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Items: 1 to 20 of 24

1.
Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer’s disease
A-Ryeong Gwon, Jong-Sung Park, Thiruma V. Arumugam, Yong-Kook Kwon, Sic L. Chan, Seol-Hee Kim, Sang-Ha Baik, Sunghee Yang, Young-Kwang Yun, Yuri Choi, Saerom Kim, Sung-Chun Tang, Dong-Hoon Hyun, Aiwu Cheng, Charles E. Dann, III, Michel Bernier, Jaewon Lee, William R. Markesbery, Mark P. Mattson, Dong-Gyu Jo
Aging Cell. Author manuscript; available in PMC 2014 Nov 3.
Published in final edited form as: Aging Cell. 2012 Aug; 11(4): 559–568. Published online 2012 Apr 9. doi: 10.1111/j.1474-9726.2012.00817.x
PMCID:
PMC4217088
AbstractArticlePDF–3.4M
2.
Synaptic function of nicastrin in hippocampal neurons
Sang Hun Lee, Manu Sharma, Thomas C. Südhof, Jie Shen
Proc Natl Acad Sci U S A. 2014 Jun 17; 111(24): 8973–8978. Published online 2014 Jun 2. doi: 10.1073/pnas.1408554111
PMCID:
PMC4066509
AbstractArticlePDF–1.1M
3.
Deep Sequencing of the Nicastrin Gene in Pooled DNA, the Identification of Genetic Variants That Affect Risk of Alzheimer's Disease
Michelle K. Lupton, Petroula Proitsi, Makrina Danillidou, Magda Tsolaki, Gillian Hamilton, Richard Wroe, Megan Pritchard, Kathryn Lord, Belinda M. Martin, Iwona Kloszewska, Hilkka Soininen, Patrizia Mecocci, Bruno Vellas, Denise Harold, Paul Hollingworth, Simon Lovestone, John F. Powell
PLoS One. 2011; 6(2): e17298. Published online 2011 Feb 25. doi: 10.1371/journal.pone.0017298
PMCID:
PMC3045431
AbstractArticlePDF–214K
4.
Cellular distribution of γ-secretase subunit nicastrin in the developing and adult rat brains
A. Kodam, K.S. Vetrivel, G. Thinakaran, S. Kar
Neurobiol Aging. Author manuscript; available in PMC 2010 May 16.
Published in final edited form as: Neurobiol Aging. 2008 May; 29(5): 724–738. Published online 2007 Jan 12. doi: 10.1016/j.neurobiolaging.2006.12.005
PMCID:
PMC2871253
AbstractArticlePDF–1.8M
5.
The Gene Encoding Nicastrin, a Major γ-Secretase Component, Modifies Risk for Familial Early-Onset Alzheimer Disease in a Dutch Population-Based Sample
Bart Dermaut, Jessie Theuns, Kristel Sleegers, Hiroshi Hasegawa, Marleen Van den Broeck, Krist'l Vennekens, Ellen Corsmit, Peter St. George-Hyslop, Marc Cruts, Cornelia M. van Duijn, Christine Van Broeckhoven
Am J Hum Genet. 2002 Jun; 70(6): 1568–1574. Published online 2002 Apr 24. doi: 10.1086/340732
PMCID:
PMC379144
AbstractArticlePDF–145K
6.
Vitamin D receptor is present on the neuronal plasma membrane and is co-localized with amyloid precursor protein, ADAM10 or Nicastrin
Erdinç Dursun, Duygu Gezen-Ak
PLoS One. 2017; 12(11): e0188605. Published online 2017 Nov 27. doi: 10.1371/journal.pone.0188605
PMCID:
PMC5703467
AbstractArticlePDF–9.7M
7.
Loss of Nicastrin from Oligodendrocytes Results in Hypomyelination and Schizophrenia with Compulsive Behavior
Daniel R. Dries, Yi Zhu, Mieu M. Brooks, Diego A. Forero, Megumi Adachi, Basar Cenik, James M. West, Yu-Hong Han, Cong Yu, Jennifer Arbella, Annelie Nordin, Rolf Adolfsson, Jurgen Del-Favero, Q. Richard Lu, Patrick Callaerts, Shari G. Birnbaum, Gang Yu
J Biol Chem. 2016 May 27; 291(22): 11647–11656. Published online 2016 Mar 23. doi: 10.1074/jbc.M116.715078
PMCID:
PMC4882434
AbstractArticlePDF–2.1M
8.
Conditional Forebrain Inactivation of Nicastrin Causes Progressive Memory Impairment and Age-Related Neurodegeneration
Katsuhiko Tabuchi, Guiquan Chen, Thomas C. Südhof, Jie Shen
J Neurosci. 2009 Jun 3; 29(22): 7290–7301. doi: 10.1523/JNEUROSCI.1320-09.2009
PMCID:
PMC2719251
AbstractArticlePDF–2.9M
9.
Proteomic and Metabolomic Analyses of Mitochondrial Complex I-deficient Mouse Model Generated by Spontaneous B2 Short Interspersed Nuclear Element (SINE) Insertion into NADH Dehydrogenase (Ubiquinone) Fe-S Protein 4 (Ndufs4) Gene
Dillon W. Leong, Jasper C. Komen, Chelsee A. Hewitt, Estelle Arnaud, Matthew McKenzie, Belinda Phipson, Melanie Bahlo, Adrienne Laskowski, Sarah A. Kinkel, Gayle M. Davey, William R. Heath, Anne K. Voss, René P. Zahedi, James J. Pitt, Roman Chrast, Albert Sickmann, Michael T. Ryan, Gordon K. Smyth, David R. Thorburn, Hamish S. Scott
J Biol Chem. 2012 Jun 8; 287(24): 20652–20663. Published online 2012 Apr 25. doi: 10.1074/jbc.M111.327601
PMCID:
PMC3370248
AbstractArticlePDF–2.6M
10.
Synaptic and Endosomal Localization of Active γ-Secretase in Rat Brain
Susanne Frykman, Ji-Yeun Hur, Jenny Frånberg, Mikio Aoki, Bengt Winblad, Jarmila Nahalkova, Homira Behbahani, Lars O. Tjernberg
PLoS One. 2010; 5(1): e8948. Published online 2010 Jan 28. doi: 10.1371/journal.pone.0008948
PMCID:
PMC2812513
AbstractArticlePDF–1.6M
11.
Moderate Reduction of γ-Secretase Attenuates Amyloid Burden and Limits Mechanism-Based Liabilities
Tong Li, Hongjin Wen, Cory Brayton, Fiona M. Laird, Guojun Ma, Shiwen Peng, Lisa Placanica, T. C. Wu, Barbara J. Crain, Donald L. Price, Charles G. Eberhart, Philip C. Wong
J Neurosci. 2007 Oct 3; 27(40): 10849–10859. doi: 10.1523/JNEUROSCI.2152-07.2007
PMCID:
PMC6672827
AbstractArticlePDF–665K
12.
Three-dimensional structure of human γ-secretase
Peilong Lu, Xiao-chen Bai, Dan Ma, Tian Xie, Chuangye Yan, Linfeng Sun, Guanghui Yang, Yanyu Zhao, Rui Zhou, Sjors H.W. Scheres, Yigong Shi
Nature. Author manuscript; available in PMC 2015 Feb 14.
Published in final edited form as: Nature. 2014 Aug 14; 512(7513): 166–170. Published online 2014 Jun 29. doi: 10.1038/nature13567
PMCID:
PMC4134323
AbstractArticlePDF–2.6M
13.
Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates
Gael Barthet, Junichi Shioi, Zhiping Shao, Yimin Ren, Anastasios Georgakopoulos, Nikolaos K. Robakis
FASEB J. 2011 Sep; 25(9): 2937–2946. doi: 10.1096/fj.11-183806
PMCID:
PMC3157694
AbstractArticle
14.
An atomic structure of human γ-secretase
Xiao-chen Bai, Chuangye Yan, Guanghui Yang, Peilong Lu, Dan Ma, Linfeng Sun, Rui Zhou, Sjors H.W. Scheres, Yigong Shi
Nature. Author manuscript; available in PMC 2016 Mar 10.
Published in final edited form as: Nature. 2015 Sep 10; 525(7568): 212–217. Published online 2015 Aug 17. doi: 10.1038/nature14892
PMCID:
PMC4568306
AbstractArticlePDF–6.7M
15.
Association of γ-Secretase with Lipid Rafts in Post-Golgi and Endosome Membranes
Kulandaivelu S. Vetrivel, Haipeng Cheng, William Lin, Takashi Sakurai, Tong Li, Nobuyuki Nukina, Philip C. Wong, Huaxi Xu, Gopal Thinakaran
J Biol Chem. Author manuscript; available in PMC 2005 Sep 13.
Published in final edited form as: J Biol Chem. 2004 Oct 22; 279(43): 44945–44954. Published online 2004 Aug 17. doi: 10.1074/jbc.M407986200
PMCID:
PMC1201506
AbstractArticlePDF–784K
16.
APH-1a Is the Principal Mammalian APH-1 Isoform Present in γ-Secretase Complexes during Embryonic Development
Guojun Ma, Tong Li, Donald L. Price, Philip C. Wong
J Neurosci. 2005 Jan 5; 25(1): 192–198. doi: 10.1523/JNEUROSCI.3814-04.2005
PMCID:
PMC6725209
AbstractArticlePDF–351K
17.
Down-regulation of the ATP-binding Cassette Transporter 2 (Abca2) Reduces Amyloid-β Production by Altering Nicastrin Maturation and Intracellular Localization
Vasiliki Michaki, Francesc X. Guix, Krist'l Vennekens, Sebastian Munck, Colin Dingwall, John B. Davis, Danyelle M. Townsend, Kenneth D. Tew, Fabian Feiguin, Bart De Strooper, Carlos G. Dotti, Tina Wahle
J Biol Chem. 2012 Jan 6; 287(2): 1100–1111. Published online 2011 Nov 15. doi: 10.1074/jbc.M111.288258
PMCID:
PMC3256850
AbstractArticlePDF–2.1M
18.
Spatial Segregation of γ-Secretase and Substrates in Distinct Membrane Domains
Kulandaivelu S. Vetrivel, Haipeng Cheng, Seong-Hun Kim, Ying Chen, Natalie Y. Barnes, Ange‘le T. Parent, Sangram S. Sisodia, Gopal Thinakaran
J Biol Chem. Author manuscript; available in PMC 2005 Sep 13.
Published in final edited form as: J Biol Chem. 2005 Jul 8; 280(27): 25892–25900. Published online 2005 May 10. doi: 10.1074/jbc.M503570200
PMCID:
PMC1201532
AbstractArticlePDF–657K
19.
An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease
Yasuhiko Kizuka, Shinobu Kitazume, Reiko Fujinawa, Takashi Saito, Nobuhisa Iwata, Takaomi C Saido, Miyako Nakano, Yoshiki Yamaguchi, Yasuhiro Hashimoto, Matthias Staufenbiel, Hiroyuki Hatsuta, Shigeo Murayama, Hiroshi Manya, Tamao Endo, Naoyuki Taniguchi
EMBO Mol Med. 2015 Feb; 7(2): 175–189. Published online 2015 Jan 15. doi: 10.15252/emmm.201404438
PMCID:
PMC4328647
AbstractArticlePDF–2.3M
20.
Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled α-subunits
Christina Valkova, Marina Albrizio, Ira V. Röder, Michael Schwake, Romeo Betto, Rüdiger Rudolf, Christoph Kaether
Proc Natl Acad Sci U S A. 2011 Jan 11; 108(2): 621–625. Published online 2010 Dec 27. doi: 10.1073/pnas.1001624108
PMCID:
PMC3021032
AbstractArticlePDF–443K

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