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Items: 1 to 20 of 332

1.
Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis
Janne Pott, Azin Kheirkhah, Jesper R. Gadin, Marcus E. Kleber, Graciela E. Delgado, Holger Kirsten, Lukas Forer, Stefanie M. Hauck, Ralph Burkhardt, Hubert Scharnagl, Markus Loeffler, Winfried März, Joachim Thiery, Christian Gieger, Annette Peters, Angela Silveira, Ferdinand van’t Hooft, Florian Kronenberg, Markus Scholz
Biol Sex Differ. 2024; 15: 26. Published online 2024 Mar 26. doi: 10.1186/s13293-024-00602-6
PMCID:
PMC10964567
ArticlePDF–1.6M
2.
PCSK9 increases vulnerability of carotid plaque by promoting mitochondrial dysfunction and apoptosis of vascular smooth muscle cells
Ran Xu, Tianhua Li, Jichang Luo, Xiao Zhang, Tao Wang, Yabing Wang, Yan Ma, Bin Yang, Jinzhu Jia, Adam A. Dmytriw, Wenjing Li, Liqun Jiao
CNS Neurosci Ther. 2024 Feb; 30(2): e14640. Published online 2024 Feb 25. doi: 10.1111/cns.14640
PMCID:
PMC10894644
ArticlePDF–16M
3.
Proteome-wide mendelian randomization investigates potential associations in heart failure and its etiology: emphasis on PCSK9
Lichao Lin, Huizhen Yu, Yan Xue, Liman Wang, Pengli Zhu
BMC Med Genomics. 2024; 17: 59. Published online 2024 Feb 21. doi: 10.1186/s12920-024-01826-6
PMCID:
PMC10882912
ArticlePDF–2.0M
4.
GWAS of lipids in Greenlanders finds association signals shared with Europeans and reveals an independent PCSK9 association signal
Ninna Karsbæk Senftleber, Mette K. Andersen, Emil Jørsboe, Frederik Filip Stæger, Anne Krogh Nøhr, Genis Garcia-Erill, Jonas Meisner, Cindy G. Santander, Renzo F. Balboa, Arthur Gilly, Peter Bjerregaard, Christina Viskum Lytken Larsen, Niels Grarup, Marit Eika Jørgensen, Eleftheria Zeggini, Ida Moltke, Torben Hansen, Anders Albrechtsen
Eur J Hum Genet. 2024 Feb; 32(2): 215–223. Published online 2023 Oct 30. doi: 10.1038/s41431-023-01485-8
PMCID:
PMC10853193
ArticlePDF–2.1M
5.
Data-driven transcriptomics analysis identifies PCSK9 as a novel key regulator in liver aging
Muhammad Arif, Csaba Matyas, Partha Mukhopadhyay, Burhan Yokus, Eszter Trojnar, Janos Paloczi, Bruno Paes-Leme, Suxian Zhao, Falk W. Lohoff, György Haskó, Pal Pacher
GeroScience. 2023 Oct; 45(5): 3059–3077. Published online 2023 Sep 20. doi: 10.1007/s11357-023-00928-w
PMCID:
PMC10643490
ArticlePDF–1.9M
6.
Induced alternative splicing an opportunity to study PCSK9 protein isoforms at physiologically relevant concentrations
Jessica M. Cale, Kristin A. Ham, Dunhui Li, Craig S. McIntosh, Gerald F. Watts, Steve D. Wilton, May T. Aung-Htut
Sci Rep. 2023; 13: 19725. Published online 2023 Nov 13. doi: 10.1038/s41598-023-47005-y
PMCID:
PMC10643364
ArticlePDF–3.0M
7.
Elevated circulating PCSK9 level is associated with 28-day mortality in patients with sepsis: a prospective cohort study
Yuanlu Shu, Ziwei Deng, Ye Deng, Jianliang Zhou, Jin Wang, Zhenxing Duan, Tao Jiang, Xiang Zhao, Zhihua Shi, Chengfeng Qiu
BMC Emerg Med. 2023; 23: 127. Published online 2023 Oct 31. doi: 10.1186/s12873-023-00896-6
PMCID:
PMC10617046
ArticlePDF–1.9M
8.
Exploring PCSK9 Genetic Impact on Lipoprotein(a) via Dual Approaches: Association and Mendelian Randomization
Ya-Ching Chang, Lung-An Hsu, Yu-Lin Ko
Int J Mol Sci. 2023 Oct; 24(19): 14668. Published online 2023 Sep 28. doi: 10.3390/ijms241914668
PMCID:
PMC10572552
ArticlePDF–819K
9.
Exploring the Link between Plasma Levels of PCSK9, Immune Dysregulation and Atherosclerosis in Patients with Primary Sjögren’s Syndrome
Vanessa Bianconi, Giacomo Cafaro, Massimo Raffaele Mannarino, Carlo Perricone, Elena Cosentini, Onelia Bistoni, Rita Paltriccia, Rita Lombardini, Roberto Gerli, Matteo Pirro, Elena Bartoloni
Biomolecules. 2023 Sep; 13(9): 1384. Published online 2023 Sep 12. doi: 10.3390/biom13091384
PMCID:
PMC10527459
ArticlePDF–1.1M
10.
PCSK9 and the nervous system: a no-brainer?
Ali K. Jaafar, Romuald Techer, Kévin Chemello, Gilles Lambert, Steeve Bourane
J Lipid Res. 2023 Sep; 64(9): 100426. Published online 2023 Aug 14. doi: 10.1016/j.jlr.2023.100426
PMCID:
PMC10491654
ArticlePDF–1.3M
11.
Plasma Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) as a Possible Biomarker for Severe COVID-19
Patricia Mester, Pablo Amend, Stephan Schmid, Martina Müller, Christa Buechler, Vlad Pavel
Viruses. 2023 Jul; 15(7): 1511. Published online 2023 Jul 6. doi: 10.3390/v15071511
PMCID:
PMC10385877
ArticlePDF–1.1M
12.
PCSK9 inhibition interrupts the cross-talk between keratinocytes and macrophages and prevents UVB-induced skin damage
Chao Luan, Yingxue He, Wen Liu, Yicheng Rong, Jian Gao, Kang Xu, Hui Yu, Yu Hu, Jiaan Zhang, Kun Chen, Wenjie Guo
J Biol Chem. 2023 Jul; 299(7): 104895. Published online 2023 Jun 6. doi: 10.1016/j.jbc.2023.104895
PMCID:
PMC10331474
ArticlePDF–6.0M
13.
Relationship between Serum Proprotein Convertase Subtilisin/Kexin Type 9 Concentration and Prevalence of Coronary Artery Calcium in a Community-Based Sample of Japanese Men
Ayako Kunimura, Katsuyuki Miura, Hiroyoshi Segawa, Sayuki Torii, Keiko Kondo, Takashi Hisamatsu, Aya Kadota, Akira Fujiyoshi, Yuichiro Yano, Yoshihisa Nakagawa, Tomonori Okamura, Hirotsugu Ueshima
J Atheroscler Thromb. 2023 Jul 1; 30(7): 767–777. Published online 2022 Sep 17. doi: 10.5551/jat.63549
PMCID:
PMC10322734
ArticlePDF–388K
14.
PCSK9 promotes T helper 1 and T helper 17 cell differentiation by activating the nuclear factor‐κB pathway in ankylosing spondylitis
Jianfei Cai, Yinghui Jiang, Fucai Chen, Shubin Wu, Hongjun Ren, Pingping Wang, Jiayong Wang, Wei Liu
Immun Inflamm Dis. 2023 May; 11(5): e870. Published online 2023 May 26. doi: 10.1002/iid3.870
PMCID:
PMC10214583
ArticlePDF–3.2M
15.
Proprotein Convertase Subtilisin Kexin 9 (PCSK9) and nonHDL particles rise during normal pregnancy and differ by BMI
R.A. Wild, E. Weedin, K. Cox, Y.D. Zhao, D.S. Wrenn, D. Lopez, C.J. Wooten, Q.M. Melendez, D. Myers, K.R. Hansen
J Clin Lipidol. Author manuscript; available in PMC 2023 Apr 21.
Published in final edited form as: J Clin Lipidol. 2022 Jul-Aug; 16(4): 483–490. Published online 2022 Jun 6. doi: 10.1016/j.jacl.2022.05.070
PMCID:
PMC10119944
ArticlePDF–526K
16.
PCSK9, a novel immune and ferroptosis related gene in abdominal aortic aneurysm neck
Junli Zhuang, Hua Zhu, Ziqi Cheng, Xinyao Hu, Xiaohui Yu, Jie Li, Huagang Liu, Peng Tang, Ying Zhang, Xiaoxing Xiong, Hongping Deng
Sci Rep. 2023; 13: 6054. Published online 2023 Apr 13. doi: 10.1038/s41598-023-33287-9
PMCID:
PMC10102181
ArticlePDF–6.2M
17.
Heparin Does Not Regulate Circulating Human PCSK9 in a General Population
Vivian Q. Xia, Chui Mei Ong, Lucas S. Zier, John S. MacGregor, Alan H. B. Wu, John S. Chorba
Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2024 Feb 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2023 Feb; 43(2): 352–358. Published online 2022 Dec 8. doi: 10.1161/ATVBAHA.122.318556
PMCID:
PMC10038152
ArticlePDF–776K
18.
Serum Levels of PCSK9 Are Increased in Patients With Active Ulcerative Colitis Representing a Potential Biomarker of Disease Activity: A Cross-sectional Study
Carla Marinelli, Fabiana Zingone, Maria Giovanna Lupo, Raffaella Marin, Renata D’Incà, Alessandro Gubbiotti, Davide Massimi, Cesare Casadei, Brigida Barberio, Nicola Ferri, Edoardo Savarino
J Clin Gastroenterol. 2022 Oct; 56(9): 787–793. Published online 2021 Sep 22. doi: 10.1097/MCG.0000000000001607
PMCID:
PMC9988229
ArticlePDF–364K
19.
Functional Characterization of p.(Arg160Gln) PCSK9 Variant Accidentally Found in a Hypercholesterolemic Subject
Asier Larrea-Sebal, Chiara Trenti, Shifa Jebari-Benslaiman, Stefano Bertolini, Sebastiano Calandra, Emanuele A. Negri, Efrem Bonelli, Asier Benito-Vicente, Leire Uraga-Gracianteparaluceta, César Martín, Tommaso Fasano
Int J Mol Sci. 2023 Feb; 24(4): 3330. Published online 2023 Feb 7. doi: 10.3390/ijms24043330
PMCID:
PMC9959173
ArticlePDF–3.1M
20.
PCSK9 as an Atherothrombotic Risk Factor
Tadeja Sotler, Miran Šebeštjen
Int J Mol Sci. 2023 Feb; 24(3): 1966. Published online 2023 Jan 19. doi: 10.3390/ijms24031966
PMCID:
PMC9916735
ArticlePDF–1.2M

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