PMC Links for Gene (Select 2327) - PMC

Sharon K. Krueger, Marilyn C. Henderson, Lisbeth K. Siddens, Jonathan E. VanDyke, Abby D. Benninghoff, P. Andrew Karplus, Bjarte Furnes, Daniel Schlenk, David E. Williams

Drug Metab Dispos. 2009 Aug; 37(8): 1785–1791. Published online 2009 May 6. doi: 10.1124/dmd.109.027201

PMCID:: PMC2712441

Abstract Article PDF–200K

Select item 26836585.

Human Flavin-Containing Monooxygenase 2.1 Catalyzes Oxygenation of the Antitubercular Drugs Thiacetazone and Ethionamide

Asvi A. Francois, Clinton R. Nishida, Paul R. Ortiz de Montellano, Ian R. Phillips, Elizabeth A. Shephard

Drug Metab Dispos. 2009 Jan; 37(1): 178–186. Published online 2008 Oct 23. doi: 10.1124/dmd.108.024158

PMCID:: PMC2683658

Abstract Article PDF–354K

Select item 26663326.

The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa

Krishna R. Veeramah, Mark G. Thomas, Michael E. Weale, David Zeitlyn, Ayele Tarekegn, Endashaw Bekele, Nancy R. Mendell, Elizabeth A. Shephard, Neil Bradman, Ian R. Phillips

Pharmacogenet Genomics. Author manuscript; available in PMC 2009 Oct 1.

Published in final edited form as: Pharmacogenet Genomics. 2008 Oct; 18(10): 877–886. doi: 10.1097/FPC.0b013e3283097311

PMCID:: PMC2666332

Abstract Article PDF–469K

Select item 26262507.

Metabolism of the Anti-Tuberculosis Drug Ethionamide by Mouse and Human FMO1, FMO2 and FMO3 and Mouse and Human Lung Microsomes

Marilyn C. Henderson, Lisbeth K. Siddens, Jeffrey T. Morré, Sharon K. Krueger, David E. Williams

Toxicol Appl Pharmacol. Author manuscript; available in PMC 2009 Dec 15.

Published in final edited form as: Toxicol Appl Pharmacol. 2008 Dec 15; 233(3): 420–427. Published online 2008 Oct 1. doi: 10.1016/j.taap.2008.09.017

PMCID:: PMC2626250

Abstract Article PDF–267K

Select item 18286028.

Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism

Sharon K. Krueger, David E. Williams

Pharmacol Ther. Author manuscript; available in PMC 2007 Mar 19.

Published in final edited form as: Pharmacol Ther. 2005 Jun; 106(3): 357–387. doi: 10.1016/j.pharmthera.2005.01.001

PMCID:: PMC1828602

Abstract Article PDF–865K

Select item 13510399.

Haplotype and functional analysis of four flavin-containing monooxygenase isoform 2 (FMO2) polymorphisms in Hispanics

Sharon K. Krueger, Lisbeth K. Siddens, Marilyn C. Henderson, Eric A. Andreasen, Robert L. Tanguay, Clifford B. Pereira, Erwin T. Cabacungan, Ronald N. Hines, Kristin G. Ardlie, David E. Williams

Pharmacogenet Genomics. Author manuscript; available in PMC 2006 Jan 25.

Published in final edited form as: Pharmacogenet Genomics. 2005 Apr; 15(4): 245–256. doi: 10.1097/01213011-200504000-00008

PMCID:: PMC1351039

Abstract Article PDF–429K

Select item 113315310.

Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family.

C T Dolphin, E A Shephard, S Povey, R L Smith, I R Phillips

Biochem J. 1992 Oct 1; 287(Pt 1): 261–267. doi: 10.1042/bj2870261

PMCID:: PMC1133153

Summary Page Browse PDF–1.5M

Select item 4851711.

Molecular cloning of the flavin-containing monooxygenase (form II) cDNA from adult human liver.

N Lomri, Q Gu, J R Cashman

Proc Natl Acad Sci U S A. 1992 Mar 1; 89(5): 1685–1689. doi: 10.1073/pnas.89.5.1685

Correction in:: Proc Natl Acad Sci U S A. 1995 Oct 10; 92(21): 9910.

PMCID:: PMC48517

Summary Page Browse PDF–1.1M

Select item 636383212.

Nicotine-N’-oxidation by flavin monooxygenase enzymes

Yadira X. Perez-Paramo, Gang Chen, Joseph H. Ashmore, Christy J. W. Watson, Shamema Nasrin, Jennifer Adams-Haduch, Renwei Wang, Yu-Tang Gao, Woon-Puay Koh, Jian-Min Yuan, Philip Lazarus

Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2020 Feb 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2019 Feb; 28(2): 311–320. Published online 2018 Oct 31. doi: 10.1158/1055-9965.EPI-18-0669

PMCID:: PMC6363832

Abstract Article PDF–1.1M

Select item 1055821413.

Flavin containing monooxygenase 2 regulates renal tubular cell fibrosis and paracrine secretion via SMURF2 in AKI-CKD transformation

Longfei Wang, Hongchu Zha, Jing Huang, Lang Shi

Int J Mol Med. 2023 Nov; 52(5): 110. Published online 2023 Oct 4. doi: 10.3892/ijmm.2023.5313

PMCID:: PMC10558214

Abstract Article PDF–1.5M

Select item 329954814.

A systematic survey of loss-of-function variants in human protein-coding genes

Daniel G. MacArthur, Suganthi Balasubramanian, Adam Frankish, Ni Huang, James Morris, Klaudia Walter, Luke Jostins, Lukas Habegger, Joseph K. Pickrell, Stephen B. Montgomery, Cornelis A. Albers, Zhengdong Zhang, Donald F. Conrad, Gerton Lunter, Hancheng Zheng, Qasim Ayub, Mark A. DePristo, Eric Banks, Min Hu, Robert E. Handsaker, Jeffrey Rosenfeld, Menachem Fromer, Mike Jin, Xinmeng Jasmine Mu, Ekta Khurana, Kai Ye, Mike Kay, Gary Ian Saunders, Marie-Marthe Suner, Toby Hunt, If H.A. Barnes, Clara Amid, Denise R. Carvalho-Silva, Alexandra H Bignell, Catherine Snow, Bryndis Yngvadottir, Suzannah Bumpstead, David N. Cooper, Yali Xue, Irene Gallego Romero, 1000 Genomes Project Consortium, Jun Wang, Yingrui Li, Richard A. Gibbs, Steven A. McCarroll, Emmanouil T. Dermitzakis, Jonathan K. Pritchard, Jeffrey C. Barrett, Jennifer Harrow, Matthew E. Hurles, Mark B. Gerstein, Chris Tyler-Smith

Science. Author manuscript; available in PMC 2012 Aug 17.

Published in final edited form as: Science. 2012 Feb 17; 335(6070): 823–828. doi: 10.1126/science.1215040

Correction in:: volume 336 on page 296

PMCID:: PMC3299548

Abstract Article PDF–1.0M

Select item 295791815.

Evaluation of Candidate Genes for Cholinesterase Activity in Farmworkers Exposed to Organophosphorus Pesticides: Association of Single Nucleotide Polymorphisms in BCHE

Timothy D. Howard, Fang-Chi Hsu, Joseph G. Grzywacz, Haiying Chen, Sara A. Quandt, Quirina M. Vallejos, Lara E. Whalley, Wei Cui, Stephanie Padilla, Thomas A. Arcury

Environ Health Perspect. 2010 Oct; 118(10): 1395–1399. Published online 2010 Jun 8. doi: 10.1289/ehp.0901764

PMCID:: PMC2957918

Abstract Article PDF–1.5M

Select item 733419716.

The mutational constraint spectrum quantified from variation in 141,456 humans

Konrad J. Karczewski, Laurent C. Francioli, Grace Tiao, Beryl B. Cummings, Jessica Alföldi, Qingbo Wang, Ryan L. Collins, Kristen M. Laricchia, Andrea Ganna, Daniel P. Birnbaum, Laura D. Gauthier, Harrison Brand, Matthew Solomonson, Nicholas A. Watts, Daniel Rhodes, Moriel Singer-Berk, Eleina M. England, Eleanor G. Seaby, Jack A. Kosmicki, Raymond K. Walters, Katherine Tashman, Yossi Farjoun, Eric Banks, Timothy Poterba, Arcturus Wang, Cotton Seed, Nicola Whiffin, Jessica X. Chong, Kaitlin E. Samocha, Emma Pierce-Hoffman, Zachary Zappala, Anne H. O’Donnell-Luria, Eric Vallabh Minikel, Ben Weisburd, Monkol Lek, James S. Ware, Christopher Vittal, Irina M. Armean, Louis Bergelson, Kristian Cibulskis, Kristen M. Connolly, Miguel Covarrubias, Stacey Donnelly, Steven Ferriera, Stacey Gabriel, Jeff Gentry, Namrata Gupta, Thibault Jeandet, Diane Kaplan, Christopher Llanwarne, Ruchi Munshi, Sam Novod, Nikelle Petrillo, David Roazen, Valentin Ruano-Rubio, Andrea Saltzman, Molly Schleicher, Jose Soto, Kathleen Tibbetts, Charlotte Tolonen, Gordon Wade, Michael E. Talkowski, Genome Aggregation Database Consortium, Benjamin M. Neale, Mark J. Daly, Daniel G. MacArthur

Nature. 2020; 581(7809): 434–443. Published online 2020 May 27. doi: 10.1038/s41586-020-2308-7

Correction in:: Nature. 2021; 590(7846): E53.

PMCID:: PMC7334197

Abstract Article PDF–3.1M

Select item 730679217.

Common homozygosity for predicted loss-of-function variants reveals both redundant and advantageous effects of dispensable human genes

Antonio Rausell, Yufei Luo, Marie Lopez, Yoann Seeleuthner, Franck Rapaport, Antoine Favier, Peter D. Stenson, David N. Cooper, Etienne Patin, Jean-Laurent Casanova, Lluis Quintana-Murci, Laurent Abel

Proc Natl Acad Sci U S A. 2020 Jun 16; 117(24): 13626–13636. Published online 2020 Jun 2. doi: 10.1073/pnas.1917993117

PMCID:: PMC7306792

Abstract Article PDF–1.0M

Select item 796225218.

The C. elegans homolog of human panic-disorder risk gene TMEM132D orchestrates neuronal morphogenesis through the WAVE-regulatory complex

Xin Wang, Wei Jiang, Shuo Luo, Xiaoyu Yang, Changnan Wang, Bingying Wang, Yongjun Dang, Yin Shen, Dengke K. Ma

Mol Brain. 2021; 14: 54. Published online 2021 Mar 16. doi: 10.1186/s13041-021-00767-w

PMCID:: PMC7962252

Abstract Article PDF–6.5M

Select item 135612919.

Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes

Kouichi Kimura, Ai Wakamatsu, Yutaka Suzuki, Toshio Ota, Tetsuo Nishikawa, Riu Yamashita, Jun-ichi Yamamoto, Mitsuo Sekine, Katsuki Tsuritani, Hiroyuki Wakaguri, Shizuko Ishii, Tomoyasu Sugiyama, Kaoru Saito, Yuko Isono, Ryotaro Irie, Norihiro Kushida, Takahiro Yoneyama, Rie Otsuka, Katsuhiro Kanda, Takahide Yokoi, Hiroshi Kondo, Masako Wagatsuma, Katsuji Murakawa, Shinichi Ishida, Tadashi Ishibashi, Asako Takahashi-Fujii, Tomoo Tanase, Keiichi Nagai, Hisashi Kikuchi, Kenta Nakai, Takao Isogai, Sumio Sugano

Genome Res. 2006 Jan; 16(1): 55–65. doi: 10.1101/gr.4039406

PMCID:: PMC1356129

Abstract Article PDF–438K

Select item 553161120.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

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