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Select item 111588441.

EphA4 receptor, overexpressed in pancreatic ductal adenocarcinoma, promotes cancer cell growth

Megumi Iiizumi, Masayo Hosokawa, Akio Takehara, Suyoun Chung, Toru Nakamura, Toyomasa Katagiri, Hidetoshi Eguchi, Hiroaki Ohigashi, Osamu Ishikawa, Yusuke Nakamura, Hidewaki Nakagawa

Cancer Sci. 2006 Nov; 97(11): 1211–1216. Published online 2006 Sep 5. doi: 10.1111/j.1349-7006.2006.00313.x

PMCID:: PMC11158844

Abstract Article PDF–225K

Select item 82608792.

A cancer mutation promotes EphA4 oligomerization and signaling by altering the conformation of the SAM domain

Taylor P. Light, Maricel Gomez-Soler, Zichen Wang, Kelly Karl, Elmer Zapata-Mercado, Marina P. Gehring, Bernhard C. Lechtenberg, Taras V. Pogorelov, Kalina Hristova, Elena B. Pasquale

J Biol Chem. 2021 Jul; 297(1): 100876. Published online 2021 Jun 15. doi: 10.1016/j.jbc.2021.100876

PMCID:: PMC8260879

Abstract Article PDF–4.2M

Select item 79806273.

Exosomal miR-106b-5p derived from melanoma cell promotes primary melanocytes epithelial-mesenchymal transition through targeting EphA4

Wenkang Luan, Yuting Ding, Haolan Xi, Hongru Ruan, Feng Lu, Shaojun Ma, Jinlong Wang

J Exp Clin Cancer Res. 2021; 40: 107. Published online 2021 Mar 19. doi: 10.1186/s13046-021-01906-w

PMCID:: PMC7980627

Abstract Article PDF–12M

Select item 68440684.

Peripheral loss of EphA4 ameliorates TBI-induced neuroinflammation and tissue damage

Elizabeth A. Kowalski, Jiang Chen, Amanda Hazy, Lauren E. Fritsch, Erwin Kristobal Gudenschwager-Basso, Michael Chen, Xia Wang, Yun Qian, Mingjun Zhou, Matthew Byerly, Alicia M. Pickrell, John B. Matson, Irving Coy Allen, Michelle H. Theus

J Neuroinflammation. 2019; 16: 210. Published online 2019 Nov 11. doi: 10.1186/s12974-019-1605-2

PMCID:: PMC6844068

Abstract Article PDF–3.1M

Select item 63812845.

Ephrin Receptor A4 is a New Kaposi’s Sarcoma-Associated Herpesvirus Virus Entry Receptor

Jia Chen, Xianming Zhang, Samantha Schaller, Theodore S. Jardetzky, Richard Longnecker

mBio. 2019 Jan-Feb; 10(1): e02892-18. Published online 2019 Feb 19. doi: 10.1128/mBio.02892-18

PMCID:: PMC6381284

Abstract Article PDF–1.7M

Select item 56702076.

Transforming Growth Factor-beta Regulation of Ephrin Type-A Receptor 4 Signaling in Breast Cancer Cellular Migration

Ibrahim Y. Hachim, Manuel Villatoro, Lucie Canaff, Mahmood Y. Hachim, Julien Boudreault, Halema Haiub, Suhad Ali, Jean-Jacques Lebrun

Sci Rep. 2017; 7: 14976. Published online 2017 Nov 3. doi: 10.1038/s41598-017-14549-9

Correction in:: Sci Rep. 2022; 12: 21613.

PMCID:: PMC5670207

Abstract Article PDF–4.5M

Select item 47416467.

EPHA4 is overexpressed but not functionally active in Sézary syndrome

Liesbeth Hameetman, Leslie van der Fits, Willem H. Zoutman, Jacoba J. Out-Luiting, Gregg Siegal, Iwan J.P. de Esch, Maarten H. Vermeer, Cornelis P. Tensen

Oncotarget. 2015 Oct 13; 6(31): 31868–31876. Published online 2015 Sep 10. doi: 10.18632/oncotarget.5573

PMCID:: PMC4741646

Abstract Article PDF–1.6M

Select item 34382838.

Global evaluation of Eph receptors and ephrins in lung adenocarcinomas identifies EphA4 as an inhibitor of cell migration and invasion

Pierre Saintigny, Shaohua Peng, Li Zhang, Banibrata Sen, Ignacio I. Wistuba, Scott M. Lippman, Luc Girard, John D. Minna, John V. Heymach, Faye M. Johnson

Mol Cancer Ther. Author manuscript; available in PMC 2013 Sep 1.

Published in final edited form as: Mol Cancer Ther. 2012 Sep; 11(9): 2021–2032. Published online 2012 Jul 17. doi: 10.1158/1535-7163.MCT-12-0030

PMCID:: PMC3438283

Abstract Article PDF–1.2M

Select item 29490579.

Crystal Structure of the ligand-binding domain of the promiscuous EphA4 receptor reveals two distinct conformations

Nikhil Singla, Yehuda Goldgur, Kai Xu, Sari Paavilainen, Dimitar B. Nikolov, Juha P. Himanen

Biochem Biophys Res Commun. Author manuscript; available in PMC 2011 Sep 3.

Published in final edited form as: Biochem Biophys Res Commun. 2010 Sep 3; 399(4): 555–559. Published online 2010 Aug 1. doi: 10.1016/j.bbrc.2010.07.109

PMCID:: PMC2949057

Abstract Article PDF–557K

Select item 274819810.

Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers

Mariko Oki, Hiroyuki Yamamoto, Hiroaki Taniguchi, Yasushi Adachi, Kohzoh Imai, Yasuhisa Shinomura

World J Gastroenterol. 2008 Oct 7; 14(37): 5650–5656. Published online 2008 Oct 7. doi: 10.3748/wjg.14.5650

PMCID:: PMC2748198

Abstract Article PDF–864K

Select item 117497311.

Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets

Nicolas Prévost, Donna S. Woulfe, Hong Jiang, Timothy J. Stalker, Patrizia Marchese, Zaverio M. Ruggeri, Lawrence F. Brass

Proc Natl Acad Sci U S A. 2005 Jul 12; 102(28): 9820–9825. Published online 2005 Jul 1. doi: 10.1073/pnas.0404065102

PMCID:: PMC1174973

Abstract Article PDF–461K

Select item 492438012.

EphA4‐deleted microenvironment regulates cancer development and leukemoid reaction of the isografted 4T1 murine breast cancer via reduction of an IGF1 signal

Xuefeng Jing, Takashi Sonoki, Masayasu Miyajima, Takahiro Sawada, Nanako Terada, Shigeki Takemura, Kazushige Sakaguchi

Cancer Med. 2016 Jun; 5(6): 1214–1227. Published online 2016 Feb 29. doi: 10.1002/cam4.670

PMCID:: PMC4924380

Abstract Article PDF–1.0M

Select item 376751713.

Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5

Kai Xu, Dorothea Tzvetkova-Robev, Yan Xu, Yehuda Goldgur, Yee-Peng Chan, Juha P. Himanen, Dimitar B. Nikolov

Proc Natl Acad Sci U S A. 2013 Sep 3; 110(36): 14634–14639. Published online 2013 Aug 19. doi: 10.1073/pnas.1311000110

PMCID:: PMC3767517

Abstract Article PDF–1.6M

Select item 356052314.

Eph-A2 and Eph-A4 expression in human benign and malignant thyroid lesions: An immunohistochemical study

Nikolaos P. Karidis, Constantinos Giaginis, Gerasimos Tsourouflis, Paraskevi Alexandrou, Ioanna Delladetsima, Stamatios Theocharis

Med Sci Monit. 2011; 17(9): BR257–BR265. Published online 2011 Sep 1. doi: 10.12659/MSM.881929

PMCID:: PMC3560523

Abstract Article PDF–1.2M

Select item 988868115.

Suppression of KSHV lytic replication and primary effusion lymphoma by selective RNF5 inhibition

Xiaojuan Li, Fan Wang, Xiaolin Zhang, Qinqin Sun, Ersheng Kuang

PLoS Pathog. 2023 Jan; 19(1): e1011103. Published online 2023 Jan 19. doi: 10.1371/journal.ppat.1011103

PMCID:: PMC9888681

Abstract Article PDF–5.6M

Select item 394102116.

Structurally encoded intraclass differences in EphA clusters drive distinct cell responses

Elena Seiradake, Andreas Schaupp, Daniel del Toro Ruiz, Rainer Kaufmann, Nikolaos Mitakidis, Karl Harlos, A Radu Aricescu, Rüdiger Klein, E Yvonne Jones

Nat Struct Mol Biol. Author manuscript; available in PMC 2014 Mar 4.

Published in final edited form as: Nat Struct Mol Biol. 2013 Aug; 20(8): 958–964. Published online 2013 Jun 30. doi: 10.1038/nsmb.2617

PMCID:: PMC3941021

Abstract Article PDF–2.7M

Select item 550160517.

Molecular interactions of EphA4, growth hormone receptor, Janus kinase 2, and signal transducer and activator of transcription 5B

Takahiro Sawada, Daiki Arai, Xuefeng Jing, Masayasu Miyajima, Stuart J. Frank, Kazushige Sakaguchi

PLoS One. 2017; 12(7): e0180785. Published online 2017 Jul 7. doi: 10.1371/journal.pone.0180785

PMCID:: PMC5501605

Abstract Article PDF–3.1M

Select item 283273518.

Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin Signaling

Thomas A. Bowden, A. Radu Aricescu, Joanne E. Nettleship, Christian Siebold, Nahid Rahman-Huq, Raymond J. Owens, David I. Stuart, E. Yvonne Jones

Structure. 2009 Oct 14; 17(10): 1386–1397. doi: 10.1016/j.str.2009.07.018

Correction in:: Structure. 2009 Dec 9; 17(12): 1679.

PMCID:: PMC2832735

Abstract Article

Select item 571604419.

SORLA attenuates EphA4 signaling and amyloid β–induced neurodegeneration

Timothy Y. Huang, Yingjun Zhao, Lu-lin Jiang, Xiaoguang Li, Yan Liu, Yu Sun, Juan C. Piña-Crespo, Bing Zhu, Eliezer Masliah, Thomas E. Willnow, Elena B. Pasquale, Huaxi Xu

J Exp Med. 2017 Dec 4; 214(12): 3669–3685. doi: 10.1084/jem.20171413