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Select item 107423191.

FoxO3a Drives the Metabolic Reprogramming in Tamoxifen-Resistant Breast Cancer Cells Restoring Tamoxifen Sensitivity

Marco Fiorillo, Elena Ricci, Mariarosa Fava, Camilla Longobucco, Federica Sotgia, Pietro Rizza, Marilena Lanzino, Daniela Bonofiglio, Francesca Luisa Conforti, Stefania Catalano, Ines Barone, Catia Morelli, Saveria Aquila, Michael P. Lisanti, Diego Sisci

Cells. 2023 Dec; 12(24): 2777. Published online 2023 Dec 6. doi: 10.3390/cells12242777

PMCID:: PMC10742319

Abstract Article PDF–5.4M

Select item 106518222.

Proteomic basis of mortality resilience mediated by FOXO3 longevity genotype

Timothy A. Donlon, Brian J. Morris, Randi Chen, Eunjung Lim, Eric K. Morgen, Kristen Fortney, Naisha Shah, Kamal H. Masaki, Bradley J. Willcox

GeroScience. 2023 Aug; 45(4): 2303–2324. Published online 2023 Mar 7. doi: 10.1007/s11357-023-00740-6

PMCID:: PMC10651822

Abstract Article PDF–2.2M

Select item 103140593.

FOXO3A acts as immune response modulator in human virus-negative inflammatory cardiomyopathy

Kamila Makrutzki-Zlotek, Felicitas Escher, Zehra Karadeniz, Ganna Aleshcheva, Heiko Pietsch, Konstanze Küchler, Heinz-Peter Schultheiss, Bettina Heidecker, Wolfgang Poller, Ulf Landmesser, Carmen Scheibenbogen, Tharusan Thevathasan, Carsten Skurk

Heart. 2023 Jun; 109(11): 846–856. Published online 2023 Jan 26. doi: 10.1136/heartjnl-2022-321732

PMCID:: PMC10314059

Abstract Article PDF–1.7M

Select item 103057404.

Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging

Ying Jing, Yuesheng Zuo, Yang Yu, Liang Sun, Zhengrong Yu, Shuai Ma, Qian Zhao, Guoqiang Sun, Huifang Hu, Jingyi Li, Daoyuan Huang, Lixiao Liu, Jiaming Li, Zijuan Xin, Haoyan Huang, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Si Wang, Jing Qu, Guang-Hui Liu

Protein Cell. 2023 Jul; 14(7): 499–514. Published online 2022 Nov 22. doi: 10.1093/procel/pwac061

PMCID:: PMC10305740

Abstract Article PDF–6.9M

Select item 102130165.

Non-canonical telomere protection role of FOXO3a of human skeletal muscle cells regulated by the TRF2-redox axis

Maria Sol Jacome Burbano, Jérôme D. Robin, Serge Bauwens, Marjorie Martin, Emma Donati, Lucia Martínez, Peipei Lin, Sabrina Sacconi, Frédérique Magdinier, Eric Gilson

Commun Biol. 2023; 6: 561. Published online 2023 May 25. doi: 10.1038/s42003-023-04903-1

PMCID:: PMC10213016

Abstract Article PDF–2.0M

Select item 100140466.

FOXO3A‐short is a novel regulator of non‐oxidative glucose metabolism associated with human longevity

Evan E. Santo, Rasmus Ribel‐Madsen, Peter J. Stroeken, Vincent C. J. de Boer, Ninna S. Hansen, Maaike Commandeur, Allan A. Vaag, Rogier Versteeg, Jihye Paik, Ellen M. Westerhout

Aging Cell. 2023 Mar; 22(3): e13763. Published online 2023 Jan 8. doi: 10.1111/acel.13763

PMCID:: PMC10014046

Abstract Article PDF–2.0M

Select item 99164527.

The Expression of FOXO3a as a Forensic Diagnostic Tool in Cases of Traumatic Brain Injury: An Immunohistochemical Study

Aniello Maiese, Federica Spina, Giacomo Visi, Fabio Del Duca, Alessandra De Matteis, Raffaele La Russa, Marco Di Paolo, Paola Frati, Vittorio Fineschi

Int J Mol Sci. 2023 Feb; 24(3): 2584. Published online 2023 Jan 30. doi: 10.3390/ijms24032584

PMCID:: PMC9916452

Abstract Article PDF–2.5M

Select item 98906248.

Effect of FOXO3 and Air Pollution on Cognitive Function: A Longitudinal Cohort Study of Older Adults in China From 2000 to 2014

John S Ji, Linxin Liu, Yi Zeng, Lijing L Yan

J Gerontol A Biol Sci Med Sci. 2022 Aug; 77(8): 1534–1541. Published online 2022 Jan 13. doi: 10.1093/gerona/glac016

PMCID:: PMC9890624

Abstract Article PDF–953K

Select item 95532729.

Forkhead box O3 longevity genotype may attenuate the impact of hypertension on risk of intracerebral haemorrhage

Kazuma Nakagawa, Randi Chen, Steven M. Greenberg, G. Webster Ross, Bradley J. Willcox, Timothy A. Donlon, Richard C. Allsopp, D. Craig Willcox, Brian J. Morris, Kamal H. Masaki

J Hypertens. 2022 Nov; 40(11): 2230–2235. Published online 2022 Aug 3. doi: 10.1097/HJH.0000000000003249

PMCID:: PMC9553272

Abstract Article PDF–4.2M

Select item 937395510.

Comparing Effects of FOXO3 and Residing in Urban Areas on Longevity: A Gene–Environment Interaction Study

John S Ji, Linxin Liu, Lijing L Yan, Yi Zeng

J Gerontol A Biol Sci Med Sci. 2022 Aug; 77(8): 1549–1556. Published online 2021 Dec 7. doi: 10.1093/gerona/glab362

PMCID:: PMC9373955

Abstract Article PDF–2.7M

Select item 937394011.

The Association Between Longevity-Associated FOXO3 Allele and Heart Disease in Septuagenarians and Octogenarians: The SONIC Study

Nonglak Klinpudtan, Richard C Allsopp, Mai Kabayama, Kayo Godai, Yasuyuki Gondo, Yukie Masui, Yuya Akagi, Werayuth Srithumsuk, Ken Sugimoto, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Koichi Yamamoto, Kazunori Ikebe, Saori Yasumoto, Madoka Ogawa, Tatsuro Ishizaki, Yasumichi Arai, Hiromi Rakugi, Randi Chen, Bradley J Willcox, D Craig Willcox, Kei Kamide

J Gerontol A Biol Sci Med Sci. 2022 Aug; 77(8): 1542–1548. Published online 2021 Jul 13. doi: 10.1093/gerona/glab204

PMCID:: PMC9373940

Abstract Article PDF–701K

Select item 930350812.

Effects of circFOXO3 on the Proliferation and Invasion of Liver Cancer Cells by Regulating PI3K/Akt Pathway

Siyu Liu, Minzi Yao, Xiaolong Li, Yumei Liu, Cuiling Xie

Contrast Media Mol Imaging. 2022; 2022: 2109908. Published online 2022 Jul 14. doi: 10.1155/2022/2109908

PMCID:: PMC9303508

Abstract Article PDF–1.0M

Select item 924717713.

FOXO3a Alleviates the Inflammation and Oxidative Stress via Regulating TGF-β and HO-1 in Ankylosing Spondylitis

Shanshan Xu, Xiaoyi Zhang, Yubo Ma, Yuting Chen, Huimin Xie, Lingxiang Yu, Jinian Wang, Sheng–qian Xu, Faming Pan

Front Immunol. 2022; 13: 935534. Published online 2022 Jun 17. doi: 10.3389/fimmu.2022.935534

PMCID:: PMC9247177

Abstract Article PDF–9.5M

Select item 913590214.

Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels

Ryan Frankum, Tom S. O. Jameson, Bridget A. Knight, Francis B. Stephens, Benjamin T. Wall, Timothy A. Donlon, Trevor Torigoe, Bradley J. Willcox, D. Craig Willcox, Richard C. Allsopp, Lorna W. Harries

GeroScience. 2022 Apr; 44(2): 1129–1140. Published online 2021 Aug 26. doi: 10.1007/s11357-021-00431-0

Correction in:: GeroScience. 2022 Apr; 44(2): 1169–1170.

PMCID:: PMC9135902

Abstract Article PDF–1.0M

Select item 897408615.

Effect of circRNA_FOXO3 rs12196996 polymorphism and FOXO3 rs2232365 polymorphism on survival rate and severity of intensive care unit-acquired sepsis

Wang Lv, Zhang Wu, Yue Lin, Yingying Jiang, Xinguo Chen, Peng Zhu, Shengnan Wang

Bioengineered. 2022; 13(3): 4821–4831. Published online 2022 Feb 13. doi: 10.1080/21655979.2022.2034567

PMCID:: PMC8974086

Abstract Article PDF–1.0M

Select item 874570316.

14-3-3η Promotes Invadosome Formation via the FOXO3–Snail Axis in Rheumatoid Arthritis Fibroblast-like Synoviocytes

Maleck Kadiri, Martine Charbonneau, Catherine Lalanne, Kelly Harper, Frédéric Balg, Anthony Marotta, Claire M. Dubois

Int J Mol Sci. 2022 Jan; 23(1): 123. Published online 2021 Dec 23. doi: 10.3390/ijms23010123

PMCID:: PMC8745703

Abstract Article PDF–2.1M

Select item 869952217.

Association of FOXO3 Blood DNA Methylation with Cancer Risk, Cancer Survival, and Mortality

Chenglong Yu, Allison M. Hodge, Ee Ming Wong, Jihoon Eric Joo, Enes Makalic, Daniel Schmidt, Daniel D. Buchanan, John L. Hopper, Graham G. Giles, Melissa C. Southey, Pierre-Antoine Dugué

Cells. 2021 Dec; 10(12): 3384. Published online 2021 Dec 1. doi: 10.3390/cells10123384

PMCID:: PMC8699522

Abstract Article PDF–1.1M

Select item 862544418.

FOXO3a and Its Regulators in Prostate Cancer

Dominika Ewa Habrowska-Górczyńska, Marta Justyna Kozieł, Karolina Kowalska, Agnieszka Wanda Piastowska-Ciesielska

Int J Mol Sci. 2021 Nov; 22(22): 12530. Published online 2021 Nov 20. doi: 10.3390/ijms222212530

PMCID:: PMC8625444

Abstract Article PDF–798K

Select item 844672619.

FOXO3a inhibits nephroblastoma cell proliferation, migration and invasion, and induces apoptosis through downregulating the Wnt/β-catenin signaling pathway

Cheng Qian, Qiang Liu

Mol Med Rep. 2021 Nov; 24(5): 796. Published online 2021 Sep 13. doi: 10.3892/mmr.2021.12436

PMCID:: PMC8446726

Abstract Article PDF–12M

Select item 822810820.

Molecular Dynamics Simulations of Human FOXO3 Reveal Intrinsically Disordered Regions Spread Spatially by Intramolecular Electrostatic Repulsion

Robert O.J. Weinzierl

Biomolecules. 2021 Jun; 11(6): 856. Published online 2021 Jun 8. doi: 10.3390/biom11060856

PMCID:: PMC8228108

Abstract Article PDF–6.2M

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