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Select item 112292101.

Emerging role of glutathione peroxidase 4 in myeloid cell lineage development and acute myeloid leukemia

Patrick Auberger, Cécile Favreau, Coline Savy, Arnaud Jacquel, Guillaume Robert

Cell Mol Biol Lett. 2024; 29: 98. Published online 2024 Jul 8. doi: 10.1186/s11658-024-00613-6

PMCID:: PMC11229210

Abstract Article PDF–1.9M

Select item 109589022.

Hypermethylation of the glutathione peroxidase 4 gene promoter is associated with the occurrence of immune tolerance phase in chronic hepatitis B

Xing Su, Zhaohui Wang, Jihui Li, Shuai Gao, Yuchen Fan, Kai Wang

Virol J. 2024; 21: 72. Published online 2024 Mar 21. doi: 10.1186/s12985-024-02346-6

PMCID:: PMC10958902

Abstract Article PDF–2.2M

Select item 107275523.

Serum glutathione peroxidase 4 as a novel biomarker for nontraumatic osteonecrosis of the femoral head: A retrospective case-control study

Qiang Zhao, Jianhong Dong, Shiying Wang, Biaofang Wei

Medicine (Baltimore) 2023 Dec 15; 102(50): e36202. Published online 2023 Dec 15. doi: 10.1097/MD.0000000000036202

PMCID:: PMC10727552

Abstract Article PDF–983K

Select item 107266164.

Lens epithelium cell ferroptosis mediated by m⁶A-lncRNA and GPX4 expression in lens tissue of age-related cataract

Yong Wang, Pengfei Li, Congyu Wang, Sijie Bao, Siwen Wang, Guowei Zhang, Xi Zou, Jian Wu, Yu Guan, Min Ji, Huaijin Guan

BMC Ophthalmol. 2023; 23: 514. Published online 2023 Dec 18. doi: 10.1186/s12886-023-03205-8

PMCID:: PMC10726616

Abstract Article PDF–2.6M

Select item 98766275.

Increased expression of GPX4 promotes the tumorigenesis of thyroid cancer by inhibiting ferroptosis and predicts poor clinical outcomes

Huanjie Chen, Fang Peng, Jingchao Xu, Guangzhi Wang, Yongfu Zhao

Aging (Albany NY) 2023 Jan 15; 15(1): 230–245. Published online 2023 Jan 9. doi: 10.18632/aging.204473

PMCID:: PMC9876627

Abstract Article PDF–2.1M

Select item 98642186.

Prospects for Anti-Tumor Mechanism and Potential Clinical Application Based on Glutathione Peroxidase 4 Mediated Ferroptosis

Mingliang Chen, Zhihao Shi, Yuqiu Sun, Haoran Ning, Xinyu Gu, Lei Zhang

Int J Mol Sci. 2023 Jan; 24(2): 1607. Published online 2023 Jan 13. doi: 10.3390/ijms24021607

PMCID:: PMC9864218

Abstract Article PDF–6.0M

Select item 97788527.

The Role of rs713041 Glutathione Peroxidase 4 (GPX4) Single Nucleotide Polymorphism on Disease Susceptibility in Humans: A Systematic Review and Meta-Analysis

Priscila Barbosa, Nada F. Abo El-Magd, John Hesketh, Giovanna Bermano

Int J Mol Sci. 2022 Dec; 23(24): 15762. Published online 2022 Dec 12. doi: 10.3390/ijms232415762

PMCID:: PMC9778852

Abstract Article PDF–2.0M

Select item 97057098.

Glutathione peroxidase 4 expression predicts poor overall survival in patients with resected lung adenocarcinoma

Chao-Yu Liu, Chen-Chi Liu, Anna Fen-Yau Li, Tien-Wei Hsu, Jiun-Han Lin, Shih-Chieh Hung, Han-Shui Hsu

Sci Rep. 2022; 12: 20462. Published online 2022 Nov 28. doi: 10.1038/s41598-022-25019-2

PMCID:: PMC9705709

Abstract Article PDF–2.1M

Select item 96534799.

Glutathione peroxidase 4 inhibition induces ferroptosis and mTOR pathway suppression in thyroid cancer

Konjeti R. Sekhar, David N. Hanna, Sriram Cyr, Jordan J. Baechle, Sudhakiranmayi Kuravi, Ramesh Balusu, Kimryn Rathmell, Naira Baregamian

Sci Rep. 2022; 12: 19396. Published online 2022 Nov 12. doi: 10.1038/s41598-022-23906-2

PMCID:: PMC9653479

Abstract Article PDF–2.5M

Select item 958169310.

Glutathione Peroxidase 4 Is a Predictor of Diabetic Kidney Disease Progression in Type 2 Diabetes Mellitus

Yi-hui Wang, Dong-yuan Chang, Ming-hui Zhao, Min Chen

Oxid Med Cell Longev. 2022; 2022: 2948248. Published online 2022 Oct 12. doi: 10.1155/2022/2948248

PMCID:: PMC9581693

Abstract Article PDF–1.4M

Select item 934600311.

EBV infection-induced GPX4 promotes chemoresistance and tumor progression in nasopharyngeal carcinoma

Li Yuan, Shibing Li, Qiuyan Chen, Tianliang Xia, Donghua Luo, Liangji Li, Sailan Liu, Shanshan Guo, Liting Liu, Chaochao Du, Guodong Jia, Xiaoyun Li, Zijian Lu, Zhenchong Yang, Huanliang Liu, Haiqiang Mai, Linquan Tang

Cell Death Differ. 2022 Aug; 29(8): 1513–1527. Published online 2022 Feb 1. doi: 10.1038/s41418-022-00939-8

PMCID:: PMC9346003

Abstract Article PDF–15M

Select item 897388912.

Platycodin D regulates high glucose-induced ferroptosis of HK-2 cells through glutathione peroxidase 4 (GPX4)

Jinzhong Huang, Gangyi Chen, Jilei Wang, Shibin Liu, Jing Su

Bioengineered. 2022; 13(3): 6627–6637. Published online 2022 Feb 28. doi: 10.1080/21655979.2022.2045834

PMCID:: PMC8973889

Abstract Article PDF–3.2M

Select item 847364513.

Glutathione peroxidase 4‐dependent glutathione high‐consumption drives acquired platinum chemoresistance in lung cancer‐derived brain metastasis

Wenwen Liu, Yang Zhou, Wenzhe Duan, Jing Song, Song Wei, Shengkai Xia, Yingyan Wang, Xiaohui Du, Encheng Li, Caixia Ren, Wei Wang, Qimin Zhan, Qi Wang

Clin Transl Med. 2021 Sep; 11(9): e517. Published online 2021 Sep 26. doi: 10.1002/ctm2.517

PMCID:: PMC8473645

Abstract Article PDF–5.2M

Select item 832243514.

Red blood cells contain enzymatically active GPx4 whose abundance anticorrelates with hemolysis during blood bank storage

Jeffrey M. Stolwijk, Jonathan A. Stefely, Mike T. Veling, Thomas J. van ‘t Erve, Brett A. Wagner, Thomas J. Raife, Garry R. Buettner

Redox Biol. 2021 Oct; 46: 102073. Published online 2021 Jul 16. doi: 10.1016/j.redox.2021.102073

PMCID:: PMC8322435

Abstract Article PDF–4.6M

Select item 769957515.

Ferroptosis Mechanisms Involved in Neurodegenerative Diseases

Cadiele Oliana Reichert, Fábio Alessandro de Freitas, Juliana Sampaio-Silva, Leonardo Rokita-Rosa, Priscila de Lima Barros, Debora Levy, Sérgio Paulo Bydlowski

Int J Mol Sci. 2020 Nov; 21(22): 8765. Published online 2020 Nov 20. doi: 10.3390/ijms21228765

PMCID:: PMC7699575

Abstract Article PDF–2.6M

Select item 768690916.

A new role of glutathione peroxidase 4 during human erythroblast enucleation

Hakim Ouled-Haddou, Kahia Messaoudi, Yohann Demont, Rogiéro Lopes dos Santos, Candice Carola, Alexis Caulier, Pascal Vong, Nicolas Jankovsky, Delphine Lebon, Alexandre Willaume, Julien Demagny, Thomas Boyer, Jean-Pierre Marolleau, Jacques Rochette, Loïc Garçon

Blood Adv. 2020 Nov 24; 4(22): 5666–5680. Published online 2020 Nov 19. doi: 10.1182/bloodadvances.2020003100

PMCID:: PMC7686909

Abstract Article PDF–1.8M

Select item 740037217.

Association between the Genetic Variants of Glutathione Peroxidase 4 and Severity of Endometriosis

Yun-Yao Huang, Cheng-Hsuan Wu, Chung-Hsien Liu, Shun-Fa Yang, Po-Hui Wang, Long-Yao Lin, Tsung-Hsien Lee, Maw-Sheng Lee

Int J Environ Res Public Health. 2020 Jul; 17(14): 5089. Published online 2020 Jul 15. doi: 10.3390/ijerph17145089

PMCID:: PMC7400372

Abstract Article PDF–303K

Select item 596287518.

Targeting dependency on the GPX4 lipid peroxide repair pathway for cancer therapy

Hengrui Liu, Stuart L Schreiber, Brent R. Stockwell

Biochemistry. Author manuscript; available in PMC 2019 Apr 10.

Published in final edited form as: Biochemistry. 2018 Apr 10; 57(14): 2059–2060. Published online 2018 Mar 27. doi: 10.1021/acs.biochem.8b00307

PMCID:: PMC5962875

Article PDF–421K

Select item 589967419.

FINO₂ Initiates Ferroptosis Through GPX4 Inactivation and Iron Oxidation

Michael M. Gaschler, Alexander A. Andia, Hengrui Liu, Joleen M. Csuka, Brisa Hurlocker, Christopher A. Vaiana, Daniel W. Heindel, Dylan S. Zuckerman, Pieter H. Bos, Eduard Reznik, Lingplak Ye, Yulia Y. Tyurina, Annie J. Lin, Mikhail S. Shchepinov, Amy Y. Chan, Eveliz Peguero-Pereira, Maksim A. Fomich, Jacob. D. Daniels, Andrei V. Bekish, Vadim V. Shmanai, Valerian E. Kagan, Lara K. Mahal, Keith A. Woerpel, Brent R. Stockwell

Nat Chem Biol. Author manuscript; available in PMC 2018 Oct 2.

Published in final edited form as: Nat Chem Biol. 2018 May; 14(5): 507–515. Published online 2018 Apr 2. doi: 10.1038/s41589-018-0031-6

PMCID:: PMC5899674

Abstract Article PDF–885K

Select item 502755920.

Evaluation of Glutathione Peroxidase 4 role in Preeclampsia

Xinguo Peng, Yan Lin, Jinling Li, Mengchun Liu, Jingli Wang, Xueying Li, Jingjing Liu, Xuewen Jia, Zhongcui Jing, Zuzhou Huang, Kaiqiu Chu, Shiguo Liu

Sci Rep. 2016; 6: 33300. Published online 2016 Sep 19. doi: 10.1038/srep33300

PMCID:: PMC5027559

Abstract Article PDF–330K

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