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Select item 111028661.

Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by DNA minor groove anchor competition

Wataru Kobayashi, Anna H. Sappler, Daniel Bollschweiler, Maximilian Kümmecke, Jérôme Basquin, Eda Nur Arslantas, Siwat Ruangroengkulrith, Renate Hornberger, Karl Duderstadt, Kikuë Tachibana

Nat Struct Mol Biol. 2024; 31(5): 757–766. Published online 2024 Feb 26. doi: 10.1038/s41594-024-01239-0

PMCID:: PMC11102866

Abstract Article PDF–16M

Select item 107253882.

Aberrant phosphorylation of human LRH1 at serine 510 is predictable of hepatocellular carcinoma recurrence

Atsushi Nishimagi, Makoto Kobayashi, Kotaro Sugimoto, Yasuhide Kofunato, Naoya Sato, Junichiro Haga, Teruhide Ishigame, Takashi Kimura, Akira Kenjo, Yasuyuki Kobayashi, Yuko Hashimoto, Shigeru Marubashi, Hideki Chiba

Clin Exp Med. 2023; 23(8): 4985–4995. Published online 2023 Jun 7. doi: 10.1007/s10238-023-01098-x

PMCID:: PMC10725388

Abstract Article PDF–3.8M

Select item 100688363.

LRH1 promotes pancreatic cancer metastasis

Qiushi Lin, Arihiro Aihara, Waihong Chung, Yu Li, Xuesong Chen, Zheping Huang, Shaofan Weng, Rolf I. Carlson, Christina Nadolny, Jack R. Wands, Xiaoqun Dong

Cancer Lett. Author manuscript; available in PMC 2023 Apr 3.

Published in final edited form as: Cancer Lett. 2014 Aug 1; 350(1-2): 15–24. Published online 2014 Apr 24. doi: 10.1016/j.canlet.2014.04.017

PMCID:: PMC10068836

Abstract Article PDF–3.8M

Select item 94423054.

LRH‐1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance

Svenja Michalek, Thomas Goj, Anna Pia Plazzo, Blerim Marovca, Beat Bornhauser, Thomas Brunner

EMBO Rep. 2022 Sep; 23(9): e54195. Published online 2022 Jul 8. doi: 10.15252/embr.202154195

PMCID:: PMC9442305

Abstract Article PDF–3.8M

Select item 84886495.

Nuclear receptor NR5A2 negatively regulates cell proliferation and tumor growth in nervous system malignancies

Dimitrios Gkikas, Dimitris Stellas, Alexia Polissidis, Theodora Manolakou, Maroula G. Kokotou, George Kokotos, Panagiotis K. Politis

Proc Natl Acad Sci U S A. 2021 Sep 28; 118(39): e2015243118. Published online 2021 Sep 24. doi: 10.1073/pnas.2015243118

PMCID:: PMC8488649

Abstract Article PDF–2.6M

Select item 78410756.

MicroRNA-219-5p Represses the Proliferation, Migration, and Invasion of Gastric Cancer Cells by Targeting the LRH-1/Wnt/β-Catenin Signaling Pathway

Chunsheng Li, Jingrong Dong, Zhenqi Han, Kai Zhang

Oncol Res. 2017; 25(4): 617–627. Published online 2017 Apr 14. doi: 10.3727/096504016X14768374457986

PMCID:: PMC7841075

Abstract Article PDF–4.6M

Select item 65964157.

Polymorphisms in NR5A2, gene encoding Liver Receptor Homolog-1 are associated with Preterm Birth

Dinushan C Kaluarachchi, Allison M Momany, Tamara D Busch, Lucas G Gimenez, Cesar Saleme, Viviana Cosentino, Kaare Christensen, John M Dagle, Kelli K Ryckman, Jeffrey C Murray

Pediatr Res. Author manuscript; available in PMC 2019 Jun 27.

Published in final edited form as: Pediatr Res. 2016 May; 79(5): 776–780. Published online 2016 Jan 13. doi: 10.1038/pr.2016.7

PMCID:: PMC6596415

Abstract Article PDF–70K

Select item 64136758.

LRH1-driven transcription factor circuitry for hepatocyte identity: Super-enhancer cistromic analysis

Min Sung Joo, Ja Hyun Koo, Tae Hyun Kim, Yun Seok Kim, Sang Geon Kim

EBioMedicine. 2019 Feb; 40: 488–503. Published online 2019 Jan 9. doi: 10.1016/j.ebiom.2018.12.056

PMCID:: PMC6413675

Abstract Article PDF–6.3M

Select item 62784929.

Targeting LRH-1 in hepatoblastoma cell lines causes decreased proliferation

Jingling Jin, Junliang Jin, Sarah E. Woodfield, Roma H. Patel, Nan Ge Jin, Yan Shi, Bin Liu, Wenjing Sun, Xiangmei Chen, Yang Yu, Sanjeev A. Vasudevan

Oncol Rep. 2019 Jan; 41(1): 143–153. Published online 2018 Oct 15. doi: 10.3892/or.2018.6793

PMCID:: PMC6278492

Abstract Article PDF–1.5M

Select item 627582210.

LRH1 as a promising prognostic biomarker and predictor of metastasis in patients with non‐small cell lung cancer

Yuechao Liu, Ying Xing, Hongmei Wang, Shi Yan, Xinzhu Wang, Li Cai

Thorac Cancer. 2018 Dec; 9(12): 1725–1732. Published online 2018 Oct 1. doi: 10.1111/1759-7714.12887

PMCID:: PMC6275822

Abstract Article PDF–677K

Select item 544863011.

Expression of Liver Receptor Homolog-1 (LRH-1) in Villi and Decidua of Patients with Unexplained Recurrent Spontaneous Abortion

Zhiyan Xu, Xiangqing Hou, Hongtao Lv, Binghui Sun, Yingying Cui, Ling Liu, Fengnian Rong

Med Sci Monit. 2017; 23: 2445–2452. Published online 2017 May 22. doi: 10.12659/MSM.904645

PMCID:: PMC5448630

Abstract Article PDF–1.1M

Select item 539212912.

Effect of NR5A2 inhibition on pancreatic cancer stem cell (CSC) properties and epithelial-mesenchymal transition (EMT) markers

Zhaofan Luo, Yanan Li, Zuo Mingxin, Chang Liu, Dong Yan, Huamin Wang, Donghui Li

Mol Carcinog. Author manuscript; available in PMC 2018 May 1.

Published in final edited form as: Mol Carcinog. 2017 May; 56(5): 1438–1448. Published online 2017 Jan 12. doi: 10.1002/mc.22604

Correction in:: Mol Carcinog. 2018 Jan; 57(1): 142.

PMCID:: PMC5392129

Abstract Article PDF–1.0M

Select item 520723213.

Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists

Suzanne G. Mays, C. Denise Okafor, Richard J. Whitby, Devrishi Goswami, Józef Stec, Autumn R. Flynn, Michael C. Dugan, Nathan T. Jui, Patrick R. Griffin, Eric A. Ortlund

J Biol Chem. 2016 Dec 2; 291(49): 25281–25291. Published online 2016 Sep 30. doi: 10.1074/jbc.M116.753541

PMCID:: PMC5207232

Abstract Article PDF–1.9M

Select item 500931514.

The characterization of an intestine-like genomic signature maintained during Barrett’s-associated adenocarcinogenesis reveals an NR5A2-mediated promotion of cancer cell survival

Shane P. Duggan, Fiona M. Behan, Murat Kirca, Abdul Zaheer, Sarah A. McGarrigle, John V. Reynolds, Gisela M. F. Vaz, Mathias O. Senge, Dermot Kelleher

Sci Rep. 2016; 6: 32638. Published online 2016 Sep 2. doi: 10.1038/srep32638

Correction in:: Sci Rep. 2016; 6: 35330.

PMCID:: PMC5009315

Abstract Article PDF–2.7M

Select item 474939015.

A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver

Miyuki Suzawa, Diego A Miranda, Karmela A Ramos, Kenny K-H Ang, Emily J Faivre, Christopher G Wilson, Laura Caboni, Michelle R Arkin, Yeong-Sang Kim, Robert J Fletterick, Aaron Diaz, John S Schneekloth, Jr, Holly A Ingraham

eLife. 2015; 4: e09003. Published online 2015 Dec 11. doi: 10.7554/eLife.09003

PMCID:: PMC4749390

Abstract Article PDF–2.7M

Select item 465546716.

Genome-wide association study-identified SNPs (rs3790844, rs3790843) in the NR5A2 gene and risk of pancreatic cancer in Japanese

Makoto Ueno, Shinichi Ohkawa, Manabu Morimoto, Hiroshi Ishii, Masato Matsuyama, Sawako Kuruma, Naoto Egawa, Haruhisa Nakao, Mitsuru Mori, Keitaro Matsuo, Satoyo Hosono, Masanori Nojima, Kenji Wakai, Kozue Nakamura, Akiko Tamakoshi, Mami Takahashi, Kazuaki Shimada, Takeshi Nishiyama, Shogo Kikuchi, Yingsong Lin

Sci Rep. 2015; 5: 17018. Published online 2015 Nov 23. doi: 10.1038/srep17018