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Items: 1 to 20 of 48

1.
VPS41, a protein involved in lysosomal trafficking, is protective in C. elegans and mammalian cellular models of Parkinson's disease
Qingmin Ruan, Adam J. Harrington, Kim A. Caldwell, Guy A. Caldwell, David G. Standaert
Neurobiol Dis. Author manuscript; available in PMC 2011 Feb 1.
Published in final edited form as: Neurobiol Dis. 2010 Feb; 37(2): 330. Published online 2009 Oct 20. doi: 10.1016/j.nbd.2009.10.011
PMCID:
PMC2818321
AbstractArticlePDF–618K
2.
Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1‐dependent TFEB/TFE3 regulation
Reini E N van der Welle, Rebekah Jobling, Christian Burns, Paolo Sanza, Jan A van der Beek, Alfonso Fasano, Lan Chen, Fried J Zwartkruis, Susan Zwakenberg, Edward F Griffin, Corlinda ten Brink, Tineke Veenendaal, Nalan Liv, Conny M A van Ravenswaaij‐Arts, Henny H Lemmink, Rolph Pfundt, Susan Blaser, Carolina Sepulveda, Andres M Lozano, Grace Yoon, Teresa Santiago‐Sim, Cedric S Asensio, Guy A Caldwell, Kim A Caldwell, David Chitayat, Judith Klumperman
EMBO Mol Med. 2021 May 7; 13(5): e13258. Published online 2021 Apr 14. doi: 10.15252/emmm.202013258
PMCID:
PMC8103106
AbstractArticlePDF–4.0M
3.
Bi-allelic variants in HOPS complex subunit VPS41 cause cerebellar ataxia and abnormal membrane trafficking
Leslie E Sanderson, Kristina Lanko, Maysoon Alsagob, Rawan Almass, Nada Al-Ahmadi, Maryam Najafi, Mohammad A Al-Muhaizea, Hamad Alzaidan, Hesham AlDhalaan, Elena Perenthaler, Herma C van der Linde, Anita Nikoncuk, Nikolas A Kühn, Dinu Antony, Tarek Mustafa Owaidah, Salmo Raskin, Luana Gabriela Dalla Rosa Vieira, Romulo Mombach, Najmeh Ahangari, Tainá Regina Damaceno Silveira, Najim Ameziane, Arndt Rolfs, Aljohara Alharbi, Raghda M Sabbagh, Khalid AlAhmadi, Bashayer Alawam, Hazem Ghebeh, Aljouhra AlHargan, Anoud A Albader, Faisal S Binhumaid, Ewa Goljan, Dorota Monies, Osama M Mustafa, Mazhor Aldosary, Albandary AlBakheet, Banan Alyounes, Faten Almutairi, Ali Al-Odaib, Durdane Bekar Aksoy, A Nazli Basak, Robin Palvadeau, Daniah Trabzuni, Jill A Rosenfeld, Ehsan Ghayoor Karimiani, Brian F Meyer, Bedri Karakas, Futwan Al-Mohanna, Stefan T Arold, Dilek Colak, Reza Maroofian, Henry Houlden, Aida M Bertoli-Avella, Miriam Schmidts, Tahsin Stefan Barakat, Tjakko J van Ham, Namik Kaya
Brain. 2021 Mar; 144(3): 769–780. Published online 2021 Mar 25. doi: 10.1093/brain/awaa459
PMCID:
PMC8041041
AbstractArticlePDF–1.1M
4.
Functional Analysis of VPS41-Mediated Neuroprotection in Caenorhabditis elegans and Mammalian Models of Parkinson's Disease
Adam J. Harrington, Talene A. Yacoubian, Sunny R. Slone, Kim A. Caldwell, Guy A. Caldwell
J Neurosci. 2012 Feb 8; 32(6): 2142–2153. doi: 10.1523/JNEUROSCI.2606-11.2012
PMCID:
PMC6621695
AbstractArticlePDF–1.7M
5.
Distinct functional roles of Vps41-mediated neuroprotection in Alzheimer’s and Parkinson’s disease models of neurodegeneration
Edward F Griffin, Xiaohui Yan, Kim A Caldwell, Guy A Caldwell
Hum Mol Genet. 2018 Dec 15; 27(24): 4176–4193. Published online 2018 Aug 24. doi: 10.1093/hmg/ddy308
PMCID:
PMC6276837
AbstractArticlePDF–14M
6.
Characterization of VPS41, a gene required for vacuolar trafficking and high-affinity iron transport in yeast
Derek C. Radisky, William B. Snyder, Scott D. Emr, Jerry Kaplan
Proc Natl Acad Sci U S A. 1997 May 27; 94(11): 5662–5666. doi: 10.1073/pnas.94.11.5662
PMCID:
PMC20835
AbstractArticlePDF–692K
7.
Self-Assembly of VPS41 Promotes Sorting Required for Biogenesis of the Regulated Secretory Pathway
Cédric S. Asensio, Daniel W. Sirkis, James W. Maas, Jr., Kiyoshi Egami, Tsz-Leung To, Frances M. Brodsky, Xiaokun Shu, Yifan Cheng, Robert H. Edwards
Dev Cell. Author manuscript; available in PMC 2014 Nov 25.
Published in final edited form as: Dev Cell. 2013 Nov 25; 27(4): 425–437. Published online 2013 Nov 7. doi: 10.1016/j.devcel.2013.10.007
PMCID:
PMC3974617
AbstractArticlePDF–3.4M
8.
The small GTPase Arl8b regulates assembly of the mammalian HOPS complex on lysosomes
Divya Khatter, Vivek B. Raina, Devashish Dwivedi, Aastha Sindhwani, Surbhi Bahl, Mahak Sharma
J Cell Sci. 2015 May 1; 128(9): 1746–1761. doi: 10.1242/jcs.162651
PMCID:
PMC4432227
AbstractArticle
9.
Vps33b pathogenic mutations preferentially affect VIPAS39/SPE-39-positive endosomes
Karine Tornieri, Stephanie A. Zlatic, Ariana P. Mullin, Erica Werner, Robert Harrison, Steven W. L'Hernault, Victor Faundez
Hum Mol Genet. 2013 Dec 20; 22(25): 5215–5228. Published online 2013 Aug 4. doi: 10.1093/hmg/ddt378
PMCID:
PMC3842178
AbstractArticlePDF–1.9M
10.
Lysosomal Trafficking, Antigen Presentation, and Microbial Killing Are Controlled by the Arf-like GTPase Arl8b
Salil Garg, Mahak Sharma, Cindy Ung, Amit Tuli, Duarte C. Barral, David L. Hava, Natacha Veerapen, Gurdyal S. Besra, Nir Hacohen, Michael B. Brenner
Immunity. 2011 Aug 26; 35(2): 182–193. doi: 10.1016/j.immuni.2011.06.009
PMCID:
PMC3584282
AbstractArticle
11.
VPS18 recruits VPS41 to the human HOPS complex via a RING–RING interaction
Morag R. Hunter, Edward J. Scourfield, Edward Emmott, Stephen C. Graham
Biochem J. 2017 Nov 1; 474(21): 3615–3626. Prepublished online 2017 Sep 20. Published online 2017 Oct 23. doi: 10.1042/BCJ20170588
PMCID:
PMC5651818
AbstractArticlePDF–6.5M
12.
RILP interacts with HOPS complex via VPS41 subunit to regulate endocytic trafficking
Xiaosi Lin, Ting Yang, Shicong Wang, Zhen Wang, Ye Yun, Lixiang Sun, Yunhe Zhou, Xiaohui Xu, Chihiro Akazawa, Wanjin Hong, Tuanlao Wang
Sci Rep. 2014; 4: 7282. Published online 2014 Dec 2. doi: 10.1038/srep07282
Correction in:
Sci Rep. 2015; 5: 8302.
PMCID:
PMC4250914
AbstractArticlePDF–1.8M
13.
Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity
Rik van der Kant, Caspar T. H. Jonker, Ruud H. Wijdeven, Jeroen Bakker, Lennert Janssen, Judith Klumperman, Jacques Neefjes
J Biol Chem. 2015 Dec 18; 290(51): 30280–30290. Published online 2015 Oct 13. doi: 10.1074/jbc.M115.688440
PMCID:
PMC4683254
AbstractArticlePDF–3.1M
14.
The HOPS complex mediates autophagosome–lysosome fusion through interaction with syntaxin 17
Peidu Jiang, Taki Nishimura, Yuriko Sakamaki, Eisuke Itakura, Tomohisa Hatta, Tohru Natsume, Noboru Mizushima
Mol Biol Cell. 2014 Apr 15; 25(8): 1327–1337. doi: 10.1091/mbc.E13-08-0447
PMCID:
PMC3982997
AbstractArticlePDF–8.1M
15.
The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes
Rituraj Marwaha, Subhash B. Arya, Divya Jagga, Harmeet Kaur, Amit Tuli, Mahak Sharma
J Cell Biol. 2017 Apr 3; 216(4): 1051–1070. doi: 10.1083/jcb.201607085
PMCID:
PMC5379943
AbstractArticlePDF–4.4M
16.
Structural basis of Vps33A recruitment to the human HOPS complex by Vps16
Stephen C. Graham, Lena Wartosch, Sally R. Gray, Edward J. Scourfield, Janet E. Deane, J. Paul Luzio, David J. Owen
Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33): 13345–13350. Published online 2013 Jul 30. doi: 10.1073/pnas.1307074110
PMCID:
PMC3746937
AbstractArticlePDF–1.1M
17.
Vps8 overexpression inhibits HOPS-dependent trafficking routes by outcompeting Vps41/Lt
Péter Lőrincz, Lili Anna Kenéz, Sarolta Tóth, Viktória Kiss, Ágnes Varga, Tamás Csizmadia, Zsófia Simon-Vecsei, Gábor Juhász
eLife. 2019; 8: e45631. Published online 2019 Jun 13. doi: 10.7554/eLife.45631
PMCID:
PMC6592680
AbstractArticlePDF–14M
18.
Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes
Lena Wartosch, Ufuk Günesdogan, Stephen C. Graham, J. Paul Luzio
Traffic. 2015 Jul; 16(7): 727–742. Published online 2015 Apr 30. doi: 10.1111/tra.12283
PMCID:
PMC4510706
AbstractArticlePDF–6.4M
19.
An FTS/Hook/p107FHIP Complex Interacts with and Promotes Endosomal Clustering by the Homotypic Vacuolar Protein Sorting Complex
Lai Xu, Mathew E. Sowa, Jing Chen, Xue Li, Steven P. Gygi, J. Wade Harper
Mol Biol Cell. 2008 Dec; 19(12): 5059–5071. doi: 10.1091/mbc.E08-05-0473
PMCID:
PMC2592673
AbstractArticlePDF–713K
20.
ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation
Guangyan Miao, Hongyu Zhao, Yan Li, Mingming Ji, Yong Chen, Yi Shi, Yuhai Bi, Peihui Wang, Hong Zhang
Dev Cell. 2021 Feb 22; 56(4): 427–442.e5. Published online 2020 Dec 16. doi: 10.1016/j.devcel.2020.12.010
PMCID:
PMC7832235
AbstractArticlePDF–5.9M

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