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Select item 105760971.

Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription

Mei Sheng Lau, Zhenhua Hu, Xiaodan Zhao, Yaw Sing Tan, Jinyue Liu, Hua Huang, Clarisse Jingyi Yeo, Hwei Fen Leong, Oleg V. Grinchuk, Justin Kaixuan Chan, Jie Yan, Wee-Wei Tee

Nat Commun. 2023; 14: 6464. Published online 2023 Oct 13. doi: 10.1038/s41467-023-42078-9

PMCID:: PMC10576097

Abstract Article PDF–1.9M

Select item 48837522.

Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms

Angela M. Mabb, Jeremy M. Simon, Ian F. King, Hyeong-Min Lee, Lin-Kun An, Benjamin D. Philpot, Mark J. Zylka

PLoS One. 2016; 11(5): e0156439. Published online 2016 May 27. doi: 10.1371/journal.pone.0156439

PMCID:: PMC4883752

Abstract Article PDF–4.7M

Select item 42605683.

Topoisomerase 1 inhibition reversibly impairs synaptic function

Angela M. Mabb, Paul H. M. Kullmann, Margaret A. Twomey, Jayalakshmi Miriyala, Benjamin D. Philpot, Mark J. Zylka

Proc Natl Acad Sci U S A. 2014 Dec 2; 111(48): 17290–17295. Published online 2014 Nov 17. doi: 10.1073/pnas.1413204111

PMCID:: PMC4260568

Abstract Article PDF–1.2M

Select item 41402774.

Mapping Topoisomerase Sites in Mitochondrial DNA with a Poisonous Mitochondrial Topoisomerase I (Top1mt)

Ilaria Dalla Rosa, Shar-yin N. Huang, Keli Agama, Salim Khiati, Hongliang Zhang, Yves Pommier

J Biol Chem. 2014 Jun 27; 289(26): 18595–18602. Published online 2014 May 5. doi: 10.1074/jbc.M114.555367

PMCID:: PMC4140277

Abstract Article PDF–1.2M

Select item 101610015.

Ago2 and a miRNA reduce Topoisomerase 1 for enhancing DNA cleavage in antibody diversification by activation-induced cytidine deaminase

Maki Kobayashi, Hiroyuki Wakaguri, Masakazu Shimizu, Koichiro Higasa, Fumihiko Matsuda, Tasuku Honjo

Proc Natl Acad Sci U S A. 2023 May 2; 120(18): e2216918120. Published online 2023 Apr 24. doi: 10.1073/pnas.2216918120

PMCID:: PMC10161001

Abstract Article PDF–4.1M

Select item 54168366.

Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis

Reeja S. Maskey, Karen S. Flatten, Cynthia J. Sieben, Kevin L. Peterson, Darren J. Baker, Hyun-Ja Nam, Myoung Shin Kim, Thomas C. Smyrk, Yusuke Kojima, Yuka Machida, Annyoceli Santiago, Jan M. van Deursen, Scott H. Kaufmann, Yuichi J. Machida

Nucleic Acids Res. 2017 May 5; 45(8): 4564–4576. Published online 2017 Feb 13. doi: 10.1093/nar/gkx107

PMCID:: PMC5416836

Abstract Article PDF–6.4M

Select item 53109767.

The transcriptional regulator Aire binds to and activates super-enhancers

Kushagra Bansal, Hideyuki Yoshida, Christophe Benoist, Diane Mathis

Nat Immunol. Author manuscript; available in PMC 2017 Jul 30.

Published in final edited form as: Nat Immunol. 2017 Mar; 18(3): 263–273. Published online 2017 Jan 30. doi: 10.1038/ni.3675

PMCID:: PMC5310976

Abstract Article PDF–2.5M

Select item 45686548.

Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration

Salim Khiati, Simone A. Baechler, Valentina M. Factor, Hongliang Zhang, Shar-yin N. Huang, Ilaria Dalla Rosa, Carole Sourbier, Leonard Neckers, Snorri S. Thorgeirsson, Yves Pommier

Proc Natl Acad Sci U S A. 2015 Sep 8; 112(36): 11282–11287. Published online 2015 Aug 24. doi: 10.1073/pnas.1511016112

PMCID:: PMC4568654

Abstract Article PDF–1.2M

Select item 44255799.

Topoisomerase I deficiency causes RNA Polymerase II accumulation and increases AID abundance in immunoglobulin variable genes

Robert W. Maul, Huseyin Saribasak, Zheng Cao, Patricia J. Gearhart

DNA Repair (Amst) Author manuscript; available in PMC 2016 Jun 1.

Published in final edited form as: DNA Repair (Amst). 2015 Jun; 30: 46–52. Published online 2015 Mar 18. doi: 10.1016/j.dnarep.2015.03.004

PMCID:: PMC4425579

Abstract Article PDF–902K

Select item 340112710.

Mitochondrial Topoisomerase I is Critical for Mitochondrial Integrity and Cellular Energy Metabolism

Céline Douarre, Carole Sourbier, Ilaria Dalla Rosa, Benu Brata Das, Christophe E. Redon, Hongliang Zhang, Len Neckers, Yves Pommier

PLoS One. 2012; 7(7): e41094. Published online 2012 Jul 20. doi: 10.1371/journal.pone.0041094

PMCID:: PMC3401127

Abstract Article PDF–805K

Select item 279969111.

AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination

Maki Kobayashi, Masatoshi Aida, Hitoshi Nagaoka, Nasim A. Begum, Yoko Kitawaki, Mikiyo Nakata, Andre Stanlie, Tomomitsu Doi, Lucia Kato, Il-mi Okazaki, Reiko Shinkura, Masamichi Muramatsu, Kazuo Kinoshita, Tasuku Honjo

Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52): 22375–22380. Published online 2009 Dec 11. doi: 10.1073/pnas.0911879106

PMCID:: PMC2799691

Abstract Article PDF–1006K

Select item 23168312.

Targeted disruption of the mouse topoisomerase I gene by camptothecin selection.

S G Morham, K D Kluckman, N Voulomanos, O Smithies

Mol Cell Biol. 1996 Dec; 16(12): 6804–6809. doi: 10.1128/mcb.16.12.6804

PMCID:: PMC231683

Summary PDF–268K

Select item 718188113.

Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration

Giulia Fragola, Angela M. Mabb, Bonnie Taylor-Blake, Jesse K. Niehaus, William D. Chronister, Hanqian Mao, Jeremy M. Simon, Hong Yuan, Zibo Li, Michael J. McConnell, Mark J. Zylka

Nat Commun. 2020; 11: 1962. Published online 2020 Apr 23. doi: 10.1038/s41467-020-15794-9

PMCID:: PMC7181881

Abstract Article PDF–4.2M

Select item 322847614.

Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation

Maki Kobayashi, Zahra Sabouri, Somayeh Sabouri, Yoko Kitawaki, Yves Pommier, Takaya Abe, Hiroshi Kiyonari, Tasuku Honjo

Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48): 19305–19310. Published online 2011 Nov 11. doi: 10.1073/pnas.1114522108

PMCID:: PMC3228476

Abstract Article PDF–516K

Select item 247569915.

A Ubiquitin-Proteasome Pathway for the Repair of Topoisomerase I-DNA Covalent Complexes

Chao-Po Lin, Yi Ban, Yi Lisa Lyu, Shyamal D. Desai, Leroy F. Liu

J Biol Chem. 2008 Jul 25; 283(30): 21074–21083. doi: 10.1074/jbc.M803493200

PMCID:: PMC2475699

Abstract Article PDF–429K

Select item 886611516.

Signatures of TOP1 transcription-associated mutagenesis in cancer and germline

Martin A. M. Reijns, David A. Parry, Thomas C. Williams, Ferran Nadeu, Rebecca L. Hindshaw, Diana O. Rios Szwed, Michael D. Nicholson, Paula Carroll, Shelagh Boyle, Romina Royo, Alex J. Cornish, Hang Xiang, Kate Ridout, The Genomics England Research Consortium, Colorectal Cancer Domain UK 100,000 Genomes Project, Anna Schuh, Konrad Aden, Claire Palles, Elias Campo, Tatjana Stankovic, Martin S. Taylor, Andrew P. Jackson

Nature. 2022; 602(7898): 623–631. Published online 2022 Feb 9. doi: 10.1038/s41586-022-04403-y

Correction in:: Nature. 2022; 605(7910): E7.

PMCID:: PMC8866115

Abstract Article PDF–6.9M

Select item 853027417.

NuMorph: Tools for cortical cellular phenotyping in tissue-cleared whole-brain images

Oleh Krupa, Giulia Fragola, Ellie Hadden-Ford, Jessica T. Mory, Tianyi Liu, Zachary Humphrey, Benjamin W. Rees, Ashok Krishnamurthy, William D. Snider, Mark J. Zylka, Guorong Wu, Lei Xing, Jason L. Stein

Cell Rep. Author manuscript; available in PMC 2021 Oct 21.

Published in final edited form as: Cell Rep. 2021 Oct 12; 37(2): 109802. doi: 10.1016/j.celrep.2021.109802

PMCID:: PMC8530274

Abstract Article PDF–4.0M

Select item 328168818.

Enhanced Killing of Cancer Cells by Poly(ADP-ribose) Polymerase Inhibitors and Topoisomerase I Inhibitors Reflects Poisoning of Both Enzymes

Anand G. Patel, Karen S. Flatten, Paula A. Schneider, Nga T. Dai, Jennifer S. McDonald, Guy G. Poirier, Scott H. Kaufmann

J Biol Chem. 2012 Feb 3; 287(6): 4198–4210. Published online 2011 Dec 12. doi: 10.1074/jbc.M111.296475

PMCID:: PMC3281688

Abstract Article PDF–2.5M

Select item 788868219.

The E3 ubiquitin ligase Cul4b promotes CD4⁺ T cell expansion by aiding the repair of damaged DNA

Asif A. Dar, Keisuke Sawada, Joseph M. Dybas, Emily K. Moser, Emma L. Lewis, Eddie Park, Hossein Fazelinia, Lynn A. Spruce, Hua Ding, Steven H. Seeholzer, Paula M. Oliver

PLoS Biol. 2021 Feb; 19(2): e3001041. Published online 2021 Feb 1. doi: 10.1371/journal.pbio.3001041

PMCID:: PMC7888682

Abstract Article PDF–4.5M

Select item 328934720.

Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II

Humaira Gowher, Kevin Brick, R. Daniel Camerini-Otero, Gary Felsenfeld

Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7): 2370–2375. Published online 2012 Jan 30. doi: 10.1073/pnas.1121538109

PMCID:: PMC3289347

Abstract Article PDF–954K

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PMC Links for Gene (Select 21969) (48)
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MULTISPECIES: nitronate monooxygenase family protein [Alphaproteobacteria]
MULTISPECIES: nitronate monooxygenase family protein [Alphaproteobacteria]
gi|493888089|ref|WP_006834188.1|

Protein
Trichorhinophalangeal dysplasia type I
Trichorhinophalangeal dysplasia type I

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C0432233[conceptid] (1)
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