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Select item 100947211.

Hydroperoxidation of Docosahexaenoic Acid by Human ALOX12 and pigALOX15-mini-LOX

Miquel Canyelles-Niño, Àngels González-Lafont, José M. Lluch

Int J Mol Sci. 2023 Apr; 24(7): 6064. Published online 2023 Mar 23. doi: 10.3390/ijms24076064

PMCID:: PMC10094721

Abstract Article PDF–20M

Select item 98884332.

Biochemical and hydrogen-deuterium exchange studies of the single nucleotide polymorphism Y649C in human platelet 12-lipoxygenase linked to a bleeding disorder

Michelle Tran, Rachel L. Signorelli, Adriana Yamaguchi, Eefie Chen, Michael Holinstat, Anthony T. Iavarone, Adam R. Offenbacher, Theodore Holman

Arch Biochem Biophys. Author manuscript; available in PMC 2023 Jan 31.

Published in final edited form as: Arch Biochem Biophys. 2023 Jan 1; 733: 109472. Published online 2022 Nov 25. doi: 10.1016/j.abb.2022.109472

PMCID:: PMC9888433

Abstract Article PDF–1.3M

Select item 92718593.

ALOX12: A Novel Insight in Bevacizumab Response, Immunotherapy Effect, and Prognosis of Colorectal Cancer

Siyuan Weng, Zaoqu Liu, Hui Xu, Xiaoyong Ge, Yuqing Ren, Qin Dang, Long Liu, Jian Zhang, Peng Luo, Jianzhuang Ren, Xinwei Han

Front Immunol. 2022; 13: 910582. Published online 2022 Jun 27. doi: 10.3389/fimmu.2022.910582

PMCID:: PMC9271859

Abstract Article PDF–26M

Select item 84560514.

Platelets induce free and phospholipid-esterified 12-hydroxyeicosatetraenoic acid generation in colon cancer cells by delivering 12-lipoxygenase

Annalisa Contursi, Simone Schiavone, Melania Dovizio, Christine Hinz, Rosa Fullone, Stefania Tacconelli, Victoria J. Tyrrell, Rosalia Grande, Paola Lanuti, Marco Marchisio, Mirco Zucchelli, Patrizia Ballerini, Angel Lanas, Valerie B. O'Donnell, Paola Patrignani

J Lipid Res. 2021; 62: 100109. Published online 2021 Aug 21. doi: 10.1016/j.jlr.2021.100109

PMCID:: PMC8456051

Abstract Article PDF–3.1M

Select item 81503725.

Regulation of Tissue Inflammation by 12-Lipoxygenases

Abhishek Kulkarni, Jerry L. Nadler, Raghavendra G. Mirmira, Isabel Casimiro

Biomolecules. 2021 May; 11(5): 717. Published online 2021 May 11. doi: 10.3390/biom11050717

PMCID:: PMC8150372

Abstract Article PDF–1.9M

Select item 72701476.

Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-type 12-Lipoxygenase

Ansari Mukhtar Aleem, Wan-Chen Tsai, Jennyfer Tena, Gabriella Alvarez, Joshua Deschamps, Chakrapani Kalyanaraman, Matthew P. Jacobson, Theodore Holman

Biochemistry. Author manuscript; available in PMC 2020 Jun 4.

Published in final edited form as: Biochemistry. 2019 Feb 12; 58(6): 848–857. Published online 2019 Jan 4. doi: 10.1021/acs.biochem.8b01167

PMCID:: PMC7270147

Abstract Article PDF–649K

Select item 72426927.

Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer

Ehab H. Sarsour, Jyung Mean Son, Amanda L. Kalen, Wusheng Xiao, Juan Du, Matthew S. Alexander, Brianne R. O'Leary, Joseph J. Cullen, Prabhat C. Goswami

J Biol Chem. 2020 May 15; 295(20): 6946–6957. Published online 2020 Apr 7. doi: 10.1074/jbc.RA120.012798

PMCID:: PMC7242692

Abstract Article PDF–2.9M

Select item 56432408.

Molecular Mechanisms of Nonalcoholic Fatty Liver Disease: Potential Role for 12-Lipoxygenase

Niharika Samala, Sarah A. Tersey, Naga Chalasani, Ryan M. Anderson, Raghavendra G. Mirmira

J Diabetes Complications. Author manuscript; available in PMC 2018 Nov 1.

Published in final edited form as: J Diabetes Complications. 2017 Nov; 31(11): 1630–1637. Published online 2017 Jul 31. doi: 10.1016/j.jdiacomp.2017.07.014

PMCID:: PMC5643240

Abstract Article PDF–501K

Select item 46372469.

A novel locus in the oxidative stress-related gene ALOX12 moderates the association between PTSD and thickness of the prefrontal cortex

Mark W. Miller, Erika J. Wolf, Naomi Sadeh, Mark Logue, Jeffrey M. Spielberg, Jasmeet P. Hayes, Emily Sperbeck, Steven A. Schichman, Angie Stone, Weleetka C. Carter, Donald E. Humphries, William Milberg, Regina McGlinchey

Psychoneuroendocrinology. Author manuscript; available in PMC 2016 Dec 1.

Published in final edited form as: Psychoneuroendocrinology. 2015 Dec; 62: 359–365. Published online 2015 Sep 5. doi: 10.1016/j.psyneuen.2015.09.003

PMCID:: PMC4637246

Abstract Article PDF–307K

Select item 456035910.

Arachidonate 12-lipoxygenase may serve as a potential marker and therapeutic target for prostate cancer stem cells

BO YIN, YANG YANG, ZHIQIANG ZHAO, YU ZENG, STEVEN M. MOONEY, MING LI, XUEWEN XU, YONGSHENG SONG, BIN WU, ZHIBO YANG

Int J Oncol. Author manuscript; available in PMC 2015 Sep 4.

Published in final edited form as: Int J Oncol. 2011 Apr; 38(4): 1041–1046. Published online 2011 Jan 11. doi: 10.3892/ijo.2011.901

PMCID:: PMC4560359

Abstract Article PDF–647K

Select item 440677611.

Associations between ALOX, COX, and CRP polymorphisms and breast cancer among Hispanic and non-Hispanic white women: The Breast Cancer Health Disparities Study

Avonne E. Connor, Richard N. Baumgartner, Kathy B. Baumgartner, Christina M. Pinkston, Stephanie D. Boone, Esther M. John, Gabriela Torres-Mejía, Lisa M. Hines, Anna R. Giuliano, Roger K. Wolff, Martha L. Slattery

Mol Carcinog. Author manuscript; available in PMC 2016 Dec 1.

Published in final edited form as: Mol Carcinog. 2015 Dec; 54(12): 1541–1553. Published online 2014 Oct 22. doi: 10.1002/mc.22228

PMCID:: PMC4406776

Abstract Article PDF–604K

Select item 433304512.

Expression Pattern of 12-Lipoxygenase in Human Islets With Type 1 Diabetes and Type 2 Diabetes

Wojciech J. Grzesik, Joseph L. Nadler, Yui Machida, Jerry L. Nadler, Yumi Imai, Margaret A. Morris

J Clin Endocrinol Metab. 2015 Mar; 100(3): E387–E395. Published online 2014 Dec 22. doi: 10.1210/jc.2014-3630

PMCID:: PMC4333045

Abstract Article

Select item 409761313.

ALOX12 in Human Toxoplasmosis

William H. Witola, Susan Ruosu Liu, Alexandre Montpetit, Ruth Welti, Magali Hypolite, Mary Roth, Ying Zhou, Ernest Mui, Marie-France Cesbron-Delauw, Gilbert J. Fournie, Pierre Cavailles, Cordelia Bisanz, Kenneth Boyer, Shawn Withers, A. Gwendolyn Noble, Charles N. Swisher, Peter T. Heydemann, Peter Rabiah, Stephen P. Muench, Rima McLeod

Infect Immun. 2014 Jul; 82(7): 2670–2679. doi: 10.1128/IAI.01505-13

PMCID:: PMC4097613

Abstract Article PDF–1.8M

Select item 398271314.

Arachidonic acid metabolism in human prostate cancer

PEIYING YANG, CARRIE A. CARTWRIGHT, JIN LI, SIJIN WEN, INA N. PROKHOROVA, IMAD SHUREIQI, PATRICIA TRONCOSO, NORA M. NAVONE, ROBERT A. NEWMAN, JERI KIM

Int J Oncol. 2012 Oct; 41(4): 1495–1503. Published online 2012 Aug 10. doi: 10.3892/ijo.2012.1588

PMCID:: PMC3982713

Abstract Article PDF–724K

Select item 306100215.

ALOX12 polymorphisms are associated with fat mass but not peak bone mineral density in Chinese nuclear families

W-J Xiao, J-W He, H Zhang, W-W Hu, J-M Gu, H Yue, G Gao, J-B Yu, C Wang, Y-H Ke, W-Z Fu, Z-L Zhang

Int J Obes (Lond) 2011 Mar; 35(3): 378–386. Published online 2010 Aug 10. doi: 10.1038/ijo.2010.157

PMCID:: PMC3061002

Abstract Article PDF–368K

Select item 292710616.

ALOX12 gene is associated with the onset of natural menopause in white women

Pengyuan Liu, Yan Lu, Robert R. Recker, Hong-Wen Deng, Volodymyr Dvornyk

Menopause. Author manuscript; available in PMC 2010 Aug 24.

Published in final edited form as: Menopause. 2010 Jan–Feb; 17(1): 152–156. doi: 10.1097/gme.0b013e3181b63c68

PMCID:: PMC2927106

Abstract Article PDF–340K

Select item 290998917.

Association between polymorphisms of arachidonate 12-lipoxygenase (ALOX12) and schizophrenia in a Korean population

Tae Kim, Hak-Jae Kim, Jin Kyung Park, Jong Woo Kim, Joo-Ho Chung

Behav Brain Funct. 2010; 6: 44. Published online 2010 Jul 14. doi: 10.1186/1744-9081-6-44

PMCID:: PMC2909989

Abstract Article PDF–604K

Select item 284085618.

12-Lipoxygenase Products Reduce Insulin Secretion and β-Cell Viability in Human Islets

K. Ma, C. S. Nunemaker, R. Wu, S. K. Chakrabarti, D. A. Taylor-Fishwick, J. L. Nadler

J Clin Endocrinol Metab. 2010 Feb; 95(2): 887–893. Published online 2010 Jan 20. doi: 10.1210/jc.2009-1102

PMCID:: PMC2840856

Abstract Article

Select item 772928119.

Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators

Cody Freedman, Adrianne Tran, Benjamin E. Tourdot, Chakrapani Kalyanaraman, Steve Perry, Michael Holinstat, Matthew P. Jacobson, Theodore R. Holman

Biochemistry. Author manuscript; available in PMC 2021 May 19.

Published in final edited form as: Biochemistry. 2020 May 19; 59(19): 1832–1844. Published online 2020 May 7. doi: 10.1021/acs.biochem.0c00233

PMCID:: PMC7729281

Abstract Article PDF–829K

Select item 724249220.

The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma

Lily Oguh-Olayinka, Vijay Agarwal, Dulani Ranatunge, Anne Campbell, Stefan Laufer, Lynn Cawkwell, Michael J. Lind

Pathol Oncol Res. 2020; 26(2): 985–995. Published online 2019 Apr 2. doi: 10.1007/s12253-019-00652-x

PMCID:: PMC7242492

Abstract Article PDF–1.7M

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PMC Links for Gene (Select 239) (84)
PMC
PREDICTED: Homo sapiens regulating synaptic membrane exocytosis 3 (RIMS3), trans...
PREDICTED: Homo sapiens regulating synaptic membrane exocytosis 3 (RIMS3), transcript variant X2, mRNA
gi|2217272577|ref|XM_047435189.1|

Nucleotide
Homo sapiens partial IGVH3 DP53 gene for immunoglobulin heavy chain V region, ca...
Homo sapiens partial IGVH3 DP53 gene for immunoglobulin heavy chain V region, case 1, cell Mo VII 116
gi|7573087|emb|AJ275412.1|

Nucleotide
PREDICTED: Homo sapiens arachidonate 12-lipoxygenase, 12S type (ALOX12), transcr...
PREDICTED: Homo sapiens arachidonate 12-lipoxygenase, 12S type (ALOX12), transcript variant X1, mRNA
gi|2217310984|ref|XM_011523780.3|

Nucleotide

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