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Select item 77734711.

The Prevalence of the EML4-ALK Fusion Gene in Cytology Specimens from Patients with Lung Adenocarcinoma

Didik S. Heriyanto, Ika Trisnawati, Evan G. Kumara, Vincent Laiman, Fara S. Yuliani, Auliya S. B. Sumpono, Rita Cempaka, Marcellus, Eko Budiono

Pulm Med. 2020; 2020: 3578748. Published online 2020 Dec 23. doi: 10.1155/2020/3578748

PMCID:: PMC7773471

Abstract Article PDF–365K

Select item 47856812.

Ground-glass nodule in a patient with echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK)-positive lung cancer: a case report

Yuki Owada, Atsushi Yonechi, Mitsunori Higuchi, Hiroyuki Suzuki

World J Surg Oncol. 2016; 14: 81. Published online 2016 Mar 10. doi: 10.1186/s12957-016-0841-5

PMCID:: PMC4785681

Abstract Article PDF–1.9M

Select item 43764323.

In vivo imaging models of bone and brain metastases and pleural carcinomatosis with a novel human EML4-ALK lung cancer cell line

Shigeki Nanjo, Takayuki Nakagawa, Shinji Takeuchi, Kenji Kita, Koji Fukuda, Mitsutoshi Nakada, Hisanori Uehara, Hiroshi Nishihara, Eiji Hara, Hidetaka Uramoto, Fumihiro Tanaka, Seiji Yano

Cancer Sci. 2015 Mar; 106(3): 244–252. Published online 2015 Feb 17. doi: 10.1111/cas.12600

PMCID:: PMC4376432

Abstract Article PDF–2.1M

Select item 43508024.

Fluorescence In Situ Hybridization, Immunohistochemistry, and Next-Generation Sequencing for Detection of EML4-ALK Rearrangement in Lung Cancer

Marina Pekar-Zlotin, Fred R. Hirsch, Lior Soussan-Gutman, Maya Ilouze, Addie Dvir, Theresa Boyle, Murry Wynes, Vincent A. Miller, Doron Lipson, Gary A. Palmer, Siraj M. Ali, Shlomi Dekel, Ronen Brenner, Paul A. Bunn, Jr., Nir Peled

Oncologist. 2015 Mar; 20(3): 316–322. Published online 2015 Feb 26. doi: 10.1634/theoncologist.2014-0389

PMCID:: PMC4350802

Abstract Article PDF–1.0M

Select item 105089335.

Clinicopathological and Prognostic Significance of the EML4-ALK Translocation and IGFR1, TTF1, Napsin A Expression in Patients with Lung Adenocarcinoma

Pınar Bulutay, Nalan Akyürek, Leyla Memış

Turk Patoloji Derg. 2021; 37(1): 7–17. Published online 2021 Jan 15. doi: 10.5146/tjpath.2020.01503

PMCID:: PMC10508933

Abstract Article PDF–4.8M

Select item 86470136.

Phase‐separated foci of EML4‐ALK facilitate signalling and depend upon an active kinase conformation

Josephina Sampson, Mark W Richards, Jene Choi, Andrew M Fry, Richard Bayliss

EMBO Rep. 2021 Dec 6; 22(12): e53693. Published online 2021 Oct 18. doi: 10.15252/embr.202153693

PMCID:: PMC8647013

Abstract Article PDF–5.7M

Select item 77276957.

Effective RNA Knockdown Using CRISPR-Cas13a and Molecular Targeting of the EML4-ALK Transcript in H3122 Lung Cancer Cells

Saifullah, Matomo Sakari, Takeshi Suzuki, Seiji Yano, Toshifumi Tsukahara

Int J Mol Sci. 2020 Dec; 21(23): 8904. Published online 2020 Nov 24. doi: 10.3390/ijms21238904

PMCID:: PMC7727695

Abstract Article PDF–4.0M

Select item 70411068.

Identification of anaplastic lymphoma kinase fusions in clear cell renal cell carcinoma

Wei Chen, Wei Li, Bing Bai, Huafeng Wei

Oncol Rep. 2020 Mar; 43(3): 817–826. Published online 2020 Jan 14. doi: 10.3892/or.2020.7462

PMCID:: PMC7041106

Abstract Article PDF–1.2M

Select item 61466129.

Circular RNA F-circEA-2a derived from EML4-ALK fusion gene promotes cell migration and invasion in non-small cell lung cancer

Shuangyan Tan, Dan Sun, Wenchen Pu, Qiheng Gou, Chenglin Guo, Youling Gong, Jiao Li, Yu-Quan Wei, Lunxu Liu, Yun Zhao, Yong Peng

Mol Cancer. 2018; 17: 138. Published online 2018 Sep 20. doi: 10.1186/s12943-018-0887-9

PMCID:: PMC6146612

Abstract Article PDF–2.8M

Select item 599374710.

Circular RNA F-circEA produced from EML4-ALK fusion gene as a novel liquid biopsy biomarker for non-small cell lung cancer

Shuangyan Tan, Qiheng Gou, Wenchen Pu, Chenglin Guo, Yun Yang, Ke Wu, Yaxin Liu, Lunxu Liu, Yu-Quan Wei, Yong Peng

Cell Res. 2018 Jun; 28(6): 693–695. Published online 2018 Apr 8. doi: 10.1038/s41422-018-0033-7

PMCID:: PMC5993747

Article PDF–2.9M

Select item 592837411.

Clinicopathological features of younger (aged ≤ 50 years) lung adenocarcinoma patients harboring the EML4‐ALK fusion gene

Takuro Kometani, Kenji Sugio, Atsushi Osoegawa, Takashi Seto, Yukito Ichinose

Thorac Cancer. 2018 May; 9(5): 563–570. Published online 2018 Mar 8. doi: 10.1111/1759-7714.12616

PMCID:: PMC5928374

Abstract Article PDF–556K

Select item 537791012.

Coupling an EML4-ALK centric interactome with RNA interference identifies sensitizers to ALK inhibitors

Guolin Zhang, Hannah Scarborough, Jihye Kim, Andrii I. Rozhok, Y. Ann Chen, Xiaohui Zhang, Lanxi Song, Yun Bai, Bin Fang, Richard Z. Liu, John Koomen, Aik Choon Tan, James Degregori, Eric B. Haura

Sci Signal. Author manuscript; available in PMC 2017 Oct 18.

Published in final edited form as: Sci Signal. 2016 Oct 18; 9(450): rs12. Published online 2016 Oct 18. doi: 10.1126/scisignal.aaf5011

PMCID:: PMC5377910

Abstract Article PDF–1.3M

Select item 526309613.

Expanded CTCs from a Patient with ALK Positive Lung Cancer Present EML4-ALK Rearrangement along with Resistance Mutation and Enable Drug Sensitivity Testing: A Case Study

Zhuo Zhang, Hiroe Shiratsuchi, Nallasivam Palanisamy, Sunitha Nagrath, Nithya Ramnath

J Thorac Oncol. Author manuscript; available in PMC 2018 Feb 1.

Published in final edited form as: J Thorac Oncol. 2017 Feb; 12(2): 397–402. Published online 2016 Aug 6. doi: 10.1016/j.jtho.2016.07.027

PMCID:: PMC5263096

Abstract Article PDF–512K

Select item 480805214.

Rearranged EML4-ALK fusion transcripts sequester in circulating blood platelets and enable blood-based crizotinib response monitoring in non-small-cell lung cancer

R. Jonas A. Nilsson, Niki Karachaliou, Jordi Berenguer, Ana Gimenez-Capitan, Pepijn Schellen, Cristina Teixido, Jihane Tannous, Justine L. Kuiper, Esther Drees, Magda Grabowska, Marte van Keulen, Danielle A.M. Heideman, Erik Thunnissen, Anne-Marie C. Dingemans, Santiago Viteri, Bakhos A. Tannous, Ana Drozdowskyj, Rafael Rosell, Egbert F. Smit, Thomas Wurdinger

Oncotarget. 2016 Jan 5; 7(1): 1066–1075. Published online 2015 Nov 2. doi: 10.18632/oncotarget.6279

PMCID:: PMC4808052

Abstract Article PDF–1.1M

Select item 476137015.

Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs

Richard Bayliss, Jene Choi, Dean A. Fennell, Andrew M. Fry, Mark W. Richards

Cell Mol Life Sci. 2016 Mar; 73(6): 1209–1224. Published online 2016 Jan 11. doi: 10.1007/s00018-015-2117-6

PMCID:: PMC4761370

Abstract Article PDF–3.0M

Select item 474189316.

Targeting stemness is an effective strategy to control EML4-ALK⁺ non-small cell lung cancer cells

Se Jin Oh, Kyung Hee Noh, Young-Ho Lee, Soon-Oh Hong, Kwon-Ho Song, Hyo-Jung Lee, Soyeon Kim, Tae Min Kim, Ju-Hong Jeon, Jae Hong Seo, Dong-Wan Kim, Tae Woo Kim

Oncotarget. 2015 Nov 24; 6(37): 40255–40267. Published online 2015 Oct 22. doi: 10.18632/oncotarget.5434

PMCID:: PMC4741893

Abstract Article PDF–4.5M

Select item 461345317.

EML4 promotes the loading of NUDC to the spindle for mitotic progression

Dan Chen, Satoko Ito, Hong Yuan, Toshinori Hyodo, Kenji Kadomatsu, Michinari Hamaguchi, Takeshi Senga

Cell Cycle. 2015 May 15; 14(10): 1529–1539. Published online 2015 Mar 19. doi: 10.1080/15384101.2015.1026514

PMCID:: PMC4613453

Abstract Article PDF–1.4M

Select item 433824318.

Clinicopathological Characteristics of Patients with Non-Small-Cell Lung Cancer Who Harbor EML4-ALK Fusion Gene: A Meta-Analysis

Fengzhi Zhao, Meng Xu, Honcho Lei, Ziqi Zhou, Liang Wang, Ping Li, Jianfu Zhao, Penghui Hu

PLoS One. 2015; 10(2): e0117333. Published online 2015 Feb 23. doi: 10.1371/journal.pone.0117333

PMCID:: PMC4338243

Abstract Article PDF–1.2M

Select item 302545119.

EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer

Jussi P. Koivunen, Craig Mermel, Kreshnik Zejnullahu, Carly Murphy, Eugene Lifshits, Alison J. Holmes, Hwan Geun Choi, Jhingook Kim, Derek Chiang, Roman Thomas, Jinseon Lee, William G. Richards, David J. Sugarbaker, Christopher Ducko, Neal Lindeman, J. Paul Marcoux, Jeffrey A. Engelman, Nathanael S. Gray, Charles Lee, Matthew Meyerson, Pasi A. Jänne

Clin Cancer Res. Author manuscript; available in PMC 2011 Jan 24.

Published in final edited form as: Clin Cancer Res. 2008 Jul 1; 14(13): 4275–4283. doi: 10.1158/1078-0432.CCR-08-0168

PMCID:: PMC3025451

Abstract Article PDF–1.3M

Select item 263057320.

EML4-ALK Rearrangement in Non-Small Cell Lung Cancer and Non-Tumor Lung Tissues

Maria Paola Martelli, Gabriella Sozzi, Luis Hernandez, Valentina Pettirossi, Alba Navarro, Davide Conte, Patrizia Gasparini, Federica Perrone, Piergiorgio Modena, Ugo Pastorino, Antonino Carbone, Alessandra Fabbri, Angelo Sidoni, Shigeo Nakamura, Marcello Gambacorta, Pedro Luis Fernández, Jose Ramirez, John K.C. Chan, Walter Franco Grigioni, Elias Campo, Stefano A. Pileri, Brunangelo Falini

Am J Pathol. 2009 Feb; 174(2): 661–670. doi: 10.2353/ajpath.2009.080755

PMCID:: PMC2630573

Abstract Article PDF–1.2M

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PMC Links for Gene (Select 27436) (61)
PMC
PREDICTED: Homo sapiens EMAP like 4 (EML4), transcript variant X3, mRNA
PREDICTED: Homo sapiens EMAP like 4 (EML4), transcript variant X3, mRNA
gi|2217326998|ref|XM_006711992.3|

Nucleotide
echinoderm microtubule-associated protein-like 4 isoform b [Homo sapiens]
echinoderm microtubule-associated protein-like 4 isoform b [Homo sapiens]
gi|1676324813|ref|NP_001138548.2|

Protein
cytochrome oxidase subunit 1, partial (mitochondrion) [Telenomus sp. BIOUG26219-...
cytochrome oxidase subunit 1, partial (mitochondrion) [Telenomus sp. BIOUG26219-A09]
gi|1488057411|gb|AYG89102.1|

Protein

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