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Select item 82386141.

UNC5B Promotes Vascular Endothelial Cell Senescence via the ROS-Mediated P53 Pathway

Zhen Yang, Han Li, Pengcheng Luo, Dan Yan, Ni Yang, Yucong Zhang, Yi Huang, Yu Liu, Le Zhang, Jinhua Yan, Cuntai Zhang

Oxid Med Cell Longev. 2021; 2021: 5546711. Published online 2021 Jun 20. doi: 10.1155/2021/5546711

PMCID:: PMC8238614

Abstract Article PDF–1.6M

Select item 78829252.

The intracellular domain of UNC5B facilities proliferation and metastasis of bladder cancer cells

Yexiang Huang, Zhe Zhang, Miao Miao, Chuize Kong

J Cell Mol Med. 2021 Feb; 25(4): 2121–2135. Published online 2020 Dec 20. doi: 10.1111/jcmm.16172

PMCID:: PMC7882925

Abstract Article PDF–3.3M

Select item 51112193.

Overexpression of UNC5B in bladder cancer cells inhibits proliferation and reduces the volume of transplantation tumors in nude mice

Chuize Kong, Bo Zhan, Chiyuan Piao, Zhe Zhang, Yuyan Zhu, Qingchang Li

BMC Cancer. 2016; 16: 892. Published online 2016 Nov 15. doi: 10.1186/s12885-016-2922-9

PMCID:: PMC5111219

Abstract Article PDF–2.2M

Select item 93803214.

Netrin-1 induces the anti-apoptotic and pro-survival effects of B-ALL cells through the Unc5b-MAPK axis

Lan Huang, Xizhou An, Yao Zhu, Kainan Zhang, Li Xiao, Xinyuan Yao, Xing Zeng, Shaoyan Liang, Jie Yu

Cell Commun Signal. 2022; 20: 122. Published online 2022 Aug 16. doi: 10.1186/s12964-022-00935-y

PMCID:: PMC9380321

Abstract Article PDF–5.1M

Select item 73432045.

Polyomavirus Small T Antigen Induces Apoptosis in Mammalian Cells through the UNC5B Pathway in a PP2A-Dependent Manner

Sameer Ahmed Bhat, Zarka Sarwar, Syed Qaaifah Gillani, Misbah Un Nisa, Irfana Reshi, Nusrat Nabi, Shaozhen Xie, Khalid M. Fazili, Thomas M. Roberts, Shaida Andrabi

J Virol. 2020 Jul; 94(14): e02187-19. Prepublished online 2020 May 13. Published online 2020 Jul 1. doi: 10.1128/JVI.02187-19

PMCID:: PMC7343204

Abstract Article PDF–4.3M

Select item 37936336.

Hypoxia induces netrin-1 and Unc5b in atherosclerotic plaques: a mechanism for macrophage retention and survival

Bhama Ramkhelawon, Yuan Yang, Janine M van Gils, Bernd Hewing, Katey J Rayner, Sajesh Parathath, Liang Guo, Scott Oldebeken, Jessica L Feig, Edward A Fisher, Kathryn J Moore

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2014 Jun 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 Jun; 33(6): 1180–1188. Published online 2013 Apr 18. doi: 10.1161/ATVBAHA.112.301008

PMCID:: PMC3793633

Abstract Article PDF–1.9M

Select item 109090827.

Hepatic Expression of NTN4 and Its Receptors in Patients with Hepatocellular Carcinoma

Jyothi Vennela, Biju Pottakkat, Bala subramaniyan Vairappan, Surendra Kumar Verma, Victor Mukherjee

Asian Pac J Cancer Prev. 2023; 24(12): 4285–4292. doi: 10.31557/APJCP.2023.24.12.4285

PMCID:: PMC10909082

Abstract Article PDF–1.8M

Select item 84335468.

Δ40p53 isoform up-regulates netrin-1/UNC5B expression and potentiates netrin-1 pro-oncogenic activity

Yan Sun, Ambroise Manceau, Lisa Frydman, Lucie Cappuccio, David Neves, Valeria Basso, Hong Wang, Joanna Fombonne, Carine Maisse, Patrick Mehlen, Andrea Paradisi

Proc Natl Acad Sci U S A. 2021 Sep 7; 118(36): e2103319118. Published online 2021 Sep 1. doi: 10.1073/pnas.2103319118

PMCID:: PMC8433546

Abstract Article PDF–1.3M

Select item 83580489.

A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis

Davide Pradella, Gianluca Deflorian, Alex Pezzotta, Anna Di Matteo, Elisa Belloni, Daniele Campolungo, Andrea Paradisi, Mattia Bugatti, William Vermi, Matteo Campioni, Antonella Chiapparino, Luigi Scietti, Federico Forneris, Costanza Giampietro, Nina Volf, Michael Rehman, Serena Zacchigna, Maria Paola Paronetto, Anna Pistocchi, Anne Eichmann, Patrick Mehlen, Claudia Ghigna

Nat Commun. 2021; 12: 4872. Published online 2021 Aug 11. doi: 10.1038/s41467-021-24998-6

PMCID:: PMC8358048

Abstract Article PDF–3.7M

Select item 393702510.

PKC α regulates netrin-1/UNC5B-mediated survival pathway in bladder cancer

Jiao Liu, Chui-ze Kong, Da-xin Gong, Zhe Zhang, Yu-yan Zhu

BMC Cancer. 2014; 14: 93. Published online 2014 Feb 15. doi: 10.1186/1471-2407-14-93

PMCID:: PMC3937025

Abstract Article PDF–1.9M

Select item 279661611.

Characterization and Expression of Netrin-1 and Its Receptors UNC5B and DCC in Human Placenta

Mbarka Dakouane-Giudicelli, Christophe Duboucher, Joanne Fortemps, Héliane Missey-Kolb, Danièle Brulé, Yves Giudicelli, Philippe de Mazancourt

J Histochem Cytochem. 2010 Jan; 58(1): 73–82. doi: 10.1369/jhc.2009.953463

PMCID:: PMC2796616

Abstract Article PDF–1.6M

Select item 268640912.

Unc5B associates with LARG to mediate the action of repulsive guidance molecule

Katsuhiko Hata, Kozo Kaibuchi, Shinobu Inagaki, Toshihide Yamashita

J Cell Biol. 2009 Mar 9; 184(5): 737–750. doi: 10.1083/jcb.200807029

PMCID:: PMC2686409

Abstract Article PDF–5.9M

Select item 15306713.

The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment

Karine Thiébault, Laetitia Mazelin, Laurent Pays, Fabien Llambi, Marie-Odile Joly, Jean-Yves Scoazec, Jean-Christophe Saurin, Giovanni Romeo, Patrick Mehlen

Proc Natl Acad Sci U S A. 2003 Apr 1; 100(7): 4173–4178. Published online 2003 Mar 24. doi: 10.1073/pnas.0738063100

PMCID:: PMC153067

Abstract Article PDF–370K

Select item 513358514.

Unc-5 homolog B (UNC5B) is one of the key downstream targets of N-α-Acetyltransferase 10 (Naa10)

Huiyu Xu, Yong Han, Bing Liu, Rong Li

Sci Rep. 2016; 6: 38508. Published online 2016 Dec 2. doi: 10.1038/srep38508

PMCID:: PMC5133585

Abstract Article PDF–816K

Select item 398193015.

Netrin-1 promotes adipose tissue macrophage accumulation and insulin resistance in obesity

Bhama Ramkhelawon, Elizabeth J Hennessy, Mickaël Ménager, Tathagat Dutta Ray, Frederick J Sheedy, Susan Hutchison, Amarylis Wanschel, Scott Oldebeken, Michele Geoffrion, Westley Spiro, George Miller, Ruth McPherson, Katey J Rayner, Kathryn J Moore

Nat Med. Author manuscript; available in PMC 2014 Oct 1.

Published in final edited form as: Nat Med. 2014 Apr; 20(4): 377–384. Published online 2014 Mar 2. doi: 10.1038/nm.3467

PMCID:: PMC3981930

Abstract Article PDF–1.4M

Select item 251882916.

Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B

Esma Lejmi, Laurence Leconte, Sandrine Pédron-Mazoyer, Stanislas Ropert, William Raoul, Sophie Lavalette, Ilyes Bouras, Jean-Guillaume Feron, Martine Maitre-Boube, Franck Assayag, Charles Feumi, Monica Alemany, Tan Xian Jie, Tatyana Merkulova, Marie-France Poupon, Marie-Magdeleine Ruchoux, Gérard Tobelem, Florian Sennlaub, Jean Plouët

Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34): 12491–12496. Published online 2008 Aug 21. doi: 10.1073/pnas.0804008105

PMCID:: PMC2518829

Abstract Article PDF–592K

Select item 55639617.

The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase

Fabien Llambi, Filipe Calheiros Lourenço, Devrim Gozuacik, Catherine Guix, Laurent Pays, Gabriel Del Rio, Adi Kimchi, Patrick Mehlen

EMBO J. 2005 Mar 23; 24(6): 1192–1201. Published online 2005 Feb 24. doi: 10.1038/sj.emboj.7600584

PMCID:: PMC556396

Abstract Article PDF–349K

Select item 485142918.

Structural Basis of Latrophilin - FLRT - UNC5 Interaction in Cell Adhesion

Yue C. Lu, Olha V. Nazarko, Richard Sando, III, Gabriel S. Salzman, Nan-Sheng Li, Thomas C. Südhof, Demet Araç

Structure. Author manuscript; available in PMC 2016 Apr 29.

Published in final edited form as: Structure. 2015 Sep 1; 23(9): 1678–1691. Published online 2015 Jul 30. doi: 10.1016/j.str.2015.06.024

PMCID:: PMC4851429

Abstract Article PDF–2.1M

Select item 283919019.

Netrin-1 Mediates Neuronal Survival Through PIKE-L Interaction With the Dependence Receptor UNC5B

Xiaoling Tang, Sung-Wuk Jang, Masashi Okada, Chi-Bun Chan, Yue Feng, Yu Liu, Shi-Wen Luo, Yan Hong, Nicolas Rama, Wen-cheng Xiong, Patrick Mehlen, Keqiang Ye

Nat Cell Biol. Author manuscript; available in PMC 2010 Mar 16.

Published in final edited form as: Nat Cell Biol. 2008 Jun; 10(6): 698–706. Published online 2008 May 11. doi: 10.1038/ncb1732

PMCID:: PMC2839190

Abstract Article PDF–2.2M

Select item 316025020.

FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons

Satoru Yamagishi, Falko Hampel, Katsuhiko Hata, Daniel del Toro, Manuela Schwark, Elena Kvachnina, Martin Bastmeyer, Toshihide Yamashita, Victor Tarabykin, Rüdiger Klein, Joaquim Egea

EMBO J. 2011 Jul 20; 30(14): 2920–2933. Published online 2011 Jun 14. doi: 10.1038/emboj.2011.189