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Select item 107254351.

Gα12 signaling regulates transcriptional and phenotypic responses that promote glioblastoma tumor invasion

Olga Meiri Chaim, Shunichiro Miki, Briana C. Prager, Jianhui Ma, Anthony Y. Jeong, Jacqueline Lara, Nancy K. Tran, Jeffrey M. Smith, Jeremy N. Rich, J. Silvio Gutkind, Shigeki Miyamoto, Frank B. Furnari, Joan Heller Brown

Sci Rep. 2023; 13: 22412. Published online 2023 Dec 16. doi: 10.1038/s41598-023-49164-4

PMCID:: PMC10725435

Abstract Article PDF–8.8M

Select item 57155912.

Gα₁₂ facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3‐kinase‐mediated activation in a RhoA‐dependent manner

Edwin J Yoo, Gaoyuan Cao, Cynthia J Koziol‐White, Christie A Ojiaku, Krishna Sunder, Joseph A Jude, James V Michael, Hong Lam, Ivan Pushkarsky, Robert Damoiseaux, Dino Di Carlo, Kwangmi Ahn, Steven S An, Raymond B Penn, Reynold A Panettieri, Jr

Br J Pharmacol. 2017 Dec; 174(23): 4383–4395. Published online 2017 Nov 12. doi: 10.1111/bph.14040

PMCID:: PMC5715591

Abstract Article PDF–1.6M

Select item 46969613.

Galpha12 Protects Vascular Endothelial Cells from Serum Withdrawal-Induced Apoptosis through Regulation of miR-155

Hyeon Jeong Lee, Eun Jig Lee, MiRan Seo

Yonsei Med J. 2016 Jan 1; 57(1): 247–253. Published online 2015 Nov 30. doi: 10.3349/ymj.2016.57.1.247

PMCID:: PMC4696961

Abstract Article PDF–806K

Select item 33388904.

Ga12 Activation in Podocytes Leads to Cumulative Changes in Glomerular Collagen Expression, Proteinuria and Glomerulosclerosis

Ilene Boucher, Wanfeng Yu, Sarah Beaudry, Hideyuki Negoro, Mei Tran, Martin Pollak, Joel Henderson, Bradley M. Denker

Lab Invest. Author manuscript; available in PMC 2012 Nov 1.

Published in final edited form as: Lab Invest. 2012 May; 92(5): 662–675. Published online 2012 Jan 16. doi: 10.1038/labinvest.2011.198

PMCID:: PMC3338890

Abstract Article PDF–2.0M

Select item 32370895.

Translational Analysis of Mouse and Human Placental Protein and mRNA Reveals Distinct Molecular Pathologies in Human Preeclampsia

Brian Cox, Parveen Sharma, Andreas I. Evangelou, Kathie Whiteley, Vladimir Ignatchenko, Alex Ignatchenko, Dora Baczyk, Marie Czikk, John Kingdom, Janet Rossant, Anthony O. Gramolini, S. Lee Adamson, Thomas Kislinger

Mol Cell Proteomics. 2011 Dec; 10(12): M111.012526. Published online 2011 Oct 10. doi: 10.1074/mcp.M111.012526

PMCID:: PMC3237089

Abstract Article PDF–2.8M

Select item 24934596.

Gα12 is targeted to the mitochondria and affects mitochondrial morphology and motility

Alexandra V. Andreeva, Mikhail A. Kutuzov, Tatyana A. Voyno-Yasenetskaya

FASEB J. 2008 Aug; 22(8): 2821–2831. doi: 10.1096/fj.07-104224

PMCID:: PMC2493459

Abstract Article

Select item 14724487.

The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis

Patrick Kelly, Benjamin J. Moeller, Juhi Juneja, Michelle A. Booden, Channing J. Der, Yehia Daaka, Mark W. Dewhirst, Timothy A. Fields, Patrick J. Casey

Proc Natl Acad Sci U S A. 2006 May 23; 103(21): 8173–8178. Published online 2006 May 16. doi: 10.1073/pnas.0510254103

PMCID:: PMC1472448

Abstract Article PDF–1.0M

Select item 3589588.

Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product.

A M Chan, T P Fleming, E S McGovern, M Chedid, T Miki, S A Aaronson

Mol Cell Biol. 1993 Feb; 13(2): 762–768. doi: 10.1128/mcb.13.2.762

PMCID:: PMC358958

Summary Page Browse PDF–2.0M

Select item 61539909.

c-Jun Contributes to Transcriptional Control of GNA12 Expression in Prostate Cancer Cells

Udhaya Kumari Udayappan, Patrick J. Casey

Molecules. 2017 Apr; 22(4): 612. Published online 2017 Apr 10. doi: 10.3390/molecules22040612

PMCID:: PMC6153990

Abstract Article PDF–1.6M

Select item 415245710.

A yeast screening method to decipher the interaction between the adenosine A_2B receptor and the C-terminus of different G protein α-subunits

Rongfang Liu, Nick J. A. Groenewoud, Miriam C. Peeters, Eelke B. Lenselink, Ad P. IJzerman

Purinergic Signal. 2014 Sep; 10(3): 441–453. Published online 2014 Jan 26. doi: 10.1007/s11302-014-9407-6

PMCID:: PMC4152457

Abstract Article PDF–1.4M

Select item 399227111.

The gep proto-oncogene Gα₁₂ mediates LPA-stimulated activation of CREB in ovarian cancer cells

Ji Hee Ha, Jeremy D. Ward, Lakshmi Varadarajalu, Danny N. Dhanasekaran

Cell Signal. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: Cell Signal. 2014 Jan; 26(1): 122–132. Published online 2013 Sep 19. doi: 10.1016/j.cellsig.2013.08.012

PMCID:: PMC3992271

Abstract Article PDF–3.9M

Select item 321011712.

G12 Signaling through c-Jun NH₂-Terminal Kinase Promotes Breast Cancer Cell Invasion

Juhi Juneja, Ian Cushman, Patrick J. Casey

PLoS One. 2011; 6(11): e26085. Published online 2011 Nov 7. doi: 10.1371/journal.pone.0026085

PMCID:: PMC3210117

Abstract Article PDF–1.1M

Select item 314331213.

G-protein alpha-s and -12 subunits are involved in androgen-stimulated PI3K activation and androgen receptor transactivation in prostate cancer cells

Jianjun Liu, Hyewon Youn, Jun Yang, Ningchao Du, Jihong Liu, Hongwei Liu, Benyi Li

Prostate. Author manuscript; available in PMC 2012 Sep 1.

Published in final edited form as: Prostate. 2011 Sep; 71(12): 1276–1286. Published online 2011 Feb 9. doi: 10.1002/pros.21345

PMCID:: PMC3143312

Abstract Article PDF–1.0M

Select item 299805914.

Identification of Polycystin-1 and Gα12 Binding Regions Necessary for Regulation of Apoptosis

Wanfeng Yu, Benjamin J. Ritchie, Xuefeng Su, Jing Zhou, Thomas E. Meigs, Bradley M. Denker

Cell Signal. Author manuscript; available in PMC 2012 Jan 1.

Published in final edited form as: Cell Signal. 2011 Jan; 23(1): 213–221. Published online 2010 Sep 17. doi: 10.1016/j.cellsig.2010.09.005

PMCID:: PMC2998059

Abstract Article PDF–938K

Select item 279525315.

Role of G12 proteins in oncogenesis and metastasis

Juhi Juneja, Patrick J Casey

Br J Pharmacol. 2009 Sep; 158(1): 32–40. Published online 2009 Apr 30. doi: 10.1111/j.1476-5381.2009.00180.x

PMCID:: PMC2795253

Abstract Article PDF–228K

Select item 279524716.

Regulation of RhoGEF proteins by G_12/13-coupled receptors

Sandra Siehler

Br J Pharmacol. 2009 Sep; 158(1): 41–49. Published online 2009 Feb 18. doi: 10.1111/j.1476-5381.2009.00121.x

PMCID:: PMC2795247

Abstract Article PDF–401K

Select item 259988017.

P2Y₆ receptor-Gα_12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis

Motohiro Nishida, Yoji Sato, Aya Uemura, Yusuke Narita, Hidetoshi Tozaki-Saitoh, Michio Nakaya, Tomomi Ide, Kazuhiro Suzuki, Kazuhide Inoue, Taku Nagao, Hitoshi Kurose

EMBO J. 2008 Dec 3; 27(23): 3104–3115. Published online 2008 Nov 13. doi: 10.1038/emboj.2008.237

PMCID:: PMC2599880

Abstract Article PDF–1.0M

Select item 47856918.

A role for Gα₁₂/Gα₁₃ in p120^ctn regulation

Beate F. Krakstad, Vandana V. Ardawatia, Anna M. Aragay

Proc Natl Acad Sci U S A. 2004 Jul 13; 101(28): 10314–10319. Published online 2004 Jul 6. doi: 10.1073/pnas.0401366101

PMCID:: PMC478569

Abstract Article PDF–483K

Select item 799004119.

G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3

Signe Mathiasen, Tiago Palmisano, Nicole A. Perry, Hannah M. Stoveken, Alex Vizurraga, Dyke P. McEwen, Najeah Okashah, Tobias Langenhan, Asuka Inoue, Nevin A. Lambert, Gregory G. Tall, Jonathan A. Javitch

Nat Chem Biol. Author manuscript; available in PMC 2021 Mar 24.

Published in final edited form as: Nat Chem Biol. 2020 Dec; 16(12): 1343–1350. Published online 2020 Aug 10. doi: 10.1038/s41589-020-0617-7