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Select item 97460461.

Polycomb EZH1 regulates cell cycle/5‐fluorouracil sensitivity of neuroblastoma cells in concert with MYCN

Yoshitaka Shinno, Hisanori Takenobu, Ryuichi P. Sugino, Yuki Endo, Ryu Okada, Masayuki Haruta, Shunpei Satoh, Kyosuke Mukae, Dilibaerguli Shaliman, Tomoko Wada, Jesmin Akter, Kiyohiro Ando, Atsuko Nakazawa, Hideo Yoshida, Miki Ohira, Tomoro Hishiki, Takehiko Kamijo

Cancer Sci. 2022 Dec; 113(12): 4193–4206. Published online 2022 Oct 7. doi: 10.1111/cas.15555

PMCID:: PMC9746046

Abstract Article PDF–33M

Select item 92854922.

Downregulation of the enhancer of zeste homolog 1 transcriptional factor predicts poor prognosis of triple-negative breast cancer patients

Wei Peng, Wei Tang, Jian-Di Li, Rong-Quan He, Jia-Yuan Luo, Zu-Xuan Chen, Jiang-Hui Zeng, Xiao-Hua Hu, Jin-Cai Zhong, Yang Li, Fu-Chao Ma, Tian-Yi Xie, Su-Ning Huang, Lian-Ying Ge

PeerJ. 2022; 10: e13708. Published online 2022 Jul 12. doi: 10.7717/peerj.13708

PMCID:: PMC9285492

Abstract Article PDF–64M

Select item 78466063.

Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction

Daniel Grau, Yixiao Zhang, Chul-Hwan Lee, Marco Valencia-Sánchez, Jenny Zhang, Miao Wang, Marlene Holder, Vladimir Svetlov, Dongyan Tan, Evgeny Nudler, Danny Reinberg, Thomas Walz, Karim-Jean Armache

Nat Commun. 2021; 12: 714. Published online 2021 Jan 29. doi: 10.1038/s41467-020-20775-z

PMCID:: PMC7846606

Abstract Article PDF–2.5M

Select item 63627604.

The Effect of Overexpression of the Enhancer of Zeste Homolog 1 (EZH1) Gene on Aristolochic Acid-Induced Injury in HK-2 Human Kidney Proximal Tubule Cells In Vitro

Liping Wang, Ning Liu, Xiaoyan Xue, Shujun Zhou

Med Sci Monit. 2019; 25: 801–810. Published online 2019 Jan 28. doi: 10.12659/MSM.911611

PMCID:: PMC6362760

Abstract Article PDF–2.2M

Select item 103360785.

Gain and loss of function variants in EZH1 disrupt neurogenesis and cause dominant and recessive neurodevelopmental disorders

Carolina Gracia-Diaz, Yijing Zhou, Qian Yang, Reza Maroofian, Paula Espana-Bonilla, Chul-Hwan Lee, Shuo Zhang, Natàlia Padilla, Raquel Fueyo, Elisa A. Waxman, Sunyimeng Lei, Garrett Otrimski, Dong Li, Sarah E. Sheppard, Paul Mark, Margaret H. Harr, Hakon Hakonarson, Lance Rodan, Adam Jackson, Pradeep Vasudevan, Corrina Powel, Shehla Mohammed, Sateesh Maddirevula, Hamad Alzaidan, Eissa A. Faqeih, Stephanie Efthymiou, Valentina Turchetti, Fatima Rahman, Shazia Maqbool, Vincenzo Salpietro, Shahnaz H. Ibrahim, Gabriella di Rosa, Henry Houlden, Maha Nasser Alharbi, Nouriya Abbas Al-Sannaa, Peter Bauer, Giovanni Zifarelli, Conchi Estaras, Anna C. E. Hurst, Michelle L. Thompson, Anna Chassevent, Constance L. Smith-Hicks, Xavier de la Cruz, Alexander M. Holtz, Houda Zghal Elloumi, M J Hajianpour, Claudine Rieubland, Dominique Braun, Siddharth Banka, Genomic England Research Consortium, Deborah L. French, Elizabeth A. Heller, Murielle Saade, Hongjun Song, Guo-li Ming, Fowzan S. Alkuraya, Pankaj B. Agrawal, Danny Reinberg, Elizabeth J. Bhoj, Marian A. Martínez-Balbás, Naiara Akizu

Nat Commun. 2023; 14: 4109. Published online 2023 Jul 11. doi: 10.1038/s41467-023-39645-5

PMCID:: PMC10336078

Abstract Article PDF–6.0M

Select item 98134276.

The role of EZH1 and EZH2 in development and cancer

Soo Hyun Lee, Yingying Li, Hanbyeol Kim, Seounghyun Eum, Kyumin Park, Chul-Hwan Lee

BMB Rep. 2022 Dec 31; 55(12): 595–601. Published online 2022 Dec 31. doi: 10.5483/BMBRep.2022.55.12.174

PMCID:: PMC9813427

Abstract Article PDF–4.5M

Select item 64425827.

EZH1/2 function mostly within canonical PRC2 and exhibit proliferation-dependent redundancy that shapes mutational signatures in cancer

Michel Wassef, Armelle Luscan, Setareh Aflaki, Dina Zielinski, Pascal W. T. C. Jansen, H. Irem Baymaz, Aude Battistella, Carole Kersouani, Nicolas Servant, Margaret R. Wallace, Pierre Romero, Olivier Kosmider, Pierre-Alexandre Just, Mikaël Hivelin, Sébastien Jacques, Anne Vincent-Salomon, Michiel Vermeulen, Michel Vidaud, Eric Pasmant, Raphaël Margueron

Proc Natl Acad Sci U S A. 2019 Mar 26; 116(13): 6075–6080. Published online 2019 Mar 13. doi: 10.1073/pnas.1814634116

PMCID:: PMC6442582

Abstract Article PDF–1.2M

Select item 56103248.

PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs

Yongli Shan, Zechuan Liang, Qi Xing, Tian Zhang, Bo Wang, Shulan Tian, Wenhao Huang, Yanqi Zhang, Jiao Yao, Yanling Zhu, Ke Huang, Yujian Liu, Xiaoshan Wang, Qianyu Chen, Jian Zhang, Bizhi Shang, Shengbiao Li, Xi Shi, Baojian Liao, Cong Zhang, Keyu Lai, Xiaofen Zhong, Xiaodong Shu, Jinyong Wang, Hongjie Yao, Jiekai Chen, Duanqing Pei, Guangjin Pan

Nat Commun. 2017; 8: 672. Published online 2017 Sep 22. doi: 10.1038/s41467-017-00668-4

PMCID:: PMC5610324

Abstract Article PDF–3.1M

Select item 50049459.

Recurrent EZH1 mutations are a second hit in autonomous thyroid adenomas

Davide Calebiro, Elisa S. Grassi, Markus Eszlinger, Cristina L. Ronchi, Amod Godbole, Kerstin Bathon, Fabiana Guizzardi, Tiziana de Filippis, Knut Krohn, Holger Jaeschke, Thomas Schwarzmayr, Rifat Bircan, Hulya Iliksu Gozu, Seda Sancak, Marek Niedziela, Tim M. Strom, Martin Fassnacht, Luca Persani, Ralf Paschke

J Clin Invest. 2016 Sep 1; 126(9): 3383–3388. Published online 2016 Aug 8. doi: 10.1172/JCI84894

PMCID:: PMC5004945

Abstract Article PDF–1.2M

Select item 683833110.

Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia

Liping Dou, Fei Yan, Jiuxia Pang, Dehua Zheng, Dandan Li, Li Gao, Lijun Wang, Yihan Xu, Jinlong Shi, Qian Wang, Lei Zhou, Na Shen, Puja Singh, Lili Wang, Yonghui Li, Yvchi Gao, Tao Liu, Chongjian Chen, Aref Al-Kali, Mark R. Litzow, Young-In Chi, Ann M. Bode, Chunhui Liu, Haojie Huang, Daihong Liu, Guido Marcucci, Shujun Liu, Li Yu

Nat Commun. 2019; 10: 5051. Published online 2019 Nov 7. doi: 10.1038/s41467-019-12960-6

PMCID:: PMC6838331

Abstract Article PDF–2.8M

Select item 603909611.

HIF Activation Causes Synthetic Lethality Between the VHL Tumor Suppressor and the EZH1 Histone Methyltransferase

Abhishek A. Chakraborty, Eijiro Nakamura, Jun Qi, Amanda Creech, Jacob D. Jaffe, Joshiawa Paulk, Jesse S. Novak, Kshithija Nagulapalli, Samuel K. McBrayer, Glenn S. Cowley, Javier Pineda, Jiaxi Song, Yaoyu E. Wang, Steven A. Carr, David E. Root, Sabina Signoretti, James E. Bradner, William G. Kaelin, Jr.

Sci Transl Med. Author manuscript; available in PMC 2018 Jul 10.

Published in final edited form as: Sci Transl Med. 2017 Jul 12; 9(398): eaal5272. doi: 10.1126/scitranslmed.aal5272

PMCID:: PMC6039096

Abstract Article PDF–3.0M

Select item 509697412.

Chronic myelogenous leukemia initiating cells require Polycomb group protein EZH2

Huafeng Xie, Cong Peng, Jialiang Huang, Bin E. Li, Woojin Kim, Elenoe C. Smith, Yuko Fujiwara, Jun Qi, Giulia Cheloni, Partha P. Das, Minh Nguyen, Shaoguang Li, James E. Bradner, Stuart H. Orkin

Cancer Discov. Author manuscript; available in PMC 2017 Nov 1.

Published in final edited form as: Cancer Discov. 2016 Nov; 6(11): 1237–1247. Published online 2016 Sep 14. doi: 10.1158/2159-8290.CD-15-1439

PMCID:: PMC5096974

Abstract Article PDF–2.0M

Select item 430500413.

Developmental control of Polycomb subunit composition by GATA factors mediates a switch to non-canonical functions

Jian Xu, Zhen Shao, Dan Li, Huafeng Xie, Woojin Kim, Jialiang Huang, Jordan E. Taylor, Luca Pinello, Kimberly Glass, Jacob D. Jaffe, Guo-Cheng Yuan, Stuart H. Orkin

Mol Cell. Author manuscript; available in PMC 2016 Jan 22.

Published in final edited form as: Mol Cell. 2015 Jan 22; 57(2): 304–316. Published online 2015 Jan 8. doi: 10.1016/j.molcel.2014.12.009

PMCID:: PMC4305004

Abstract Article PDF–3.1M

Select item 578546114.

Regulation of haematopoietic multipotency by EZH1

Linda T. Vo, Melissa A. Kinney, Xin Liu, Yuannyu Zhang, Jessica Barragan, Patricia M. Sousa, Deepak K. Jha, Areum Han, Marcella Cesana, Zhen Shao, Trista E. North, Stuart H. Orkin, Sergei Doulatov, Jian Xu, George Q. Daley

Nature. Author manuscript; available in PMC 2018 Jul 17.

Published in final edited form as: Nature. 2018 Jan 25; 553(7689): 506–510. Published online 2018 Jan 17. doi: 10.1038/nature25435

PMCID:: PMC5785461

Abstract Article PDF–1.7M

Select item 541290215.

A covalently bound inhibitor triggers EZH2 degradation through CHIP‐mediated ubiquitination

Xu Wang, Wei Cao, Jianjun Zhang, Ming Yan, Qin Xu, Xiangbing Wu, Lixin Wan, Zhiyuan Zhang, Chenping Zhang, Xing Qin, Meng Xiao, Dongxia Ye, Yuyang Liu, Zeguang Han, Shaomeng Wang, Li Mao, Wenyi Wei, Wantao Chen

EMBO J. 2017 May 2; 36(9): 1243–1260. Published online 2017 Mar 20. doi: 10.15252/embj.201694058