PMC Links for Gene (Select 23365) - PMC

Geneviève M. C. Gasmi-Seabrook, Christopher B. Marshall, Melissa Cheung, Bryan Kim, Feng Wang, Ying Ju Jang, Tak W. Mak, Vuk Stambolic, Mitsuhiko Ikura

J Biol Chem. 2010 Feb 19; 285(8): 5137–5145. Published online 2009 Dec 17. doi: 10.1074/jbc.M109.064691

PMCID:: PMC2820740

Abstract Article PDF–4.2M

Select item 27356205.

A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells

Mohamed Aittaleb, Guang Gao, Chris R. Evelyn, Richard R. Neubig, John J. G. Tesmer

Cell Signal. Author manuscript; available in PMC 2010 Nov 1.

Published in final edited form as: Cell Signal. 2009 Nov; 21(11): 1569–1578. Published online 2009 Jun 26. doi: 10.1016/j.cellsig.2009.06.003

PMCID:: PMC2735620

Abstract Article PDF–3.7M

Select item 23867356.

Conformational change upon ligand binding and dynamics of the PDZ domain from leukemia-associated Rho guanine nucleotide exchange factor

Jiangxin Liu, Jiahai Zhang, Yinshan Yang, Hongda Huang, Weiqun Shen, Qi Hu, Xingsheng Wang, Jihui Wu, Yunyu Shi

Protein Sci. 2008 Jun; 17(6): 1003–1014. doi: 10.1110/ps.073416508

PMCID:: PMC2386735

Abstract Article PDF–983K

Select item 157687.

Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: Evidence for its fusion with MLL in acute myeloid leukemia

Peter J. Kourlas, Matthew P. Strout, Brian Becknell, Maria Luisa Veronese, Carlo M. Croce, Karl S. Theil, Ralf Krahe, Tapani Ruutu, Sakari Knuutila, Clara D. Bloomfield, Michael A. Caligiuri

Proc Natl Acad Sci U S A. 2000 Feb 29; 97(5): 2145–2150. Published online 2000 Feb 11. doi: 10.1073/pnas.040569197

PMCID:: PMC15768

Abstract Article PDF–213K

Select item 91038448.

ArhGEF12 activates Rap1A and not RhoA in human dermal microvascular endothelial cells to reduce tumor necrosis factor-induced leak

Alamzeb Khan, Weiming Ni, Tania Baltazar, F. Lopez-Giraldez, Jordan S. Pober, Richard W. Pierce

FASEB J. Author manuscript; available in PMC 2023 Apr 1.

Published in final edited form as: FASEB J. 2022 Apr; 36(4): e22254. doi: 10.1096/fj.202101873RR

PMCID:: PMC9103844

Abstract Article PDF–1.9M

Select item 58457819.

Leukemia-associated Rho guanine nucleotide exchange factor (LARG) plays an agonist specific role in platelet function through RhoA activation

Siying Zou, Alexandra M. Teixeira, Mingzhu Yin, Yaozu Xiang, Juliana Xavier-Ferruccio, Ping-xia Zhang, John Hwa, Wang Min, Diane S. Krause

Thromb Haemost. Author manuscript; available in PMC 2018 Mar 12.

Published in final edited form as: Thromb Haemost. 2016 Aug 30; 116(3): 506–516. Published online 2016 Jun 23. doi: 10.1160/TH15-11-0848

PMCID:: PMC5845781

Abstract Article PDF–846K

Select item 467966710.

Mitotic-dependent phosphorylation of leukemia-associated RhoGEF (LARG) by Cdk1

Michelle C. Helms, Elda Grabocka, Matthew K. Martz, Christopher C. Fischer, Nobuchika Suzuki, Philip B. Wedegaertner

Cell Signal. Author manuscript; available in PMC 2017 Jan 1.

Published in final edited form as: Cell Signal. 2016 Jan; 28(1): 43–52. Published online 2015 Oct 19. doi: 10.1016/j.cellsig.2015.10.004

PMCID:: PMC4679667

Abstract Article PDF–1.0M

Select item 399123211.

The RhoA GEF, LARG, mediates ICAM-1-dependent mechanotransduction in endothelial cells to stimulate transendothelial migration

Elizabeth C. Lessey-Morillon, Lukas D. Osborne, Elizabeth Monaghan-Benson, Christophe Guilluy, E. Timothy O’Brien, Richard Superfine, Keith Burridge

J Immunol. Author manuscript; available in PMC 2015 Apr 1.

Published in final edited form as: J Immunol. 2014 Apr 1; 192(7): 3390–3398. Published online 2014 Feb 28. doi: 10.4049/jimmunol.1302525

PMCID:: PMC3991232

Abstract Article PDF–1.2M

Select item 264352112.

Activation of Leukemia-associated RhoGEF by Gα₁₃ with Significant Conformational Rearrangements in the Interface

Nobuchika Suzuki, Kouhei Tsumoto, Nicole Hajicek, Kenji Daigo, Reiko Tokita, Shiro Minami, Tatsuhiko Kodama, Takao Hamakubo, Tohru Kozasa

J Biol Chem. 2009 Feb 20; 284(8): 5000–5009. doi: 10.1074/jbc.M804073200

PMCID:: PMC2643521

Abstract Article PDF–671K

Select item 215086713.

Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF

Shinichiro Taya, Naoyuki Inagaki, Hiroaki Sengiku, Hiroshi Makino, Akihiro Iwamatsu, Itaru Urakawa, Kenji Nagao, Shiro Kataoka, Kozo Kaibuchi

J Cell Biol. 2001 Nov 26; 155(5): 809–820. doi: 10.1083/jcb.200106139

PMCID:: PMC2150867

Abstract Article PDF–364K

Select item 577702914.

RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases

Geng-Xian Shi, Won Seok Yang, Ling Jin, Michelle L. Matter, Joe W. Ramos

Proc Natl Acad Sci U S A. 2018 Jan 9; 115(2): E190–E199. Published online 2017 Dec 26. doi: 10.1073/pnas.1708584115

PMCID:: PMC5777029

Abstract Article PDF–1.6M

Select item 467277315.

Secondary PDZ domain-binding site on class B plexins enhances the affinity for PDZ–RhoGEF

Heath G. Pascoe, Stephen Gutowski, Hua Chen, Chad A. Brautigam, Zhe Chen, Paul C. Sternweis, Xuewu Zhang

Proc Natl Acad Sci U S A. 2015 Dec 1; 112(48): 14852–14857. Published online 2015 Nov 16. doi: 10.1073/pnas.1508931112

PMCID:: PMC4672773

Abstract Article PDF–1.9M

Select item 423061416.

TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion

Lukas D. Osborne, George Z. Li, Tam How, E. Tim O'Brien, Gerard C. Blobe, Richard Superfine, Karthikeyan Mythreye

Mol Biol Cell. 2014 Nov 5; 25(22): 3528–3540. doi: 10.1091/mbc.E14-05-1015

PMCID:: PMC4230614

Abstract Article PDF–2.4M

Select item 309389217.

Mechanistic Insights into Specificity, Activity, and Regulatory Elements of the Regulator of G-protein Signaling (RGS)-containing Rho-specific Guanine Nucleotide Exchange Factors (GEFs) p115, PDZ-RhoGEF (PRG), and Leukemia-associated RhoGEF (LARG)

Mamta Jaiswal, Lothar Gremer, Radovan Dvorsky, Lars Christian Haeusler, Ion C. Cirstea, Katharina Uhlenbrock, Mohammad Reza Ahmadian

J Biol Chem. 2011 May 20; 286(20): 18202–18212. Published online 2011 Mar 28. doi: 10.1074/jbc.M111.226431

PMCID:: PMC3093892

Abstract Article PDF–2.2M

Select item 301253918.

HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway

Xiaoyu Jiang, Xiaoqing Lu, George McNamara, Xiaofei Liu, Elena Cubedo, Kristopher A. Sarosiek, Isidro Sánchez-García, David M. Helfman, Izidore S. Lossos

Blood. 2010 Dec 9; 116(24): 5217–5227. Prepublished online 2010 Sep 15. doi: 10.1182/blood-2010-04-281568

PMCID:: PMC3012539

Abstract Article

Select item 293083219.

S1P Receptor 2 Signals Through the RGS-RhoGEF, LARG, To Promote Smooth Muscle Cell Differentiation

Matt D. Medlin, Dean P. Staus, Adi D. Dubash, Joan M. Taylor, Christopher P. Mack

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2011 Sep 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2010 Sep; 30(9): 1779–1786. Published online 2010 Aug 11. doi: 10.1161/ATVBAHA.110.209395

PMCID:: PMC2930832

Abstract Article PDF–948K

Select item 287150420.

Binding of PDZ-RhoGEF to ATP-binding Cassette Transporter A1 (ABCA1) Induces Cholesterol Efflux through RhoA Activation and Prevention of Transporter Degradation

Keiichiro Okuhira, Michael L. Fitzgerald, Norimasa Tamehiro, Nobumichi Ohoka, Kazuhiro Suzuki, Jun-ichi Sawada, Mikihiko Naito, Tomoko Nishimaki-Mogami

J Biol Chem. 2010 May 21; 285(21): 16369–16377. Published online 2010 Mar 26. doi: 10.1074/jbc.M109.061424

PMCID:: PMC2871504

Abstract Article PDF–1.0M

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rho guanine nucleotide exchange factor 12 isoform 1 [Homo sapiens]
rho guanine nucleotide exchange factor 12 isoform 1 [Homo sapiens]
gi|7662088|ref|NP_056128.1|

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