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Select item 75049321.

Anterograde trafficking of ciliary MAP kinase–like ICK/CILK1 by the intraflagellar transport machinery is required for intraciliary retrograde protein trafficking

Kentaro Nakamura, Tatsuro Noguchi, Mariko Takahara, Yoshihiro Omori, Takahisa Furukawa, Yohei Katoh, Kazuhisa Nakayama

J Biol Chem. 2020 Sep 18; 295(38): 13363–13376. Published online 2020 Jul 29. doi: 10.1074/jbc.RA120.014142

PMCID:: PMC7504932

Abstract Article PDF–4.9M

Select item 71406392.

Functional Alterations in Ciliogenesis-Associated Kinase 1 (CILK1) that Result from Mutations Linked to Juvenile Myoclonic Epilepsy

Eric J. Wang, Casey D. Gailey, David L. Brautigan, Zheng Fu

Cells. 2020 Mar; 9(3): 694. Published online 2020 Mar 12. doi: 10.3390/cells9030694

PMCID:: PMC7140639

Abstract Article PDF–1.7M

Select item 68487643.

Ciliogenesis associated kinase 1 (CILK1): targets and functions in various organ systems

Zheng Fu, Casey D. Gailey, Eric J. Wang, David L. Brautigan

FEBS Lett. Author manuscript; available in PMC 2020 Nov 1.

Published in final edited form as: FEBS Lett. 2019 Nov; 593(21): 2990–3002. Published online 2019 Sep 20. doi: 10.1002/1873-3468.13600

PMCID:: PMC6848764

Abstract Article PDF–850K

Select item 27638054.

Intestinal cell kinase, a MAP kinase-related kinase, regulates proliferation and G₁ cell cycle progression of intestinal epithelial cells

Zheng Fu, Jungeun Kim, Alda Vidrich, Thomas W. Sturgill, Steven M. Cohn

Am J Physiol Gastrointest Liver Physiol. 2009 Oct; 297(4): G632–G640. doi: 10.1152/ajpgi.00066.2009

PMCID:: PMC2763805

Abstract Article

Select item 11688345.

Activation of a Nuclear Cdc2-Related Kinase within a Mitogen-Activated Protein Kinase-Like TDY Motif by Autophosphorylation and Cyclin-Dependent Protein Kinase-Activating Kinase

Zheng Fu, Melanie J. Schroeder, Jeffrey Shabanowitz, Philipp Kaldis, Kasumi Togawa, Anil K. Rustgi, Donald F. Hunt, Thomas W. Sturgill

Mol Cell Biol. 2005 Jul; 25(14): 6047–6064. doi: 10.1128/MCB.25.14.6047-6064.2005

PMCID:: PMC1168834

Abstract Article PDF–1.3M

Select item 110773716.

Ciliogenesis-associated Kinase 1 Promotes Breast Cancer Cell Proliferation and Chemoresistance via Phosphorylating ERK1

Yanling He, Xinyuan Zhang, Weijun Pan, Jiebiao Zhang, Weiliang Zhu, Jian Zhang, Jian Shi

Int J Biol Sci. 2024; 20(7): 2403–2421. Published online 2024 Apr 8. doi: 10.7150/ijbs.87442

PMCID:: PMC11077371

Abstract Article PDF–10M

Select item 66789847.

Ciliopathy-Associated Protein Kinase ICK Requires Its Non-Catalytic Carboxyl-Terminal Domain for Regulation of Ciliogenesis

Yoon Seon Oh, Eric J. Wang, Casey D. Gailey, David L. Brautigan, Benjamin L. Allen, Zheng Fu

Cells. 2019 Jul; 8(7): 677. Published online 2019 Jul 4. doi: 10.3390/cells8070677

PMCID:: PMC6678984

Abstract Article PDF–1.5M

Select item 41537208.

Intestinal Cell Kinase Is a Novel Participant in Intestinal Cell Signaling Responses to Protein Malnutrition

David T. Bolick, Tufeng Chen, Luís Antonio O. Alves, Yixin Tong, Di Wu, Linwood T. Joyner, II, Reinaldo B. Oriá, Richard L. Guerrant, Zheng Fu

PLoS One. 2014; 9(9): e106902. Published online 2014 Sep 3. doi: 10.1371/journal.pone.0106902

PMCID:: PMC4153720

Abstract Article PDF–2.6M

Select item 26680009.

A Multiplex Human Syndrome Implicates a Key Role for Intestinal Cell Kinase in Development of Central Nervous, Skeletal, and Endocrine Systems

Piya Lahiry, Jian Wang, John F. Robinson, Jacob P. Turowec, David W. Litchfield, Matthew B. Lanktree, Gregory B. Gloor, Erik G. Puffenberger, Kevin A. Strauss, Mildred B. Martens, David A. Ramsay, C. Anthony Rupar, Victoria Siu, Robert A. Hegele

Am J Hum Genet. 2009 Feb 13; 84(2): 134–147. doi: 10.1016/j.ajhg.2008.12.017

Correction in:: Am J Hum Genet. 2009 Jun 12; 84(6): 822.

PMCID:: PMC2668000

Abstract Article PDF–2.0M

Select item 373612610.

CCRK depletion inhibits glioblastoma cell proliferation in a cilium-dependent manner

Ying Yang, Niina Roine, Tomi P Mäkelä

EMBO Rep. 2013 Aug; 14(8): 741–747. Published online 2013 Jun 7. doi: 10.1038/embor.2013.80

PMCID:: PMC3736126

Abstract Article PDF–739K

Select item 338461111.

Identification of Kinases Regulating Prostate Cancer Cell Growth Using an RNAi Phenotypic Screen

Hilary Whitworth, Shriti Bhadel, Melissa Ivey, Mark Conaway, Andrea Spencer, Ronald Hernan, Heather Holemon, Daniel Gioeli

PLoS One. 2012; 7(6): e38950. Published online 2012 Jun 27. doi: 10.1371/journal.pone.0038950

PMCID:: PMC3384611

Abstract Article PDF–1.9M

Select item 332100012.

Intestinal Cell Kinase (ICK) Promotes Activation of mTOR Complex 1 (mTORC1) through Phosphorylation of Raptor Thr-908

Di Wu, Jessica R. Chapman, Lifu Wang, Thurl E. Harris, Jeffrey Shabanowitz, Donald F. Hunt, Zheng Fu

J Biol Chem. 2012 Apr 6; 287(15): 12510–12519. Published online 2012 Feb 22. doi: 10.1074/jbc.M111.302117

PMCID:: PMC3321000

Abstract Article PDF–1.9M

Select item 958263613.

BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36 contributes to intraflagellar transport turnaround involving ICK/CILK1

Yuuki Satoda, Tatsuro Noguchi, Taiju Fujii, Aoi Taniguchi, Yohei Katoh, Kazuhisa Nakayama

Mol Biol Cell. 2022 Aug 1; 33(9): ar79. Published online 2022 Jul 21. doi: 10.1091/mbc.E22-03-0089

PMCID:: PMC9582636

Abstract Article PDF–6.5M

Select item 955804814.

Isc10, an inhibitor of the Smk1 MAPK, prevents activation loop autophosphorylation and substrate phosphorylation through separate mechanisms

Abhimannyu Rimal, Thomas M. Swayne, Zeal P. Kamdar, Madison A. Tewey, Edward Winter

J Biol Chem. 2022 Oct; 298(10): 102450. Published online 2022 Sep 3. doi: 10.1016/j.jbc.2022.102450

PMCID:: PMC9558048

Abstract Article PDF–1.2M

Select item 382070215.

Distinct Expression Patterns of ICK/MAK/MOK Protein Kinases in the Intestine Implicate Functional Diversity

Tufeng Chen, Di Wu, Christopher A. Moskaluk, Zheng Fu

PLoS One. 2013; 8(11): e79359. Published online 2013 Nov 7. doi: 10.1371/journal.pone.0079359

PMCID:: PMC3820702

Abstract Article PDF–2.0M

Select item 529123416.

An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome

S. Paige Taylor, Michaela Kunova Bosakova, Miroslav Varecha, Lukas Balek, Tomas Barta, Lukas Trantirek, Iva Jelinkova, Ivan Duran, Iva Vesela, Kimberly N. Forlenza, Jorge H. Martin, Ales Hampl, University of Washington Center for Mendelian Genomics, Michael Bamshad, Deborah Nickerson, Margie L. Jaworski, Jieun Song, Hyuk Wan Ko, Daniel H. Cohn, Deborah Krakow, Pavel Krejci

Hum Mol Genet. 2016 Sep 15; 25(18): 3998–4011. Published online 2016 Jul 27. doi: 10.1093/hmg/ddw240

PMCID:: PMC5291234

Abstract Article PDF–2.1M

Select item 287699317.

The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors

Thomas W Sturgill, Paul B Stoddard, Steven M Cohn, Marty W Mayo

Mol Cancer. 2010; 9: 104. Published online 2010 May 11. doi: 10.1186/1476-4598-9-104

PMCID:: PMC2876993

Abstract Article PDF–1.0M

Select item 163678318.

Identification of Yin-Yang Regulators and a Phosphorylation Consensus for Male Germ Cell-Associated Kinase (MAK)-Related Kinase

Zheng Fu, Katherine A. Larson, Raghu K. Chitta, Sirlester A. Parker, Benjamin E. Turk, Matthew W. Lawrence, Philipp Kaldis, Konstantin Galaktionov, Steven M. Cohn, Jeffrey Shabanowitz, Donald F. Hunt, Thomas W. Sturgill

Mol Cell Biol. 2006 Nov; 26(22): 8639–8654. Published online 2006 Sep 5. doi: 10.1128/MCB.00816-06

PMCID:: PMC1636783

Abstract Article PDF–1.2M

Select item 419802619.

ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport

Taro Chaya, Yoshihiro Omori, Ryusuke Kuwahara, Takahisa Furukawa

EMBO J. 2014 Jun 2; 33(11): 1227–1242. Published online 2014 May 5. doi: 10.1002/embj.201488175

PMCID:: PMC4198026

Abstract Article PDF–2.7M

Select item 381740420.

A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities

Franco J Vizeacoumar, Roland Arnold, Frederick S Vizeacoumar, Megha Chandrashekhar, Alla Buzina, Jordan T F Young, Julian H M Kwan, Azin Sayad, Patricia Mero, Steffen Lawo, Hiromasa Tanaka, Kevin R Brown, Anastasia Baryshnikova, Anthony B Mak, Yaroslav Fedyshyn, Yadong Wang, Glauber C Brito, Dahlia Kasimer, Taras Makhnevych, Troy Ketela, Alessandro Datti, Mohan Babu, Andrew Emili, Laurence Pelletier, Jeff Wrana, Zev Wainberg, Philip M Kim, Robert Rottapel, Catherine A O’Brien, Brenda Andrews, Charles Boone, Jason Moffat

Mol Syst Biol. 2013; 9: 696. Published online 2013 Oct 8. doi: 10.1038/msb.2013.54

PMCID:: PMC3817404

Abstract Article PDF–13M

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PMC Links for Gene (Select 22858) (39)
PMC
dual specificity protein phosphatase CDC14B isoform X5 [Homo sapiens]
dual specificity protein phosphatase CDC14B isoform X5 [Homo sapiens]
gi|2462627001|ref|XP_054220049.1|

Protein
serine/threonine-protein kinase ICK isoform 1 [Homo sapiens]
serine/threonine-protein kinase ICK isoform 1 [Homo sapiens]
gi|1769843744|ref|NP_001362329.1|

Protein
Epilepsy, juvenile myoclonic, susceptibility to, 10
Epilepsy, juvenile myoclonic, susceptibility to, 10

MedGen
C4693613[conceptid] (1)
MedGen

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