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Select item 97537171.

Deubiquitinase OTUD1 Resolves Stalled Translation on polyA and Rare Codon Rich mRNAs

Renata Snaurova, Alexander Vdovin, Michal Durech, Jakub Nezval, David Zihala, Tomas Jelinek, Roman Hajek, Michal Simicek

Mol Cell Biol. 2022 Dec; 42(12): e00265-22. Published online 2022 Nov 29. doi: 10.1128/mcb.00265-22

PMCID:: PMC9753717

Abstract Article PDF–1.6M

Select item 41199882.

A putative OTU domain-containing protein 1 deubiquitinating enzyme is differentially expressed in thyroid cancer and identifies less-aggressive tumours

A P Carneiro, C F Reis, E C Morari, Y C P Maia, R Nascimento, J M C Bonatto, M A de Souza, L R Goulart, L S Ward

Br J Cancer. 2014 Jul 29; 111(3): 551–558. Published online 2014 Jun 17. doi: 10.1038/bjc.2014.331

PMCID:: PMC4119988

Abstract Article PDF–1.3M

Select item 106025263.

The Deubiquitinase OTUD1 Suppresses Secretory Neutrophil Polarization And Ameliorates Immunopathology of Periodontitis

Jia Song, Yuning Zhang, Yunyang Bai, Xiaowen Sun, Yanhui Lu, Yusi Guo, Ying He, Min Gao, Xiaopei Chi, Boon Chin Heng, Xin Zhang, Wenjing Li, Mingming Xu, Yan Wei, Fuping You, Xuehui Zhang, Dan Lu, Xuliang Deng

Adv Sci (Weinh) 2023 Oct; 10(30): 2303207. Published online 2023 Aug 28. doi: 10.1002/advs.202303207

PMCID:: PMC10602526

Abstract Article PDF–5.1M

Select item 67126164.

The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein

Lanqin Wu, Yingying Lin, Jinan Feng, Yuanlin Qi, Xinrui Wang, Qiaofa Lin, Wanyan Shi, Enrun Zheng, Wei Wang, Zhenzhu Hou, Hanbin Lin, Cheng Yu, Yan He, Yan Xu, Hong Yang, Ling Lin, Lisheng Li

Cancer Cell Int. 2019; 19: 222. Published online 2019 Aug 27. doi: 10.1186/s12935-019-0936-5

PMCID:: PMC6712616

Abstract Article PDF–1.6M

Select item 59574515.

Induction of OTUD1 by RNA viruses potently inhibits innate immune responses by promoting degradation of the MAVS/TRAF3/TRAF6 signalosome

Liting Zhang, Jin Liu, Liping Qian, Qian Feng, Xiaofang Wang, Yukang Yuan, Yibo Zuo, Qiao Cheng, Ying Miao, Tingting Guo, Xiaofeng Zheng, Hui Zheng

PLoS Pathog. 2018 May; 14(5): e1007067. Published online 2018 May 7. doi: 10.1371/journal.ppat.1007067

PMCID:: PMC5957451

Abstract Article PDF–17M

Select item 88038536.

The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-κB signaling

Bo Wu, Lihua Qiang, Yong Zhang, Yesheng Fu, Mengyuan Zhao, Zehui Lei, Zhe Lu, Yan-Ge Wei, Hongmiao Dai, Yingwei Ge, Mingqiu Liu, Xuemei Zhou, Zhiqiang Peng, Hongchang Li, Chun-Ping Cui, Jing Wang, Hui Zheng, Cui Hua Liu, Lingqiang Zhang

Cell Mol Immunol. 2022 Feb; 19(2): 276–289. Published online 2021 Dec 7. doi: 10.1038/s41423-021-00810-9

PMCID:: PMC8803853

Abstract Article PDF–4.7M

Select item 57274337.

Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7

Zhengkui Zhang, Yao Fan, Feng Xie, Hang Zhou, Ke Jin, Li Shao, Wenhao Shi, Pengfei Fang, Bing Yang, Hans van Dam, Peter ten Dijke, Xiaofeng Zheng, Xiaohua Yan, Junling Jia, Min Zheng, Jin Jin, Chen Ding, Sheng Ye, Fangfang Zhou, Long Zhang

Nat Commun. 2017; 8: 2116. Published online 2017 Dec 13. doi: 10.1038/s41467-017-02029-7

PMCID:: PMC5727433

Abstract Article PDF–4.6M

Select item 78574368.

The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity

Jia Song, Tongtong Liu, Yue Yin, Wei Zhao, Zhiqiang Lin, Yuxin Yin, Dan Lu, Fuping You

EMBO Rep. 2021 Feb 3; 22(2): e51162. Published online 2021 Jan 4. doi: 10.15252/embr.202051162

PMCID:: PMC7857436

Abstract Article PDF–3.0M

Select item 80613619.

OTUD1 Activates Caspase‐Independent and Caspase‐Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation

Qingyu Luo, Xiaowei Wu, Pengfei Zhao, Yabing Nan, Wan Chang, Xiaolin Zhu, Dan Su, Zhihua Liu

Adv Sci (Weinh) 2021 Apr; 8(8): 2002874. Published online 2021 Feb 8. doi: 10.1002/advs.202002874

PMCID:: PMC8061361

Abstract Article PDF–6.1M

Select item 964977010.

The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma

Alexander Vdovin, Tomas Jelinek, David Zihala, Tereza Sevcikova, Michal Durech, Hana Sahinbegovic, Renata Snaurova, Dhwani Radhakrishnan, Marcello Turi, Zuzana Chyra, Tereza Popkova, Ondrej Venglar, Matous Hrdinka, Roman Hajek, Michal Simicek

Nat Commun. 2022; 13: 6820. Published online 2022 Nov 10. doi: 10.1038/s41467-022-34654-2

PMCID:: PMC9649770

Abstract Article PDF–3.2M

Select item 905064711.

OVOL1 inhibits breast cancer cell invasion by enhancing the degradation of TGF-β type I receptor

Chuannan Fan, Qian Wang, Gerard van der Zon, Jiang Ren, Cedrick Agaser, Roderick C. Slieker, Prasanna Vasudevan Iyengar, Hailiang Mei, Peter ten Dijke

Signal Transduct Target Ther. 2022; 7: 126. Published online 2022 Apr 29. doi: 10.1038/s41392-022-00944-w

PMCID:: PMC9050647

Abstract Article PDF–6.9M

Select item 998681512.

Mouse endothelial OTUD1 promotes angiotensin II‐induced vascular remodeling by deubiquitinating SMAD3

Zhuqi Huang, Sirui Shen, Mengyang Wang, Weixin Li, Gaojun Wu, Weijian Huang, Wu Luo, Guang Liang

EMBO Rep. 2023 Mar; 24(3): e56135. Published online 2022 Dec 29. doi: 10.15252/embr.202256135

PMCID:: PMC9986815

Abstract Article PDF–5.1M

Select item 937779713.

Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression

Qiangqiang Liu, Qian Luo, Jianyu Feng, Yanping Zhao, Biao Ma, Hongcheng Cheng, Tian Zhao, Hong Lei, Chenglong Mu, Linbo Chen, Yuanyuan Meng, Jiaojiao Zhang, Yijia Long, Jingyi Su, Guo Chen, Yanjun Li, Gang Hu, Xudong Liao, Quan Chen, Yushan Zhu

eLife. 2022; 11: e81247. Published online 2022 Aug 1. doi: 10.7554/eLife.81247

PMCID:: PMC9377797

Abstract Article PDF–4.9M

Select item 927418614.

Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis

Hong-Guang Zhang, Bin Wang, Yong Yang, Xuan Liu, Junjie Wang, Ning Xin, Shifeng Li, Ying Miao, Qiuyu Wu, Tingting Guo, Yukang Yuan, Yibo Zuo, Xiangjie Chen, Tengfei Ren, Chunsheng Dong, Jun Wang, Hang Ruan, Miao Sun, Xingshun Xu, Hui Zheng

Cell Res. 2022 Oct; 32(10): 897–913. Published online 2022 Jul 12. doi: 10.1038/s41422-022-00689-9

PMCID:: PMC9274186

Abstract Article PDF–6.7M

Select item 599587015.

SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity

Fan Yao, Zhicheng Zhou, Jongchan Kim, Qinglei Hang, Zhenna Xiao, Baochau N. Ton, Liang Chang, Na Liu, Liyong Zeng, Wenqi Wang, Yumeng Wang, Peijing Zhang, Xiaoyu Hu, Xiaohua Su, Han Liang, Yutong Sun, Li Ma

Nat Commun. 2018; 9: 2269. Published online 2018 Jun 11. doi: 10.1038/s41467-018-04620-y

PMCID:: PMC5995870

Abstract Article PDF–7.5M

Select item 936000016.

OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways

Daisuke Oikawa, Min Gi, Hidetaka Kosako, Kouhei Shimizu, Hirotaka Takahashi, Masayuki Shiota, Shuhei Hosomi, Keidai Komakura, Hideki Wanibuchi, Daisuke Tsuruta, Tatsuya Sawasaki, Fuminori Tokunaga

Cell Death Dis. 2022 Aug; 13(8): 694. Published online 2022 Aug 8. doi: 10.1038/s41419-022-05145-5

PMCID:: PMC9360000

Abstract Article PDF–6.1M

Select item 410623517.

Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity

Eleanor Wheeler, Ni Huang, Elena Bochukova, Julia M. Keogh, Sarah Lindsay, Sumedha Garg, Elana Henning, Hannah Blackburn, Ruth J.F. Loos, Nick J Wareham, Stephen O’Rahilly, Matthew E. Hurles, Inês Barroso, I. Sadaf Farooqi

Nat Genet. Author manuscript; available in PMC 2014 Jul 22.

Published in final edited form as: Nat Genet. 2013 May; 45(5): 513–517. Published online 2013 Apr 7. doi: 10.1038/ng.2607

PMCID:: PMC4106235

Article PDF–756K

Select item 694334618.

USP37 is a SNAI1 deubiquitinase

Zhenna Xiao, Liang Chang, Jongchan Kim, Peijing Zhang, Qinglei Hang, Shannon Yap, Youming Guo, Zhicheng Zhou, Liyong Zeng, Xiaoyu Hu, Ashley Siverly, Yutong Sun, Li Ma

Am J Cancer Res. 2019; 9(12): 2749–2759. Published online 2019 Dec 1.