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Select item 105624931.

The role of GCNT1 mediated O-glycosylation in aggressive prostate cancer

Kirsty Hodgson, Margarita Orozco-Moreno, Emma Scott, Rebecca Garnham, Karen Livermore, Huw Thomas, Yuhan Zhou, Jiepei He, Abel Bermudez, Fernando Jose Garcia Marques, Kayla Bastian, Gerald Hysenaj, Emily Archer Goode, Rakesh Heer, Sharon Pitteri, Ning Wang, David J. Elliott, Jennifer Munkley

Sci Rep. 2023; 13: 17031. Published online 2023 Oct 9. doi: 10.1038/s41598-023-43019-8

PMCID:: PMC10562493

Abstract Article PDF–5.4M

Select item 45771282.

Detection of Core2 β-1,6-N-Acetylglucosaminyltransferase in Post-Digital Rectal Examination Urine Is a Reliable Indicator for Extracapsular Extension of Prostate Cancer

Yuta Kojima, Tohru Yoneyama, Shingo Hatakeyama, Jotaro Mikami, Tendo Sato, Kazuyuki Mori, Yasuhiro Hashimoto, Takuya Koie, Chikara Ohyama, Minoru Fukuda, Yuki Tobisawa

PLoS One. 2015; 10(9): e0138520. Published online 2015 Sep 21. doi: 10.1371/journal.pone.0138520

PMCID:: PMC4577128

Abstract Article PDF–1.1M

Select item 35730343.

Core2 O-glycan-expressing prostate cancer cells are resistant to NK cell immunity

TEPPEI OKAMOTO, MIHOKO SUTOH YONEYAMA, SHINGO HATAKEYAMA, KAZUYUKI MORI, HAYATO YAMAMOTO, TAKUYA KOIE, HISAO SAITOH, KANEMITSU YAMAYA, TOMIHISA FUNYU, MINORU FUKUDA, CHIKARA OHYAMA, SHIGERU TSUBOI

Mol Med Rep. 2013 Feb; 7(2): 359–364. Published online 2012 Nov 19. doi: 10.3892/mmr.2012.1189

PMCID:: PMC3573034

Abstract Article PDF–623K

Select item 28979294.

Core 2 N-acetylglucosaminyltransferase-1 expression induces aggressive potential of testicular germ cell tumor

Shingo Hatakeyama, Atsushi Kyan, Hayato Yamamoto, Akiko Okamoto, Naoki Sugiyama, Yuichiro Suzuki, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Shigeyuki Yamada, Hideo Saito, Yoichi Arai, Minoru Fukuda, Chikara Ohyama

Int J Cancer. Author manuscript; available in PMC 2010 Sep 1.

Published in final edited form as: Int J Cancer. 2010 Sep 1; 127(5): 1052–1059. doi: 10.1002/ijc.25117

PMCID:: PMC2897929

Abstract Article PDF–2.8M

Select item 26628735.

The high affinity selectin glycan ligand C2-O-sLe^xand mRNA transcripts of the core 2 β-1,6-N-acetylglusaminyltransferase (C2GnT1) gene are highly expressed in human colorectal adenocarcinomas

Catherine A St Hill, Mariya Farooqui, Gregory Mitcheltree, H Evin Gulbahce, Jose Jessurun, Qing Cao, Bruce Walcheck

BMC Cancer. 2009; 9: 79. Published online 2009 Mar 6. doi: 10.1186/1471-2407-9-79

PMCID:: PMC2662873

Abstract Article PDF–2.3M

Select item 18955626.

Haploinsufficiency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell death

Paula V. Cabrera, Maho Amano, Junya Mitoma, Jessica Chan, Jonathan Said, Minoru Fukuda, Linda G. Baum

Blood. 2006 Oct 1; 108(7): 2399–2406. Prepublished online 2006 Jun 15. doi: 10.1182/blood-2006-04-018556

PMCID:: PMC1895562

Abstract Article

Select item 501197.

Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen.

M F Bierhuizen, M Fukuda

Proc Natl Acad Sci U S A. 1992 Oct 1; 89(19): 9326–9330. doi: 10.1073/pnas.89.19.9326

PMCID:: PMC50119

Summary Page Browse PDF–1.3M

Select item 42726418.

Restoration of Compact Golgi Morphology in Advanced Prostate Cancer Enhances Susceptibility to Galectin-1-induced Apoptosis by Modifying Mucin O-glycan Synthesis

Armen Petrosyan, Melissa S. Holzapfel, David E. Muirhead, Pi-Wan Cheng

Mol Cancer Res. Author manuscript; available in PMC 2015 Dec 1.

Published in final edited form as: Mol Cancer Res. 2014 Dec; 12(12): 1704–1716. Published online 2014 Aug 1. doi: 10.1158/1541-7786.MCR-14-0291-T

PMCID:: PMC4272641

Abstract Article PDF–3.8M

Select item 58621409.

Increased Expression of GCNT1 is Associated With Altered O-glycosylation of PSA, PAP, and MUC1 in Human Prostate Cancers

Zuxiong Chen, Zulfiqar G. Gulzar, Catherine A. St. Hill, Bruce Walcheck, James D. Brooks

Prostate. Author manuscript; available in PMC 2018 Mar 21.

Published in final edited form as: Prostate. 2014 Jul; 74(10): 1059–1067. Published online 2014 May 22. doi: 10.1002/pros.22826

PMCID:: PMC5862140

Abstract Article PDF–649K

Select item 350102710.

Golgi Phosphoprotein 3 Determines Cell Binding Properties under Dynamic Flow by Controlling Golgi Localization of Core 2 N-Acetylglucosaminyltransferase 1

Mohamed F. Ali, Vishwanath B. Chachadi, Armen Petrosyan, Pi-Wan Cheng

J Biol Chem. 2012 Nov 16; 287(47): 39564–39577. Published online 2012 Oct 1. doi: 10.1074/jbc.M112.346528

PMCID:: PMC3501027

Abstract Article PDF–2.9M

Select item 127695011.

N-glycans of core2 β(1,6)-N-acetylglucosaminyltransferase-I (C2GnT-I) but not those of α(1,3)-fucosyltransferase-VII (FucT-VII) are required for the synthesis of functional P-selectin glycoprotein ligand-1 (PSGL-1): effects on P-, L- and E-selectin binding

Maëlle Prorok-Hamon, Frédéric Notel, Sylvie Mathieu, Claire Langlet, Minoru Fukuda, Assou El-Battari

Biochem J. 2005 Nov 1; 391(Pt 3): 491–502. Prepublished online 2005 Jun 1. Published online 2005 Oct 25. doi: 10.1042/BJ20050344

PMCID:: PMC1276950

Abstract Article PDF–1.5M

Select item 393362012.

Golgi fragmentation induced by heat shock or inhibition of heat shock proteins is mediated by non-muscle myosin IIA via its interaction with glycosyltransferases

Armen Petrosyan, Pi-Wan Cheng

Cell Stress Chaperones. 2014 Mar; 19(2): 241–254. Published online 2013 Aug 30. doi: 10.1007/s12192-013-0450-y

PMCID:: PMC3933620

Abstract Article PDF–939K

Select item 316018913.

A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans

Shigeru Tsuboi, Mihoko Sutoh, Shingo Hatakeyama, Nobuyoshi Hiraoka, Tomonori Habuchi, Yohei Horikawa, Yasuhiro Hashimoto, Takahiro Yoneyama, Kazuyuki Mori, Takuya Koie, Toshiya Nakamura, Hisao Saitoh, Kanemitsu Yamaya, Tomihisa Funyu, Minoru Fukuda, Chikara Ohyama

EMBO J. 2011 Aug 3; 30(15): 3173–3185. Published online 2011 Jun 28. doi: 10.1038/emboj.2011.215

PMCID:: PMC3160189

Abstract Article PDF–908K

Select item 298837314.

Core2 O-Glycan Structure Is Essential for the Cell Surface Expression of Sucrase Isomaltase and Dipeptidyl Peptidase-IV during Intestinal Cell Differentiation

Seung Ho Lee, Shin-Yi Yu, Jun Nakayama, Kai-Hooi Khoo, Erica L. Stone, Michiko N. Fukuda, Jamey D. Marth, Minoru Fukuda

J Biol Chem. 2010 Nov 26; 285(48): 37683–37692. Published online 2010 Sep 14. doi: 10.1074/jbc.M110.162735

PMCID:: PMC2988373

Abstract Article PDF–2.9M

Select item 842126715.

GOLPH3 and GOLPH3L are broad-spectrum COPI adaptors for sorting into intra-Golgi transport vesicles

Lawrence G. Welch, Sew-Yeu Peak-Chew, Farida Begum, Tim J. Stevens, Sean Munro

J Cell Biol. 2021 Oct 4; 220(10): e202106115. Published online 2021 Sep 2. doi: 10.1083/jcb.202106115

PMCID:: PMC8421267

Abstract Article PDF–5.4M

Select item 320295916.

Genome-Wide Association Scan for Survival on Dialysis in African-Americans with Type 2 Diabetes

Mariana Murea, Lingyi Lu, Lijun Ma, Pamela J. Hicks, Jasmin Divers, Caitrin W. McDonough, Carl D. Langefeld, Donald W. Bowden, Barry I. Freedman

Am J Nephrol. 2011 Jun; 33(6): 502–509. Published online 2011 May 5. doi: 10.1159/000327985

PMCID:: PMC3202959

Abstract Article PDF–425K

Select item 629936817.

The intracellular NADH level regulates atrophic nonunion pathogenesis through the CtBP2-p300-Runx2 transcriptional complex

Wentao Zhang, Ning Duan, Qian Zhang, Tao Song, Zhong Li, Xun Chen, Kunzheng Wang

Int J Biol Sci. 2018; 14(14): 2023–2036. Published online 2018 Nov 3. doi: 10.7150/ijbs.28302

PMCID:: PMC6299368

Abstract Article PDF–2.0M

Select item 923162318.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 51531619.

Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions

Yutaka Suzuki, Riu Yamashita, Matsuyuki Shirota, Yuta Sakakibara, Joe Chiba, Junko Mizushima-Sugano, Kenta Nakai, Sumio Sugano

Genome Res. 2004 Sep; 14(9): 1711–1718. doi: 10.1101/gr.2435604

PMCID:: PMC515316

Abstract Article PDF–181K

Select item 732206720.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117