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Select item 110753941.

Early and late-onset preeclampsia: effects of DDAH2 polymorphisms on ADMA levels and association with DDAH2 haplotypes

Fernanda Santos Mendes, Marcelo Rizzatti Luizon, Ana Cristina dos Santos Lopes, Daniela Alves Pereira, Fernanda Cristina Gontijo Evangelista, Lara Carvalho Godoi, Luci Maria Dusse, Patrícia Nessralla Alpoim

Rev Bras Ginecol Obstet. 2024; 46: e-rbgo19. Published online 2024 Mar 15. doi: 10.61622/rbgo/2024AO19

PMCID:: PMC11075394

Abstract Article PDF–183K

Select item 105221922.

Polymorphism (-499C/G) in DDAH2 promoter may act as a protective factor for metabolic syndrome: A case-control study in Azar-Cohort population

Elnaz Faramarzi, Younes Aftabi, Khalil Ansarin, Mohammad Hossein Somi, Neda Gilani, Ensiyeh Seyedrezazadeh

Arch Endocrinol Metab. 2021 Jul-Aug; 65(4): 443–449. Published online 2021 Jul 16. doi: 10.20945/2359-3997000000391

PMCID:: PMC10522192

Abstract Article PDF–619K

Select item 66931963.

A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with myocardial infarction in type 2 diabetic patients

Gaia Chiara Mannino, Serena Pezzilli, Carolina Averta, Anastasia Fuoco, Rosangela Spiga, Elettra Mancuso, Concetta Di Fatta, Francesco Perticone, Sabrina Prudente, Vincenzo Trischitta, Francesco Andreozzi, Giorgio Sesti

Cardiovasc Diabetol. 2019; 18: 102. Published online 2019 Aug 13. doi: 10.1186/s12933-019-0906-1

PMCID:: PMC6693196

Abstract Article PDF–709K

Select item 47781514.

Dimethylarginine dimethylaminohydrolase 2 promotes tumor angiogenesis in lung adenocarcinoma

Toshihiro Shiozawa, Shinji Iyama, Shotaro Toshima, Akiko Sakata, Shingo Usui, Yuko Minami, Yukio Sato, Nobuyuki Hizawa, Masayuki Noguchi

Virchows Arch. 2016; 468: 179–190. Published online 2015 Oct 29. doi: 10.1007/s00428-015-1863-z

PMCID:: PMC4778151

Abstract Article PDF–3.5M

Select item 45305845.

Hepatic Dimethylarginine-Dimethylaminohydrolase1 is Reduced in Cirrhosis and is a Target for Therapy in Portal Hypertension

Rajeshwar P Mookerjee, Gautam Mehta, Vairappan Balasubramaniyan, Fatma Mohamed, Nathan Davies, Vikram Sharma, Yasuko Iwakiri, Rajiv Jalan

J Hepatol. Author manuscript; available in PMC 2015 Aug 10.

Published in final edited form as: J Hepatol. 2015 Feb; 62(2): 325–331. Published online 2014 Aug 23. doi: 10.1016/j.jhep.2014.08.024

Correction in:: J Hepatol. 2017 Sep 8

PMCID:: PMC4530584

Abstract Article PDF–1.9M

Select item 40690846.

Hypermethylation of DDAH2 promoter contributes to the dysfunction of endothelial progenitor cells in coronary artery disease patients

Pan-Pan Niu, Yu Cao, Ting Gong, Jin-Hui Guo, Bi-Kui Zhang, Su-Jie Jia

J Transl Med. 2014; 12: 170. Published online 2014 Jun 16. doi: 10.1186/1479-5876-12-170

PMCID:: PMC4069084

Abstract Article PDF–2.4M

Select item 40689337.

Dimethylarginine Dimethylaminohydrolase II Overexpression Attenuates LPS-Mediated Lung Leak in Acute Lung Injury

Saurabh Aggarwal, Christine M. Gross, Sanjiv Kumar, Christiana Dimitropoulou, Shruti Sharma, Boris A. Gorshkov, Supriya Sridhar, Qing Lu, Natalia V. Bogatcheva, Agnieszka J. Jezierska-Drutel, Rudolf Lucas, Alexander D. Verin, John D. Catravas, Stephen M. Black

Am J Respir Cell Mol Biol. 2014 Mar; 50(3): 614–625. doi: 10.1165/rcmb.2013-0193OC

PMCID:: PMC4068933

Abstract Article PDF–1.9M

Select item 38350678.

DDAH2 mRNA Expression Is Inversely Associated with Some Cardiovascular Risk-Related Features in Healthy Young Adults

Blanca Puchau, Helen Hermana M. Hermsdorff, M. Ángeles Zulet, J. Alfredo Martínez

Dis Markers. 2009; 27(1): 37–44. Published online 2009 Oct 12. doi: 10.3233/DMA-2009-0650

PMCID:: PMC3835067

Summary PDF–165K

Select item 33386969.

A Functional Variant of the Dimethylarginine Dimethylaminohydrolase-2 Gene Is Associated with Insulin Sensitivity

Francesco Andreozzi, Ivan Presta, Gaia Chiara Mannino, Daniela Scarpelli, Sara Di Silvestre, Natalia Di Pietro, Elena Succurro, Angela Sciacqua, Assunta Pandolfi, Agostino Consoli, Marta Letizia Hribal, Francesco Perticone, Giorgio Sesti

PLoS One. 2012; 7(4): e36224. Published online 2012 Apr 27. doi: 10.1371/journal.pone.0036224

PMCID:: PMC3338696

Abstract Article PDF–134K

Select item 329978110.

Pilot Study of the Association of the DDAH2 −449G Polymorphism with Asymmetric Dimethylarginine and Hemodynamic Shock in Pediatric Sepsis

Scott L. Weiss, Min Yu, Lawrence Jennings, Shannon Haymond, Gang Zhang, Mark S. Wainwright

PLoS One. 2012; 7(3): e33355. Published online 2012 Mar 12. doi: 10.1371/journal.pone.0033355

PMCID:: PMC3299781

Abstract Article PDF–303K

Select item 175107211.

Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational study

Michael J O'Dwyer, Felicity Dempsey, Vivion Crowley, Dermot P Kelleher, Ross McManus, Thomas Ryan

Crit Care. 2006; 10(5): R139. Published online 2006 Sep 26. doi: 10.1186/cc5053

PMCID:: PMC1751072

Abstract Article PDF–135K

Select item 12970712.

S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: Further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase

James Leiper, Judith Murray-Rust, Neil McDonald, Patrick Vallance

Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21): 13527–13532. Published online 2002 Oct 7. doi: 10.1073/pnas.212269799

PMCID:: PMC129707

Abstract Article PDF–315K

Select item 1049660313.

Association between variation in the genes DDAH1 and DDAH2 and hypertension among Uygur, Kazakh and Han ethnic groups in China: Associação entre variação de genes DDAH1 e DDAH2 com hipertensão nos grupos étnicos uygur, kazakh e han na China

Zhong Wang, Shaoze Chen, Lina Zhang, Guilin Lu, Chengming Zhou, Dao Wen Wang, Li Wang, Bayinbate Badengmu, Zhihong Zhai, Lian Qin

Sao Paulo Med J. 2016; 134(3): 205–210. Published online 2016 Jan 19. doi: 10.1590/1516-3180.2015.01150108

PMCID:: PMC10496603

Abstract Article PDF–148K

Select item 956990314.

Assessment of DDAH1 and DDAH2 Contributions to Psychiatric Disorders via In Silico Methods

Alena A. Kozlova, Anastasia N. Vaganova, Roman N. Rodionov, Raul R. Gainetdinov, Nadine Bernhardt

Int J Mol Sci. 2022 Oct; 23(19): 11902. Published online 2022 Oct 7. doi: 10.3390/ijms231911902

PMCID:: PMC9569903

Abstract Article PDF–2.4M

Select item 628890215.

Evidence for a protective role for the rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) in septic shock through the regulation of DDAH activity

Simon Lambden, James Tomlinson, Sophie Piper, Anthony C. Gordon, James Leiper

Crit Care. 2018; 22: 336. Published online 2018 Dec 11. doi: 10.1186/s13054-018-2277-5

PMCID:: PMC6288902

Abstract Article PDF–1.4M

Select item 450733216.

Inhibition of DDAH1, but not DDAH2, results in apoptosis of a human trophoblast cell line in response to TRAIL

B.A. Lumicisi, J.E. Cartwright, K. Leslie, A.E. Wallace, G.S. Whitley

Hum Reprod. 2015 Aug; 30(8): 1813–1819. Published online 2015 Jun 16. doi: 10.1093/humrep/dev138

PMCID:: PMC4507332

Abstract Article PDF–325K

Select item 283088317.

Sequence Variation in DDAH1 and DDAH2 Genes Is Strongly and Additively Associated with Serum ADMA Concentrations in Individuals with Type 2 Diabetes

Sotoodeh Abhary, Kathryn P. Burdon, Abraham Kuot, Shahrbanou Javadiyan, Malcolm J. Whiting, Nicholas Kasmeridis, Nikolai Petrovsky, Jamie E. Craig

PLoS One. 2010; 5(3): e9462. Published online 2010 Mar 1. doi: 10.1371/journal.pone.0009462

PMCID:: PMC2830883

Abstract Article PDF–185K

Select item 380592518.

DNA Methylation Profiling Revealed Promoter Hypermethylation-induced Silencing of p16, DDAH2 and DUSP1 in Primary Oral Squamous Cell Carcinoma

Goot Heah Khor, Gabriele Ruth Anisah Froemming, Rosnah Binti Zain, Mannil Thomas Abraham, Effat Omar, Su Keng Tan, Aik Choon Tan, Vui King Vincent-Chong, Kwai Lin Thong

Int J Med Sci. 2013; 10(12): 1727–1739. Published online 2013 Oct 12. doi: 10.7150/ijms.6884

PMCID:: PMC3805925

Abstract Article PDF–1.3M

Select item 1025680119.

A multicentric consortium study demonstrates that dimethylarginine dimethylaminohydrolase 2 is not a dimethylarginine dimethylaminohydrolase

Vinitha N. Ragavan, Pramod C. Nair, Natalia Jarzebska, Ramcharan Singh Angom, Luana Ruta, Elisa Bianconi, Silvia Grottelli, Natalia D. Tararova, Daniel Ryazanskiy, Steven R. Lentz, Sara Tommasi, Jens Martens-Lobenhoffer, Toshiko Suzuki-Yamamoto, Masumi Kimoto, Elena Rubets, Sarah Chau, Yingjie Chen, Xinli Hu, Nadine Bernhardt, Peter M. Spieth, Norbert Weiss, Stefan R. Bornstein, Debabrata Mukhopadhyay, Stefanie M. Bode-Böger, Renke Maas, Ying Wang, Antonio Macchiarulo, Arduino A. Mangoni, Barbara Cellini, Roman N. Rodionov

Nat Commun. 2023; 14: 3392. Published online 2023 Jun 9. doi: 10.1038/s41467-023-38467-9

PMCID:: PMC10256801

Abstract Article PDF–2.8M

Select item 311703720.

Global DDAH1 gene deficient mice reveal that DDAH1 is the critical enzyme for degrading the cardiovascular risk factor ADMA

Xinli Hu, Dorothee Atzler, Xin Xu, Ping Zhang, Haipeng Guo, Zhongbing Lu, John Fassett, Edzard Schwedhelm, Rainer H. Böger, Robert J. Bache, Yingjie Chen

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2012 Jul 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2011 Jul; 31(7): 1540–1546. Published online 2011 Apr 14. doi: 10.1161/ATVBAHA.110.222638

PMCID:: PMC3117037

Abstract Article PDF–634K

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