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Select item 101480711.

Loss of F-Box and Leucine Rich Repeat Protein 5 (FBXL5) Expression Is Associated With Poor Survival in Patients With Hepatocellular Carcinoma After Curative Resection: A Two-institute Study

YOON AH CHO, SUNG-EUN KIM, CHEOL KEUN PARK, HYUN HEE KOH, CHEOL-KEUN PARK, SANG YUN HA

Cancer Genomics Proteomics. 2023 May-Jun; 20(3): 298–307. Published online 2023 May 3. doi: 10.21873/cgp.20382

PMCID:: PMC10148071

Abstract Article PDF–4.1M

Select item 33906452.

Hemerythrin-like Domain within F-box and Leucine-rich Repeat Protein 5 (FBXL5) Communicates Cellular Iron and Oxygen Availability by Distinct Mechanisms

Srinivas Chollangi, Joel W. Thompson, Julio C. Ruiz, Kevin H. Gardner, Richard K. Bruick

J Biol Chem. 2012 Jul 6; 287(28): 23710–23717. Published online 2012 May 30. doi: 10.1074/jbc.M112.360404

PMCID:: PMC3390645

Abstract Article PDF–1.3M

Select item 32935403.

Structural and Molecular Characterization of Iron-sensing Hemerythrin-like Domain within F-box and Leucine-rich Repeat Protein 5 (FBXL5)

Joel W. Thompson, Ameen A. Salahudeen, Srinivas Chollangi, Julio C. Ruiz, Chad A. Brautigam, Thomas M. Makris, John D. Lipscomb, Diana R. Tomchick, Richard K. Bruick

J Biol Chem. 2012 Mar 2; 287(10): 7357–7365. Published online 2012 Jan 17. doi: 10.1074/jbc.M111.308684

PMCID:: PMC3293540

Abstract Article PDF–1.2M

Select item 85240064.

Ferroportin and FBXL5 as Prognostic Markers in Advanced Stage Clear Cell Renal Cell Carcinoma

Cheol Keun Park, Jayoon Heo, Won Sik Ham, Young-Deuk Choi, Sang Joon Shin, Nam Hoon Cho

Cancer Res Treat. 2021 Oct; 53(4): 1174–1183. Published online 2021 Mar 17. doi: 10.4143/crt.2021.031

PMCID:: PMC8524006

Abstract Article PDF–3.5M

Select item 56121275.

A synergistic role of IRP1 and FBXL5 proteins in coordinating iron metabolism during cell proliferation

Nathan B. Johnson, Kathryn M. Deck, Christopher P. Nizzi, Richard S. Eisenstein

J Biol Chem. 2017 Sep 22; 292(38): 15976–15989. Published online 2017 Aug 2. doi: 10.1074/jbc.M117.785741

PMCID:: PMC5612127

Abstract Article PDF–1.8M

Select item 71599946.

FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster

Hui Wang, Hui Shi, Malini Rajan, Elizabeth R. Canarie, Seoyeon Hong, Daniele Simoneschi, Michele Pagano, Matthew F. Bush, Stefan Stoll, Elizabeth A. Leibold, Ning Zheng

Mol Cell. Author manuscript; available in PMC 2021 Apr 2.

Published in final edited form as: Mol Cell. 2020 Apr 2; 78(1): 31–41.e5. Published online 2020 Mar 2. doi: 10.1016/j.molcel.2020.02.011

PMCID:: PMC7159994

Abstract Article PDF–2.4M

Select item 64468707.

Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis

Yoshiharu Muto, Toshiro Moroishi, Kazuya Ichihara, Masaaki Nishiyama, Hideyuki Shimizu, Hidetoshi Eguchi, Kyoji Moriya, Kazuhiko Koike, Koshi Mimori, Masaki Mori, Yuta Katayama, Keiichi I. Nakayama

J Exp Med. 2019 Apr 1; 216(4): 950–965. Published online 2019 Mar 15. doi: 10.1084/jem.20180900

PMCID:: PMC6446870

Abstract Article PDF–3.4M

Select item 35370528.

F-box and Leucine-rich Repeat Protein 5 (FBXL5) Is Required for Maintenance of Cellular and Systemic Iron Homeostasis

Julio C. Ruiz, Scott D. Walker, Sheila A. Anderson, Richard S. Eisenstein, Richard K. Bruick

J Biol Chem. 2013 Jan 4; 288(1): 552–560. Published online 2012 Nov 7. doi: 10.1074/jbc.M112.426171

PMCID:: PMC3537052

Abstract Article PDF–2.4M

Select item 90565259.

Deubiquitylase OTUD3 prevents Parkinson’s disease through stabilizing iron regulatory protein 2

Fengju Jia, Hongchang Li, Qian Jiao, Chaonan Li, Lin Fu, Chunping Cui, Hong Jiang, Lingqiang Zhang

Cell Death Dis. 2022 Apr; 13(4): 418. Published online 2022 Apr 30. doi: 10.1038/s41419-022-04704-0

PMCID:: PMC9056525

Abstract Article PDF–6.3M

Select item 552005410.

Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells

Yoshiharu Muto, Masaaki Nishiyama, Akihiro Nita, Toshiro Moroishi, Keiichi I. Nakayama

Nat Commun. 2017; 8: 16114. Published online 2017 Jul 17. doi: 10.1038/ncomms16114

PMCID:: PMC5520054

Abstract Article PDF–1.2M

Select item 419143011.

FBXL5-mediated degradation of single-stranded DNA-binding protein hSSB1 controls DNA damage response

Zhi-Wei Chen, Bin Liu, Nai-Wang Tang, Yun-Hua Xu, Xiang-Yun Ye, Zi-Ming Li, Xiao-Min Niu, Sheng-Ping Shen, Shun Lu, Ling Xu

Nucleic Acids Res. 2014 Oct 13; 42(18): 11560–11569. Published online 2014 Sep 23. doi: 10.1093/nar/gku876

PMCID:: PMC4191430

Abstract Article PDF–2.4M

Select item 404741012.

HERC2 Targets the Iron Regulator FBXL5 for Degradation and Modulates Iron Metabolism

Toshiro Moroishi, Takayoshi Yamauchi, Masaaki Nishiyama, Keiichi I. Nakayama

J Biol Chem. 2014 Jun 6; 289(23): 16430–16441. Published online 2014 Apr 28. doi: 10.1074/jbc.M113.541490

PMCID:: PMC4047410

Abstract Article PDF–997K

Select item 292918013.

Control of Iron Homeostasis by an Iron-Regulated Ubiquitin Ligase

Ajay A. Vashisht, Kimberly B. Zumbrennen, Xinhua Huang, David N. Powers, Armando Durazo, Dahui Sun, Nimesh Bhaskaran, Anja Persson, Mathias Uhlen, Olle Sangfelt, Charles Spruck, Elizabeth A. Leibold, James A. Wohlschlegel

Science. Author manuscript; available in PMC 2010 Aug 27.

Published in final edited form as: Science. 2009 Oct 30; 326(5953): 718–721. Published online 2009 Sep 17. doi: 10.1126/science.1176333

PMCID:: PMC2929180

Abstract Article PDF–704K

Select item 666039214.

Oxygen-dependent interaction between FBXL5 and CIA targeting complex regulates iron homeostasis

Adarsh K. Mayank, Vijaya Pandey, Ajay A. Vashisht, William D. Barshop, Shima Rayatpisheh, Tanu Sharma, Tisha Haque, David N. Powers, James A. Wohlschlegel

Mol Cell. Author manuscript; available in PMC 2020 Jul 25.

Published in final edited form as: Mol Cell. 2019 Jul 25; 75(2): 382–393.e5. Published online 2019 Jun 19. doi: 10.1016/j.molcel.2019.05.020

PMCID:: PMC6660392

Abstract Article PDF–2.1M

Select item 390292815.

Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability

Rosa Viñas-Castells, Álex Frías, Estefanía Robles-Lanuza, Kun Zhang, Gregory D. Longmore, Antonio García de Herreros, Víctor M. Díaz

Nucleic Acids Res. 2014 Jan; 42(2): 1079–1094. Published online 2013 Oct 23. doi: 10.1093/nar/gkt935

PMCID:: PMC3902928

Abstract Article PDF–14M

Select item 358219716.

An E3 Ligase Possessing an Iron-Responsive Hemerythrin Domain Is a Regulator of Iron Homeostasis

Ameen A. Salahudeen, Joel W. Thompson, Julio C. Ruiz, He-Wen Ma, Lisa N. Kinch, Qiming Li, Nick V. Grishin, Richard K. Bruick

Science. Author manuscript; available in PMC 2013 Feb 26.

Published in final edited form as: Science. 2009 Oct 30; 326(5953): 722–726. Published online 2009 Sep 17. doi: 10.1126/science.1176326

PMCID:: PMC3582197

Abstract Article PDF–1.6M

Select item 1069766217.

A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body–like pathology

Juan A. Gerez, Natalia C. Prymaczok, Edward Rockenstein, Uli S. Herrmann, Petra Schwarz, Anthony Adame, Radoslav I. Enchev, Thibault Courtheoux, Paul J. Boersema, Roland Riek, Matthias Peter, Adriano Aguzzi, Eliezer Masliah, Paola Picotti

Sci Transl Med. Author manuscript; available in PMC 2023 Dec 5.

Published in final edited form as: Sci Transl Med. 2019 Jun 5; 11(495): eaau6722. doi: 10.1126/scitranslmed.aau6722

PMCID:: PMC10697662

Abstract Article PDF–2.4M

Select item 315529418.

SCF^FBXL15 regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1

Yu Cui, Shan He, Cencan Xing, Kefeng Lu, Jian Wang, Guichun Xing, Anming Meng, Shunji Jia, Fuchu He, Lingqiang Zhang

EMBO J. 2011 Jul 6; 30(13): 2675–2689. Published online 2011 May 13. doi: 10.1038/emboj.2011.155

Correction in:: EMBO J. 2011 Jul 6; 30(13): 2748.

PMCID:: PMC3155294

Abstract Article PDF–1.7M

Select item 398146819.

Parallel SCF Adaptor Capture Proteomics Reveals a Role for SCF^FBXL17 in NRF2 Activation via BACH1 Repressor Turnover

Meng-Kwang Marcus Tan, Hui-Jun Lim, Eric J. Bennett, Yang Shi, J. Wade Harper

Mol Cell. Author manuscript; available in PMC 2014 Oct 10.

Published in final edited form as: Mol Cell. 2013 Oct 10; 52(1): 9–24. Published online 2013 Sep 12. doi: 10.1016/j.molcel.2013.08.018

PMCID:: PMC3981468

Abstract Article PDF–5.8M

Select item 1015617520.

Systemwide disassembly and assembly of SCF ubiquitin ligase complexes

Kheewoong Baek, Daniel C. Scott, Lukas T. Henneberg, Moeko T. King, Matthias Mann, Brenda A. Schulman

Cell. 2023 Apr 27; 186(9): 1895–1911.e21. doi: 10.1016/j.cell.2023.02.035

Correction in:: Cell. 2023 May 25; 186(11): 2492.

PMCID:: PMC10156175

Abstract Article

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PMC Links for Gene (Select 26234) (38)
PMC
PREDICTED: Homo sapiens F-box and leucine rich repeat protein 5 (FBXL5), transcr...
PREDICTED: Homo sapiens F-box and leucine rich repeat protein 5 (FBXL5), transcript variant X8, mRNA
gi|2462596431|ref|XM_054349659.1|

Nucleotide
F-box/LRR-repeat protein 5 isoform X1 [Homo sapiens]
F-box/LRR-repeat protein 5 isoform X1 [Homo sapiens]
gi|2462596440|ref|XP_054205638.1|

Protein
PREDICTED: Homo sapiens F-box and leucine rich repeat protein 5 (FBXL5), transcr...
PREDICTED: Homo sapiens F-box and leucine rich repeat protein 5 (FBXL5), transcript variant X13, mRNA
gi|2217350128|ref|XM_047450059.1|

Nucleotide
PREDICTED: Homo sapiens F-box and leucine rich repeat protein 5 (FBXL5), transcr...
PREDICTED: Homo sapiens F-box and leucine rich repeat protein 5 (FBXL5), transcript variant X6, mRNA
gi|2462596427|ref|XM_054349657.1|

Nucleotide

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