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Select item 99576291.

APPL1 Is a Prognostic Biomarker and Correlated with Treg Cell Infiltration via Oxygen-Consuming Metabolism in Renal Clear Cell Carcinoma

Ming Yang, Chuhui Gong, Kangping Song, Ning Huang, Honghan Chen, Hui Gong, Yu Yang, Shujing Guo, Hengyi Xiao

Oxid Med Cell Longev. 2023; 2023: 5885203. Published online 2023 Feb 17. doi: 10.1155/2023/5885203

PMCID:: PMC9957629

Abstract Article PDF–7.4M

Select item 46020422.

APPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments

Inna Kalaidzidis, Marta Miaczynska, Marta Brewińska-Olchowik, Anna Hupalowska, Charles Ferguson, Robert G. Parton, Yannis Kalaidzidis, Marino Zerial

J Cell Biol. 2015 Oct 12; 211(1): 123–144. doi: 10.1083/jcb.201311117

PMCID:: PMC4602042

Abstract Article PDF–11M

Select item 33273163.

The endosomal adaptor protein APPL1 impairs the turnover of leading edge adhesions to regulate cell migration

Joshua A. Broussard, Wan-hsin Lin, Devi Majumdar, Bridget Anderson, Brady Eason, Claire M. Brown, Donna J. Webb

Mol Biol Cell. 2012 Apr 15; 23(8): 1486–1499. doi: 10.1091/mbc.E11-02-0124

PMCID:: PMC3327316

Abstract Article PDF–5.2M

Select item 31315114.

Increased abundance of the adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif (APPL1) in patients with obesity and type 2 diabetes: evidence for altered adiponectin signalling

R. M. Holmes, Z. Yi, E. De Filippis, R. Berria, S. Shahani, P. Sathyanarayana, V. Sherman, K. Fujiwara, C. Meyer, C. Christ-Roberts, H. Hwang, J. Finlayson, L. Q. Dong, L. J. Mandarino, M. Bajaj

Diabetologia. 2011; 54(8): 2122–2131. Published online 2011 May 12. doi: 10.1007/s00125-011-2173-x

PMCID:: PMC3131511

Abstract Article PDF–518K

Select item 30725275.

Recruitment of APPL1 to ubiquitin-rich aggresomes in response to proteasomal impairment

Iwona Pilecka, Lukasz Sadowski, Yannis Kalaidzidis, Marta Miaczynska

Exp Cell Res. 2011 May 1; 317(8): 1093–1107. doi: 10.1016/j.yexcr.2011.02.002

PMCID:: PMC3072527

Abstract Article

Select item 28453046.

Identification of Phosphorylation Sites within the Signaling Adaptor APPL1 by Mass Spectrometry

Randi L. Gant-Branum, Joshua A. Broussard, Ablatt Mahsut, Donna J. Webb, John A. McLean

J Proteome Res. Author manuscript; available in PMC 2011 Mar 5.

Published in final edited form as: J Proteome Res. 2010 Mar 5; 9(3): 1541–1548. doi: 10.1021/pr901043e

PMCID:: PMC2845304

Abstract Article PDF–1015K

Select item 103185297.

Reduced APPL1 impairs osteogenic differentiation of mesenchymal stem cells by facilitating MGP expression to disrupt the BMP2 pathway in osteoporosis

Weiquan Yuan, Wenjie Liu, Yunhui Zhang, Xinglang Wang, Chenhao Xu, Quanfeng Li, Pengfei Ji, Jiaxin Wang, Pei Feng, Yanfeng Wu, Huiyong Shen, Peng Wang

J Biol Chem. 2023 Jun; 299(6): 104823. Published online 2023 May 13. doi: 10.1016/j.jbc.2023.104823

PMCID:: PMC10318529

Abstract Article PDF–7.1M

Select item 78896938.

Rapid whole cell imaging reveals a calcium-APPL1-dynein nexus that regulates cohort trafficking of stimulated EGF receptors

H. M. York, A. Patil, U. K. Moorthi, A. Kaur, A. Bhowmik, G. J. Hyde, H. Gandhi, A. Fulcher, K. Gaus, S. Arumugam

Commun Biol. 2021; 4: 224. Published online 2021 Feb 17. doi: 10.1038/s42003-021-01740-y

PMCID:: PMC7889693

Abstract Article PDF–6.8M

Select item 45710029.

Loss-of-Function Mutations in APPL1 in Familial Diabetes Mellitus

Sabrina Prudente, Prapaporn Jungtrakoon, Antonella Marucci, Ornella Ludovico, Patinut Buranasupkajorn, Tommaso Mazza, Timothy Hastings, Teresa Milano, Eleonora Morini, Luana Mercuri, Diego Bailetti, Christine Mendonca, Federica Alberico, Giorgio Basile, Marta Romani, Elide Miccinilli, Antonio Pizzuti, Massimo Carella, Fabrizio Barbetti, Stefano Pascarella, Piero Marchetti, Vincenzo Trischitta, Rosa Di Paola, Alessandro Doria

Am J Hum Genet. 2015 Jul 2; 97(1): 177–185. doi: 10.1016/j.ajhg.2015.05.011

PMCID:: PMC4571002

Abstract Article PDF–983K

Select item 438026810.

APPL1 Potentiates Insulin Sensitivity by Facilitating the Binding of IRS1/2 to the Insulin Receptor

Jiyoon Ryu, Amanda K. Galan, Xiaoban Xin, Feng Dong, Muhammad A. Abdul-Ghani, Lijun Zhou, Changhua Wang, Cuiling Li, Bekke M. Holmes, Lauren B. Sloane, Steven N. Austad, Shaodong Guo, Nicolas Musi, Ralph A. DeFronzo, Chuxia Deng, Morris F. White, Feng Liu, Lily Q. Dong

Cell Rep. Author manuscript; available in PMC 2015 May 22.

Published in final edited form as: Cell Rep. 2014 May 22; 7(4): 1227–1238. Published online 2014 May 10. doi: 10.1016/j.celrep.2014.04.006

PMCID:: PMC4380268

Abstract Article PDF–2.2M

Select item 382024011.

SNX15 links clathrin endocytosis to the PtdIns3P early endosome independently of the APPL1 endosome

Chris Danson, Edward Brown, Oliver J. Hemmings, Ian J. McGough, Sam Yarwood, Kate J. Heesom, Jeremy G. Carlton, Juan Martin-Serrano, Margaret T. May, Paul Verkade, Peter J. Cullen

J Cell Sci. 2013 Nov 1; 126(21): 4885–4899. doi: 10.1242/jcs.125732

PMCID:: PMC3820240

Abstract Article

Select item 374713712.

Association of Genetic Variation in Adaptor Protein APPL1/APPL2 Loci with Non-Alcoholic Fatty Liver Disease

Michelangela Barbieri, Antonietta Esposito, Edith Angellotti, Maria Rosaria Rizzo, Raffaele Marfella, Giuseppe Paolisso

PLoS One. 2013; 8(8): e71391. Published online 2013 Aug 19. doi: 10.1371/journal.pone.0071391

PMCID:: PMC3747137

Abstract Article PDF–209K

Select item 367639113.

A Saccharomyces cerevisiae Assay System to Investigate Ligand/AdipoR1 Interactions That Lead to Cellular Signaling

Mustapha Aouida, Kangchang Kim, Abdul Rajjak Shaikh, Jose M. Pardo, Jörg Eppinger, Dae-Jin Yun, Ray A. Bressan, Meena L. Narasimhan

PLoS One. 2013; 8(6): e65454. Published online 2013 Jun 7. doi: 10.1371/journal.pone.0065454

PMCID:: PMC3676391

Abstract Article PDF–2.7M

Select item 340669214.

Phosphorylation of Adaptor Protein Containing Pleckstrin Homology Domain, Phosphotyrosine Binding Domain, and Leucine Zipper Motif 1 (APPL1) at Ser⁴³⁰ Mediates Endoplasmic Reticulum (ER) Stress-induced Insulin Resistance in Hepatocytes

Meilian Liu, Lijun Zhou, Li Wei, Ricardo Villarreal, Xin Yang, Derong Hu, Ramon A. Riojas, Bekke M. Holmes, Paul R. Langlais, Hakjoo Lee, Lily Q. Dong

J Biol Chem. 2012 Jul 27; 287(31): 26087–26093. Published online 2012 Jun 8. doi: 10.1074/jbc.M112.372292

PMCID:: PMC3406692

Abstract Article PDF–1.2M

Select item 306064015.

The Adapter Protein APPL1 Links FSH Receptor to Inositol 1,4,5-Trisphosphate Production and Is Implicated in Intracellular Ca²⁺ Mobilization

Richard M. Thomas, Cheryl A. Nechamen, Joseph E. Mazurkiewicz, Alfredo Ulloa-Aguirre, James A. Dias

Endocrinology. 2011 Apr; 152(4): 1691–1701. Published online 2011 Feb 1. doi: 10.1210/en.2010-1353

PMCID:: PMC3060640

Abstract Article

Select item 302321116.

APPL1 mediates adiponectin-stimulated p38 MAPK activation by scaffolding the TAK1-MKK3-p38 MAPK pathway

Xiaoban Xin, Lijun Zhou, Caleb M. Reyes, Feng Liu, Lily Q. Dong

Am J Physiol Endocrinol Metab. 2011 Jan; 300(1): E103–E110. Published online 2010 Oct 26. doi: 10.1152/ajpendo.00427.2010

PMCID:: PMC3023211

Abstract Article

Select item 293000417.

APPL Proteins FRET at the BAR: Direct Observation of APPL1 and APPL2 BAR Domain-Mediated Interactions on Cell Membranes Using FRET Microscopy

Heidi J. Chial, Peter Lenart, Yong Q. Chen

PLoS One. 2010; 5(8): e12471. Published online 2010 Aug 30. doi: 10.1371/journal.pone.0012471

PMCID:: PMC2930004

Abstract Article PDF–983K

Select item 1115992818.

Rab5a overexpression promoting ovarian cancer cell proliferation may be associated with APPL1‐related epidermal growth factor signaling pathway

Zhen Zhao, Xiang‐Fan Liu, Hua‐Cheng Wu, Shu‐Biao Zou, Jia‐Yi Wang, Pei‐Hua Ni, Xin‐Hua Chen, Qi‐Shi Fan

Cancer Sci. 2010 Jun; 101(6): 1454–1462. Published online 2010 Mar 10. doi: 10.1111/j.1349-7006.2010.01558.x

PMCID:: PMC11159928

Abstract Article PDF–2.0M

Select item 474197419.

Endosomal gene expression: a new indicator for prostate cancer patient prognosis?

Ian R.D. Johnson, Emma J. Parkinson-Lawrence, Helen Keegan, Cathy D. Spillane, Jacqui Barry-O'Crowley, William R. Watson, Stavros Selemidis, Lisa M. Butler, John J. O'Leary, Doug A. Brooks

Oncotarget. 2015 Nov 10; 6(35): 37919–37929. Published online 2015 Oct 14. doi: 10.18632/oncotarget.6114

PMCID:: PMC4741974

Abstract Article PDF–1.7M

Select item 472194820.

Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease

S Kim, Y Sato, P S Mohan, C Peterhoff, A Pensalfini, A Rigoglioso, Y Jiang, R A Nixon

Mol Psychiatry. 2016 May; 21(5): 707–716. Published online 2015 Jul 21. doi: 10.1038/mp.2015.97

PMCID:: PMC4721948

Abstract Article PDF–743K

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