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Select item 100791551.

Factor Xa cleaves SARS-CoV-2 spike protein to block viral entry and infection

Wenjuan Dong, Jing Wang, Lei Tian, Jianying Zhang, Erik W. Settles, Chao Qin, Daniel R. Steinken-Kollath, Ashley N. Itogawa, Kimberly R. Celona, Jinhee Yi, Mitchell Bryant, Heather Mead, Sierra A. Jaramillo, Hongjia Lu, Aimin Li, Ross E. Zumwalt, Sanjeet Dadwal, Pinghui Feng, Weiming Yuan, Sean P. J. Whelan, Paul S. Keim, Bridget Marie Barker, Michael A. Caligiuri, Jianhua Yu

Nat Commun. 2023; 14: 1936. Published online 2023 Apr 6. doi: 10.1038/s41467-023-37336-9

PMCID:: PMC10079155

Abstract Article PDF–5.0M

Select item 98660722.

Influence of Heparan Sulfate Proteoglycans and Factor X on species D Human Adenovirus Uptake and Transduction

Katrin Schröer, Montaha Alshawabkeh, Sebastian Schellhorn, Katrin Bronder, Wenli Zhang, Anja Ehrhardt

Viruses. 2023 Jan; 15(1): 55. Published online 2022 Dec 24. doi: 10.3390/v15010055

PMCID:: PMC9866072

Abstract Article PDF–1.6M

Select item 96997873.

Spike Protein Subunits of SARS-CoV-2 Alter Mitochondrial Metabolism in Human Pulmonary Microvascular Endothelial Cells: Involvement of Factor Xa

Khaoula Zekri-Nechar, José J. Zamorano-León, Carmen Reche, Manel Giner, Ana López-de-Andrés, Rodrigo Jiménez-García, Antonio J. López-Farré, Carlos Hugo Martínez-Martínez

Dis Markers. 2022; 2022: 1118195. Published online 2022 Nov 18. doi: 10.1155/2022/1118195

PMCID:: PMC9699787

Abstract Article PDF–1.2M

Select item 76502554.

Exosite binding drives substrate affinity for the activation of coagulation factor X by the intrinsic Xase complex

Manjunath Goolyam Basavaraj, Sriram Krishnaswamy

J Biol Chem. 2020 Nov 6; 295(45): 15198–15207. Published online 2020 Aug 28. doi: 10.1074/jbc.RA120.015325

PMCID:: PMC7650255

Abstract Article PDF–1.1M

Select item 73276515.

Rare variants lowering the levels of coagulation factor X are protective against ischemic heart disease

Elvezia Maria Paraboschi, Amit Vikram Khera, Piera Angelica Merlini, Laura Gigante, Flora Peyvandi, Mark Chaffin, Marzia Menegatti, Fabiana Busti, Domenico Girelli, Nicola Martinelli, Oliviero Olivieri, Sekar Kathiresan, Diego Ardissino, Rosanna Asselta, Stefano Duga

Haematologica. 2020 Jul; 105(7): e365–e369. doi: 10.3324/haematol.2019.237750

PMCID:: PMC7327651

Article PDF–1.4M

Select item 70052606.

Production and control of coagulation proteins for factor X activation in human endothelial cells and fibroblasts

Clay T. Cohen, Nancy A. Turner, Joel L. Moake

Sci Rep. 2020; 10: 2005. Published online 2020 Feb 6. doi: 10.1038/s41598-020-59058-4

PMCID:: PMC7005260

Abstract Article PDF–4.5M

Select item 63490327.

Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass

Ruwan Gunaratne, Shekhar Kumar, James W. Frederiksen, Steven Stayrook, Jens L. Lohrmann, Kay Perry, Kristin M. Bompiani, Charlene V. Chabata, Nabil K. Thalji, Michelle D. Ho, Gowthami Arepally, Rodney M. Camire, Sriram Krishnaswamy, Bruce A. Sullenger

Nat Biotechnol. Author manuscript; available in PMC 2019 Jan 28.

Published in final edited form as: Nat Biotechnol. 2018 Aug; 36(7): 606–613. Published online 2018 Jun 4. doi: 10.1038/nbt.4153

PMCID:: PMC6349032

Abstract Article PDF–983K

Select item 62743698.

Novel Anthranilamide-Based FXa Inhibitors: Drug Design, Synthesis and Biological Evaluation

Wenzhi Wang, Jing Yuan, Xiaoli Fu, Fancui Meng, Shijun Zhang, Weiren Xu, Yongnan Xu, Changjiang Huang

Molecules. 2016 Apr; 21(4): 491. Published online 2016 Apr 14. doi: 10.3390/molecules21040491

PMCID:: PMC6274369

Abstract Article PDF–2.8M

Select item 56290159.

Rendering Factor Xa Zymogen-like as a Therapeutic Strategy to Treat Bleeding

Nabil K. Thalji, Rodney M. Camire

Curr Opin Hematol. Author manuscript; available in PMC 2018 Sep 1.

Published in final edited form as: Curr Opin Hematol. 2017 Sep; 24(5): 453–459. doi: 10.1097/MOH.0000000000000369

PMCID:: PMC5629015

Abstract Article PDF–326K

Select item 503081610.

Molecular Dynamics Simulations of Factor Xa: Insight into Conformational Transition of its Binding Subsites

Narender Singh, James M. Briggs

Biopolymers. Author manuscript; available in PMC 2016 Sep 21.

Published in final edited form as: Biopolymers. 2008 Dec; 89(12): 1104–1113. doi: 10.1002/bip.21062

PMCID:: PMC5030816

Abstract Article PDF–1.1M

Select item 458233611.

Acylcarnitines are anticoagulants that inhibit factor Xa and are reduced in venous thrombosis, based on metabolomics data

Hiroshi Deguchi, Yajnavalka Banerjee, Sunia Trauger, Gary Siuzdak, Ewa Kalisiak, José A. Fernández, Linh Hoang, Minerva Tran, Subramanian Yegneswaran, Darlene J. Elias, John H. Griffin

Blood. 2015 Sep 24; 126(13): 1595–1600. Prepublished online 2015 Jul 14. doi: 10.1182/blood-2015-03-636761

PMCID:: PMC4582336

Abstract Article

Select item 425404012.

Molecular Basis of the Clotting Defect in a Bleeding Patient Missing the Asp-185 Codon in the Factor X Gene

Qiuya Lu, Likui Yang, Chandrashekhara Manithody, Xuefeng Wang, Alireza R. Rezaie

Thromb Res. Author manuscript; available in PMC 2015 Nov 1.

Published in final edited form as: Thromb Res. 2014 Nov; 134(5): 1103–1109. Published online 2014 Aug 20. doi: 10.1016/j.thromres.2014.08.004

PMCID:: PMC4254040

Abstract Article PDF–574K

Select item 400242313.

Procoagulant, Tissue Factor-Bearing Microparticles in Bronchoalveolar Lavage of Interstitial Lung Disease Patients: An Observational Study

Federica Novelli, Tommaso Neri, Laura Tavanti, Chiara Armani, Concettina Noce, Fabio Falaschi, Maria Laura Bartoli, Federica Martino, Antonio Palla, Alessandro Celi, Pierluigi Paggiaro

PLoS One. 2014; 9(4): e95013. Published online 2014 Apr 28. doi: 10.1371/journal.pone.0095013

PMCID:: PMC4002423

Abstract Article PDF–455K

Select item 370065814.

The missense Thr211Pro mutation in the factor X activation peptide of a bleeding patient causes molecular defect in the clotting cascade

Qiulan Ding, Yiping Shen, Likui Yang, Xuefeng Wang, Alireza R. Rezaie

Thromb Haemost. Author manuscript; available in PMC 2014 Jul 1.

Published in final edited form as: Thromb Haemost. 2013 Jul 1; 110(1): 53–61. Published online 2013 May 16. doi: 10.1160/TH13-03-0184

PMCID:: PMC3700658

Abstract Article PDF–496K

Select item 318748515.

A Cluster of Basic Amino Acids in the Factor X Serine Protease Mediates Surface Attachment of Adenovirus/FX Complexes

Margaret R. Duffy, Angela C. Bradshaw, Alan L. Parker, John H. McVey, Andrew H. Baker

J Virol. 2011 Oct; 85(20): 10914–10919. doi: 10.1128/JVI.05382-11

PMCID:: PMC3187485

Abstract Article PDF–1.2M

Select item 317046016.

Determination of rivaroxaban by different factor Xa specific chromogenic substrate assays: reduction of interassay variability

Job Harenberg, Roland Krämer, Christina Giese, Svetlana Marx, Christel Weiss, Martin Wehling

J Thromb Thrombolysis. 2011; 32(3): 267–271. Published online 2011 Aug 3. doi: 10.1007/s11239-011-0622-5

PMCID:: PMC3170460

Abstract Article PDF–1.6M

Select item 315104517.

Alboserpin, a Factor Xa Inhibitor from the Mosquito Vector of Yellow Fever, Binds Heparin and Membrane Phospholipids and Exhibits Antithrombotic Activity

Eric Calvo, Daniella M. Mizurini, Anderson Sá-Nunes, José M. C. Ribeiro, John F. Andersen, Ben J. Mans, Robson Q. Monteiro, Michail Kotsyfakis, Ivo M. B. Francischetti

J Biol Chem. 2011 Aug 12; 286(32): 27998–28010. Published online 2011 Jun 14. doi: 10.1074/jbc.M111.247924