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Select item 111619701.

Spatiotemporal heterogeneity of LMOD1 expression summarizes two modes of cell communication in colorectal cancer

Jie-pin Li, Yuan-jie Liu, Yang Li, Yi Yin, Qian-wen Ye, Zhi-hua Lu, Yu-wei Dong, Jin-yong Zhou, Xi Zou, Yu-gen Chen

J Transl Med. 2024; 22: 549. Published online 2024 Jun 7. doi: 10.1186/s12967-024-05369-3

PMCID:: PMC11161970

Abstract Article PDF–27M

Select item 90557202.

LMOD1, an oncogene associated with Lauren classification, regulates the metastasis of gastric cancer cells through the FAK-AKT/mTOR pathway

Yuen Tan, Qingchuan Chen, Siwei Pan, Wen An, Huimian Xu, Yao Xing, Jianjun Zhang

BMC Cancer. 2022; 22: 474. Published online 2022 Apr 30. doi: 10.1186/s12885-022-09541-0

PMCID:: PMC9055720

Abstract Article PDF–7.5M

Select item 62680023.

Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus

Vivek Nanda, Ting Wang, Milos Pjanic, Boxiang Liu, Trieu Nguyen, Ljubica Perisic Matic, Ulf Hedin, Simon Koplev, Lijiang Ma, Oscar Franzén, Arno Ruusalepp, Eric E. Schadt, Johan L. M. Björkegren, Stephen B. Montgomery, Michael P. Snyder, Thomas Quertermous, Nicholas J. Leeper, Clint L. Miller

PLoS Genet. 2018 Nov; 14(11): e1007755. Published online 2018 Nov 16. doi: 10.1371/journal.pgen.1007755

PMCID:: PMC6268002

Abstract Article PDF–3.5M

Select item 48562854.

MEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension

Sanghamitra Sahoo, Daniel N. Meijles, Imad Al Ghouleh, Manuj Tandon, Eugenia Cifuentes-Pagano, John Sembrat, Mauricio Rojas, Elena Goncharova, Patrick J. Pagano

PLoS One. 2016; 11(5): e0153780. Published online 2016 May 4. doi: 10.1371/journal.pone.0153780

PMCID:: PMC4856285

Abstract Article PDF–2.9M

Select item 89918165.

Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM

Ljubica Perisic Matic, Urszula Rykaczewska, Anton Razuvaev, Maria Sabater-Lleal, Mariette Lengquist, Clint L. Miller, Ida Ericsson, Samuel Röhl, Malin Kronqvist, Silvia Aldi, Joelle Magné, Valentina Paloschi, Mattias Vesterlund, Yuhuang Li, Hong Jin, Maria Gonzalez Diez, Joy Roy, Damiano Baldassarre, Fabrizio Veglia, Steve E. Humphries, Ulf de Faire, Elena Tremoli, Jacob Odeberg, Vladana Vukojević, Janne Lehtiö, Lars Maegdefessel, Ewa Ehrenborg, Gabrielle Paulsson-Berne, Göran K. Hansson, Jan H.N. Lindeman, Per Eriksson, Thomas Quertermous, Anders Hamsten, Ulf Hedin

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2022 Apr 8.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 Sep; 36(9): 1947–1961. Published online 2016 Jul 28. doi: 10.1161/ATVBAHA.116.307893

PMCID:: PMC8991816

Abstract Article PDF–3.9M

Select item 45712916.

How Leiomodin and Tropomodulin use a common fold for different actin assembly functions

Malgorzata Boczkowska, Grzegorz Rebowski, Elena Kremneva, Pekka Lappalainen, Roberto Dominguez

Nat Commun. 2015; 6: 8314. Published online 2015 Sep 15. doi: 10.1038/ncomms9314

PMCID:: PMC4571291

Abstract Article PDF–4.1M

Select item 53800767.

Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice

Danny Halim, Michael P. Wilson, Daniel Oliver, Erwin Brosens, Joke B. G. M. Verheij, Yu Han, Vivek Nanda, Qing Lyu, Michael Doukas, Hans Stoop, Rutger W. W. Brouwer, Wilfred F. J. van IJcken, Orazio J. Slivano, Alan J. Burns, Christine K. Christie, Karen L. de Mesy Bentley, Alice S. Brooks, Dick Tibboel, Suowen Xu, Zheng Gen Jin, Tono Djuwantono, Wei Yan, Maria M. Alves, Robert M. W. Hofstra, Joseph M. Miano

Proc Natl Acad Sci U S A. 2017 Mar 28; 114(13): E2739–E2747. Published online 2017 Mar 14. doi: 10.1073/pnas.1620507114

PMCID:: PMC5380076

Abstract Article PDF–1.8M

Select item 32684068.

Leiomodin 1, a New Serum Response Factor-dependent Target Gene Expressed Preferentially in Differentiated Smooth Muscle Cells

Vivek Nanda, Joseph M. Miano

J Biol Chem. 2012 Jan 20; 287(4): 2459–2467. Published online 2011 Dec 7. doi: 10.1074/jbc.M111.302224

PMCID:: PMC3268406

Abstract Article PDF–2.1M

Select item 34832469.

Genetic variants associated with breast size also influence breast cancer risk

Nicholas Eriksson, Geoffrey M Benton, Chuong B Do, Amy K Kiefer, Joanna L Mountain, David A Hinds, Uta Francke, Joyce Y Tung

BMC Med Genet. 2012; 13: 53. Published online 2012 Jun 30. doi: 10.1186/1471-2350-13-53

PMCID:: PMC3483246

Abstract Article PDF–1.1M

Select item 650411910.

Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer‐related pathways in breast cancer

Yan Liu, Jian Li, Zhifang Ma, Jun Zhang, Yuzhi Wang, Zhenghong Yu, Xue Lin, Zhi Xu, Qian Su, Li An, Yehui Zhou, Xinxing Ma, Yiwen Yang, Feifei Wang, Qingfei Chen, Yunchao Zhang, Jilinlin Wang, Huilin Zheng, Aihua Shi, Shuang Yu, Jingzhong Zhang, Weiyong Zhao, Liming Chen

Cancer Med. 2019 Feb; 8(2): 729–741. Published online 2019 Jan 16. doi: 10.1002/cam4.1938

PMCID:: PMC6504119

Abstract Article PDF–1.3M

Select item 278379911.

PTEN IDENTIFIED AS IMPORTANT RISK FACTOR OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

H Dean Hosgood, III, Idan Menashe, Xingzhou He, Stephen Chanock, Qing Lan

Respir Med. Author manuscript; available in PMC 2010 Dec 1.

Published in final edited form as: Respir Med. 2009 Dec; 103(12): 1866–1870. Published online 2009 Jul 21. doi: 10.1016/j.rmed.2009.06.016

PMCID:: PMC2783799

Abstract Article PDF–315K

Select item 272285712.

Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway

H.Dean Hosgood, III, Idan Menashe, Min Shen, Meredith Yeager, Jeff Yuenger, Preetha Rajaraman, Xingzhou He, Nilanjan Chatterjee, Neil E. Caporaso, Yong Zhu, Stephen J. Chanock, Tongzhang Zheng, Qing Lan

Carcinogenesis. 2008 Oct; 29(10): 1938–1943. Published online 2008 Aug 1. doi: 10.1093/carcin/bgn178

PMCID:: PMC2722857

Abstract Article PDF–181K

Select item 266678113.

Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China

Min Shen, Roel Vermeulen, Preetha Rajaraman, Idan Menashe, Xingzhou He, Robert S. Chapman, Meredith Yeager, Gilles Thomas, Laurie Burdett, Amy Hutchinson, Jeff Yuenger, Stephen Chanock, Qing Lan

Environ Mol Mutagen. Author manuscript; available in PMC 2010 May 1.

Published in final edited form as: Environ Mol Mutagen. 2009 May; 50(4): 285–290. doi: 10.1002/em.20452

PMCID:: PMC2666781

Abstract Article PDF–311K

Select item 322018614.

Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes

Lin T. Guey, Montserrat García-Closas, Cristiane Murta-Nascimento, Josep Lloreta, Laia Palencia, Manolis Kogevinas, Nathaniel Rothman, Gemma Vellalta, Malu Calle, Gaëlle Marenne, Adonina Tardón, Alfredo Carrato, Reina García-Closas, Consol Serra, Debra T Silverman, Stephen Chanock, Francisco X. Real, Núria Malats

Eur Urol. Author manuscript; available in PMC 2011 Nov 18.

Published in final edited form as: Eur Urol. 2010 Feb; 57(2): 283–292. Published online 2009 Aug 12. doi: 10.1016/j.eururo.2009.08.001

PMCID:: PMC3220186

Abstract Article PDF–595K

Select item 660091515.

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile

Karen Dendoncker, Steven Timmermans, Jolien Vandewalle, Melanie Eggermont, Joanna Lempiäinen, Evelien Van Hamme, Sylviane Dewaele, Sofie Vandevyver, Marlies Ballegeer, Jolien Souffriau, Lise Van Wyngene, Kelly Van Looveren, Tineke Vanderhaeghen, Rudi Beyaert, Karolien De Bosscher, Jorma J. Palvimo, Marc Van Montagu, Claude Libert

Proc Natl Acad Sci U S A. 2019 Jun 25; 116(26): 12942–12951. Published online 2019 Jun 10. doi: 10.1073/pnas.1821565116

Correction in:: Proc Natl Acad Sci U S A. 2019 Jul 30; 116(31): 15745.

PMCID:: PMC6600915

Abstract Article PDF–1.7M

Select item 294516816.

Variation at the NFATC2 Locus Increases the Risk of Thiazolidinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study

Swneke D. Bailey, Changchun Xie, Ron Do, Alexandre Montpetit, Rafael Diaz, Viswanathan Mohan, Bernard Keavney, Salim Yusuf, Hertzel C. Gerstein, James C. Engert, Sonia Anand, on behalf of the DREAM investigators

Diabetes Care. 2010 Oct; 33(10): 2250–2253. Published online 2010 Jul 13. doi: 10.2337/dc10-0452

PMCID:: PMC2945168

Abstract Article PDF–153K

Select item 277583217.

Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip

Philippa J. Talmud, Fotios Drenos, Sonia Shah, Tina Shah, Jutta Palmen, Claudio Verzilli, Tom R. Gaunt, Jacky Pallas, Ruth Lovering, Kawah Li, Juan Pablo Casas, Reecha Sofat, Meena Kumari, Santiago Rodriguez, Toby Johnson, Stephen J. Newhouse, Anna Dominiczak, Nilesh J. Samani, Mark Caulfield, Peter Sever, Alice Stanton, Denis C. Shields, on behalf of the ASCOT investigators, Sandosh Padmanabhan, Olle Melander, Claire Hastie, Christian Delles, on behalf of the NORDIL investigators, Shah Ebrahim, Michael G. Marmot, George Davey Smith, Debbie A. Lawlor, Patricia B. Munroe, for the BRIGHT Consortium, Ian N. Day, Mika Kivimaki, John Whittaker, Steve E. Humphries, Aroon D. Hingorani

Am J Hum Genet. 2009 Nov 13; 85(5): 628–642. doi: 10.1016/j.ajhg.2009.10.014

PMCID:: PMC2775832

Abstract Article PDF–2.8M

Select item 836418118.

Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118

PMCID:: PMC8364181

Abstract Article PDF–3.0M

Select item 616668219.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 911973620.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

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