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Select item 105241821.

The exoribonuclease XRN2 mediates degradation of the long non-coding telomeric RNA TERRA

Matthew Reiss, Joshua Keegan, Anne Aldrich, Shawn M. Lyons, Rachel Litman Flynn

FEBS Lett. Author manuscript; available in PMC 2024 Jul 1.

Published in final edited form as: FEBS Lett. 2023 Jul; 597(14): 1818–1836. Published online 2023 May 26. doi: 10.1002/1873-3468.14639

PMCID:: PMC10524182

Abstract Article PDF–1.9M

Select item 91001752.

XRN2 Is Required for Cell Motility and Invasion in Glioblastomas

Tuyen T. Dang, Megan Lerner, Debra Saunders, Nataliya Smith, Rafal Gulej, Michelle Zalles, Rheal A. Towner, Julio C. Morales

Cells. 2022 May; 11(9): 1481. Published online 2022 Apr 28. doi: 10.3390/cells11091481

PMCID:: PMC9100175

Abstract Article PDF–11M

Select item 61506253.

An end in sight? Xrn2 and transcriptional termination by RNA polymerase II

Joshua D. Eaton, Steven West

Transcription. 2018; 9(5): 321–326. Published online 2018 Aug 2. doi: 10.1080/21541264.2018.1498708

PMCID:: PMC6150625

Abstract Article PDF–579K

Select item 49547314.

XRN2 Links Transcription Termination to DNA Damage and Replication Stress

Julio C. Morales, Patricia Richard, Praveen L. Patidar, Edward A. Motea, Tuyen T. Dang, James L. Manley, David A. Boothman

PLoS Genet. 2016 Jul; 12(7): e1006107. Published online 2016 Jul 20. doi: 10.1371/journal.pgen.1006107

PMCID:: PMC4954731

Abstract Article PDF–3.7M

Select item 47019745.

P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates

Miriam Sansó, Rebecca S. Levin, Jesse J. Lipp, Vivien Ya-Fan Wang, Ann Katrin Greifenberg, Elizabeth M. Quezada, Akbar Ali, Animesh Ghosh, Stéphane Larochelle, Tariq M. Rana, Matthias Geyer, Liang Tong, Kevan M. Shokat, Robert P. Fisher

Genes Dev. 2016 Jan 1; 30(1): 117–131. doi: 10.1101/gad.269589.115

PMCID:: PMC4701974

Abstract Article PDF–1.2M

Select item 46541106.

Effects of transcription elongation rate and Xrn2 exonuclease activity on RNA polymerase II termination suggest widespread kinetic competition

Nova Fong, Kristopher Brannan, Benjamin Erickson, Hyunmin Kim, Michael Cortazar, Ryan M. Sheridan, Tram Nguyen, Shai Karp, David L. Bentley

Mol Cell. Author manuscript; available in PMC 2016 Oct 15.

Published in final edited form as: Mol Cell. 2015 Oct 15; 60(2): 256–267. doi: 10.1016/j.molcel.2015.09.026

PMCID:: PMC4654110

Abstract Article PDF–899K

Select item 33654147.

Co-transcriptional degradation of aberrant pre-mRNA by Xrn2

Lee Davidson, Alastair Kerr, Steven West

EMBO J. 2012 May 30; 31(11): 2566–2578. Published online 2012 Apr 20. doi: 10.1038/emboj.2012.101

PMCID:: PMC3365414

Abstract Article PDF–714K

Select item 98725538.

The transcriptional terminator XRN2 and the RNA-binding protein Sam68 link alternative polyadenylation to cell cycle progression in prostate cancer

Marco Pieraccioli, Cinzia Caggiano, Luca Mignini, Chuwei Zhong, Gabriele Babini, Rossano Lattanzio, Savino Di Stasi, Bin Tian, Claudio Sette, Pamela Bielli

Nat Struct Mol Biol. Author manuscript; available in PMC 2023 Jan 24.

Published in final edited form as: Nat Struct Mol Biol. 2022 Nov; 29(11): 1101–1112. Published online 2022 Nov 7. doi: 10.1038/s41594-022-00853-0

PMCID:: PMC9872553

Abstract Article PDF–5.1M

Select item 66645979.

Novel Insight Into the Etiology of Autism Spectrum Disorder Gained by Integrating Expression Data With Genome-wide Association Statistics

Oliver Pain, Andrew J. Pocklington, Peter A. Holmans, Nicholas J. Bray, Heath E. O’Brien, Lynsey S. Hall, Antonio F. Pardiñas, Michael C. O’Donovan, Michael J. Owen, Richard Anney

Biol Psychiatry. 2019 Aug 15; 86(4): 265–273. doi: 10.1016/j.biopsych.2019.04.034

PMCID:: PMC6664597

Abstract Article

Select item 466635710.

Collaborator of alternative reading frame protein (CARF) regulates early processing of pre-ribosomal RNA by retaining XRN2 (5′-3′ exoribonuclease) in the nucleoplasm

Shigeko Sato, Hideaki Ishikawa, Harunori Yoshikawa, Keiichi Izumikawa, Richard J. Simpson, Nobuhiro Takahashi

Nucleic Acids Res. 2015 Dec 2; 43(21): 10397–10410. Published online 2015 Nov 3. doi: 10.1093/nar/gkv1069

PMCID:: PMC4666357

Abstract Article PDF–4.6M

Select item 440345111.

Dissecting the Roles of the 5′ Exoribonucleases Xrn1 and Xrn2 in Restricting Hepatitis C Virus Replication

You Li, Daisuke Yamane, Stanley M. Lemon

J Virol. 2015 May 1; 89(9): 4857–4865. Published online 2015 Feb 11. doi: 10.1128/JVI.03692-14

PMCID:: PMC4403451

Abstract Article PDF–2.5M

Select item 422761512.

Hepatitis C virus subverts liver-specific miR-122 to protect the viral genome from exoribonuclease Xrn2

Cecilia D. Sedano, Peter Sarnow

Cell Host Microbe. Author manuscript; available in PMC 2015 Aug 13.

Published in final edited form as: Cell Host Microbe. 2014 Aug 13; 16(2): 257–264. doi: 10.1016/j.chom.2014.07.006

PMCID:: PMC4227615

Abstract Article PDF–941K

Select item 380645613.

mRNA decapping factors and the exonuclease Xrn2 function in widespread premature termination of RNA polymerase II transcription

Kris Brannan, Hyunmin Kim, Benjamin Erickson, Kira Glover-Cutter, Soojin Kim, Nova Fong, Lauren Kiemele, Kirk Hansen, Richard Davis, Jens Lykke-Andersen, David L. Bentley

Mol Cell. Author manuscript; available in PMC 2013 Oct 23.

Published in final edited form as: Mol Cell. 2012 May 11; 46(3): 311–324. Published online 2012 Apr 5. doi: 10.1016/j.molcel.2012.03.006

PMCID:: PMC3806456

Abstract Article PDF–3.4M

Select item 148899714.

Pause Sites Promote Transcriptional Termination of Mammalian RNA Polymerase II

Natalia Gromak, Steven West, Nick J. Proudfoot

Mol Cell Biol. 2006 May; 26(10): 3986–3996. doi: 10.1128/MCB.26.10.3986-3996.2006

PMCID:: PMC1488997

Abstract Article PDF–487K

Select item 740953815.

Genome-wide R-loop analysis defines unique roles for DDX5, XRN2, and PRMT5 in DNA/RNA hybrid resolution

Oscar D Villarreal, Sofiane Y Mersaoui, Zhenbao Yu, Jean-Yves Masson, Stéphane Richard

Life Sci Alliance. 2020 Oct; 3(10): e202000762. Published online 2020 Aug 3. doi: 10.26508/lsa.202000762

PMCID:: PMC7409538

Abstract Article PDF–2.7M

Select item 640336216.

Rapid Depletion of DIS3, EXOSC10, or XRN2 Reveals the Immediate Impact of Exoribonucleolysis on Nuclear RNA Metabolism and Transcriptional Control

Lee Davidson, Laura Francis, Ross A. Cordiner, Joshua D. Eaton, Chris Estell, Sara Macias, Javier F. Cáceres, Steven West

Cell Rep. 2019 Mar 5; 26(10): 2779–2791.e5. Published online 2019 Mar 5. doi: 10.1016/j.celrep.2019.02.012

PMCID:: PMC6403362

Abstract Article PDF–3.6M

Select item 601962117.

Genetic variants cis-regulating Xrn2 expression contribute to the risk of spontaneous lung tumor

Y Lu, P Liu, M James, HG Vikis, H Liu, W Wen, A Franklin, M You

Oncogene. Author manuscript; available in PMC 2018 Jun 27.

Published in final edited form as: Oncogene. 2010 Feb 18; 29(7): 1041–1049. Published online 2009 Nov 16. doi: 10.1038/onc.2009.396

PMCID:: PMC6019621

Abstract Article PDF–595K

Select item 543591618.

The G-patch protein NF-κB-repressing factor mediates the recruitment of the exonuclease XRN2 and activation of the RNA helicase DHX15 in human ribosome biogenesis

Indira Memet, Carmen Doebele, Katherine E. Sloan, Markus T. Bohnsack

Nucleic Acids Res. 2017 May 19; 45(9): 5359–5374. Published online 2017 Jan 23. doi: 10.1093/nar/gkx013

PMCID:: PMC5435916

Abstract Article PDF–6.1M

Select item 375017419.

Heterogeneous Nuclear Ribonucleoprotein (HnRNP) K Genome-wide Binding Survey Reveals Its Role in Regulating 3′-End RNA Processing and Transcription Termination at the Early Growth Response 1 (EGR1) Gene through XRN2 Exonuclease

Michal Mikula, Karol Bomsztyk, Krzysztof Goryca, Krzysztof Chojnowski, Jerzy Ostrowski

J Biol Chem. 2013 Aug 23; 288(34): 24788–24798. Published online 2013 Jul 15. doi: 10.1074/jbc.M113.496679

PMCID:: PMC3750174

Abstract Article PDF–1.5M

Select item 359599720.

Microprocessor, Setx, Xrn2, and Rrp6 Co-operate to Induce Premature Termination of Transcription by RNAPII

Alexandre Wagschal, Emilie Rousset, Poornima Basavarajaiah, Xavier Contreras, Alex Harwig, Sabine Laurent-Chabalier, Mirai Nakamura, Xin Chen, Ke Zhang, Oussama Meziane, Frédéric Boyer, Hugues Parrinello, Ben Berkhout, Christophe Terzian, Monsef Benkirane, Rosemary Kiernan

Cell. Author manuscript; available in PMC 2013 Mar 13.

Published in final edited form as: Cell. 2012 Sep 14; 150(6): 1147–1157. doi: 10.1016/j.cell.2012.08.004