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Items: 1 to 20 of 135

1.
Cardiac-Specific Deletion of Scn8a Mitigates Dravet Syndrome-Associated Sudden Death in Adults
D. Ryan King, Mustafa Demirtas, Mikhail Tarasov, Heather L. Struckman, Xiaolei Meng, Drew Nassal, Nicolae Moise, Alec Miller, Dennison Min, Andrew M. Soltisz, Midhun N.K. Anne, Patrícia A. Alves Dias, Jacy L. Wagnon, Seth H. Weinberg, Thomas J. Hund, Rengasayee Veeraraghavan, Przemysław B. Radwański
JACC Clin Electrophysiol. Author manuscript; available in PMC 2024 Jul 29.
Published in final edited form as: JACC Clin Electrophysiol. 2024 May; 10(5): 829–842. Published online 2024 Feb 28. doi: 10.1016/j.jacep.2024.01.003
PMCID:
PMC11285447
AbstractArticlePDF–3.3M
2.
Clinical and electrophysiological features of SCN8A variants causing episodic or chronic ataxia
Hang Lyu, Christian M. Boßelmann, Katrine M. Johannesen, Mahmoud Koko, Juan Dario Ortigoza-Escobar, Sergio Aguilera-Albesa, Deyanira Garcia-Navas Núñez, Tarja Linnankivi, Eija Gaily, Henriette J.A. van Ruiten, Ruth Richardson, Cornelia Betzler, Gabriella Horvath, Eva Brilstra, Niels Geerdink, Daniele Orsucci, Alessandra Tessa, Elena Gardella, Zofia Fleszar, Ludger Schöls, Holger Lerche, Rikke S. Møller, Yuanyuan Liu
eBioMedicine. 2023 Dec; 98: 104855. Published online 2023 Oct 28. doi: 10.1016/j.ebiom.2023.104855
PMCID:
PMC10628346
AbstractArticlePDF–2.8M
3.
Social Deficits and Cerebellar Degeneration in Purkinje Cell Scn8a Knockout Mice
Xiaofan Yang, Hongqiang Yin, Xiaojing Wang, Yueqing Sun, Xianli Bian, Gaorui Zhang, Anning Li, Aihua Cao, Baomin Li, Darius Ebrahimi-Fakhari, Zhuo Yang, Miriam H. Meisler, Qiji Liu
Front Mol Neurosci. 2022; 15: 822129. Published online 2022 Apr 26. doi: 10.3389/fnmol.2022.822129
PMCID:
PMC9087741
AbstractArticlePDF–3.8M
4.
NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats
JP Johnson, Thilo Focken, Kuldip Khakh, Parisa Karimi Tari, Celine Dube, Samuel J Goodchild, Jean-Christophe Andrez, Girish Bankar, David Bogucki, Kristen Burford, Elaine Chang, Sultan Chowdhury, Richard Dean, Gina de Boer, Shannon Decker, Christoph Dehnhardt, Mandy Feng, Wei Gong, Michael Grimwood, Abid Hasan, Angela Hussainkhel, Qi Jia, Stephanie Lee, Jenny Li, Sophia Lin, Andrea Lindgren, Verner Lofstrand, Janette Mezeyova, Rostam Namdari, Karen Nelkenbrecher, Noah Gregory Shuart, Luis Sojo, Shaoyi Sun, Matthew Taron, Matthew Waldbrook, Diana Weeratunge, Steven Wesolowski, Aaron Williams, Michael Wilson, Zhiwei Xie, Rhena Yoo, Clint Young, Alla Zenova, Wei Zhang, Alison J Cutts, Robin P Sherrington, Simon N Pimstone, Raymond Winquist, Charles J Cohen, James R Empfield
eLife. 2022; 11: e72468. Published online 2022 Mar 2. doi: 10.7554/eLife.72468
PMCID:
PMC8903829
AbstractArticlePDF–2.4M
5.
Peri-Ictal Autonomic Control of Cardiac Function and Seizure-Induced Death
Ian C. Wenker, Elizabeth A. Blizzard, Pravin K. Wagley, Manoj K. Patel
Front Neurosci. 2021; 15: 795145. Published online 2022 Jan 21. doi: 10.3389/fnins.2021.795145
PMCID:
PMC8813980
AbstractArticlePDF–3.6M
6.
Pathogenic in-Frame Variants in SCN8A: Expanding the Genetic Landscape of SCN8A-Associated Disease
Jennifer C. Wong, Kameryn M. Butler, Lindsey Shapiro, Jacquelyn T. Thelin, Kari A. Mattison, Kathryn B. Garber, Paula C. Goldenberg, Shobana Kubendran, G. Bradley Schaefer, Andrew Escayg
Front Pharmacol. 2021; 12: 748415. Published online 2021 Nov 17. doi: 10.3389/fphar.2021.748415
PMCID:
PMC8635767
AbstractArticlePDF–2.3M
7.
Autistic-like behavior, spontaneous seizures, and increased neuronal excitability in a Scn8a mouse model
Jennifer C. Wong, Steven F. Grieco, Karoni Dutt, Lujia Chen, Jacquelyn T. Thelin, George Andrew S. Inglis, Shangrila Parvin, Sandra M. Garraway, Xiangmin Xu, Alan L. Goldin, Andrew Escayg
Neuropsychopharmacology. 2021 Oct; 46(11): 2011–2020. Published online 2021 Mar 3. doi: 10.1038/s41386-021-00985-9
PMCID:
PMC8429750
AbstractArticlePDF–2.2M
8.
Mice Heterozygous for the Sodium Channel Scn8a (Nav1.6) Have Reduced Inflammatory Responses During EAE and Following LPS Challenge
Barakat Alrashdi, Bassel Dawod, Sabine Tacke, Stefanie Kuerten, Patrice D. Côté, Jean S. Marshall
Front Immunol. 2021; 12: 533423. Published online 2021 Mar 19. doi: 10.3389/fimmu.2021.533423
PMCID:
PMC8017164
AbstractArticlePDF–2.6M
9.
Adrenergic Mechanisms of Audiogenic Seizure-Induced Death in a Mouse Model of SCN8A Encephalopathy
Eric R. Wengert, Ian C. Wenker, Elizabeth L. Wagner, Pravin K. Wagley, Ronald P. Gaykema, Jung-Bum Shin, Manoj K. Patel
Front Neurosci. 2021; 15: 581048. Published online 2021 Mar 4. doi: 10.3389/fnins.2021.581048
PMCID:
PMC7982890
AbstractArticlePDF–3.6M
10.
Nav1.6 promotes inflammation and neuronal degeneration in a mouse model of multiple sclerosis
Barakat Alrashdi, Bassel Dawod, Andrea Schampel, Sabine Tacke, Stefanie Kuerten, Jean S. Marshall, Patrice D. Côté
J Neuroinflammation. 2019; 16: 215. Published online 2019 Nov 13. doi: 10.1186/s12974-019-1622-1
PMCID:
PMC6852902
AbstractArticlePDF–2.1M
11.
The Sodium Channel Scn8a Is the Major Contributor to the Postnatal Developmental Increase of Sodium Current Density in Spinal Motoneurons
Kelly D. García, Leslie K. Sprunger, Miriam H. Meisler, Kurt G. Beam
J Neurosci. 1998 Jul 15; 18(14): 5234–5239. doi: 10.1523/JNEUROSCI.18-14-05234.1998
PMCID:
PMC6793491
AbstractArticlePDF–136K
12.
Functional Analysis of the Mouse Scn8a Sodium Channel
Marianne R. Smith, Raymond D. Smith, Nicholas W. Plummer, Miriam H. Meisler, Alan L. Goldin
J Neurosci. 1998 Aug 15; 18(16): 6093–6102. doi: 10.1523/JNEUROSCI.18-16-06093.1998
PMCID:
PMC6793187
AbstractArticlePDF–211K
13.
A Role for Phosphorylation in the Maintenance of Resurgent Sodium Current in Cerebellar Purkinje Neurons
Tina M. Grieco, Fatemeh S. Afshari, Indira M. Raman
J Neurosci. 2002 Apr 15; 22(8): 3100–3107. doi: 10.1523/JNEUROSCI.22-08-03100.2002
PMCID:
PMC6757525
AbstractArticlePDF–268K
14.
Amyloid β-Induced Upregulation of Nav1.6 Underlies Neuronal Hyperactivity in Tg2576 Alzheimer’s Disease Mouse Model
Roselia Ciccone, Cristina Franco, Ilaria Piccialli, Francesca Boscia, Antonella Casamassa, Valeria de Rosa, Pasquale Cepparulo, Mauro Cataldi, Lucio Annunziato, Anna Pannaccione
Sci Rep. 2019; 9: 13592. Published online 2019 Sep 19. doi: 10.1038/s41598-019-50018-1
PMCID:
PMC6753212
AbstractArticlePDF–6.3M
15.
The Contribution of Resurgent Sodium Current to High-Frequency Firing in Purkinje Neurons: An Experimental and Modeling Study
Zayd M. Khaliq, Nathan W. Gouwens, Indira M. Raman
J Neurosci. 2003 Jun 15; 23(12): 4899–4912. doi: 10.1523/JNEUROSCI.23-12-04899.2003
PMCID:
PMC6741194
AbstractArticlePDF–605K
16.
Robustness of Burst Firing in Dissociated Purkinje Neurons with Acute or Long-Term Reductions in Sodium Conductance
Andrew M. Swensen, Bruce P. Bean
J Neurosci. 2005 Apr 6; 25(14): 3509–3520. doi: 10.1523/JNEUROSCI.3929-04.2005
PMCID:
PMC6725377
AbstractArticlePDF–556K
17.
Physiological Maturation of Photoreceptors Depends on the Voltage-Gated Sodium Channel NaV1.6 (Scn8a)
Patrice D. Côté, Yves De Repentigny, Stuart G. Coupland, Yannick Schwab, Michel J. Roux, S. Rock Levinson, Rashmi Kothary
J Neurosci. 2005 May 18; 25(20): 5046–5050. doi: 10.1523/JNEUROSCI.4692-04.2005
PMCID:
PMC6724868
AbstractArticlePDF–318K
18.
Impaired Firing and Cell-Specific Compensation in Neurons Lacking Nav1.6 Sodium Channels
Audra Van Wart, Gary Matthews
J Neurosci. 2006 Jul 5; 26(27): 7172–7180. doi: 10.1523/JNEUROSCI.1101-06.2006
PMCID:
PMC6673932
AbstractArticlePDF–628K
19.
Nav1.6 Sodium Channels Are Critical to Pacemaking and Fast Spiking in Globus Pallidus Neurons
Jeff N. Mercer, C. Savio Chan, Tatiana Tkatch, Joshua Held, D. James Surmeier
J Neurosci. 2007 Dec 5; 27(49): 13552–13566. doi: 10.1523/JNEUROSCI.3430-07.2007
PMCID:
PMC6673100
AbstractArticlePDF–3.5M
20.
A Missense Mutation in the Sodium Channel Scn8a Is Responsible for Cerebellar Ataxia in the Mouse Mutant jolting
David C. Kohrman, Marianne R. Smith, Alan L. Goldin, John Harris, Miriam H. Meisler
J Neurosci. 1996 Oct 1; 16(19): 5993–5999. doi: 10.1523/JNEUROSCI.16-19-05993.1996
Correction in:
J Neurosci. 2013 Mar 13; 33(11): 5079.
PMCID:
PMC6579185
AbstractArticlePDF–383K

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