID:: PMC7817833

Abstract Article PDF–6.3M

Select item 424998013.

The Proapoptotic Protein BNIP3 Interacts with VDAC to Induce Mitochondrial Release of Endonuclease G

Xiaosha Zhang, Xiuwu Bian, Jiming Kong

PLoS One. 2014; 9(12): e113642. Published online 2014 Dec 1. doi: 10.1371/journal.pone.0113642

PMCID:: PMC4249980

Abstract Article PDF–4.6M

Select item 347278314.

Ethyl Gallate Induces Apoptosis of HL-60 Cells by Promoting the Expression of Caspases-8, -9, -3, Apoptosis-Inducing Factor and Endonuclease G

Woong-Hyun Kim, Hyun-Ok Song, Hwa-Jung Choi, Ho-Il Bang, Du-Young Choi, Hyun Park

Int J Mol Sci. 2012; 13(9): 11912–11922. Published online 2012 Sep 20. doi: 10.3390/ijms130911912

PMCID:: PMC3472783

Abstract Article PDF–1.2M

Select item 391296215.

Impact of promoter polymorphisms in key regulators of the intrinsic apoptosis pathway on the outcome of childhood acute lymphoblastic leukemia

Rocio Sanchez, Janick St-Cyr, Marie-Eve Lalonde, Jasmine Healy, Chantal Richer, Vincent Gagné, Caroline Laverdière, Lewis B. Silverman, Stephen E. Sallan, Donna Neuberg, Jeffery L. Kutok, Ekaterini A. Kritikou, Maja Krajinovic, Daniel Sinnett

Haematologica. 2014 Feb; 99(2): 314–321. doi: 10.3324/haematol.2013.085340

PMCID:: PMC3912962

Abstract Article PDF–1002K

Select item 291777716.

No death without life: vital functions of apoptotic effectors

L Galluzzi, N Joza, E Tasdemir, MC Maiuri, M Hengartner, JM Abrams, N Tavernarakis, J Penninger, F Madeo, G Kroemer

Cell Death Differ. Author manuscript; available in PMC 2010 Aug 9.

Published in final edited form as: Cell Death Differ. 2008 Jul; 15(7): 1113–1123. Published online 2008 Feb 29. doi: 10.1038/cdd.2008.28

PMCID:: PMC2917777

Abstract Article PDF–347K

Select item 301760217.

Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing

Wenyi Wang, Peidong Shen, Sreedevi Thiyagarajan, Shengrong Lin, Curtis Palm, Rita Horvath, Thomas Klopstock, David Cutler, Lynn Pique, Iris Schrijver, Ronald W. Davis, Michael Mindrinos, Terence P. Speed, Curt Scharfe

Nucleic Acids Res. 2011 Jan; 39(1): 44–58. Published online 2010 Sep 15. doi: 10.1093/nar/gkq750

PMCID:: PMC3017602

Abstract Article PDF–1.4M

Select item 410454418.

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways

Mikko Taipale, George Tucker, Jian Peng, Irina Krykbaeva, Zhen-Yuan Lin, Brett Larsen, Hyungwon Choi, Bonnie Berger, Anne-Claude Gingras, Susan Lindquist

Cell. Author manuscript; available in PMC 2015 Jul 17.

Published in final edited form as: Cell. 2014 Jul 17; 158(2): 434–448. doi: 10.1016/j.cell.2014.05.039

PMCID:: PMC4104544

Abstract Article PDF–3.2M

Select item 876007719.

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin

Dragomir B. Krastev, Shudong Li, Yilun Sun, Andrew J. Wicks, Gwendoline Hoslett, Daniel Weekes, Luned M. Badder, Eleanor G. Knight, Rebecca Marlow, Mercedes Calvo Pardo, Lu Yu, Tanaji T. Talele, Jiri Bartek, Jyoti S. Choudhary, Yves Pommier, Stephen J. Pettitt, Andrew N. J. Tutt, Kristijan Ramadan, Christopher J. Lord

Nat Cell Biol. 2022; 24(1): 62–73. Published online 2022 Jan 10. doi: 10.1038/s41556-021-00807-6

PMCID:: PMC8760077

Abstract Article PDF–12M

Select item 876907220.

Proteome‐scale mapping of binding sites in the unstructured regions of the human proteome

Caroline Benz, Muhammad Ali, Izabella Krystkowiak, Leandro Simonetti, Ahmed Sayadi, Filip Mihalic, Johanna Kliche, Eva Andersson, Per Jemth, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2022 Jan; 18(1): e10584. Published online 2022 Jan 19. doi: 10.15252/msb.202110584

PMCID:: PMC8769072

Abstract Article PDF–2.9M

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