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Select item 85670531.

Large‐scale genomic sequencing reveals adaptive opportunity of targeting mutated‐PI3Kα in early and advanced HER2‐positive breast cancer

Lin‐Wei Guo, Xiao‐Guang Li, Yun‐Song Yang, Xun‐Xi Lu, Xiang‐Chen Han, Guan‐Tian Lang, Li Chen, Zhi‐Ming Shao, Xin Hu

Clin Transl Med. 2021 Nov; 11(11): e589. Published online 2021 Nov 4. doi: 10.1002/ctm2.589

PMCID:: PMC8567053

Abstract Article PDF–13M

Select item 67424182.

A region-based gene association study combined with a leave-one-out sensitivity analysis identifies SMG1 as a pancreatic cancer susceptibility gene

Cavin Wong, Fei Chen, Najmeh Alirezaie, Yifan Wang, Adeline Cuggia, Ayelet Borgida, Spring Holter, Tatiana Lenko, Celine Domecq, Alzheimer’s Disease Neuroimaging Initiative, Gloria M. Petersen, Sapna Syngal, Randall Brand, Anil K. Rustgi, Michele L. Cote, Elena Stoffel, Sara H. Olson, Nicholas J. Roberts, Mohammad R. Akbari, Jacek Majewski, Alison P. Klein, Celia M. T. Greenwood, Steven Gallinger, George Zogopoulos

PLoS Genet. 2019 Aug; 15(8): e1008344. Published online 2019 Aug 30. doi: 10.1371/journal.pgen.1008344

PMCID:: PMC6742418

Abstract Article PDF–1.8M

Select item 59568943.

SMG-1 kinase attenuates mitochondrial ROS production but not cell respiration deficits during hyperoxia

Emily A. Resseguie, Paul S. Brookes, Michael A. O’Reilly

Exp Lung Res. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Exp Lung Res. 2017 Aug-Sep; 43(6-7): 229–239. Published online 2017 Jul 27. doi: 10.1080/01902148.2017.1339143

PMCID:: PMC5956894

Abstract Article PDF–908K

Select item 42004224.

SMG1 Acts as a Novel Potential Tumor Suppressor with Epigenetic Inactivation in Acute Myeloid Leukemia

Yahui Du, Fei Lu, Peng Li, Jingjing Ye, Min Ji, Daoxin Ma, Chunyan Ji

Int J Mol Sci. 2014 Sep; 15(9): 17065–17076. Published online 2014 Sep 25. doi: 10.3390/ijms150917065

PMCID:: PMC4200422

Abstract Article PDF–976K

Select item 40102555.

Downregulation of SMG-1 in HPV-positive head and neck squamous cell carcinoma due to promoter hypermethylation correlates with improved survival

Evgenia Gubanova, Brandee Brown, Sergei V. Ivanov, Thomas Helleday, Gordon B Mills, Wendell G. Yarbrough, Natalia Issaeva

Clin Cancer Res. Author manuscript; available in PMC 2014 May 5.

Published in final edited form as: Clin Cancer Res. 2012 Mar 1; 18(5): 1257–1267. Published online 2012 Jan 13. doi: 10.1158/1078-0432.CCR-11-2058

PMCID:: PMC4010255

Abstract Article PDF–1.6M

Select item 39050696.

SMG-1 suppresses CDK2 and tumor growth by regulating both the p53 and Cdc25A signaling pathways

Evgenia Gubanova, Natalia Issaeva, Camilla Gokturk, Tatjana Djureinovic, Thomas Helleday

Cell Cycle. 2013 Dec 15; 12(24): 3770–3780. Published online 2013 Oct 4. doi: 10.4161/cc.26660

PMCID:: PMC3905069

Abstract Article PDF–2.2M

Select item 32092447.

A Novel Role for hSMG-1 in Stress Granule Formation

James A. L. Brown, Tara L. Roberts, Renee Richards, Rick Woods, Geoff Birrell, Y. C. Lim, Shigeo Ohno, Akio Yamashita, Robert T. Abraham, Nuri Gueven, Martin F. Lavin

Mol Cell Biol. 2011 Nov; 31(22): 4417–4429. doi: 10.1128/MCB.05987-11

PMCID:: PMC3209244

Abstract Article PDF–3.4M

Select item 31801948.

The RNA surveillance protein SMG1 activates p53 in response to DNA double-strand breaks but not exogenously oxidized mRNA

Jennifer S Gewandter, Robert A Bambara, Michael A O'Reilly

Cell Cycle. 2011 Aug 1; 10(15): 2561–2567. Published online 2011 Aug 1. doi: 10.4161/cc.10.15.16347

PMCID:: PMC3180194

Abstract Article PDF–1.9M

Select item 31432669.

Effect of Hyperglycemia on Human Monocyte Activation

Debashis Nandy, Rajiv Janardhanan, Debabrata Mukhopadhyay, Ananda Basu

J Investig Med. Author manuscript; available in PMC 2012 Apr 1.

Published in final edited form as: J Investig Med. 2011 Apr; 59(4): 661–667. doi: 10.231/JIM.0b013e31820ee432

PMCID:: PMC3143266

Abstract Article PDF–835K

Select item 244236010.

A Protective Role for the Human SMG-1 Kinase against Tumor Necrosis Factor-α-induced Apoptosis

Vasco Oliveira, William J. Romanow, Christoph Geisen, Diane M. Otterness, Frank Mercurio, Hong Gang Wang, William S. Dalton, Robert T. Abraham

J Biol Chem. 2008 May 9; 283(19): 13174–13184. doi: 10.1074/jbc.M708008200

PMCID:: PMC2442360

Abstract Article PDF–596K

Select item 1065364511.

SMG1 and CDK12 Link ΔNp63α Phosphorylation to RNA Surveillance in Keratinocytes

Casimir Bamberger, Sandra Pankow, John R. Yates, III

J Proteome Res. Author manuscript; available in PMC 2023 Nov 16.

Published in final edited form as: J Proteome Res. 2021 Dec 3; 20(12): 5347–5358. Published online 2021 Nov 11. doi: 10.1021/acs.jproteome.1c00427

PMCID:: PMC10653645

Abstract Article PDF–1.6M

Select item 989282312.

SMG1, a nonsense‐mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma

Alexander C. Leeksma, Ingrid A. M. Derks, Brett Garrick, Aldo Jongejan, Martino Colombo, Timon Bloedjes, Torsten Trowe, Jim C. Leisten, Michelle Howarth, Mehnaz Malek, Deborah S. Mortensen, Kate Blease, Mathew C. Groza, Rama Krishna Narla, Remco Loos, Marie‐José Kersten, Perry D. Moerland, Jeroen E. J. Guikema, Arnon P. Kater, Eric Eldering, Ellen H. Filvaroff

Mol Oncol. 2023 Feb; 17(2): 284–297. Published online 2022 Dec 16. doi: 10.1002/1878-0261.13343

PMCID:: PMC9892823

Abstract Article PDF–941K

Select item 381377313.

SMG1 Identified as a Regulator of Parkinson’s Disease-Associated alpha-Synuclein through siRNA Screening

Adrienne Henderson-Smith, Donald Chow, Bessie Meechoovet, Meraj Aziz, Sandra A. Jacobson, Holly A. Shill, Marwan N. Sabbagh, John N. Caviness, Charles H. Adler, Erika D. Driver-Dunckley, Thomas G. Beach, Hongwei Yin, Travis Dunckley

PLoS One. 2013; 8(10): e77711. Published online 2013 Oct 30. doi: 10.1371/journal.pone.0077711

PMCID:: PMC3813773

Abstract Article PDF–1.7M

Select item 355709614.

Smg1 haploinsufficiency predisposes to tumor formation and inflammation

Tara L. Roberts, Uda Ho, John Luff, C. Soon Lee, Simon H. Apte, Kelli P. A. MacDonald, Liza J. Raggat, Allison R. Pettit, Carl A. Morrow, Michael J. Waters, Phil Chen, Rick G. Woods, Gethin P. Thomas, Liam St. Pierre, Camile S. Farah, Raymond A. Clarke, James A. L. Brown, Martin F. Lavin

Proc Natl Acad Sci U S A. 2013 Jan 22; 110(4): E285–E294. Published online 2012 Dec 31. doi: 10.1073/pnas.1215696110