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Select item 69575241.

SIK2 enhances synthesis of fatty acid and cholesterol in ovarian cancer cells and tumor growth through PI3K/Akt signaling pathway

Jing Zhao, Xiaohong Zhang, Tian Gao, Shanci Wang, Yiran Hou, Peng Yuan, Yi Yang, Tao Yang, Jinliang Xing, Jibin Li, Shujuan Liu

Cell Death Dis. 2020 Jan; 11(1): 25. Published online 2020 Jan 13. doi: 10.1038/s41419-019-2221-x

PMCID:: PMC6957524

Abstract Article PDF–3.0M

Select item 51262922.

SIK2 Restricts Autophagic Flux To Support Triple-Negative Breast Cancer Survival

Kimberly E. Maxfield, Jennifer Macion, Hariprasad Vankayalapati, Angelique W. Whitehurst

Mol Cell Biol. 2016 Dec 15; 36(24): 3048–3057. Prepublished online 2016 Oct 3. Published online 2016 Nov 28. doi: 10.1128/MCB.00380-16

PMCID:: PMC5126292

Abstract Article PDF–1.1M

Select item 49733653.

Activation of salt-inducible kinase 2 promotes the viability of peritoneal mesothelial cells exposed to stress of peritoneal dialysis

H-H Wang, C-Y Lin, S-H Su, C-T Chuang, Y-L Chang, T-Y Lee, S-C Lee, C-J Chang

Cell Death Dis. 2016 Jul; 7(7): e2298. Published online 2016 Jul 21. doi: 10.1038/cddis.2016.79

PMCID:: PMC4973365

Abstract Article PDF–1.5M

Select item 43836404.

Salt-inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer

Hélène Bon, Karan Wadhwa, Alexander Schreiner, Michelle Osborne, Thomas Carroll, Antonio Ramos-Montoya, Helen Ross-Adams, Matthieu Visser, Ralf Hoffmann, Ahmed Ashour Ahmed, David E. Neal, Ian G. Mills

Mol Cancer Res. Author manuscript; available in PMC 2015 Oct 1.

Published in final edited form as: Mol Cancer Res. 2015 Apr; 13(4): 620–635. Published online 2014 Dec 29. doi: 10.1158/1541-7786.MCR-13-0182-T

PMCID:: PMC4383640

Abstract Article PDF–1.8M

Select item 35850585.

Reversible Acetylation Regulates Salt-inducible Kinase (SIK2) and Its Function in Autophagy

Fu-Chia Yang, Bertrand Chin-Ming Tan, Wei-Hao Chen, Ya-Huei Lin, Jing-Yi Huang, Hsin-Yun Chang, Hui-Yu Sun, Pang-Hung Hsu, Gunn-Guang Liou, James Shen, Ching-Jin Chang, Chau-Chung Han, Ming-Daw Tsai, Sheng-Chung Lee

J Biol Chem. 2013 Mar 1; 288(9): 6227–6237. Published online 2013 Jan 15. doi: 10.1074/jbc.M112.431239

PMCID:: PMC3585058

Abstract Article PDF–2.8M

Select item 92518376.

SIK2 promotes ovarian cancer cell motility and metastasis by phosphorylating MYLK

Xiu Shi, Xuejiao Yu, Juan Wang, Shimin Bian, Qiutong Li, Fengqing Fu, Xinwei Zou, Lin Zhang, Robert C. Bast, Jr., Zhen Lu, Lingchuan Guo, Youguo Chen, Jinhua Zhou

Mol Oncol. 2022 Jul; 16(13): 2558–2574. Published online 2022 Mar 25. doi: 10.1002/1878-0261.13208

PMCID:: PMC9251837

Abstract Article PDF–12M

Select item 88479937.

SIK2 kinase synthetic lethality is driven by spindle assembly defects in FANCA‐deficient cells

Ka‐Kui Chan, Zahi Abdul‐Sater, Aditya Sheth, Dana K. Mitchell, Richa Sharma, Donna M. Edwards, Ying He, Grzegorz Nalepa, Steven D. Rhodes, D. Wade Clapp, Elizabeth A. Sierra Potchanant

Mol Oncol. 2022 Feb; 16(4): 860–884. Published online 2021 Jun 28. doi: 10.1002/1878-0261.13027

PMCID:: PMC8847993

Abstract Article PDF–5.3M

Select item 84851228.

Role of salt-inducible kinase 2 in the malignant behavior and glycolysis of colorectal cancer cells

Xiaohong Ni, Yongjiang Feng, Xiangwei Fu

Mol Med Rep. 2021 Nov; 24(5): 822. Published online 2021 Sep 24. doi: 10.3892/mmr.2021.12460

PMCID:: PMC8485122

Abstract Article PDF–6.6M

Select item 83027599.

Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation

Caterina Iorio, Jillian L. Rourke, Lisa Wells, Jun-Ichi Sakamaki, Emily Moon, Queenie Hu, Tatsuya Kin, Robert A. Screaton

Commun Biol. 2021; 4: 907. Published online 2021 Jul 23. doi: 10.1038/s42003-021-02433-2

PMCID:: PMC8302759

Abstract Article PDF–3.4M

Select item 697665810.

Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses

Luke D. Hutchinson, Nicola J. Darling, Stephanos Nicolaou, Ilaria Gori, Daniel R. Squair, Philip Cohen, Caroline S. Hill, Gopal P. Sapkota

Cell Death Dis. 2020 Jan; 11(1): 49. Published online 2020 Jan 22. doi: 10.1038/s41419-020-2241-6

PMCID:: PMC6976658

Abstract Article PDF–2.7M

Select item 651808611.

Salt-inducible kinase 2 and -3 are downregulated in adipose tissue from obese or insulin-resistant individuals: implications for insulin signalling and glucose uptake in human adipocytes

Johanna Säll, Annie M. L. Pettersson, Christel Björk, Emma Henriksson, Sebastian Wasserstrom, Wilhelm Linder, Yuedan Zhou, Ola Hansson, Daniel P. Andersson, Mikael Ekelund, Eva Degerman, Karin G. Stenkula, Jurga Laurencikiene, Olga Göransson

Diabetologia. 2017; 60(2): 314–323. Published online 2016 Nov 2. doi: 10.1007/s00125-016-4141-y

PMCID:: PMC6518086

Abstract Article PDF–631K

Select item 395454112.

SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer

Ahmed Ashour Ahmed, Zhen Lu, Nicholas B Jennings, Dariush Etemadmoghadam, Luisa Capalbo, Rodrigo O. Jacamo, Nuno Barbosa-Morais, Xiao-Feng Le, Australian Ovarian Cancer Study Group, Pablo Vivas-Mejia, Gabriel Lopez-Berestein, Geoffrey Grandjean, Geoffrey Bartholomeusz, Warren Liao, Michael Andreeff, David Bowtell, David M Glover, Anil K Sood, Robert C. Bast, Jr

Cancer Cell. Author manuscript; available in PMC 2014 Mar 14.

Published in final edited form as: Cancer Cell. 2010 Aug 9; 18(2): 109–121. doi: 10.1016/j.ccr.2010.06.018

PMCID:: PMC3954541

Abstract Article PDF–5.1M

Select item 1070160113.

LKB1‐SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition

Sarah Proteau, Imène Krossa, Chrystel Husser, Maxime Guéguinou, Federica Sella, Karine Bille, Marie Irondelle, Mélanie Dalmasso, Thibault Barouillet, Yann Cheli, Céline Pisibon, Nicole Arrighi, Sacha Nahon‐Estève, Arnaud Martel, Lauris Gastaud, Sandra Lassalle, Olivier Mignen, Patrick Brest, Nathalie M Mazure, Frédéric Bost, Stéphanie Baillif, Solange Landreville, Simon Turcotte, Dan Hasson, Saul Carcamo, Christophe Vandier, Emily Bernstein, Laurent Yvan‐Charvet, Mitchell P Levesque, Robert Ballotti, Corine Bertolotto, Thomas Strub

EMBO Mol Med. 2023 Dec; 15(12): e17719. Published online 2023 Nov 15. doi: 10.15252/emmm.202317719

PMCID:: PMC10701601

Abstract Article PDF–3.7M

Select item 778207414.

SIK2 represses AKT/GSK3β/β‐catenin signaling and suppresses gastric cancer by inhibiting autophagic degradation of protein phosphatases

Xiao‐man Dai, Yan‐hui Zhang, Xiao‐han Lin, Xiao‐xing Huang, Yi Zhang, Chao‐rong Xue, Wan‐nan Chen, Jian‐xin Ye, Xin‐jian Lin, Xu Lin

Mol Oncol. 2021 Jan; 15(1): 228–245. Published online 2020 Nov 20. doi: 10.1002/1878-0261.12838

PMCID:: PMC7782074

Abstract Article PDF–5.2M

Select item 364095015.

LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription

Hei-Man Vincent Tang, Wei-Wei Gao, Ching-Ping Chan, Yeung-Tung Siu, Chi-Ming Wong, Kin-Hang Kok, Yick-Pang Ching, Hiroshi Takemori, Dong-Yan Jin

Retrovirology. 2013; 10: 40. Published online 2013 Apr 11. doi: 10.1186/1742-4690-10-40

PMCID:: PMC3640950

Abstract Article PDF–1.4M

Select item 728662016.

Salt-inducible Kinases Are Critical Determinants of Female Fertility

Marah Armouti, Nicola Winston, Osamu Hatano, Elie Hobeika, Jennifer Hirshfeld-Cytron, Juergen Liebermann, Hiroshi Takemori, Carlos Stocco

Endocrinology. 2020 Jul; 161(7): bqaa069. Published online 2020 Apr 28. doi: 10.1210/endocr/bqaa069

PMCID:: PMC7286620

Abstract Article

Select item 507580617.

SIKs control osteocyte responses to parathyroid hormone

Marc N. Wein, Yanke Liang, Olga Goransson, Thomas B. Sundberg, Jinhua Wang, Elizabeth A. Williams, Maureen J. O'Meara, Nicolas Govea, Belinda Beqo, Shigeki Nishimori, Kenichi Nagano, Daniel J. Brooks, Janaina S. Martins, Braden Corbin, Anthony Anselmo, Ruslan Sadreyev, Joy Y. Wu, Kei Sakamoto, Marc Foretz, Ramnik J. Xavier, Roland Baron, Mary L. Bouxsein, Thomas J. Gardella, Paola Divieti-Pajevic, Nathanael S. Gray, Henry M. Kronenberg

Nat Commun. 2016; 7: 13176. Published online 2016 Oct 19. doi: 10.1038/ncomms13176

Correction in:: Nat Commun. 2017; 8: 14745.

PMCID:: PMC5075806

Abstract Article PDF–2.4M

Select item 479475918.

SIK2 regulates fasting-induced PPARα activity and ketogenesis through p300

Zhen-Ning Zhang, Lulu Gong, Sihan Lv, Jian Li, Xiaolu Tai, Wenqi Cao, Bing Peng, Shen Qu, Weida Li, Chao Zhang, Bing Luan

Sci Rep. 2016; 6: 23317. Published online 2016 Mar 17. doi: 10.1038/srep23317

PMCID:: PMC4794759

Abstract Article PDF–1.1M

Select item 383712819.

Interaction between Salt-inducible Kinase 2 (SIK2) and p97/Valosin-containing Protein (VCP) Regulates Endoplasmic Reticulum (ER)-associated Protein Degradation in Mammalian Cells

Fu-Chia Yang, Ya-Huei Lin, Wei-Hao Chen, Jing-Yi Huang, Hsin-Yun Chang, Su-Hui Su, Hsiao-Ting Wang, Chun-Yi Chiang, Pang-Hung Hsu, Ming-Daw Tsai, Bertrand Chin-Ming Tan, Sheng-Chung Lee

J Biol Chem. 2013 Nov 22; 288(47): 33861–33872. Published online 2013 Oct 15. doi: 10.1074/jbc.M113.492199

PMCID:: PMC3837128

Abstract Article PDF–2.5M

Select item 579900720.

14-3-3 proteins mediate inhibitory effects of cAMP on salt-inducible kinases (SIKs)

Tim Sonntag, Joan M. Vaughan, Marc Montminy

FEBS J. Author manuscript; available in PMC 2019 Feb 1.

Published in final edited form as: FEBS J. 2018 Feb; 285(3): 467–480. Published online 2018 Jan 9. doi: 10.1111/febs.14351

PMCID:: PMC5799007

Abstract Article PDF–2.3M

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