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Items: 1 to 20 of 39

1.
Vitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional Werner syndrome (Wrn) mutant protein
Lucie Aumailley, Florence Roux-Dalvai, Isabelle Kelly, Arnaud Droit, Michel Lebel
PLoS One. 2018; 13(3): e0193170. Published online 2018 Mar 1. doi: 10.1371/journal.pone.0193170
PMCID:
PMC5832228
AbstractArticlePDF–5.4M
2.
Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice
Lucie Aumailley, Chantal Garand, Marie Julie Dubois, F. Brad Johnson, André Marette, Michel Lebel
PLoS One. 2015; 10(10): e0140292. Published online 2015 Oct 8. doi: 10.1371/journal.pone.0140292
PMCID:
PMC4598085
AbstractArticlePDF–3.1M
3.
Serum vitamin C levels modulate the lifespan and endoplasmic reticulum stress response pathways in mice synthesizing a nonfunctional mutant WRN protein
Lucie Aumailley, Marie Julie Dubois, Tracy A. Brennan, Chantal Garand, Eric R. Paquet, Robert J. Pignolo, André Marette, Michel Lebel
FASEB J. 2018 Jul; 32(7): 3623–3640. Published online 2018 Feb 8. doi: 10.1096/fj.201701176R
PMCID:
PMC5998970
AbstractArticle
4.
Mouse models of telomere dysfunction phenocopy skeletal changes found in human age-related osteoporosis
Tracy A. Brennan, Kevin P. Egan, Carter M. Lindborg, Qijun Chen, Mariya T. Sweetwyne, Kurt D. Hankenson, Sharon X. Xie, Frederick B. Johnson, Robert J. Pignolo
Dis Model Mech. 2014 May; 7(5): 583–592. Published online 2014 Mar 13. doi: 10.1242/dmm.014928
PMCID:
PMC4007409
AbstractArticle
5.
MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency
Russell Moser, Masafumi Toyoshima, Kristin Robinson, Kay E. Gurley, Heather L. Howie, Jerry Davison, Martin Morgan, Christopher J. Kemp, Carla Grandori
Mol Cancer Res. Author manuscript; available in PMC 2013 Jul 10.
Published in final edited form as: Mol Cancer Res. 2012 Apr; 10(4): 535–545. Published online 2012 Feb 1. doi: 10.1158/1541-7786.MCR-11-0508
PMCID:
PMC3707802
AbstractArticlePDF–2.0M
6.
Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage
Radhakrishnan Kanagaraj, Prasanna Parasuraman, Boris Mihaljevic, Barbara van Loon, Kamila Burdova, Christiane König, Antonia Furrer, Vilhelm A. Bohr, Ulrich Hübscher, Pavel Janscak
Nucleic Acids Res. 2012 Sep; 40(17): 8449–8459. Published online 2012 Jun 29. doi: 10.1093/nar/gks648
PMCID:
PMC3458577
AbstractArticlePDF–5.8M
7.
Loss of p16Ink4a Function Rescues Cellular Senescence Induced by Telomere Dysfunction
Xiufeng Zhang, Xiaoming Wu, Wenru Tang, Ying Luo
Int J Mol Sci. 2012; 13(5): 5866–5877. Published online 2012 May 16. doi: 10.3390/ijms13055866
PMCID:
PMC3382785
AbstractArticlePDF–465K
8.
The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold Attachment Factor B1 deficient mice
Sophie Lachapelle, Steffi Oesterreich, Michel Lebel
Aging (Albany NY) 2011 Mar; 3(3): 277–290. Published online 2011 Mar 20. doi: 10.18632/aging.100300
PMCID:
PMC3091521
AbstractArticlePDF–4.6M
9.
BCR/ABL stimulates WRN to promote survival and genomic instability
Artur Slupianek, Tomasz Poplawski, Stanislaw K. Jozwiakowski, Kimberly Cramer, Dariusz Pytel, Ewelina Stoczynska, Michal O. Nowicki, Janusz Blasiak, Tomasz Skorski
Cancer Res. Author manuscript; available in PMC 2012 Feb 1.
Published in final edited form as: Cancer Res. 2011 Feb 1; 71(3): 842–851. Published online 2010 Dec 1. doi: 10.1158/0008-5472.CAN-10-1066
PMCID:
PMC3032814
AbstractArticlePDF–1.4M
10.
Depletion of Werner helicase results in mitotic hyperrecombination and pleiotropic homologous and nonhomologous recombination phenotypes
Jennifer J. Rahn, Megan P. Lowery, Luis Della-Coletta, Gerald M. Adair, Rodney S. Nairn
Mech Ageing Dev. Author manuscript; available in PMC 2011 Sep 1.
Published in final edited form as: Mech Ageing Dev. 2010 Sep; 131(9): 562–573. Published online 2010 Aug 12. doi: 10.1016/j.mad.2010.08.001
PMCID:
PMC2949496
AbstractArticlePDF–1.5M
11.
Divergent cellular phenotypes of human and mouse cells lacking the Werner syndrome RecQ helicase
Kiranjit K. Dhillon, Julia M. Sidorova, Tina M. Albertson, Judith B. Anderson, Warren C. Ladiges, Peter S. Rabinovitch, Bradley D. Preston, Raymond J. Monnat, Jr.
DNA Repair (Amst) Author manuscript; available in PMC 2011 Jan 2.
Published in final edited form as: DNA Repair (Amst). 2010 Jan 2; 9(1): 11. Published online 2009 Nov 5. doi: 10.1016/j.dnarep.2009.09.013
PMCID:
PMC2818259
AbstractArticlePDF–3.1M
12.
Hyperinsulinemia and insulin resistance in Wrn null mice fed a diabetogenic diet
Gina Moore, Susan Knoblaugh, Kathryn Gollahon, Peter Rabinovitch, Warren Ladiges
Mech Ageing Dev. Author manuscript; available in PMC 2009 Jul 6.
Published in final edited form as: Mech Ageing Dev. 2008 Apr; 129(4): 201–206. Published online 2008 Jan 17. doi: 10.1016/j.mad.2007.12.009
PMCID:
PMC2706000
AbstractArticlePDF–678K
13.
Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway
Purnima R. Laud, Asha S. Multani, Susan M. Bailey, Ling Wu, Jin Ma, Charles Kingsley, Michel Lebel, Sen Pathak, Ronald A. DePinho, Sandy Chang
Genes Dev. 2005 Nov 1; 19(21): 2560–2570. doi: 10.1101/gad.1321305
PMCID:
PMC1276730
AbstractArticlePDF–699K
14.
R-Spondin 1 promotes vibration-induced bone formation in mouse models of osteoporosis
Haitao Wang, Tracy A. Brennan, Elizabeth Russell, Jung-Hoon Kim, Kevin P. Egan, Qijun Chen, Craig Israelite, David C. Schultz, Frederick B. Johnson, Robert J. Pignolo
J Mol Med (Berl) Author manuscript; available in PMC 2014 Dec 1.
Published in final edited form as: J Mol Med (Berl). 2013 Dec; 91(12): 10.1007/s00109-013-1068-3. Published online 2013 Aug 24. doi: 10.1007/s00109-013-1068-3
PMCID:
PMC3834172
AbstractArticlePDF–1.5M
15.
Impairment of Osteoblast Differentiation Due to Proliferation-independent Telomere Dysfunction in Mouse Models of Accelerated Aging
Haitao Wang, Qijun Chen, Seoung-Hoon Lee, Yongwon Choi, F. Brad Johnson, Robert J. Pignolo
Aging Cell. Author manuscript; available in PMC 2013 Aug 1.
Published in final edited form as: Aging Cell. 2012 Aug; 11(4): 704–713. Published online 2012 Jun 11. doi: 10.1111/j.1474-9726.2012.00838.x
PMCID:
PMC3400025
AbstractArticlePDF–2.2M
16.
Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis
Robert J. Pignolo, Robin K. Suda, Emily A. McMillan, Johnny Shen, Seoung-Hoon Lee, Yongwon Choi, Alexander C. Wright, F. Brad Johnson
Aging Cell. Author manuscript; available in PMC 2009 Jan 1.
Published in final edited form as: Aging Cell. 2008 Jan; 7(1): 23–31. Published online 2007 Nov 20. doi: 10.1111/j.1474-9726.2007.00350.x
PMCID:
PMC2394673
AbstractArticlePDF–1.5M
17.
Mutations in the WRN Gene in Mice Accelerate Mortality in a p53-Null Background
David B. Lombard, Caroline Beard, Brad Johnson, Robert A. Marciniak, Jessie Dausman, Roderick Bronson, Janet E. Buhlmann, Ruth Lipman, Ruth Curry, Arlene Sharpe, Rudolf Jaenisch, Leonard Guarente
Mol Cell Biol. 2000 May; 20(9): 3286–3291. doi: 10.1128/mcb.20.9.3286-3291.2000
PMCID:
PMC85622
AbstractArticlePDF–797K
18.
Nucleolar localization of the Werner syndrome protein in human cells
Robert A. Marciniak, David B. Lombard, F. Bradley Johnson, Leonard Guarente
Proc Natl Acad Sci U S A. 1998 Jun 9; 95(12): 6887–6892. doi: 10.1073/pnas.95.12.6887
PMCID:
PMC22674
AbstractArticlePDF–352K
19.
WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells
Arindam Datta, Kajal Biswas, Joshua A. Sommers, Haley Thompson, Sanket Awate, Claudia M. Nicolae, Tanay Thakar, George-Lucian Moldovan, Robert H. Shoemaker, Shyam K. Sharan, Robert M. Brosh, Jr
Nat Commun. 2021; 12: 6561. Published online 2021 Nov 12. doi: 10.1038/s41467-021-26811-w
PMCID:
PMC8590011
AbstractArticlePDF–6.8M
20.
Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A
So-mi Kang, Min-Ho Yoon, Su-Jin Lee, Jinsook Ahn, Sang Ah Yi, Ki Hong Nam, Soyoung Park, Tae-Gyun Woo, Jung-Hyun Cho, Jaecheol Lee, Nam-Chul Ha, Bum-Joon Park
Sci Rep. 2021; 11: 9122. Published online 2021 Apr 27. doi: 10.1038/s41598-021-88325-1
Correction in:
Sci Rep. 2021; 11: 17776.
PMCID:
PMC8079706
AbstractArticlePDF–3.6M

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