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Select item 75743851.

Tissue and cancer-specific expression of DIEXF is epigenetically mediated by an Alu repeat

Berta Martín, Stella Pappa, Anna Díez-Villanueva, Izaskun Mallona, Joaquín Custodio, María José Barrero, Miguel A. Peinado, Mireia Jordà

Epigenetics. 2020; 15(6-7): 765–779. Published online 2020 Feb 11. doi: 10.1080/15592294.2020.1722398

PMCID:: PMC7574385

Abstract Article PDF–5.2M

Select item 40994042.

MiR-195 affects cell migration and cell proliferation by down-regulating DIEXF in Hirschsprung’s Disease

Hao Lei, Junwei Tang, Hongxing Li, Hongwei Zhang, Changgui Lu, Huan Chen, Wei Li, Yankai Xia, Weibing Tang

BMC Gastroenterol. 2014; 14: 123. Published online 2014 Jul 9. doi: 10.1186/1471-230X-14-123

PMCID:: PMC4099404

Abstract Article PDF–2.0M

Select item 50335813.

Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3

Yihong Guan, Delai Huang, Feng Chen, Ce Gao, Ting Tao, Hui Shi, Shuyi Zhao, Zuyuan Liao, Li Jan Lo, Yingchun Wang, Jun Chen, Jinrong Peng

PLoS Biol. 2016 Sep; 14(9): e1002555. Published online 2016 Sep 22. doi: 10.1371/journal.pbio.1002555

PMCID:: PMC5033581

Abstract Article PDF–4.1M

Select item 55017634.

The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma

T Tao, S B Sondalle, H Shi, S Zhu, A R Perez-Atayde, J Peng, S J Baserga, A T Look

Oncogene. 2017 Jul 6; 36(27): 3852–3867. Published online 2017 Mar 6. doi: 10.1038/onc.2016.527

PMCID:: PMC5501763

Abstract Article PDF–3.9M

Select item 36415915.

Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation

Ting Tao, Hui Shi, Yihong Guan, Delai Huang, Ye Chen, David P Lane, Jun Chen, Jinrong Peng

Cell Res. 2013 May; 23(5): 620–634. Published online 2013 Jan 29. doi: 10.1038/cr.2013.16

PMCID:: PMC3641591

Abstract Article PDF–3.1M

Select item 13153966.

Loss of function of def selectively up-regulates Δ113p53 expression to arrest expansion growth of digestive organs in zebrafish

Jun Chen, Hua Ruan, Sok Meng Ng, Chuan Gao, Hui Meng Soo, Wei Wu, Zhenhai Zhang, Zilong Wen, David P. Lane, Jinrong Peng

Genes Dev. 2005 Dec 1; 19(23): 2900–2911. doi: 10.1101/gad.1366405

PMCID:: PMC1315396

Abstract Article PDF–1.1M

Select item 66675007.

A protein-RNA interaction atlas of the ribosome biogenesis factor AATF

Rainer W. J. Kaiser, Michael Ignarski, Eric L. Van Nostrand, Christian K. Frese, Manaswita Jain, Sadrija Cukoski, Heide Heinen, Melanie Schaechter, Lisa Seufert, Konstantin Bunte, Peter Frommolt, Patrick Keller, Mark Helm, Katrin Bohl, Martin Höhne, Bernhard Schermer, Thomas Benzing, Katja Höpker, Christoph Dieterich, Gene W. Yeo, Roman-Ulrich Müller, Francesca Fabretti

Sci Rep. 2019; 9: 11071. Published online 2019 Jul 30. doi: 10.1038/s41598-019-47552-3

PMCID:: PMC6667500

Abstract Article PDF–2.8M

Select item 51776018.

FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3

Kamila M. Jozwik, Igor Chernukhin, Aurelien A. Serandour, Sankari Nagarajan, Jason S. Carroll

Cell Rep. 2016 Dec 6; 17(10): 2715–2723. Published online 2016 Dec 6. doi: 10.1016/j.celrep.2016.11.028

PMCID:: PMC5177601

Abstract Article PDF–2.9M

Select item 82708989.

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability

Helin Wang, Kangze Feng, Qingtao Wang, Haiteng Deng

Sci Rep. 2021; 11: 14253. Published online 2021 Jul 9. doi: 10.1038/s41598-021-93684-w

PMCID:: PMC8270898

Abstract Article PDF–2.6M

Select item 1016456410.

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing

Yingxiao Chen, Yanping Li, Roselyn S Dai, Jonathan C Savage, Ujwal Shinde, John Klimek, Larry L David, Emma A Young, Markus Hafner, Rosalie C Sears, Xiao-Xin Sun, Mu-Shui Dai

Nucleic Acids Res. 2023 May 8; 51(8): 3934–3949. Published online 2023 Mar 13. doi: 10.1093/nar/gkad140

PMCID:: PMC10164564

Abstract Article PDF–3.8M

Select item 631495711.

An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders

Siwei Chen, Robert Fragoza, Lambertus Klei, Yuan Liu, Jiebiao Wang, Kathryn Roeder, Bernie Devlin, Haiyuan Yu

Nat Genet. Author manuscript; available in PMC 2019 Jul 1.

Published in final edited form as: Nat Genet. 2018 Jul; 50(7): 1032–1040. Published online 2018 Jun 11. doi: 10.1038/s41588-018-0130-z

PMCID:: PMC6314957

Abstract Article PDF–1.3M

Select item 341884312.

Functional Proteomics Establishes the Interaction of SIRT7 with Chromatin Remodeling Complexes and Expands Its Role in Regulation of RNA Polymerase I Transcription

Yuan-Chin Tsai, Todd M. Greco, Apaporn Boonmee, Yana Miteva, Ileana M. Cristea

Mol Cell Proteomics. 2012 May; 11(5): 60–76. Published online 2011 Dec 6. doi: 10.1074/mcp.A111.015156

PMCID:: PMC3418843

Abstract Article PDF–2.5M

Select item 752655113.

ZZW-115–dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents

Wenjun Lan, Patricia Santofimia-Castaño, Mirna Swayden, Yi Xia, Zhengwei Zhou, Stephane Audebert, Luc Camoin, Can Huang, Ling Peng, Ana Jiménez-Alesanco, Adrián Velázquez-Campoy, Olga Abián, Gwen Lomberk, Raul Urrutia, Bruno Rizzuti, Vincent Geli, Philippe Soubeyran, José L. Neira, Juan Iovanna

JCI Insight. 2020 Sep 17; 5(18): e138117. Published online 2020 Sep 17. doi: 10.1172/jci.insight.138117

PMCID:: PMC7526551

Abstract Article PDF–9.1M

Select item 826661714.

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins

Benjamin Lang, Jae-Seong Yang, Mireia Garriga-Canut, Silvia Speroni, Moritz Aschern, Maria Gili, Tobias Hoffmann, Gian Gaetano Tartaglia, Sebastian P Maurer

Nucleic Acids Res. 2021 Jul 9; 49(12): 6702–6721. Published online 2021 Jun 16. doi: 10.1093/nar/gkab490

PMCID:: PMC8266617

Abstract Article PDF–4.0M

Select item 1007290615.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 694204416.

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity

Jae Jin Kim, Seo Yun Lee, Fade Gong, Anna M. Battenhouse, Daniel R. Boutz, Aarti Bashyal, Samantha T. Refvik, Cheng-Ming Chiang, Blerta Xhemalce, Tanya T. Paull, Jennifer S. Brodbelt, Edward M. Marcotte, Kyle M. Miller

Genes Dev. 2019 Dec 1; 33(23-24): 1751–1774. doi: 10.1101/gad.331231.119

PMCID:: PMC6942044

Abstract Article PDF–10M

Select item 674682217.

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei

Giovanni Nassa, Giorgio Giurato, Annamaria Salvati, Valerio Gigantino, Giovanni Pecoraro, Jessica Lamberti, Francesca Rizzo, Tuula A. Nyman, Roberta Tarallo, Alessandro Weisz

Sci Data. 2019; 6: 173. Published online 2019 Sep 16. doi: 10.1038/s41597-019-0179-2

PMCID:: PMC6746822

Abstract Article PDF–2.0M

Select item 976969818.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 674264619.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Abstract Article PDF–1.2M

Select item 1056587620.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644