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Items: 1 to 20 of 49

1.
A Phase 1 study of GDC‐0134, a dual leucine zipper kinase inhibitor, in ALS
Jonathan S. Katz, Jeffrey D. Rothstein, Merit E. Cudkowicz, Angela Genge, Björn Oskarsson, Avis B. Hains, Chen Chen, Joshua Galanter, Braydon L. Burgess, William Cho, Geoffrey A. Kerchner, Felix L. Yeh, Arundhati Sengupta Ghosh, Sravanthi Cheeti, Logan Brooks, Lee Honigberg, Jessica A. Couch, Michael E. Rothenberg, Flavia Brunstein, Khema R. Sharma, Leonard van den Berg, James D. Berry, Jonathan D. Glass
Ann Clin Transl Neurol. 2022 Jan; 9(1): 50–66. Published online 2022 Jan 10. doi: 10.1002/acn3.51491
PMCID:
PMC8791798
AbstractArticlePDF–291K
2.
High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity
Marlies Verschuuren, Peter Verstraelen, Gerardo García-Díaz Barriga, Ines Cilissen, Emma Coninx, Mieke Verslegers, Peter H. Larsen, Rony Nuydens, Winnok H. De Vos
Acta Neuropathol Commun. 2019; 7: 6. Published online 2019 Jun 4. doi: 10.1186/s40478-019-0741-3
Correction in:
Acta Neuropathol Commun. 2019; 7: 131.
PMCID:
PMC6549294
AbstractArticlePDF–5.6M
3.
Dual leucine zipper kinase regulates expression of axon guidance genes in mouse neuronal cells
Andréanne Blondeau, Jean-François Lucier, Dominick Matteau, Lauralyne Dumont, Sébastien Rodrigue, Pierre-Étienne Jacques, Richard Blouin
Neural Dev. 2016; 11: 13. Published online 2016 Jul 28. doi: 10.1186/s13064-016-0068-8
PMCID:
PMC4965899
AbstractArticlePDF–2.1M
4.
Cytoskeletal disruption activates the DLK/JNK pathway, which promotes axonal regeneration and mimics a preconditioning injury
Vera Valakh, Erin Frey, Elisabetta Babetto, Lauren J Walker, Aaron DiAntonio
Neurobiol Dis. Author manuscript; available in PMC 2016 May 1.
Published in final edited form as: Neurobiol Dis. 2015 May; 77: 13–25. Published online 2015 Feb 26. doi: 10.1016/j.nbd.2015.02.014
PMCID:
PMC4402261
AbstractArticlePDF–1.7M
5.
An In Vitro Assay to Study Induction of the Regenerative State in Sensory Neurons
E. Frey, V. Valakh, S. Karney-Grobe, Y. Shi, J. Milbrandt, A. DiAntonio
Exp Neurol. Author manuscript; available in PMC 2016 Jan 1.
Published in final edited form as: Exp Neurol. 2015 Jan; 263: 350–363. Published online 2014 Nov 4. doi: 10.1016/j.expneurol.2014.10.012
PMCID:
PMC4266464
AbstractArticlePDF–2.3M
6.
The Mixed-Lineage Kinase DLK Is a Key Regulator of 3T3-L1 Adipocyte Differentiation
Jean-Philippe Couture, Alex Daviau, Julie Fradette, Richard Blouin
PLoS One. 2009; 4(3): e4743. Published online 2009 Mar 9. doi: 10.1371/journal.pone.0004743
PMCID:
PMC2649434
AbstractArticlePDF–1.9M
7.
MiR-191-5p alleviates microglial cell injury by targeting Map3k12 (mitogen-activated protein kinase kinase kinase 12) to inhibit the MAPK (mitogen-activated protein kinase) signaling pathway in Alzheimer’s disease
Wenjun Wan, Ganzhe Liu, Xia Li, Yu Liu, Ying Wang, Haisong Pan, Jun Hu
Bioengineered. 2021; 12(2): 12678–12690. Published online 2021 Dec 22. doi: 10.1080/21655979.2021.2008638
PMCID:
PMC8810200
AbstractArticlePDF–2.1M
8.
DLK regulates a distinctive transcriptional regeneration program after peripheral nerve injury
Jung Eun Shin, Hongseok Ha, Yoon Ki Kim, Yongcheol Cho, Aaron DiAntonio
Neurobiol Dis. Author manuscript; available in PMC 2020 Jul 1.
Published in final edited form as: Neurobiol Dis. 2019 Jul; 127: 178–192. Published online 2019 Feb 5. doi: 10.1016/j.nbd.2019.02.001
PMCID:
PMC6588443
AbstractArticlePDF–2.1M
9.
Dual leucine zipper kinase is required for mechanical allodynia and microgliosis after nerve injury
Josette J Wlaschin, Jacob M Gluski, Eileen Nguyen, Hanna Silberberg, James H Thompson, Alexander T Chesler, Claire E Le Pichon
eLife. 2018; 7: e33910. Published online 2018 Jul 3. doi: 10.7554/eLife.33910
PMCID:
PMC6029846
AbstractArticlePDF–4.7M
10.
DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury
Trent A. Watkins, Bei Wang, Sarah Huntwork-Rodriguez, Jing Yang, Zhiyu Jiang, Jeffrey Eastham-Anderson, Zora Modrusan, Joshua S. Kaminker, Marc Tessier-Lavigne, Joseph W. Lewcock
Proc Natl Acad Sci U S A. 2013 Mar 5; 110(10): 4039–4044. Published online 2013 Feb 19. doi: 10.1073/pnas.1211074110
PMCID:
PMC3593899
AbstractArticlePDF–1.2M
11.
Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death
Derek S. Welsbie, Zhiyong Yang, Yan Ge, Katherine L. Mitchell, Xinrong Zhou, Scott E. Martin, Cynthia A. Berlinicke, Laszlo Hackler, Jr., John Fuller, Jie Fu, Li-hui Cao, Bing Han, Douglas Auld, Tian Xue, Syu-ichi Hirai, Lucie Germain, Caroline Simard-Bisson, Richard Blouin, Judy V. Nguyen, Chung-ha O. Davis, Raymond A. Enke, Sanford L. Boye, Shannath L. Merbs, Nicholas Marsh-Armstrong, William W. Hauswirth, Aaron DiAntonio, Robert W. Nickells, James Inglese, Justin Hanes, King-Wai Yau, Harry A. Quigley, Donald J. Zack
Proc Natl Acad Sci U S A. 2013 Mar 5; 110(10): 4045–4050. Published online 2013 Feb 19. doi: 10.1073/pnas.1211284110
PMCID:
PMC3593842
AbstractArticlePDF–1.4M
12.
Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration
Jung Eun Shin, Yongcheol Cho, Bogdan Beirowski, Jeffrey Milbrandt, Valeria Cavalli, Aaron DiAntonio
Neuron. Author manuscript; available in PMC 2013 Jun 21.
Published in final edited form as: Neuron. 2012 Jun 21; 74(6): 1015–1022. doi: 10.1016/j.neuron.2012.04.028
PMCID:
PMC3383631
AbstractArticlePDF–3.2M
13.
Activating injury-responsive genes with hypoxia enhances axon regeneration through neuronal HIF-1α
Yongcheol Cho, Jung Eun Shin, Eric Edward Ewan, Young Mi Oh, Wolfgang Pita-Thomas, Valeria Cavalli
Neuron. Author manuscript; available in PMC 2016 Nov 18.
Published in final edited form as: Neuron. 2015 Nov 18; 88(4): 720–734. Published online 2015 Oct 29. doi: 10.1016/j.neuron.2015.09.050
PMCID:
PMC4655162
AbstractArticlePDF–4.0M
14.
A DLK-dependent axon self-destruction program promotes Wallerian degeneration
Bradley R. Miller, Craig Press, Richard W. Daniels, Yo Sasaki, Jeffrey Milbrandt, Aaron DiAntonio
Nat Neurosci. Author manuscript; available in PMC 2009 Oct 1.
Published in final edited form as: Nat Neurosci. 2009 Apr; 12(4): 387–389. Published online 2009 Mar 15. doi: 10.1038/nn.2290
Correction in:
volume 12 on page 808
PMCID:
PMC2696160
AbstractArticlePDF–1.9M
15.
Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength
Yunbo Li, Erin M Ritchie, Christopher L Steinke, Cai Qi, Lizhen Chen, Binhai Zheng, Yishi Jin
eLife. 2021; 10: e63509. Published online 2021 Jan 21. doi: 10.7554/eLife.63509
Correction in:
eLife. 2023; 12: e86472.
PMCID:
PMC7870138
AbstractArticlePDF–8.1M
16.
Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons
Meifan Chen, Cédric G. Geoffroy, Hetty N. Wong, Oliver Tress, Mallorie T. Nguyen, Lawrence B. Holzman, Yishi Jin, Binhai Zheng
Sci Rep. 2016; 6: 31482. Published online 2016 Aug 11. doi: 10.1038/srep31482
PMCID:
PMC4980599
AbstractArticlePDF–2.3M
17.
DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury
Kimberly A. Fernandes, Jeffrey M. Harder, Simon W. John, Peter Shrager, Richard T. Libby
Neurobiol Dis. Author manuscript; available in PMC 2015 Sep 1.
Published in final edited form as: Neurobiol Dis. 2014 Sep; 69: 108–116. Published online 2014 May 27. doi: 10.1016/j.nbd.2014.05.015
PMCID:
PMC4099422
AbstractArticlePDF–1.4M
18.
DLK signaling in axotomized neurons triggers complement activation and loss of upstream synapses
Elham Asghari Adib, Jennifer L. Shadrach, Lauren Reilly-Jankowiak, Manish K. Dwivedi, Abigail E. Rogers, Shameena Shahzad, Ryan Passino, Roman J. Giger, Brian A. Pierchala, Catherine A. Collins
Cell Rep. Author manuscript; available in PMC 2024 May 11.
Published in final edited form as: Cell Rep. 2024 Feb 27; 43(2): 113801. Published online 2024 Feb 14. doi: 10.1016/j.celrep.2024.113801
PMCID:
PMC11088462
AbstractArticlePDF–3.9M
19.
Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult
Martin Larhammar, Sarah Huntwork-Rodriguez, Zhiyu Jiang, Hilda Solanoy, Arundhati Sengupta Ghosh, Bei Wang, Joshua S Kaminker, Kevin Huang, Jeffrey Eastham-Anderson, Michael Siu, Zora Modrusan, Madeline M Farley, Marc Tessier-Lavigne, Joseph W Lewcock, Trent A Watkins
eLife. 2017; 6: e20725. Published online 2017 Apr 25. doi: 10.7554/eLife.20725
PMCID:
PMC5404924
AbstractArticlePDF–5.7M
20.
An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK
Yan Hao, Erin Frey, Choya Yoon, Hetty Wong, Douglas Nestorovski, Lawrence B Holzman, Roman J Giger, Aaron DiAntonio, Catherine Collins
eLife. 2016; 5: e14048. Published online 2016 Jun 7. doi: 10.7554/eLife.14048
PMCID:
PMC4896747
AbstractArticlePDF–3.0M

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