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Select item 55167511.

Association of GCLM -588C/T and GCLC -129T/C Promoter Polymorphisms of Genes Coding the Subunits of Glutamate Cysteine Ligase with Ischemic Heart Disease Development in Kazakhstan Population

Liliya Skvortsova, Anastasia Perfelyeva, Elmira Khussainova, Alma Mansharipova, Henry Jay Forman, Leyla Djansugurova

Dis Markers. 2017; 2017: 4209257. Published online 2017 Jul 5. doi: 10.1155/2017/4209257

PMCID:: PMC5516751

Abstract Article PDF–662K

Select item 45185932.

Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase

Anna R. Malik, Ewa Liszewska, Agnieszka Skalecka, Malgorzata Urbanska, Anand M. Iyer, Lukasz J. Swiech, Malgorzata Perycz, Kamil Parobczak, Patrycja Pietruszka, Malgorzata M. Zarebska, Matylda Macias, Katarzyna Kotulska, Julita Borkowska, Wieslawa Grajkowska, Magdalena E. Tyburczy, Sergiusz Jozwiak, David J. Kwiatkowski, Eleonora Aronica, Jacek Jaworski

Acta Neuropathol Commun. 2015; 3: 48. Published online 2015 Jul 30. doi: 10.1186/s40478-015-0225-z

PMCID:: PMC4518593

Abstract Article PDF–1.9M

Select item 43661983.

Knockdown of Glutamate Cysteine Ligase Catalytic Subunit by siRNA Causes the Gold Nanoparticles-Induced Cytotoxicity in Lung Cancer Cells

Min Liu, Yunxue Zhao, Xiumei Zhang

PLoS One. 2015; 10(3): e0118870. Published online 2015 Mar 19. doi: 10.1371/journal.pone.0118870

PMCID:: PMC4366198

Abstract Article PDF–792K

Select item 31034164.

Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study

Karin S Engström, Maria Wennberg, Ulf Strömberg, Ingvar A Bergdahl, Göran Hallmans, Jan-Håkan Jansson, Thomas Lundh, Margareta Norberg, Gerda Rentschler, Bengt Vessby, Staffan Skerfving, Karin Broberg

Environ Health. 2011; 10: 33. Published online 2011 Apr 19. doi: 10.1186/1476-069X-10-33

PMCID:: PMC3103416

Abstract Article PDF–471K

Select item 26749845.

Overexpression of glutamate–cysteine ligase protects human COV434 granulosa tumour cells against oxidative and γ-radiation-induced cell death

Mabel M. Cortes-Wanstreet, Erich Giedzinski, Charles L. Limoli, Ulrike Luderer

Mutagenesis. 2009 May; 24(3): 211–224. Published online 2009 Jan 18. doi: 10.1093/mutage/gen073

PMCID:: PMC2674984

Abstract Article PDF–477K

Select item 15595556.

Schizophrenia and Oxidative Stress: Glutamate Cysteine Ligase Modifier as a Susceptibility Gene

Mirjana Tosic, Jurg Ott, Sandra Barral, Pierre Bovet, Patricia Deppen, Fulvia Gheorghita, Marie-Louise Matthey, Josef Parnas, Martin Preisig, Michael Saraga, Alessandra Solida, Sally Timm, August G. Wang, Thomas Werge, Michel Cuénod, Kim Quang Do

Am J Hum Genet. 2006 Sep; 79(3): 586–592. Published online 2006 Jul 31. doi: 10.1086/507566

PMCID:: PMC1559555

Abstract Article PDF–1.2M

Select item 56999587.

Temporal changes in glutathione biosynthesis during the lipopolysaccharide-induced inflammatory response of THP-1 macrophages

Hongqiao Zhang, Honglei Liu, Lulu Zhou, Jenay Yuen, Henry Jay Forman

Free Radic Biol Med. Author manuscript; available in PMC 2018 Dec 1.

Published in final edited form as: Free Radic Biol Med. 2017 Dec; 113: 304–310. Published online 2017 Oct 7. doi: 10.1016/j.freeradbiomed.2017.10.010

PMCID:: PMC5699958

Abstract Article PDF–680K

Select item 41188198.

Conotruncal Heart Defects and Common Variants in Maternal and Fetal Genes in Folate, Homocysteine and Transsulfuration Pathways

Charlotte A. Hobbs, Mario A. Cleves, Stewart L. MacLeod, Stephen W. Erickson, Xinyu Tang, Jingyun Li, Ming Li, Todd Nick, Sadia Malik, the National Birth Defects Prevention Study

Birth Defects Res A Clin Mol Teratol. Author manuscript; available in PMC 2015 Feb 18.

Published in final edited form as: Birth Defects Res A Clin Mol Teratol. 2014 Feb; 100(2): 116–126. Published online 2014 Feb 18. doi: 10.1002/bdra.23225

PMCID:: PMC4118819

Abstract Article PDF–832K

Select item 30147309.

Post-Translational Modification and Regulation of Glutamate Cysteine Ligase by the α,β-Unsaturated Aldehyde 4-Hydroxy-2-Nonenal (4-HNE)

Donald S. Backos, Kristofer S. Fritz, James R. Roede, Dennis R. Petersen, Christopher C. Franklin

Free Radic Biol Med. Author manuscript; available in PMC 2012 Jan 1.

Published in final edited form as: Free Radic Biol Med. 2011 Jan 1; 50(1): 14–26. Published online 2010 Oct 21. doi: 10.1016/j.freeradbiomed.2010.10.694

PMCID:: PMC3014730

Abstract Article PDF–2.0M

Select item 122001010.

Overexpression of the regulatory subunit of gamma-glutamylcysteine synthetase in HeLa cells increases gamma-glutamylcysteine synthetase activity and confers drug resistance.

S R Tipnis, D G Blake, A G Shepherd, L I McLellan

Biochem J. 1999 Feb 1; 337(Pt 3): 559–566.

PMCID:: PMC1220010

Summary PDF–151K

Select item 492474211.

Nrf2 is the key to chemotherapy resistance in MCF7 breast cancer cells under hypoxia

Jhih-Pu Syu, Jen-Tsan Chi, Hsiu-Ni Kung

Oncotarget. 2016 Mar 22; 7(12): 14659–14672. Published online 2016 Feb 15. doi: 10.18632/oncotarget.7406

PMCID:: PMC4924742

Abstract Article PDF–8.9M

Select item 465752112.

Targeting of Gamma-Glutamyl-Cysteine Ligase by miR-433 Reduces Glutathione Biosynthesis and Promotes TGF-β-Dependent Fibrogenesis

Cristina Espinosa-Diez, Marta Fierro-Fernández, Francisco Sánchez-Gómez, Fernando Rodríguez-Pascual, Matilde Alique, Marta Ruiz-Ortega, Naiara Beraza, Maria L. Martínez-Chantar, Carlos Fernández-Hernando, Santiago Lamas

Antioxid Redox Signal. 2015 Nov 10; 23(14): 1092–1105. doi: 10.1089/ars.2014.6025

PMCID:: PMC4657521

Abstract Article PDF–827K

Select item 399111813.

Upregulation of capacity for glutathione synthesis in response to amino acid deprivation: regulation of glutamate-cysteine ligase subunits

Angelos K. Sikalidis, Kevin M. Mazor, Jeong-In Lee, Heather B. Roman, Lawrence L. Hirschberger, Martha H. Stipanuk

Amino Acids. Author manuscript; available in PMC 2015 May 1.

Published in final edited form as: Amino Acids. 2014 May; 46(5): 1285–1296. Published online 2014 Feb 21. doi: 10.1007/s00726-014-1687-1

PMCID:: PMC3991118

Abstract Article PDF–2.7M

Select item 243022814.

Genetic Variation in Glutathione-Related Genes and Body Burden of Methylmercury

Karin Schläwicke Engström, Ulf Strömberg, Thomas Lundh, Ingegerd Johansson, Bengt Vessby, Göran Hallmans, Staffan Skerfving, Karin Broberg

Environ Health Perspect. 2008 Jun; 116(6): 734–739. Published online 2008 Feb 14. doi: 10.1289/ehp.10804

PMCID:: PMC2430228

Abstract Article PDF–192K

Select item 278516615.

Nrf2-dependent and -independent Responses to Nitro-fatty Acids in Human Endothelial Cells: IDENTIFICATION OF HEAT SHOCK RESPONSE AS THE MAJOR PATHWAY ACTIVATED BY NITRO-OLEIC ACID

Emilia Kansanen, Henna-Kaisa Jyrkkänen, Oscar L. Volger, Hanna Leinonen, Annukka M. Kivelä, Sanna-Kaisa Häkkinen, Steven R. Woodcock, Francisco J. Schopfer, Anton J. Horrevoets, Seppo Ylä-Herttuala, Bruce A. Freeman, Anna-Liisa Levonen

J Biol Chem. 2009 Nov 27; 284(48): 33233–33241. Published online 2009 Oct 5. doi: 10.1074/jbc.M109.064873

PMCID:: PMC2785166

Abstract Article PDF–3.6M

Select item 121991916.

Identification of an important cysteine residue in human glutamate-cysteine ligase catalytic subunit by site-directed mutagenesis.

Z Tu, M W Anders

Biochem J. 1998 Dec 15; 336(Pt 3): 675–680. doi: 10.1042/bj3360675

PMCID:: PMC1219919

Summary PDF–143K

Select item 283736717.

Glutathione Pathway Genetic Polymorphisms and Lung Cancer Survival After Platinum-Based Chemotherapy

Ann M. Moyer, Zhifu Sun, Anthony J. Batzler, Liang Li, Daniel J. Schaid, Ping Yang, Richard M. Weinshilboum

Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2011 Mar 3.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2010 Mar; 19(3): 811–821. Published online 2010 Mar 3. doi: 10.1158/1055-9965.EPI-09-0871

PMCID:: PMC2837367

Abstract Article PDF–1.5M

Select item 312311518.

The BTB and CNC Homology 1 (BACH1) Target Genes Are Involved in the Oxidative Stress Response and in Control of the Cell Cycle

Hans-Jörg Warnatz, Dominic Schmidt, Thomas Manke, Ilaria Piccini, Marc Sultan, Tatiana Borodina, Daniela Balzereit, Wasco Wruck, Alexey Soldatov, Martin Vingron, Hans Lehrach, Marie-Laure Yaspo

J Biol Chem. 2011 Jul 1; 286(26): 23521–23532. Published online 2011 May 9. doi: 10.1074/jbc.M111.220178

PMCID:: PMC3123115

Abstract Article PDF–2.2M

Select item 381232419.

Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans

J L Del-Aguila, A L Beitelshees, R M Cooper-DeHoff, A B Chapman, J G Gums, K Bailey, Y Gong, S T Turner, J A Johnson, E Boerwinkle

Pharmacogenomics J. 2014 Feb; 14(1): 35–40. Published online 2013 Feb 12. doi: 10.1038/tpj.2013.3

PMCID:: PMC3812324

Abstract Article PDF–662K

Select item 979335920.

SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis

Saisai Guo, Xiaobo Lei, Yan Chang, Jianyuan Zhao, Jing Wang, Xiaojing Dong, Qian Liu, Zixiong Zhang, Lidan Wang, Dongrong Yi, Ling Ma, Quanjie Li, Yongxin Zhang, Jiwei Ding, Chen Liang, Xiaoyu Li, Fei Guo, Jianwei Wang, Shan Cen

Signal Transduct Target Ther. 2022; 7: 400. Published online 2022 Dec 27. doi: 10.1038/s41392-022-01239-w