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Select item 99030431.

The FOXC2 Transcription Factor: A Master Regulator of Chemoresistance in Cancer

Kristian M. Hargadon, Elijah W. Strong

Technol Cancer Res Treat. 2023; 22: 15330338231155284. Published online 2023 Feb 6. doi: 10.1177/15330338231155284

PMCID:: PMC9903043

Abstract Article PDF–3.0M

Select item 81468682.

Imbalance between Expression of FOXC2 and Its lncRNA in Lymphedema-Distichiasis Caused by Frameshift Mutations

Sara Missaglia, Daniela Tavian, Sandro Michelini, Paolo Enrico Maltese, Andrea Bonanomi, Matteo Bertelli

Genes (Basel) 2021 May; 12(5): 650. Published online 2021 Apr 27. doi: 10.3390/genes12050650

PMCID:: PMC8146868

Abstract Article PDF–16M

Select item 76580073.

The Effect of FOXC2-AS1 on White Adipocyte Browning and the Possible Regulatory Mechanism

Yan Wang, Siyu Hua, Xianwei Cui, Yan Cao, Juan Wen, Xia Chi, Chenbo Ji, LingXia Pang, Lianghui You

Front Endocrinol (Lausanne) 2020; 11: 565483. Published online 2020 Oct 29. doi: 10.3389/fendo.2020.565483

PMCID:: PMC7658007

Abstract Article PDF–2.4M

Select item 76542434.

Forkhead box protein C2 contributes to invasion and metastasis of extrahepatic cholangiocarcinoma, resulting in a poor prognosis

Akira Watanabe, Hideki Suzuki, Takehiko Yokobori, Bolag Altan, Norio Kubo, Kenichiro Araki, Satoshi Wada, Yasushi Mochida, Shigeru Sasaki, Kenji Kashiwabara, Yasuo Hosouchi, Hiroyuki Kuwano

Cancer Sci. 2013 Nov; 104(11): 1427–1432. Published online 2013 Sep 15. doi: 10.1111/cas.12249

PMCID:: PMC7654243

Abstract Article PDF–678K

Select item 74041465.

FOXC2 Disease Mutations Identified in Lymphedema Distichiasis Patients Impair Transcriptional Activity and Cell Proliferation

Daniela Tavian, Sara Missaglia, Sandro Michelini, Paolo Enrico Maltese, Elena Manara, Alvaro Mordente, Matteo Bertelli

Int J Mol Sci. 2020 Jul; 21(14): 5112. Published online 2020 Jul 20. doi: 10.3390/ijms21145112

PMCID:: PMC7404146

Abstract Article PDF–7.1M

Select item 71030666.

Functional polymorphisms in FOXC2 gene and Epithelial ovarian Cancer susceptibility in Chinese population

Zhijiao Zhou, Xiang Ou, Qiong Zou, Ling Chu, Xiyun Quan, Yong Chen, Yang Liu

J Ovarian Res. 2020; 13: 34. Published online 2020 Mar 28. doi: 10.1186/s13048-020-00634-7

PMCID:: PMC7103066

Abstract Article PDF–1.4M

Select item 68178347.

FOXC2 expression and epithelial–mesenchymal phenotypes are associated with castration resistance, metastasis and survival in prostate cancer

Astrid Børretzen, Karsten Gravdal, Svein A Haukaas, Christian Beisland, Lars A Akslen, Ole J Halvorsen

J Pathol Clin Res. 2019 Oct; 5(4): 272–286. Published online 2019 Oct 1. doi: 10.1002/cjp2.142

PMCID:: PMC6817834

Abstract Article PDF–1.9M

Select item 59704578.

High expression of forkhead box protein C2 is associated with aggressive phenotypes and poor prognosis in clinical hepatocellular carcinoma

Yuki Shimoda, Yasunari Ubukata, Tadashi Handa, Takehiko Yokobori, Takayoshi Watanabe, Dolgormaa Gantumur, Kei Hagiwara, Takahiro Yamanaka, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Kenichiro Araki, Norifumi Harimoto, Ayaka Katayama, Toshiaki Hikino, Takaaki Sano, Kyoichi Ogata, Hiroyuki Kuwano, Ken Shirabe, Tetsunari Oyama

BMC Cancer. 2018; 18: 597. Published online 2018 May 25. doi: 10.1186/s12885-018-4503-6

PMCID:: PMC5970457

Abstract Article PDF–866K

Select item 53423379.

FOXC2 disease-mutations identified in lymphedema-distichiasis patients cause both loss and gain of protein function

Daniela Tavian, Sara Missaglia, Paolo E. Maltese, Sandro Michelini, Alessandro Fiorentino, Maurizio Ricci, Roberta Serrani, Michael A. Walter, Matteo Bertelli

Oncotarget. 2016 Aug 23; 7(34): 54228–54239. Published online 2016 Jun 2. doi: 10.18632/oncotarget.9797

PMCID:: PMC5342337

Abstract Article PDF–2.0M

Select item 511655910.

Inhibition of FOXC2 restores epithelial phenotype and drug sensitivity in prostate cancer cells with stem-cell properties

A N Paranjape, R Soundararajan, S J Werden, R Joseph, J H Taube, H Liu, J Rodriguez-Canales, N Sphyris, I Wistuba, N Miura, J Dhillon, N Mahajan, K Mahajan, J T Chang, M Ittmann, S N Maity, C Logothetis, D G Tang, S A Mani

Oncogene. 2016 Nov 17; 35(46): 5963–5976. Published online 2016 Jan 25. doi: 10.1038/onc.2015.498

PMCID:: PMC5116559

Abstract Article PDF–3.2M

Select item 499705511.

Novel FOXC2 Mutation in Hereditary Distichiasis Impairs DNA-Binding Activity and Transcriptional Activation

Leilei Zhang, Jie He, Bing Han, Linna Lu, Jiayan Fan, He Zhang, Shengfang Ge, Yixiong Zhou, Renbing Jia, Xianqun Fan

Int J Biol Sci. 2016; 12(9): 1114–1120. Published online 2016 Aug 6. doi: 10.7150/ijbs.13774

PMCID:: PMC4997055

Abstract Article PDF–738K

Select item 383841812.

FOXC2 Mutations in Familial and Sporadic Spinal Extradural Arachnoid Cyst

Yoji Ogura, Shoji Yabuki, Aritoshi Iida, Ikuyo Kou, Masahiro Nakajima, Hiroki Kano, Masaaki Shiina, Shinichi Kikuchi, Yoshiaki Toyama, Kazuhiro Ogata, Masaya Nakamura, Morio Matsumoto, Shiro Ikegawa

PLoS One. 2013; 8(11): e80548. Published online 2013 Nov 22. doi: 10.1371/journal.pone.0080548

PMCID:: PMC3838418

Abstract Article PDF–348K

Select item 360216013.

FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer

Brett G. Hollier, Agata A. Tinnirello, Steven J. Werden, Kurt W. Evans, Joseph H. Taube, Tapasree Roy Sarkar, Nathalie Sphyris, Maryam Shariati, Sreedevi V. Kumar, Venkata L. Battula, Jason I. Herschkowitz, Rudy Guerra, Jeffrey T. Chang, Naoyuki Miura, Jeffrey M. Rosen, Sendurai A. Mani

Cancer Res. Author manuscript; available in PMC 2014 Mar 15.

Published in final edited form as: Cancer Res. 2013 Mar 15; 73(6): 1981–1992. Published online 2013 Feb 1. doi: 10.1158/0008-5472.CAN-12-2962

PMCID:: PMC3602160

Abstract Article PDF–5.4M

Select item 267437114.

Foxc2 transcription factor: a newly described regulator of angiogenesis

Tsutomu Kume

Trends Cardiovasc Med. Author manuscript; available in PMC 2009 Aug 1.

Published in final edited form as: Trends Cardiovasc Med. 2008 Aug; 18(6): 224–228. doi: 10.1016/j.tcm.2008.11.003

PMCID:: PMC2674371

Abstract Article PDF–196K

Select item 173477115.

Clinical heterogeneity in lymphoedema-distichiasis with FOXC2 truncating mutations

R. Erickson, S. Dagenais, M. Caulder, C. Downs, G. Herman, M. Jones, W. Kerstjens-Frederi..., A. Lidral, M. McDonald, C. Nelson, M. Witte, T. Glover

J Med Genet. 2001 Nov; 38(11): 761–766. doi: 10.1136/jmg.38.11.761

PMCID:: PMC1734771

Summary PDF–167K

Select item 137794116.

A gene for lymphedema-distichiasis maps to 16q24.3.

J Mangion, N Rahman, S Mansour, G Brice, J Rosbotham, A H Child, V A Murday, P S Mortimer, R Barfoot, A Sigurdsson, S Edkins, M Sarfarazi, K Burnand, A L Evans, T O Nunan, M R Stratton, S Jeffery

Am J Hum Genet. 1999 Aug; 65(2): 427–432. doi: 10.1086/302500

PMCID:: PMC1377941

Summary PDF–196K

Select item 1110510517.

Evidence for miR-548c-5p regulation of FOXC2 transcription through a distal genomic target site in human podocytes

Andrea Christofides, Gregory Papagregoriou, Harsh Dweep, Neoklis Makrides, Norbert Gretz, Kyriacos Felekkis, Constantinos Deltas

Cell Mol Life Sci. 2020 Jun; 77(12): 2441–2459. Published online 2019 Sep 17. doi: 10.1007/s00018-019-03294-z

PMCID:: PMC11105105

Abstract Article PDF–4.9M

Select item 1049650118.

FOXC2-AS1/FOXC2 axis mediates matrix stiffness-induced trans-differentiation of hepatic stellate cells into fibrosis-promoting myofibroblasts

Liankang Sun, Yue Li, Hao Wang, Xuelian Xiao, Xuenan Luo, Ruida Yang, Jinyan Li, Yifei Ma, Qingguang Liu, Kangsheng Tu, Yu Shi

Int J Biol Sci. 2023; 19(13): 4206–4222. Published online 2023 Aug 6. doi: 10.7150/ijbs.81581

PMCID:: PMC10496501

Abstract Article PDF–2.9M

Select item 893930119.

Digenic Inheritance of a FOXC2 Mutation and Two PIEZO1 Mutations Underlies Congenital Lymphedema in a Multigeneration Family

Debbie J. Mustacich, Li-Wen Lai, Michael J. Bernas, Jazmine A. Jones, Reginald J. Myles, Phillip H. Kuo, Walter H. Williams, Charles L. Witte, Robert P. Erickson, Marlys Hearst Witte

Am J Med. Author manuscript; available in PMC 2023 Feb 1.

Published in final edited form as: Am J Med. 2022 Feb; 135(2): e31–e41. Published online 2021 Oct 15. doi: 10.1016/j.amjmed.2021.09.007

PMCID:: PMC8939301

Abstract Article PDF–1.4M

Select item 828129920.

MicroRNA-199a-5p regulates FOXC2 to control human vascular smooth muscle cell phenotypic switch

Yushi Cao, Zhongwen Cao, Weitie Wang, Xiangyu Jie, Lei Li

Mol Med Rep. 2021 Sep; 24(3): 627. Published online 2021 Jul 1. doi: 10.3892/mmr.2021.12266

PMCID:: PMC8281299

Abstract Article PDF–3.8M

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