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Select item 63921011.

Metabolic regulation of T cell development by Sin1–mTORC2 is mediated by pyruvate kinase M2

Xinxing Ouyang, Yuheng Han, Guojun Qu, Man Li, Ningbo Wu, Hongzhi Liu, Omotooke Arojo, Hongxiang Sun, Xiaobo Liu, Dou Liu, Lei Chen, Qiang Zou, Bing Su

J Mol Cell Biol. 2019 Feb; 11(2): 93–106. Published online 2018 Nov 14. doi: 10.1093/jmcb/mjy065

PMCID:: PMC6392101

Abstract Article PDF–1.5M

Select item 68048162.

Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc

Man Li, Adam S. Lazorchak, Xinxing Ouyang, Huihui Zhang, Hongzhi Liu, Omotooke A. Arojo, Lichong Yan, Jingsi Jin, Yuheng Han, Guojun Qu, Yuhong Fu, Xiaocao Xu, Xiaobo Liu, Wenqian Zhang, Zhengfeng Yang, Chuan Ruan, Qijun Wang, Dou Liu, Chuanxin Huang, Lu Lu, Shibo Jiang, Fubin Li, Bing Su

Cell Mol Immunol. 2019 Sep; 16(9): 757–769. Published online 2019 Jan 31. doi: 10.1038/s41423-018-0185-x

PMCID:: PMC6804816

Abstract Article PDF–1.7M

Select item 53777873.

Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses

Barbara Kroczynska, Gavin T. Blyth, Robert L. Rafidi, Beata Majchrzak-Kita, Lucy Xu, Diana Saleiro, Ewa M. Kosciuczuk, Jacek Jemielity, Bing Su, Jessica K. Altman, Elizabeth A. Eklund, Eleanor N. Fish, Leonidas C. Platanias

J Biol Chem. 2017 Mar 17; 292(11): 4743–4752. Published online 2017 Feb 7. doi: 10.1074/jbc.M116.757666

PMCID:: PMC5377787

Abstract Article PDF–1.1M

Select item 39453214.

Critical Roles for Rictor/Sin1 Complexes in Interferon-dependent Gene Transcription and Generation of Antiproliferative Responses

Surinder Kaur, Barbara Kroczynska, Bhumika Sharma, Antonella Sassano, Ahmet Dirim Arslan, Beata Majchrzak-Kita, Brady L. Stein, Brandon McMahon, Jessica K. Altman, Bing Su, Raffaele A. Calogero, Eleanor N. Fish, Leonidas C. Platanias

J Biol Chem. 2014 Mar 7; 289(10): 6581–6591. Published online 2014 Jan 27. doi: 10.1074/jbc.M113.537852

PMCID:: PMC3945321

Abstract Article PDF–1.9M

Select item 105145205.

Ang II Controls the Expression of Mapkap1 by miR-375 and Affects the Function of Islet β Cells

Xiuhong Lin, Lin Cheng, Yan Wan, Yuerong Yan, Zhuo Zhang, Xiaohui Li, Jiayun Wu, Xiaoyi Wang, Mingtong Xu

Endocr Metab Immune Disord Drug Targets. 2023 Jul 19; 23(9): 1186–1200. Published online 2023 Jul 19. doi: 10.2174/1871530323666230206121715

PMCID:: PMC10514520

Abstract Article PDF–3.3M

Select item 36904796.

Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2

Sean J. Humphrey, Guang Yang, Pengyi Yang, Daniel J. Fazakerley, Jacqueline Stöckli, Jean Y. Yang, David E. James

Cell Metab. 2013 Jun 4; 17(6): 1009–1020. doi: 10.1016/j.cmet.2013.04.010

PMCID:: PMC3690479

Abstract Article PDF–3.9M

Select item 36638717.

Sin1 regulates Treg development but is not required for T cell growth and proliferation

Xing Chang, Adam S. Lazorchak, Dou Liu, Bing Su

Eur J Immunol. Author manuscript; available in PMC 2013 Jun 1.

Published in final edited form as: Eur J Immunol. 2012 Jun; 42(6): 1639–1647. doi: 10.1002/eji.201142066

PMCID:: PMC3663871

Abstract Article PDF–1.0M

Select item 35349318.

mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8

Sung Jin Kim, Michael A. DeStefano, Won Jun Oh, Chang-chih Wu, Nicole M. Vega-Cotto, Monica Finlan, Dou Liu, Bing Su, Estela Jacinto

Mol Cell. Author manuscript; available in PMC 2013 Dec 28.

Published in final edited form as: Mol Cell. 2012 Dec 28; 48(6): 875–887. Published online 2012 Nov 8. doi: 10.1016/j.molcel.2012.09.029

PMCID:: PMC3534931

Abstract Article PDF–3.7M

Select item 31745779.

The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile

Beatrice T. Wang, Gregory S. Ducker, Andrea J. Barczak, Rebecca Barbeau, David J. Erle, Kevan M. Shokat

Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37): 15201–15206. Published online 2011 Aug 29. doi: 10.1073/pnas.1103746108

PMCID:: PMC3174577

Abstract Article PDF–833K

Select item 568013310.

Tumor suppressor Pdcd4attenuates Sin1 translation to inhibit invasion in colon carcinoma

Qing Wang, Jiang Zhu, Ya-Wen Wang, Yong Dai, Yanlei Wang, Chi Wang, Jinpeng Liu, Alyson Baker, Nancy H. Colburn, Hsin-Sheng Yang

Oncogene. Author manuscript; available in PMC 2018 Jan 10.

Published in final edited form as: Oncogene. 2017 Nov 9; 36(45): 6225–6234. Published online 2017 Jul 10. doi: 10.1038/onc.2017.228

PMCID:: PMC5680133

Abstract Article PDF–3.1M

Select item 382711711.

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signaling to suppress tumorigenesis

Pengda Liu, Wenjian Gan, Hiroyuki Inuzuka, Adam S Lazorchak, Daming Gao, Omotooke Arojo, Dou Liu, Lixin Wan, Bo Zhai, Yonghao Yu, Min Yuan, Byeong Mo Kim, Shavali Shaik, Suchithra Menon, Steven P. Gygi, Tae Ho Lee, John M Asara, Brendan D. Manning, John Blenis, Bing Su, Wenyi Wei

Nat Cell Biol. Author manuscript; available in PMC 2014 May 1.

Published in final edited form as: Nat Cell Biol. 2013 Nov; 15(11): 1340–1350. Published online 2013 Oct 27. doi: 10.1038/ncb2860

PMCID:: PMC3827117

Abstract Article PDF–1.6M

Select item 289014512.

Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis

Gretchen A. LaRusch, Fakhri Mahdi, Zia Shariat-Madar, Gregory Adams, Robert G. Sitrin, Wan Ming Zhang, Keith R. McCrae, Alvin H. Schmaier

Blood. 2010 Jun 17; 115(24): 5111–5120. Prepublished online 2010 Mar 12. doi: 10.1182/blood-2009-08-236430

PMCID:: PMC2890145

Abstract Article

Select item 1002198913.

Maternal hyperglycemia inhibits pulmonary vasculogenesis during mouse fetal lung development by promoting GβL Ubiquitination-dependent mammalian target of Rapamycin assembly

Qingqing Luo, Xinqun Chai, Xiaoyan Xin, Weixiang Ouyang, Feitao Deng

Diabetol Metab Syndr. 2023; 15: 49. Published online 2023 Mar 17. doi: 10.1186/s13098-022-00974-y

PMCID:: PMC10021989

Abstract Article PDF–1.5M

Select item 335663014.

Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses

Surinder Kaur, Antonella Sassano, Beata Majchrzak-Kita, Darren P. Baker, Bing Su, Eleanor N. Fish, Leonidas C. Platanias

Proc Natl Acad Sci U S A. 2012 May 15; 109(20): 7723–7728. Published online 2012 May 1. doi: 10.1073/pnas.1118122109

PMCID:: PMC3356630

Abstract Article PDF–1.7M

Select item 316242515.

mSIN1 Protein Mediates SGK1 Protein Interaction with mTORC2 Protein Complex and Is Required for Selective Activation of the Epithelial Sodium Channel

Ming Lu, Jian Wang, Harlan E. Ives, David Pearce

J Biol Chem. 2011 Sep 2; 286(35): 30647–30654. Published online 2011 Jul 11. doi: 10.1074/jbc.M111.257592

PMCID:: PMC3162425

Abstract Article PDF–655K

Select item 374287216.

Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through β₁-integrin and VEGFR2

Gretchen A. LaRusch, Alona Merkulova, Fakhri Mahdi, Zia Shariat-Madar, Robert G. Sitrin, Douglas B. Cines, Alvin H. Schmaier

Am J Physiol Heart Circ Physiol. 2013 Aug 1; 305(3): H305–H320. Published online 2013 May 24. doi: 10.1152/ajpheart.00110.2013

PMCID:: PMC3742872

Abstract Article

Select item 295780017.

Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells

Adam S Lazorchak, Dou Liu, Valeria Facchinetti, Annarita Di Lorenzo, William C Sessa, David G Schatz, Bing Su

Mol Cell. Author manuscript; available in PMC 2011 Aug 13.

Published in final edited form as: Mol Cell. 2010 Aug 13; 39(3): 433–443. doi: 10.1016/j.molcel.2010.07.031

PMCID:: PMC2957800

Abstract Article PDF–630K

Select item 329800718.

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

Carmine Settembre, Roberto Zoncu, Diego L Medina, Francesco Vetrini, Serkan Erdin, SerpilUckac Erdin, Tuong Huynh, Mathieu Ferron, Gerard Karsenty, Michel C Vellard, Valeria Facchinetti, David M Sabatini, Andrea Ballabio

EMBO J. 2012 Mar 7; 31(5): 1095–1108. Published online 2012 Feb 17. doi: 10.1038/emboj.2012.32

PMCID:: PMC3298007

Abstract Article PDF–2.6M

Select item 248627619.

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

Valeria Facchinetti, Weiming Ouyang, Hua Wei, Nelyn Soto, Adam Lazorchak, Christine Gould, Carolyn Lowry, Alexandra C Newton, Yuxin Mao, Robert Q Miao, William C Sessa, Jun Qin, Pumin Zhang, Bing Su, Estela Jacinto

EMBO J. 2008 Jul 23; 27(14): 1932–1943. Published online 2008 Jun 19. doi: 10.1038/emboj.2008.120

PMCID:: PMC2486276

Abstract Article PDF–975K

Select item 492686120.

Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival

Laura J. Smithson, David H. Gutmann

Genes Dev. 2016 Jun 15; 30(12): 1383–1388. doi: 10.1101/gad.279661.116

PMCID:: PMC4926861

Abstract Article PDF–500K

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PMC Links for Gene (Select 227743) (38)
PMC
PREDICTED: Mus musculus kringle containing transmembrane protein 2 (Kremen2), tr...
PREDICTED: Mus musculus kringle containing transmembrane protein 2 (Kremen2), transcript variant X2, mRNA
gi|1720391183|ref|XM_006524984.4|

Nucleotide
alpha-S1-casein isoform c precursor [Mus musculus]
alpha-S1-casein isoform c precursor [Mus musculus]
gi|553727030|ref|NP_001272945.1|

Protein
Mus musculus formation of mitochondrial complex V assembly factor 1 (Fmc1), mRNA
Mus musculus formation of mitochondrial complex V assembly factor 1 (Fmc1), mRNA
gi|141801827|ref|NM_025363.3|

Nucleotide
H4072H10-5 NIA Mouse 7.4K cDNA Clone Set Mus musculus cDNA clone H4072H10 5', mR...
H4072H10-5 NIA Mouse 7.4K cDNA Clone Set Mus musculus cDNA clone H4072H10 5', mRNA sequence
gi|21462773|gnl|dbEST|12673833|gb|B 87.1|

Nucleotide

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