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Select item 108440881.

SRSF2 mutation cooperates with ASXL1 truncated alteration to accelerate leukemogenesis

Pinpin Sui, Guo Ge, Shi Chen, Jiaojiao Bai, Ivan P. Rubalcava, Hui Yang, Ying Guo, Peng Zhang, Ying Li, Edward A. Medina, Mingjiang Xu, Omar Abdel-Wahab, Robert Bradley, Feng-Chun Yang

Leukemia. 2024; 38(2): 408–411. Published online 2023 Nov 28. doi: 10.1038/s41375-023-02094-6

PMCID:: PMC10844088

Article PDF–2.5M

Select item 106820232.

SRSF2 mutation reduces polycythemia and impairs hematopoietic progenitor functions in JAK2V617F-driven myeloproliferative neoplasm

Yue Yang, Salar Abbas, Mohammad A. Sayem, Avik Dutta, Golam Mohi

Blood Cancer J. 2023 Dec; 13(1): 171. Published online 2023 Nov 27. doi: 10.1038/s41408-023-00947-y

PMCID:: PMC10682023

Abstract Article PDF–2.7M

Select item 59570723.

The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations

Liang Chen, Jia-Yu Chen, Yi-Jou Huang, Ying Gu, Jinsong Qiu, Hao Qian, Changwei Shao, Xuan Zhang, Jing Hu, Hairi Li, Shunmin He, Yu Zhou, Omar Abdel-Wahab, Dong-Er Zhang, Xiang-Dong Fu

Mol Cell. Author manuscript; available in PMC 2018 May 17.

Published in final edited form as: Mol Cell. 2018 Feb 1; 69(3): 412–425.e6. Published online 2018 Jan 27. doi: 10.1016/j.molcel.2017.12.029

PMCID:: PMC5957072

Abstract Article PDF–1.2M

Select item 53556014.

A Cytoplasmic RNA Virus Alters the Function of the Cell Splicing Protein SRSF2

Efraín E. Rivera-Serrano, Ethan J. Fritch, Elizabeth H. Scholl, Barbara Sherry

J Virol. 2017 Apr 1; 91(7): e02488-16. Prepublished online 2017 Jan 11. Published online 2017 Mar 13. doi: 10.1128/JVI.02488-16

PMCID:: PMC5355601

Abstract Article PDF–4.7M

Select item 48991915.

Modulation of splicing catalysis for therapeutic targeting of leukemias with spliceosomal mutations

Stanley Chun-Wei Lee, Heidi Dvinge, Eunhee Kim, Hana Cho, Jean-Baptiste Micol, Young Rock Chung, Benjamin H. Durham, Akihide Yoshimi, Young Joon Kim, Michael Thomas, Camille Lobry, Chun-Wei Chen, Alessandro Pastore, Justin Taylor, Xujun Wang, Andrei Krivtsov, Scott A. Armstrong, James Palacino, Silvia Buonamici, Peter G. Smith, Robert K. Bradley, Omar Abdel-Wahab

Nat Med. Author manuscript; available in PMC 2016 Nov 2.

Published in final edited form as: Nat Med. 2016 Jun; 22(6): 672–678. Published online 2016 May 2. doi: 10.1038/nm.4097

Correction in:: Nat Med. 2016 Jun 7; 22(6): 692.

PMCID:: PMC4899191

Abstract Article PDF–1.3M

Select item 44299206.

SRSF2 Mutations Contribute to Myelodysplasia Through Mutant-Specific Effects on Exon Recognition

Eunhee Kim, Janine O. Ilagan, Yang Liang, Gerrit M. Daubner, Stanley C.-W. Lee, Aravind Ramakrishnan, Yue Li, Young Rock Chung, Jean-Baptiste Micol, Michele Murphy, Hana Cho, Min-Kyung Hana, Ahmad S. Zebari, Shlomzion Aumann, Christopher Y. Park, Silvia Buonamici, Peter G. Smith, H. Joachim Deeg, Camille Lobry, Iannis Aifantis, Yorgo Modis, Frederic H.-T. Allain, Stephanie Halene, Robert K. Bradley, Omar Abdel-Wahab

Cancer Cell. Author manuscript; available in PMC 2016 May 11.

Published in final edited form as: Cancer Cell. 2015 May 11; 27(5): 617–630. doi: 10.1016/j.ccell.2015.04.006

PMCID:: PMC4429920

Abstract Article PDF–2.6M

Select item 3075407.

Repositioning of Muscle-specific Genes Relative to the Periphery of SC-35 Domains during Skeletal Myogenesis

Phillip T. Moen, Jr., Carol Villnave Johnson, Meg Byron, Lindsay S. Shopland, Ivana L. de la Serna, Anthony N. Imbalzano, Jeanne Bentley Lawrence

Mol Biol Cell. 2004 Jan; 15(1): 197–206. doi: 10.1091/mbc.E03-06-0388

PMCID:: PMC307540

Abstract Article PDF–621K

Select item 500238.

Molecular cloning and characterization of additional factors that bind to the interferon-alpha/beta response element B of the murine (2'-5')oligoadenylate synthetase ME-12 gene.

C Yan, I Tamm

Proc Natl Acad Sci U S A. 1992 Oct 1; 89(19): 8859–8863. doi: 10.1073/pnas.89.19.8859

PMCID:: PMC50023

Summary Page Browse PDF–1.2M

Select item 111785359.

A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies

Xiaolei Liu, Sudhish A. Devadiga, Robert F. Stanley, Ryan M. Morrow, Kevin A. Janssen, Mathieu Quesnel-Vallières, Oz Pomp, Adam A. Moverley, Chenchen Li, Nicolas Skuli, Martin Carroll, Jian Huang, Douglas C. Wallace, Kristen W. Lynch, Omar Abdel-Wahab, Peter S. Klein

J Clin Invest. 2024 Jun 17; 134(12): e175619. Published online 2024 May 7. doi: 10.1172/JCI175619

PMCID:: PMC11178535

Abstract Article PDF–3.7M

Select item 1059137710.

SRSF2 is required for mRNA splicing during spermatogenesis

Wen-Long Lei, Zongchang Du, Tie-Gang Meng, Ruibao Su, Yuan-Yuan Li, Wenbo Liu, Si-Min Sun, Meng-Yu Liu, Yi Hou, Chun-Hui Zhang, Yaoting Gui, Heide Schatten, Zhiming Han, Chenli Liu, Fei Sun, Zhen-Bo Wang, Wei-Ping Qian, Qing-Yuan Sun

BMC Biol. 2023; 21: 231. Published online 2023 Oct 23. doi: 10.1186/s12915-023-01736-6

PMCID:: PMC10591377

Abstract Article PDF–9.5M

Select item 1026602211.

Ablation of ZC3H11A causes early embryonic lethality and dysregulation of metabolic processes

Shady Younis, Alice Jouneau, Mårten Larsson, Jean-Francois Oudin, Pierre Adenot, Jihad Omar, Vincent Brochard, Leif Andersson

Proc Natl Acad Sci U S A. 2023 Jun 6; 120(23): e2216799120. Published online 2023 May 30. doi: 10.1073/pnas.2216799120

PMCID:: PMC10266022

Abstract Article PDF–3.2M

Select item 977248712.

RUNX1 deficiency cooperates with SRSF2 mutation to induce multilineage hematopoietic defects characteristic of MDS

Yi-Jou Huang, Jia-Yu Chen, Ming Yan, Amanda G. Davis, Sayuri Miyauchi, Liang Chen, Yajing Hao, Sigrid Katz, Rafael Bejar, Omar Abdel-Wahab, Xiang-Dong Fu, Dong-Er Zhang

Blood Adv. 2022 Dec 13; 6(23): 6078–6092. Published online 2022 Oct 10. doi: 10.1182/bloodadvances.2022007804

PMCID:: PMC9772487

Abstract Article PDF–2.1M

Select item 900627513.

Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2^P95H mutation

Jane Jialu Xu, Alistair M. Chalk, Iva Nikolic, Kaylene J. Simpson, Monique F. Smeets, Carl R. Walkley

Blood Adv. 2022 Apr 12; 6(7): 2092–2106. Published online 2022 Mar 30. doi: 10.1182/bloodadvances.2021004571

PMCID:: PMC9006275

Abstract Article PDF–2.3M

Select item 588828514.

Physiological Srsf2 P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice

Ayana Kon, Satoshi Yamazaki, Yasuhito Nannya, Keisuke Kataoka, Yasunori Ota, Masahiro Marshall Nakagawa, Kenichi Yoshida, Yusuke Shiozawa, Maiko Morita, Tetsuichi Yoshizato, Masashi Sanada, Manabu Nakayama, Haruhiko Koseki, Hiromitsu Nakauchi, Seishi Ogawa

Blood. 2018 Feb 8; 131(6): 621–635. Prepublished online 2017 Nov 16. doi: 10.1182/blood-2017-01-762393

PMCID:: PMC5888285

Abstract Article

Select item 452530915.

SRSF2 Is Essential for Hematopoiesis, and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing

Yukiko Komeno, Yi-Jou Huang, Jinsong Qiu, Leo Lin, YiJun Xu, Yu Zhou, Liang Chen, Dora D. Monterroza, Hairi Li, Russell C. DeKelver, Ming Yan, Xiang-Dong Fu, Dong-Er Zhang

Mol Cell Biol. 2015 Sep; 35(17): 3071–3082. Prepublished online 2015 Jun 29. Published online 2015 Aug 4. doi: 10.1128/MCB.00202-15

PMCID:: PMC4525309

Abstract Article PDF–2.3M

Select item 364035616.

Genome-wide Analysis Reveals SR Protein Cooperation and Competition in Regulated Splicing

Shatakshi Pandit, Yu Zhou, Lily Shiue, Gabriela Coutinho-Mansfield, Hairi Li, Jinsong Qiu, Jie Huang, Gene W. Yeo, Manuel Ares, Jr., Xiang-Dong Fu

Mol Cell. Author manuscript; available in PMC 2014 Apr 25.

Published in final edited form as: Mol Cell. 2013 Apr 25; 50(2): 223–235. Published online 2013 Apr 4. doi: 10.1016/j.molcel.2013.03.001

PMCID:: PMC3640356

Abstract Article PDF–2.2M

Select item 271499817.

UBE2I (UBC9), a SUMO-Conjugating Enzyme, Localizes to Nuclear Speckles and Stimulates Transcription in Mouse Oocytes

Motomasa Ihara, Paula Stein, Richard M. Schultz

Biol Reprod. 2008 Nov; 79(5): 906–913. Prepublished online 2008 Aug 13. doi: 10.1095/biolreprod.108.070474

PMCID:: PMC2714998

Abstract Article PDF–4.6M

Select item 195209218.

Splicing Regulator SC35 Is Essential for Genomic Stability and Cell Proliferation during Mammalian Organogenesis

Ran Xiao, Ye Sun, Jian-Hua Ding, Shengrong Lin, Dave W. Rose, Michael G. Rosenfeld, Xiang-Dong Fu, Xue Li

Mol Cell Biol. 2007 Aug; 27(15): 5393–5402. Published online 2007 May 25. doi: 10.1128/MCB.00288-07

PMCID:: PMC1952092

Abstract Article PDF–882K

Select item 1009766819.

Inflammatory signals from fatty bone marrow support DNMT3A driven clonal hematopoiesis

N. Zioni, A. Akhiad Bercovich, N. Chapal-Ilani, Tal Bacharach, N. Rappoport, A. Solomon, R. Avraham, E. Kopitman, Z. Porat, M. Sacma, G. Hartmut, M. Scheller, C. Muller-Tidow, D. Lipka, E. Shlush, M. Minden, N. Kaushansky, Liran I. Shlush

Nat Commun. 2023; 14: 2070. Published online 2023 Apr 12. doi: 10.1038/s41467-023-36906-1

PMCID:: PMC10097668

Abstract Article PDF–7.3M

Select item 720075220.

Loss of SRSF2 triggers hepatic progenitor cell activation and tumor development in mice

Chang Zhang, Lei Shen, Wei Yuan, Yuguo Liu, Ruochen Guo, Yangjun Luo, Zheng Zhan, Zhiqin Xie, Guohao Wu, Wenwu Wu, Ying Feng

Commun Biol. 2020; 3: 210. Published online 2020 May 5. doi: 10.1038/s42003-020-0893-5

PMCID:: PMC7200752

Abstract Article PDF–3.6M

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PMC Links for Gene (Select 20382) (76)
PMC
PREDICTED: Mus musculus serine and arginine-rich splicing factor 2 (Srsf2), tran...
PREDICTED: Mus musculus serine and arginine-rich splicing factor 2 (Srsf2), transcript variant X5, misc_RNA
gi|1907080720|ref|XR_003949365.2|

Nucleotide
multiple C2 and transmembrane domain-containing protein 2 isoform X3 [Mus muscul...
multiple C2 and transmembrane domain-containing protein 2 isoform X3 [Mus musculus]
gi|755521044|ref|XP_011249166.1|

Protein
laccase 17 [Arabidopsis thaliana]
laccase 17 [Arabidopsis thaliana]
gi|1063742281|ref|NP_001330991.1|

Protein
Mus musculus serine and arginine-rich splicing factor 2 (Srsf2), mRNA
Mus musculus serine and arginine-rich splicing factor 2 (Srsf2), mRNA
gi|226958315|ref|NM_011358.2|

Nucleotide

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