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Select item 67509081.

SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors

Akihiro Yoshida, Yiwen Bu, Shuo Qie, John Wrangle, E. Ramsay Camp, E. Starr Hazard, Gary Hardiman, Renée de Leeuw, Karen E. Knudsen, J. Alan Diehl

Sci Adv. 2019 Sep; 5(9): eaax6352. Published online 2019 Sep 18. doi: 10.1126/sciadv.aax6352

PMCID:: PMC6750908

Abstract Article PDF–3.1M

Select item 42534282.

Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy

Elisa Donnard, Paula F. Asprino, Bruna R. Correa, Fabiana Bettoni, Fernanda C. Koyama, Fabio C.P. Navarro, Rodrigo O. Perez, John Mariadason, Oliver M. Sieber, Robert L. Strausberg, Andrew J.G. Simpson, Denis L.F. Jardim, Luiz Fernando L. Reis, Raphael B. Parmigiani, Pedro A.F. Galante, Anamaria A. Camargo

Oncotarget. 2014 Oct; 5(19): 9199–9213. Published online 2014 Aug 25. doi: 10.18632/oncotarget.2374

PMCID:: PMC4253428

Abstract Article PDF–1.7M

Select item 42000843.

Identification of 33 candidate oncogenes by screening for base-specific mutations

S Tuupanen, U A Hänninen, J Kondelin, P von Nandelstadh, T Cajuso, A E Gylfe, R Katainen, T Tanskanen, H Ristolainen, J Böhm, J-P Mecklin, H Järvinen, L Renkonen-Sinisalo, C L Andersen, M Taipale, J Taipale, P Vahteristo, K Lehti, E Pitkänen, L A Aaltonen

Br J Cancer. 2014 Oct 14; 111(8): 1657–1662. Published online 2014 Aug 12. doi: 10.1038/bjc.2014.429

PMCID:: PMC4200084

Abstract Article PDF–740K

Select item 40022274.

Insulin increases mRNA abundance of the amino acid transporter SLC7A5/LAT1 via an mTORC1‐dependent mechanism in skeletal muscle cells

Dillon K. Walker, Micah J. Drummond, Jared M. Dickinson, Michael S. Borack, Kristofer Jennings, Elena Volpi, Blake B. Rasmussen

Physiol Rep. 2014 Mar; 2(3): e00238. Published online 2014 Mar 20. doi: 10.1002/phy2.238

PMCID:: PMC4002227

Abstract Article PDF–468K

Select item 27559365.

Identification of a Disulfide Bridge Essential for Transport Function of the Human Proton-coupled Amino Acid Transporter hPAT1

Madlen Dorn, Matthias Weiwad, Fritz Markwardt, Linda Laug, Rainer Rudolph, Matthias Brandsch, Eva Bosse-Doenecke

J Biol Chem. 2009 Aug 14; 284(33): 22123–22132. Published online 2009 Jun 23. doi: 10.1074/jbc.M109.023713

PMCID:: PMC2755936

Abstract Article PDF–1.8M

Select item 23425086.

Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2

Zhong Chen, You-Jun Fei, Catriona M H Anderson, Katherine A Wake, Seiji Miyauchi, Wei Huang, David T Thwaites, Vadivel Ganapathy

J Physiol. 2003 Jan 15; 546(Pt 2): 349–361. Published online 2002 Dec 13. doi: 10.1113/jphysiol.2002.026500

PMCID:: PMC2342508

Abstract Article PDF–535K

Select item 17513037.

Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H⁺-coupled amino-acid transporter hPAT1

Emily L Abbot, Danielle S Grenade, David J Kennedy, Kelly M Gatfield, David T Thwaites

Br J Pharmacol. 2006 Feb; 147(3): 298–306. Published online 2005 Dec 5. doi: 10.1038/sj.bjp.0706557

PMCID:: PMC1751303

Abstract Article PDF–251K

Select item 67422898.

The H⁺-Coupled Electrogenic Lysosomal Amino Acid Transporter LYAAT1 Localizes to the Axon and Plasma Membrane of Hippocampal Neurons

Christopher C. Wreden, Juliette Johnson, Cindy Tran, Rebecca P. Seal, David R. Copenhagen, Richard J. Reimer, Robert H. Edwards

J Neurosci. 2003 Feb 15; 23(4): 1265–1275. doi: 10.1523/JNEUROSCI.23-04-01265.2003

PMCID:: PMC6742289

Abstract Article PDF–1.1M

Select item 39496529.

Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro

C U Nielsen, S Frølund, S Abdulhadi, H Sari, L Langthaler, M K Nøhr, M A Kall, B Brodin, R Holm

Br J Pharmacol. 2013 Nov; 170(5): 1041–1052. Published online 2013 Oct 15. doi: 10.1111/bph.12341

PMCID:: PMC3949652

Abstract Article PDF–1.1M

Select item 3464710.

Identification and characterization of a lysosomal transporter for small neutral amino acids

Corinne Sagné, Cendra Agulhon, Philippe Ravassard, Michèle Darmon, Michel Hamon, Salah El Mestikawy, Bruno Gasnier, Bruno Giros

Proc Natl Acad Sci U S A. 2001 Jun 19; 98(13): 7206–7211. Published online 2001 Jun 5. doi: 10.1073/pnas.121183498

PMCID:: PMC34647

Abstract Article PDF–675K

Select item 435597511.

PAT1 inversely regulates the surface Amyloid Precursor Protein level in mouse primary neurons

Aysegul Dilsizoglu Senol, Lidia Tagliafierro, Léa Huguet, Lucie Gorisse-Hussonnois, Stéphanie Chasseigneaux, Bernadette Allinquant

BMC Neurosci. 2015; 16: 10. Published online 2015 Mar 7. doi: 10.1186/s12868-015-0152-8

PMCID:: PMC4355975

Abstract Article PDF–3.8M

Select item 266996712.

Taurine uptake across the human intestinal brush-border membrane is via two transporters: H⁺-coupled PAT1 (SLC36A1) and Na⁺- and Cl⁻-dependent TauT (SLC6A6)

Catriona M H Anderson, Alison Howard, Julian R F Walters, Vadivel Ganapathy, David T Thwaites

J Physiol. 2009 Feb 15; 587(Pt 4): 731–744. Published online 2008 Dec 22. doi: 10.1113/jphysiol.2008.164228

PMCID:: PMC2669967

Abstract Article PDF–433K

Select item 301827713.

Proton-assisted amino acid transporters are conserved regulators of proliferation and amino acid-dependent mTORC1 activation

S Heublein, S Kazi, M H Ögmundsdóttir, E V Attwood, S Kala, C A R Boyd, C Wilson, D C I Goberdhan

Oncogene. Author manuscript; available in PMC 2011 Jan 10.

Published in final edited form as: Oncogene. 2010 Jul 15; 29(28): 4068–4079. Published online 2010 May 24. doi: 10.1038/onc.2010.177

PMCID:: PMC3018277

Abstract Article PDF–2.3M

Select item 334491514.

Proton-Assisted Amino Acid Transporter PAT1 Complexes with Rag GTPases and Activates TORC1 on Late Endosomal and Lysosomal Membranes

Margrét H. Ögmundsdóttir, Sabine Heublein, Shubana Kazi, Bruno Reynolds, Shivanthy M. Visvalingam, Michael K. Shaw, Deborah C. I. Goberdhan

PLoS One. 2012; 7(5): e36616. Published online 2012 May 4. doi: 10.1371/journal.pone.0036616

PMCID:: PMC3344915

Abstract Article PDF–2.9M

Select item 381740415.

A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities

Franco J Vizeacoumar, Roland Arnold, Frederick S Vizeacoumar, Megha Chandrashekhar, Alla Buzina, Jordan T F Young, Julian H M Kwan, Azin Sayad, Patricia Mero, Steffen Lawo, Hiromasa Tanaka, Kevin R Brown, Anastasia Baryshnikova, Anthony B Mak, Yaroslav Fedyshyn, Yadong Wang, Glauber C Brito, Dahlia Kasimer, Taras Makhnevych, Troy Ketela, Alessandro Datti, Mohan Babu, Andrew Emili, Laurence Pelletier, Jeff Wrana, Zev Wainberg, Philip M Kim, Robert Rottapel, Catherine A O’Brien, Brenda Andrews, Charles Boone, Jason Moffat

Mol Syst Biol. 2013; 9: 696. Published online 2013 Oct 8. doi: 10.1038/msb.2013.54

PMCID:: PMC3817404

Abstract Article PDF–13M

Select item 108373216.

Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing

Jeremy C. Simpson, Ruth Wellenreuther, Annemarie Poustka, Rainer Pepperkok, Stefan Wiemann

EMBO Rep. 2000 Sep 15; 1(3): 287–292. doi: 10.1093/embo-reports/kvd058

PMCID:: PMC1083732

Abstract Article PDF–375K

Select item 134750117.

The LIFEdb database in 2006

Alexander Mehrle, Heiko Rosenfelder, Ingo Schupp, Coral del Val, Dorit Arlt, Florian Hahne, Stephanie Bechtel, Jeremy Simpson, Oliver Hofmann, Winston Hide, Karl-Heinz Glatting, Wolfgang Huber, Rainer Pepperkok, Annemarie Poustka, Stefan Wiemann

Nucleic Acids Res. 2006 Jan 1; 34(Database issue): D415–D418. Published online 2005 Dec 28. doi: 10.1093/nar/gkj139

PMCID:: PMC1347501

Abstract Article PDF–301K

Select item 52893018.

From ORFeome to Biology: A Functional Genomics Pipeline

Stefan Wiemann, Dorit Arlt, Wolfgang Huber, Ruth Wellenreuther, Simone Schleeger, Alexander Mehrle, Stephanie Bechtel, Mamatha Sauermann, Ulrike Korf, Rainer Pepperkok, Holger Sültmann, Annemarie Poustka

Genome Res. 2004 Oct; 14(10b): 2136–2144. doi: 10.1101/gr.2576704

PMCID:: PMC528930

Abstract Article PDF–459K

Select item 31107219.

Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs

Stefan Wiemann, Bernd Weil, Ruth Wellenreuther, Johannes Gassenhuber, Sabine Glassl, Wilhelm Ansorge, Michael Böcher, Helmut Blöcker, Stefan Bauersachs, Helmut Blum, Jürgen Lauber, Andreas Düsterhöft, Andreas Beyer, Karl Köhrer, Normann Strack, Hans-Werner Mewes, Birgit Ottenwälder, Brigitte Obermaier, Jens Tampe, Dagmar Heubner, Rolf Wambutt, Bernhard Korn, Michaela Klein, Annemarie Poustka

Genome Res. 2001 Mar; 11(3): 422–435. doi: 10.1101/gr.154701

PMCID:: PMC311072

Abstract Article PDF–542K

Select item 31094820.

DNA Cloning Using In Vitro Site-Specific Recombination

James L. Hartley, Gary F. Temple, Michael A. Brasch

Genome Res. 2000 Nov; 10(11): 1788–1795. doi: 10.1101/gr.143000

PMCID:: PMC310948

Abstract Article PDF–1.7M

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PREDICTED: Homo sapiens solute carrier family 36 member 1 (SLC36A1), transcript ...
PREDICTED: Homo sapiens solute carrier family 36 member 1 (SLC36A1), transcript variant X17, mRNA
gi|2462601387|ref|XM_054352039.1|

Nucleotide
PREDICTED: Homo sapiens solute carrier family 36 member 1 (SLC36A1), transcript ...
PREDICTED: Homo sapiens solute carrier family 36 member 1 (SLC36A1), transcript variant X14, mRNA
gi|2217355046|ref|XM_047416924.1|

Nucleotide

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