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Select item 107308361.

RBFOX2 deregulation promotes pancreatic cancer progression and metastasis through alternative splicing

Michelle Maurin, Mohammadreza Ranjouri, Cristina Megino-Luque, Justin Y. Newberg, Dongliang Du, Katelyn Martin, Robert E. Miner, III, Mollie S. Prater, Dave Keng Boon Wee, Barbara Centeno, Shondra M. Pruett-Miller, Paul Stewart, Jason B. Fleming, Xiaoqing Yu, Jose Javier Bravo-Cordero, Ernesto Guccione, Michael A. Black, Karen M. Mann

Nat Commun. 2023; 14: 8444. Published online 2023 Dec 19. doi: 10.1038/s41467-023-44126-w

PMCID:: PMC10730836

Abstract Article PDF–3.2M

Select item 101565902.

RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer

Amina Jbara, Kuan-Ting Lin, Chani Stossel, Zahava Siegfried, Haya Shqerat, Adi Amar-Schwartz, Ela Elyada, Maxim Mogilevsky, Maria Raitses-Gurevich, Jared L. Johnson, Tomer M. Yaron, Ofek Ovadia, Gun Ho Jang, Miri Danan-Gotthold, Lewis C. Cantley, Erez Y. Levanon, Steven Gallinger, Adrian R. Krainer, Talia Golan, Rotem Karni

Nature. 2023; 617(7959): 147–153. Published online 2023 Mar 22. doi: 10.1038/s41586-023-05820-3

PMCID:: PMC10156590

Abstract Article PDF–18M

Select item 48720983.

Rbfox proteins regulate microRNA biogenesis by sequence-specific binding to their precursors and target downstream Dicer

Yu Chen, Lorena Zubovic, Fan Yang, Katherine Godin, Tom Pavelitz, Javier Castellanos, Paolo Macchi, Gabriele Varani

Nucleic Acids Res. 2016 May 19; 44(9): 4381–4395. Published online 2016 Mar 21. doi: 10.1093/nar/gkw177

PMCID:: PMC4872098

Abstract Article PDF–5.3M

Select item 35541294.

RBFOX2 Is an Important Regulator of Mesenchymal Tissue-Specific Splicing in both Normal and Cancer Tissues

Julian P. Venables, Jean-Philippe Brosseau, Gilles Gadea, Roscoe Klinck, Panagiotis Prinos, Jean-François Beaulieu, Elvy Lapointe, Mathieu Durand, Philippe Thibault, Karine Tremblay, François Rousset, Jamal Tazi, Sherif Abou Elela, Benoit Chabot

Mol Cell Biol. 2013 Jan; 33(2): 396–405. doi: 10.1128/MCB.01174-12

PMCID:: PMC3554129

Abstract Article PDF–696K

Select item 27352545.

An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells

Gene W Yeo, Nicole G Coufal, Tiffany Y Liang, Grace E Peng, Xiang-Dong Fu, Fred H Gage

Nat Struct Mol Biol. Author manuscript; available in PMC 2009 Aug 31.

Published in final edited form as: Nat Struct Mol Biol. 2009 Feb; 16(2): 130–137. Published online 2009 Jan 11. doi: 10.1038/nsmb.1545

PMCID:: PMC2735254

Abstract Article PDF–2.2M

Select item 106678386.

FBXO7 Confers Mesenchymal Properties and Chemoresistance in Glioblastoma by Controlling Rbfox2‐Mediated Alternative Splicing

Shangbiao Li, Yanwen Chen, Yuxin Xie, Hongchao Zhan, Yu Zeng, Kunlin Zeng, Li Wang, Ziling Zhan, Cuiying Li, Liqian Zhao, Xiaoxia Chen, Yujing Tan, Zhongyong Wang, Junguo Bu, Ye Song, Fan Deng, Aidong Zhou

Adv Sci (Weinh) 2023 Nov; 10(33): 2303561. Published online 2023 Oct 11. doi: 10.1002/advs.202303561

PMCID:: PMC10667838

Abstract Article PDF–5.8M

Select item 97120157.

The Role of Alternative Splicing Factors hnRNP G and Fox-2 in the Progression and Prognosis of Esophageal Cancer

Yuanyuan Zheng, Xiaoyu Niu, Wenhua Xue, Lifeng Li, Qishun Geng, Zhirui Fan, Jie Zhao

Dis Markers. 2022; 2022: 3043737. Published online 2022 Nov 23. doi: 10.1155/2022/3043737

PMCID:: PMC9712015

Abstract Article PDF–2.1M

Select item 91190658.

Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies

Amy M. Cooper, Curtis A. Nutter, Muge N. Kuyumcu-Martinez, Casey W. Wright

Mol Cell Biol. 2022 May; 42(5): e00503-21. Published online 2022 Apr 11. doi: 10.1128/mcb.00503-21

PMCID:: PMC9119065

Abstract Article PDF–667K

Select item 83731209.

RBFOX2/GOLIM4 Splicing Axis Activates Vesicular Transport Pathway to Promote Nasopharyngeal Carcinogenesis

Chun‐Ling Luo, Xiao‐Chen Xu, Chu‐Jun Liu, Shuai He, Jie‐Rong Chen, Yan‐Chun Feng, Shu‐Qiang Liu, Wan Peng, Ya‐Qing Zhou, Yu‐Xiang Liu, Pan‐Pan Wei, Bo Li, Hai‐Qiang Mai, Xiao‐Jun Xia, Jin‐Xin Bei

Adv Sci (Weinh) 2021 Aug; 8(16): 2004852. Published online 2021 Jun 28. doi: 10.1002/advs.202004852

PMCID:: PMC8373120

Abstract Article PDF–7.6M

Select item 755419910.

Concentration-dependent splicing is enabled by Rbfox motifs of intermediate affinity

Bridget E. Begg, Marvin Jens, Peter Y. Wang, Christine M. Minor, Christopher B. Burge

Nat Struct Mol Biol. Author manuscript; available in PMC 2021 Feb 17.

Published in final edited form as: Nat Struct Mol Biol. 2020 Oct; 27(10): 901–912. Published online 2020 Aug 17. doi: 10.1038/s41594-020-0475-8

PMCID:: PMC7554199

Abstract Article PDF–4.5M

Select item 559383511.

Stress Granules Contain Rbfox2 with Cell Cycle-related mRNAs

Chungoo Park, Sunkyung Choi, Yong-Eun Kim, Siyeo Lee, Su-Hyung Park, Robert S. Adelstein, Sachiyo Kawamoto, Kee K. Kim

Sci Rep. 2017; 7: 11211. Published online 2017 Sep 11. doi: 10.1038/s41598-017-11651-w

PMCID:: PMC5593835

Abstract Article PDF–4.7M

Select item 497151512.

Rbfox2 function in RNA metabolism is impaired in hypoplastic left heart syndrome patient hearts

Sunil K. Verma, Vaibhav Deshmukh, Curtis A. Nutter, Elizabeth Jaworski, Wenhao Jin, Lalita Wadhwa, Joshua Abata, Marco Ricci, Joy Lincoln, James F. Martin, Gene W. Yeo, Muge N. Kuyumcu-Martinez

Sci Rep. 2016; 6: 30896. Published online 2016 Aug 3. doi: 10.1038/srep30896

PMCID:: PMC4971515

Abstract Article PDF–1.7M

Select item 416577213.

Genome-wide screening for DNA variants associated with reading and language traits

A Gialluisi, D F Newbury, E G Wilcutt, R K Olson, J C DeFries, W M Brandler, B F Pennington, S D Smith, T S Scerri, N H Simpson, The SLI Consortium, M Luciano, D M Evans, T C Bates, J F Stein, J B Talcott, A P Monaco, S Paracchini, C Francks, S E Fisher

Genes Brain Behav. 2014 Sep; 13(7): 686–701. Published online 2014 Aug 29. doi: 10.1111/gbb.12158

PMCID:: PMC4165772

Abstract Article PDF–967K

Select item 326491414.

Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2

Shuying Sun, Zuo Zhang, Oliver Fregoso, Adrian R. Krainer

RNA. 2012 Feb; 18(2): 274–283. doi: 10.1261/rna.030486.111

PMCID:: PMC3264914

Abstract Article PDF–789K

Select item 315804815.

An EMT–Driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype

Irina M. Shapiro, Albert W. Cheng, Nicholas C. Flytzanis, Michele Balsamo, John S. Condeelis, Maja H. Oktay, Christopher B. Burge, Frank B. Gertler

PLoS Genet. 2011 Aug; 7(8): e1002218. Published online 2011 Aug 18. doi: 10.1371/journal.pgen.1002218

PMCID:: PMC3158048

Abstract Article PDF–4.3M

Select item 291582616.

FOX-2 PROTEIN REGULATES THE ALTERNATE SPLICING OF SCLERODERMA -ASSOCIATED LYSYL HYDROXYLASE 2 mRNA

Puneet Seth, Heather N. Yeowell

Arthritis Rheum. Author manuscript; available in PMC 2011 Apr 1.

Published in final edited form as: Arthritis Rheum. 2010 Apr; 62(4): 1167–1175. doi: 10.1002/art.27315

PMCID:: PMC2915826

Abstract Article PDF–1.4M

Select item 254669917.

Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2

Chaolin Zhang, Zuo Zhang, John Castle, Shuying Sun, Jason Johnson, Adrian R. Krainer, Michael Q. Zhang

Genes Dev. 2008 Sep 15; 22(18): 2550–2563. doi: 10.1101/gad.1703108

Correction in:: Genes Dev. 2008 Oct 15; 22(20): 2902.

PMCID:: PMC2546699

Abstract Article PDF–706K

Select item 251974218.

Repression of Prespliceosome Complex Formation at Two Distinct Steps by Fox-1/Fox-2 Proteins

Hua-Lin Zhou, Hua Lou

Mol Cell Biol. 2008 Sep; 28(17): 5507–5516. Published online 2008 Jun 23. doi: 10.1128/MCB.00530-08

PMCID:: PMC2519742

Abstract Article PDF–659K

Select item 890999019.

The Splicing of the Mitochondrial Calcium Uniporter Genuine Activator MICU1 Is Driven by RBFOX2 Splicing Factor during Myogenic Differentiation

Denis Vecellio Reane, Cristina Cerqua, Sabrina Sacconi, Leonardo Salviati, Eva Trevisson, Anna Raffaello

Int J Mol Sci. 2022 Mar; 23(5): 2517. Published online 2022 Feb 24. doi: 10.3390/ijms23052517

PMCID:: PMC8909990

Abstract Article PDF–4.8M

Select item 813681520.

ERG transcription factors have a splicing regulatory function involving RBFOX2 that is altered in the EWS-FLI1 oncogenic fusion

Olivier Saulnier, Katia Guedri-Idjouadiene, Marie-Ming Aynaud, Alina Chakraborty, Jonathan Bruyr, Joséphine Pineau, Tina O’Grady, Olivier Mirabeau, Sandrine Grossetête, Bartimée Galvan, Margaux Claes, Zahra Al Oula Hassoun, Benjamin Sadacca, Karine Laud, Sakina Zaïdi, Didier Surdez, Sylvain Baulande, Xavier Rambout, Franck Tirode, Martin Dutertre, Olivier Delattre, Franck Dequiedt

Nucleic Acids Res. 2021 May 21; 49(9): 5038–5056. Published online 2021 May 1. doi: 10.1093/nar/gkab305

PMCID:: PMC8136815

Abstract Article PDF–2.5M

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PMC Links for Gene (Select 23543) (107)
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PREDICTED: Homo sapiens karyopherin subunit alpha 6 (KPNA6), transcript variant ...
PREDICTED: Homo sapiens karyopherin subunit alpha 6 (KPNA6), transcript variant X1, mRNA
gi|2462507384|ref|XM_054335736.1|

Nucleotide
importin subunit alpha-7 isoform X1 [Homo sapiens]
importin subunit alpha-7 isoform X1 [Homo sapiens]
gi|2462507385|ref|XP_054191711.1|

Protein

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