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Select item 39373181.

Gem-Induced Cytoskeleton Remodeling Increases Cellular Migration of HTLV-1-Infected Cells, Formation of Infected-to-Target T-Cell Conjugates and Viral Transmission

Sébastien A. Chevalier, Jocelyn Turpin, Anne Cachat, Philippe V. Afonso, Antoine Gessain, John N. Brady, Cynthia A. Pise-Masison, Renaud Mahieux

PLoS Pathog. 2014 Feb; 10(2): e1003917. Published online 2014 Feb 27. doi: 10.1371/journal.ppat.1003917

PMCID:: PMC3937318

Abstract Article PDF–4.3M

Select item 105485612.

Decreased expression of GEM in osteoarthritis cartilage regulates chondrogenic differentiation via Wnt/β-catenin signaling

Lu Gan, Zhonghao Deng, Yiran Wei, Hongfang Li, Liang Zhao

J Orthop Surg Res. 2023; 18: 751. Published online 2023 Oct 4. doi: 10.1186/s13018-023-04236-z

PMCID:: PMC10548561

Abstract Article PDF–1.7M

Select item 88731193.

Inhibitory effects on L- and N-type calcium channels by a novel Ca_Vβ₁ variant identified in a patient with autism spectrum disorder

Patrick Despang, Sarah Salamon, Alexandra Breitenkamp, Elza Kuzmenkina, Jan Matthes

Naunyn Schmiedebergs Arch Pharmacol. 2022; 395(4): 459–470. Published online 2022 Feb 5. doi: 10.1007/s00210-022-02213-7

PMCID:: PMC8873119

Abstract Article PDF–2.1M

Select item 64782834.

Identification of key regulatory genes connected to NF-κB family of proteins in visceral adipose tissues using gene expression and weighted protein interaction network

Jamal S. M. Sabir, Abdelfatteh El Omri, Noor A. Shaik, Babajan Banaganapalli, Majed A. Al-Shaeri, Naser A. Alkenani, Nahid H. Hajrah, Zuhier A. Awan, Houda Zrelli, Ramu Elango, Muhummadh Khan

PLoS One. 2019; 14(4): e0214337. Published online 2019 Apr 23. doi: 10.1371/journal.pone.0214337

PMCID:: PMC6478283

Abstract Article PDF–7.6M

Select item 29304215.

Direct inhibition of P/Q-type voltage-gated Ca²⁺ channels by Gem does not require a direct Gem/Ca_vβ interaction

Mingming Fan, Zafir Buraei, Huai-Rong Luo, Rose Levenson-Palmer, Jian Yang

Proc Natl Acad Sci U S A. 2010 Aug 17; 107(33): 14887–14892. Published online 2010 Aug 2. doi: 10.1073/pnas.1007543107

PMCID:: PMC2930421

Abstract Article PDF–599K

Select item 454556.

Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases.

L Cohen, R Mohr, Y Y Chen, M Huang, R Kato, D Dorin, F Tamanoi, A Goga, D Afar, N Rosenberg, et al.

Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26): 12448–12452. doi: 10.1073/pnas.91.26.12448

PMCID:: PMC45455

Summary Page Browse PDF–1.3M

Select item 83641627.

Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke

Hiroo Takahashi, Ryo Asahina, Masayuki Fujioka, Takeshi K. Matsui, Shigeki Kato, Eiichiro Mori, Hiroyuki Hioki, Tohru Yamamoto, Kazuto Kobayashi, Akio Tsuboi

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2018850118. Published online 2021 Aug 4. doi: 10.1073/pnas.2018850118

PMCID:: PMC8364162

Abstract Article PDF–1.9M

Select item 33911548.

Molecular Determinants of Gem Protein Inhibition of P/Q-type Ca²⁺ Channels

Mingming Fan, Wei K. Zhang, Zafir Buraei, Jian Yang

J Biol Chem. 2012 Jun 29; 287(27): 22749–22758. Published online 2012 May 15. doi: 10.1074/jbc.M111.291872

PMCID:: PMC3391154

Abstract Article PDF–3.3M

Select item 19344129.

Structure–function studies of the G-domain from human gem, a novel small G-protein

Yarden Opatowsky, Yehezkel Sasson, Isabella Shaked, Yvona Ward, Orna Chomsky-Hecht, Yael Litvak, Zvi Selinger, Kathleen Kelly, Joel A. Hirsch

FEBS Lett. Author manuscript; available in PMC 2007 Jul 30.

Published in final edited form as: FEBS Lett. 2006 Oct 30; 580(25): 5959–5964. Published online 2006 Oct 6. doi: 10.1016/j.febslet.2006.09.067

PMCID:: PMC1934412

Abstract Article PDF–929K

Select item 34381810.

Phosphorylation of Critical Serine Residues in Gem Separates Cytoskeletal Reorganization from Down-Regulation of Calcium Channel Activity

Y. Ward, B. Spinelli, M. J. Quon, H. Chen, S. R. Ikeda, K. Kelly

Mol Cell Biol. 2004 Jan; 24(2): 651. doi: 10.1128/MCB.24.2.651-661.2004

PMCID:: PMC343818

Abstract Article PDF–574K

Select item 219924811.

The GTP binding proteins Gem and Rad are negative regulators of the Rho–Rho kinase pathway

Yvona Ward, Seow-Fong Yap, V. Ravichandran, Fumio Matsumura, Masaaki Ito, Beth Spinelli, Kathleen Kelly

J Cell Biol. 2002 Apr 15; 157(2): 291–302. doi: 10.1083/jcb.200111026

PMCID:: PMC2199248

Abstract Article PDF–424K

Select item 122286612.

A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPases.

Sandra Aresta, Marie-France de Tand-Heim, Florence Béranger, Jean de Gunzburg

Biochem J. 2002 Oct 1; 367(Pt 1): 57–65. doi: 10.1042/BJ20020829

PMCID:: PMC1222866

Summary PDF–359K

Select item 287649913.

A Systemic Network for Chlamydia pneumoniae Entry into Human Cells

Anyou Wang, S. Claiborne Johnston, Joyce Chou, Deborah Dean

J Bacteriol. 2010 Jun; 192(11): 2809–2815. Published online 2010 Mar 16. doi: 10.1128/JB.01462-09

PMCID:: PMC2876499

Abstract Article PDF–1.4M

Select item 642327814.

Network-based prediction of protein interactions

István A. Kovács, Katja Luck, Kerstin Spirohn, Yang Wang, Carl Pollis, Sadie Schlabach, Wenting Bian, Dae-Kyum Kim, Nishka Kishore, Tong Hao, Michael A. Calderwood, Marc Vidal, Albert-László Barabási

Nat Commun. 2019; 10: 1240. Published online 2019 Mar 18. doi: 10.1038/s41467-019-09177-y

PMCID:: PMC6423278

Abstract Article PDF–1.1M

Select item 405025015.

Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood–brain barrier dysfunction

Shawna M Woollard, Biju Bhargavan, Fang Yu, Georgette D Kanmogne

J Cereb Blood Flow Metab. 2014 Jun; 34(6): 1047–1059. Published online 2014 Mar 26. doi: 10.1038/jcbfm.2014.54

PMCID:: PMC4050250

Abstract Article PDF–932K

Select item 287256116.

An empirical framework for binary interactome mapping

Kavitha Venkatesan, Jean-François Rual, Alexei Vazquez, Ulrich Stelzl, Irma Lemmens, Tomoko Hirozane-Kishikawa, Tong Hao, Martina Zenkner, Xiaofeng Xin, Kwang-II Goh, Muhammed A Yildirim, Nicolas Simonis, Kathrin Heinzmann, Fana Gebreab, Julie M Sahalie, Sebiha Cevik, Christophe Simon, Anne-Sophie de Smet, Elizabeth Dann, Alex Smolyar, Arunachalam Vinayagam, Haiyuan Yu, David Szeto, Heather Borick, Amélie Dricot, Niels Klitgord, Ryan R Murray, Chenwei Lin, Maciej Lalowski, Jan Timm, Kirstin Rau, Charles Boone, Pascal Braun, Michael E Cusick, Frederick P Roth, David E Hill, Jan Tavernier, Erich E Wanker, Albert-László Barabási, Marc Vidal

Nat Methods. Author manuscript; available in PMC 2010 May 18.

Published in final edited form as: Nat Methods. 2009 Jan; 6(1): 83–90. Published online 2008 Dec 7. doi: 10.1038/nmeth.1280

PMCID:: PMC2872561

Abstract Article PDF–1.0M

Select item 674264617.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Abstract Article PDF–1.2M

Select item 326170818.

Toward an understanding of the protein interaction network of the human liver

Jian Wang, Keke Huo, Lixin Ma, Liujun Tang, Dong Li, Xiaobi Huang, Yanzhi Yuan, Chunhua Li, Wei Wang, Wei Guan, Hui Chen, Chaozhi Jin, Junchen Wei, Wanqiao Zhang, Yongsheng Yang, Qiongming Liu, Ying Zhou, Cuili Zhang, Zhihao Wu, Wangxiang Xu, Ying Zhang, Tao Liu, Donghui Yu, Yaping Zhang, Liang Chen, Dewu Zhu, Xing Zhong, Lixin Kang, Xiang Gan, Xiaolan Yu, Qi Ma, Jing Yan, Li Zhou, Zhongyang Liu, Yunping Zhu, Tao Zhou, Fuchu He, Xiaoming Yang

Mol Syst Biol. 2011; 7: 536. Published online 2011 Oct 11. doi: 10.1038/msb.2011.67

Correction in:: Mol Syst Biol. 2017 Dec; 13(12): 965.

PMCID:: PMC3261708

Abstract Article PDF–2.0M

Select item 616668219.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 426658820.

A proteome-scale map of the human interactome network

Thomas Rolland, Murat Taşan, Benoit Charloteaux, Samuel J. Pevzner, Quan Zhong, Nidhi Sahni, Song Yi, Irma Lemmens, Celia Fontanillo, Roberto Mosca, Atanas Kamburov, Susan D. Ghiassian, Xinping Yang, Lila Ghamsari, Dawit Balcha, Bridget E. Begg, Pascal Braun, Marc Brehme, Martin P. Broly, Anne-Ruxandra Carvunis, Dan Convery-Zupan, Roser Corominas, Jasmin Coulombe-Huntington, Elizabeth Dann, Matija Dreze, Amélie Dricot, Changyu Fan, Eric Franzosa, Fana Gebreab, Bryan J. Gutierrez, Madeleine F. Hardy, Mike Jin, Shuli Kang, Ruth Kiros, Guan Ning Lin, Katja Luck, Andrew MacWilliams, Jörg Menche, Ryan R. Murray, Alexandre Palagi, Matthew M. Poulin, Xavier Rambout, John Rasla, Patrick Reichert, Viviana Romero, Elien Ruyssinck, Julie M. Sahalie, Annemarie Scholz, Akash A. Shah, Amitabh Sharma, Yun Shen, Kerstin Spirohn, Stanley Tam, Alexander O. Tejeda, Shelly A. Wanamaker, Jean-Claude Twizere, Kerwin Vega, Jennifer Walsh, Michael E. Cusick, Yu Xia, Albert-László Barabási, Lilia M. Iakoucheva, Patrick Aloy, Javier De Las Rivas, Jan Tavernier, Michael A. Calderwood, David E. Hill, Tong Hao, Frederick P. Roth, Marc Vidal

Cell. Author manuscript; available in PMC 2015 Nov 20.

Published in final edited form as: Cell. 2014 Nov 20; 159(5): 1212–1226. doi: 10.1016/j.cell.2014.10.050

PMCID:: PMC4266588

Abstract Article PDF–3.1M

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