PMC Links for Gene (Select 27102) - PMC

Links from Gene

Items: 1 to 20 of 39

<< First< Prev

Page of 2

Select item 105284471.

DELE1 oligomerization promotes integrated stress response activation

Jie Yang, Kelsey R. Baron, Daniel E. Pride, Anette Schneemann, Xiaoyan Guo, Wenqian Chen, Albert S. Song, Giovanni Aviles, Martin Kampmann, R. Luke Wiseman, Gabriel C. Lander

Nat Struct Mol Biol. Author manuscript; available in PMC 2023 Sep 27.

Published in final edited form as: Nat Struct Mol Biol. 2023 Sep; 30(9): 1295–1302. Published online 2023 Aug 7. doi: 10.1038/s41594-023-01061-0

PMCID:: PMC10528447

Abstract Article PDF–3.1M

Select item 62579812.

Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells

Jeremy D. Grevet, Xianjiang Lan, Nicole Hamagami, Christopher R. Edwards, Laavanya Sankaranarayanan, Xinjun Ji, Saurabh K. Bhardwaj, Carolyne J. Face, David F. Posocco, Osheiza Abdulmalik, Cheryl A. Keller, Belinda Giardine, Simone Sidoli, Ben A. Garcia, Stella T. Chou, Stephen A. Liebhaber, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Science. Author manuscript; available in PMC 2018 Nov 27.

Published in final edited form as: Science. 2018 Jul 20; 361(6399): 285–290. doi: 10.1126/science.aao0932

PMCID:: PMC6257981

Abstract Article PDF–1.7M

Select item 53122823.

Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2α kinase in cortical neurons

Eva Ramos-Fernández, Marta Tajes, Gerard ILL-Raga, Lina Vargas, Arnau Busquets-García, Mònica Bosch-Morató, Biuse Guivernau, Victòria Valls-Comamala, Maria Gomis, Cristina Grau, César Fandos, Mark D. Rosen, Michael H. Rabinowitz, Nibaldo Inestrosa, Rafael Maldonado, Xavier Altafaj, Andrés Ozaita, Alejandra Alvarez, Rubén Vicente, Miguel A. Valverde, Francisco J. Muñoz

Oncotarget. 2016 Sep 13; 7(37): 58876–58892. Published online 2016 Aug 19. doi: 10.18632/oncotarget.11417

PMCID:: PMC5312282

Abstract Article PDF–4.0M

Select item 37078554.

The Host-Encoded Heme Regulated Inhibitor (HRI) Facilitates Virulence-Associated Activities of Bacterial Pathogens

Niraj Shrestha, Justin Boucher, Wael Bahnan, Emily S. Clark, Roland Rosqvist, Kenneth A. Fields, Wasif N. Khan, Kurt Schesser

PLoS One. 2013; 8(7): e68754. Published online 2013 Jul 10. doi: 10.1371/journal.pone.0068754

PMCID:: PMC3707855

Abstract Article PDF–696K

Select item 98945665.

Targeting the EIF2AK1 Signaling Pathway Rescues Red Blood Cell Production in SF3B1-Mutant Myelodysplastic Syndromes With Ringed Sideroblasts

Vera Adema, Feiyang Ma, Rashmi Kanagal-Shamanna, Natthakan Thongon, Guillermo Montalban-Bravo, Hui Yang, Scott A. Peslak, Feng Wang, Pamela Acha, Francesc Sole, Pamela Lockyer, Margherita Cassari, Jaroslaw P. Maciejewski, Valeria Visconte, Irene Gañán-Gómez, Yuanbin Song, Carlos Bueso-Ramos, Matteo Pellegrini, Tuyet M. Tan, Rafael Bejar, Jennifer S. Carew, Stephanie Halene, Valeria Santini, Gheath Al-Atrash, Karen Clise-Dwyer, Guillermo Garcia-Manero, Gerd A. Blobel, Simona Colla

Blood Cancer Discov. 2022 Nov 2; 3(6): 554–567. Published online 2022 Aug 3. doi: 10.1158/2643-3230.BCD-21-0220

PMCID:: PMC9894566

Abstract Article PDF–9.1M

Select item 79489856.

The eIF2α kinase HRI triggers the autophagic clearance of cytosolic protein aggregates

Tapas Mukherjee, Valeria Ramaglia, Mena Abdel-Nour, Athanasia A. Bianchi, Jessica Tsalikis, Hien N. Chau, Suneil K. Kalia, Lorraine V. Kalia, Jane-Jane Chen, Damien Arnoult, Jennifer L. Gommerman, Dana J. Philpott, Stephen E. Girardin

J Biol Chem. 2021 Jan-Jun; 296: 100050. Published online 2020 Dec 2. doi: 10.1074/jbc.RA120.014415

PMCID:: PMC7948985

Abstract Article PDF–2.9M

Select item 71186947.

De novo EIF2AK1 and EIF2AK2 Variants Are Associated with Developmental Delay, Leukoencephalopathy, and Neurologic Decompensation

Dongxue Mao, Chloe M. Reuter, Maura R.Z. Ruzhnikov, Anita E. Beck, Emily G. Farrow, Lisa T. Emrick, Jill A. Rosenfeld, Katherine M. Mackenzie, Laurie Robak, Matthew T. Wheeler, Lindsay C. Burrage, Mahim Jain, Pengfei Liu, Daniel Calame, Sébastien Küry, Martin Sillesen, Klaus Schmitz-Abe, Davide Tonduti, Luigina Spaccini, Maria Iascone, Casie A. Genetti, Mary K. Koenig, Madeline Graf, Alyssa Tran, Mercedes Alejandro, Undiagnosed Diseases Network, Brendan H. Lee, Isabelle Thiffault, Pankaj B. Agrawal, Jonathan A. Bernstein, Hugo J. Bellen, Hsiao-Tuan Chao

Am J Hum Genet. 2020 Apr 2; 106(4): 570–583. Published online 2020 Mar 19. doi: 10.1016/j.ajhg.2020.02.016

PMCID:: PMC7118694

Abstract Article PDF–2.0M

Select item 66191688.

Blocking the eIF2α Kinase (PKR) Enhances Positive and Negative Forms of Cortex-Dependent Taste Memory

Elad Stern, Adaikkan Chinnakkaruppan, Orit David, Nahum Sonenberg, Kobi Rosenblum

J Neurosci. 2013 Feb 6; 33(6): 2517–2525. doi: 10.1523/JNEUROSCI.2322-12.2013

PMCID:: PMC6619168

Abstract Article PDF–2.5M

Select item 71167159.

A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol

Evelyn Fessler, Eva-Maria Eckl, Sabine Schmitt, Igor Alves Mancilla, Matthias F. Meyer-Bender, Monika Hanf, Julia Philippou-Massier, Stefan Krebs, Hans Zischka, Lucas T. Jae

Nature. Author manuscript; available in PMC 2021 Feb 9.

Published in final edited form as: Nature. 2020 Mar 1; 579(7799): 433–437. Published online 2020 Mar 4. doi: 10.1038/s41586-020-2076-4

PMCID:: PMC7116715

Abstract Article PDF–6.3M

Select item 530996710.

Mechanism of Protein Kinase R Inhibition by Human Cytomegalovirus pTRS1

Heather A. Vincent, Benjamin Ziehr, Nathaniel J. Moorman

J Virol. 2017 Mar 1; 91(5): e01574-16. Prepublished online 2016 Dec 14. Published online 2017 Feb 14. doi: 10.1128/JVI.01574-16

PMCID:: PMC5309967

Abstract Article PDF–1.0M

Select item 1043372911.

The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling

Mena Abdel-Nour, Leticia A. M. Carneiro, Jeffrey Downey, Jessica Tsalikis, Ahmed Outlioua, Dave Prescott, Leandro Silva Da Costa, Elise S. Hovingh, Armin Farahvash, Ryan G. Gaudet, Raphael Molinaro, Rob van Dalen, Charles C. Y. Lau, Farshad C. Azimi, Nichole K. Escalante, Aaron Trotman-Grant, Jeffrey E. Lee, Scott D. Gray-Owen, Maziar Divangahi, Jane-Jane Chen, Dana J. Philpott, Damien Arnoult, Stephen E. Girardin

Science. Author manuscript; available in PMC 2023 Aug 17.

Published in final edited form as: Science. 2019 Jul 5; 365(6448): eaaw4144. doi: 10.1126/science.aaw4144

PMCID:: PMC10433729

Abstract Article PDF–2.2M

Select item 729009712.

The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

Peng Huang, Scott A. Peslak, Xianjiang Lan, Eugene Khandros, Jennifer A. Yano, Malini Sharma, Cheryl A. Keller, Belinda Giardine, Kunhua Qin, Osheiza Abdulmalik, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood. 2020 Jun 11; 135(24): 2121–2132. Prepublished online 2020 Apr 16. doi: 10.1182/blood.2020005301

PMCID:: PMC7290097

Abstract Article

Select item 714783213.

Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway

Xiaoyan Guo, Giovanni Aviles, Yi Liu, Ruilin Tian, Bret A. Unger, Yu-Hsiu T. Lin, Arun P. Wiita, Ke Xu, M. Almira Correia, Martin Kampmann

Nature. Author manuscript; available in PMC 2020 Sep 4.

Published in final edited form as: Nature. 2020 Mar; 579(7799): 427–432. Published online 2020 Mar 4. doi: 10.1038/s41586-020-2078-2

PMCID:: PMC7147832

Abstract Article PDF–3.1M

Select item 685698514.

Heme-regulated eIF2α kinase in erythropoiesis and hemoglobinopathies

Jane-Jane Chen, Shuping Zhang

Blood. 2019 Nov 14; 134(20): 1697–1707. Prepublished online 2019 Sep 25. doi: 10.1182/blood.2019001915

PMCID:: PMC6856985

Abstract Article

Select item 10933015.

Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in Translational Control

Yuguang Shi, Krishna M. Vattem, Ruchira Sood, Jie An, Jingdong Liang, Lawrence Stramm, Ronald C. Wek

Mol Cell Biol. 1998 Dec; 18(12): 7499–7509. doi: 10.1128/mcb.18.12.7499

PMCID:: PMC109330

Abstract Article PDF–1.1M

Select item 379567316.

Endogenous Human MDM2-C Is Highly Expressed in Human Cancers and Functions as a p53-Independent Growth Activator

Danielle R. Okoro, Nicoleta Arva, Chong Gao, Alla Polotskaia, Cindy Puente, Melissa Rosso, Jill Bargonetti

PLoS One. 2013; 8(10): e77643. Published online 2013 Oct 11. doi: 10.1371/journal.pone.0077643

PMCID:: PMC3795673

Abstract Article PDF–3.0M

Select item 1690117.

Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning

R.-M. Hu, Z.-G. Han, H.-D. Song, Y.-D. Peng, Q.-H. Huang, S.-X. Ren, Y.-J. Gu, C.-H. Huang, Y.-B. Li, C.-L. Jiang, G. Fu, Q.-H. Zhang, B.-W. Gu, M. Dai, Y.-F. Mao, G.-F. Gao, R. Rong, M. Ye, J. Zhou, S.-H. Xu, J. Gu, J.-X. Shi, W.-R. Jin, C.-K. Zhang, T.-M. Wu, G.-Y. Huang, Z. Chen, M.-D. Chen, J.-L. Chen

Proc Natl Acad Sci U S A. 2000 Aug 15; 97(17): 9543–9548. Published online 2000 Aug 8. doi: 10.1073/pnas.160270997

PMCID:: PMC16901

Abstract Article PDF–801K

Select item 389478618.

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

Mikko Taipale, Irina Krykbaeva, Martina Koeva, Can Kayatekin, Kenneth D. Westover, Georgios I. Karras, Susan Lindquist

Cell. Author manuscript; available in PMC 2014 Jan 17.

Published in final edited form as: Cell. 2012 Aug 31; 150(5): 987–1001. doi: 10.1016/j.cell.2012.06.047

PMCID:: PMC3894786

Abstract Article PDF–5.0M

Select item 108373219.

Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing

Jeremy C. Simpson, Ruth Wellenreuther, Annemarie Poustka, Rainer Pepperkok, Stefan Wiemann

EMBO Rep. 2000 Sep 15; 1(3): 287–292. doi: 10.1093/embo-reports/kvd058

PMCID:: PMC1083732

Abstract Article PDF–375K

Select item 288296120.

Human Chromosome 7: DNA Sequence and Biology

Stephen W. Scherer, Joseph Cheung, Jeffrey R. MacDonald, Lucy R. Osborne, Kazuhiko Nakabayashi, Jo-Anne Herbrick, Andrew R. Carson, Layla Parker-Katiraee, Jennifer Skaug, Razi Khaja, Junjun Zhang, Alexander K. Hudek, Martin Li, May Haddad, Gavin E. Duggan, Bridget A. Fernandez, Emiko Kanematsu, Simone Gentles, Constantine C. Christopoulos, Sanaa Choufani, Dorota Kwasnicka, Xiangqun H. Zheng, Zhongwu Lai, Deborah Nusskern, Qing Zhang, Zhiping Gu, Fu Lu, Susan Zeesman, Malgorzata J. Nowaczyk, Ikuko Teshima, David Chitayat, Cheryl Shuman, Rosanna Weksberg, Elaine H. Zackai, Theresa A. Grebe, Sarah R. Cox, Susan J. Kirkpatrick, Nazneen Rahman, Jan M. Friedman, Henry H. Q. Heng, Pier Giuseppe Pelicci, Francesco Lo-Coco, Elena Belloni, Lisa G. Shaffer, Barbara Pober, Cynthia C. Morton, James F. Gusella, Gail A. P. Bruns, Bruce R. Korf, Bradley J. Quade, Azra H. Ligon, Heather Ferguson, Anne W. Higgins, Natalia T. Leach, Steven R. Herrick, Emmanuelle Lemyre, Chantal G. Farra, Hyung-Goo Kim, Anne M. Summers, Karen W. Gripp, Wendy Roberts, Peter Szatmari, Elizabeth J. T. Winsor, Karl-Heinz Grzeschik, Ahmed Teebi, Berge A. Minassian, Juha Kere, Lluis Armengol, Miguel Angel Pujana, Xavier Estivill, Michael D. Wilson, Ben F. Koop, Sabrina Tosi, Gudrun E. Moore, Andrew P. Boright, Eitan Zlotorynski, Batsheva Kerem, Peter M. Kroisel, Erwin Petek, David G. Oscier, Sarah J. Mould, Hartmut Döhner, Konstanze Döhner, Johanna M. Rommens, John B. Vincent, J. Craig Venter, Peter W. Li, Richard J. Mural, Mark D. Adams, Lap-Chee Tsui

Science. Author manuscript; available in PMC 2010 Jun 9.

Published in final edited form as: Science. 2003 May 2; 300(5620): 767–772. Published online 2003 Apr 10. doi: 10.1126/science.1083423

PMCID:: PMC2882961

Abstract Article PDF–1.2M

PMC

Result Filters

Article attributes

Text availability

Publication date

Custom date range

Research Funder

Additional filters

Display Settings:

Send to:

Links from Gene

Items: 1 to 20 of 39

Display Settings:

Send to:

Supplemental Content

Find related data

Recent activity