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Items: 1 to 20 of 41

1.
A complex immunodeficiency is based on U1 snRNP-mediated poly(A) site suppression
Jörg Langemeier, Eva-Maria Schrom, Alona Rabner, Maximilian Radtke, Daniela Zychlinski, Anna Saborowski, Georg Bohn, Yael Mandel-Gutfreund, Jochen Bodem, Christoph Klein, Jens Bohne
EMBO J. 2012 Oct 17; 31(20): 4035–4044. Published online 2012 Sep 11. doi: 10.1038/emboj.2012.252
PMCID:
PMC3474926
AbstractArticlePDF–630K
2.
Polymorphisms in the Gene Regions of the Adaptor Complex LAMTOR2/LAMTOR3 and Their Association with Breast Cancer Risk
Mariana E. De Araujo, Gertraud Erhart, Katharina Buck, Elisabeth Müller-Holzner, Michael Hubalek, Heidelinde Fiegl, Daniele Campa, Federico Canzian, Ursula Eilber, Jenny Chang-Claude, Stefan Coassin, Margot Haun, Lyudmyla Kedenko, Bernhard Paulweber, Roland Reitsamer, Irmgard Himmel, Dieter Flesch-Janys, Claudia Lamina, Florian Kronenberg, Lukas A. Huber, Anita Kloss-Brandstätter
PLoS One. 2013; 8(1): e53768. Published online 2013 Jan 16. doi: 10.1371/journal.pone.0053768
PMCID:
PMC3547070
AbstractArticlePDF–239K
3.
VSIG2 promotes malignant progression of pancreatic ductal adenocarcinoma by enhancing LAMTOR2-mediated mTOR activation
Jichuan Xu, Gang Quan, Wei Huang, Jianxin Jiang
Cell Commun Signal. 2023; 21: 223. Published online 2023 Aug 25. doi: 10.1186/s12964-023-01209-x
PMCID:
PMC10463957
AbstractArticlePDF–13M
4.
The late endosomal adaptor molecule p14 (LAMTOR2) represents a novel regulator of Langerhans cell homeostasis
Florian Sparber, Julia M. Scheffler, Nicole Amberg, Christoph H. Tripp, Valeska Heib, Martin Hermann, Sonja P. Zahner, Björn E. Clausen, Boris Reizis, Lukas A. Huber, Patrizia Stoitzner, Nikolaus Romani
Blood. 2014 Jan 9; 123(2): 217–227. Prepublished online 2013 Oct 3. doi: 10.1182/blood-2013-08-518555
PMCID:
PMC3888288
AbstractArticle
5.
Structural basis for the assembly of the Ragulator-Rag GTPase complex
Ryo Yonehara, Shigeyuki Nada, Tomokazu Nakai, Masahiro Nakai, Ayaka Kitamura, Akira Ogawa, Hirokazu Nakatsumi, Keiichi I. Nakayama, Songling Li, Daron M. Standley, Eiki Yamashita, Atsushi Nakagawa, Masato Okada
Nat Commun. 2017; 8: 1625. Published online 2017 Nov 20. doi: 10.1038/s41467-017-01762-3
PMCID:
PMC5696360
AbstractArticlePDF–6.3M
6.
Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1
Tianlong Zhang, Rong Wang, Zhijing Wang, Xiangxiang Wang, Fang Wang, Jianping Ding
Nat Commun. 2017; 8: 1394. Published online 2017 Nov 9. doi: 10.1038/s41467-017-01567-4
PMCID:
PMC5680233
AbstractArticlePDF–3.1M
7.
Simulating EGFR-ERK Signaling Control by Scaffold Proteins KSR and MP1 Reveals Differential Ligand-Sensitivity Co-Regulated by Cbl-CIN85 and Endophilin
Lu Huang, Catherine Qiurong Pan, Baowen Li, Lisa Tucker-Kellogg, Bruce Tidor, Yuzong Chen, Boon Chuan Low
PLoS One. 2011; 6(8): e22933. Published online 2011 Aug 1. doi: 10.1371/journal.pone.0022933
PMCID:
PMC3148240
AbstractArticlePDF–2.0M
8.
A Novel 14-Kilodalton Protein Interacts with the Mitogen-Activated Protein Kinase Scaffold Mp1 on a Late Endosomal/Lysosomal Compartment
Winfried Wunderlich, Irene Fialka, David Teis, Arno Alpi, Andrea Pfeifer, Robert G. Parton, Friedrich Lottspeich, Lukas A. Huber
J Cell Biol. 2001 Feb 19; 152(4): 765–776. doi: 10.1083/jcb.152.4.765
PMCID:
PMC2195784
AbstractArticlePDF–940K
9.
Structural basis for the docking of mTORC1 on the lysosomal surface
Kacper B. Rogala, Xin Gu, Jibril F. Kedir, Monther Abu-Remaileh, Laura F. Bianchi, Alexia M. S. Bottino, Rikke Dueholm, Anna Niehaus, Daan Overwijn, Ange-Célia Priso Fils, Sherry X. Zhou, Daniel Leary, Nouf N. Laqtom, Edward J. Brignole, David M. Sabatini
Science. Author manuscript; available in PMC 2020 Apr 22.
Published in final edited form as: Science. 2019 Oct 25; 366(6464): 468–475. Published online 2019 Oct 10. doi: 10.1126/science.aay0166
PMCID:
PMC7176403
AbstractArticlePDF–2.8M
10.
Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation
Rachel M. Jansen, Roberta Peruzzo, Simon A. Fromm, Adam L. Yokom, Roberto Zoncu, James H. Hurley
Sci Adv. 2022 Sep; 8(37): eadd2926. Published online 2022 Sep 14. doi: 10.1126/sciadv.add2926
PMCID:
PMC9473554
AbstractArticlePDF–3.2M
11.
The amino acid transporter SLC38A9 is a key component of a lysosomal membrane complex that signals arginine sufficiency to mTORC1
Shuyu Wang, Zhi-Yang Tsun, Rachel Wolfson, Kuang Shen, Gregory A. Wyant, Molly E. Plovanich, Elizabeth D. Yuan, Tony D. Jones, Lynne Chantranupong, William Comb, Tim Wang, Liron Bar-Peled, Roberto Zoncu, Christoph Straub, Choah Kim, Jiwon Park, Bernardo L. Sabatini, David M. Sabatini
Science. Author manuscript; available in PMC 2015 Jan 15.
Published in final edited form as: Science. 2015 Jan 9; 347(6218): 188–194. Published online 2015 Jan 7. doi: 10.1126/science.1257132
PMCID:
PMC4295826
AbstractArticlePDF–1.6M
12.
SLC38A9 is a component of the lysosomal amino acid-sensing machinery that controls mTORC1
Manuele Rebsamen, Lorena Pochini, Taras Stasyk, Mariana E. G. de Araújo, Michele Galluccio, Richard K. Kandasamy, Berend Snijder, Astrid Fauster, Elena L. Rudashevskaya, Manuela Bruckner, Stefania Scorzoni, Przemyslaw A. Filipek, Kilian V. M. Huber, Johannes Bigenzahn, Leonhard X. Heinz, Claudine Kraft, Keiryn L. Bennett, Cesare Indiveri, Lukas A. Huber, Giulio Superti-Furga
Nature. Author manuscript; available in PMC 2015 Sep 26.
Published in final edited form as: Nature. 2015 Mar 26; 519(7544): 477–481. Published online 2015 Jan 7. doi: 10.1038/nature14107
PMCID:
PMC4376665
AbstractArticlePDF–2.4M
13.
SNAT7 regulates mTORC1 via macropinocytosis
Delong Meng, Qianmei Yang, Mi-Hyeon Jeong, Adna Curukovic, Shweta Tiwary, Chase H. Melick, Tshering D. Lama-Sherpa, Huanyu Wang, Mariela Huerta-Rosario, Greg Urquhart, Lauren G. Zacharias, Cheryl Lewis, Ralph J. DeBerardinis, Jenna L. Jewell
Proc Natl Acad Sci U S A. 2022 May 17; 119(20): e2123261119. Published online 2022 May 13. doi: 10.1073/pnas.2123261119
PMCID:
PMC9171778
AbstractArticlePDF–1.9M
14.
The late endosomal p14–MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration
Natalia Schiefermeier, Julia M. Scheffler, Mariana E.G. de Araujo, Taras Stasyk, Teodor Yordanov, Hannes L. Ebner, Martin Offterdinger, Sebastian Munck, Michael W. Hess, Sara A. Wickström, Anika Lange, Winfried Wunderlich, Reinhard Fässler, David Teis, Lukas A. Huber
J Cell Biol. 2014 May 26; 205(4): 525–540. doi: 10.1083/jcb.201310043
PMCID:
PMC4033770
AbstractArticlePDF–4.0M
15.
An expanded Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1
Liron Bar-Peled, Lawrence D. Schweitzer, Roberto Zoncu, David M. Sabatini
Cell. Author manuscript; available in PMC 2013 Mar 14.
Published in final edited form as: Cell. 2012 Sep 14; 150(6): 1196–1208. doi: 10.1016/j.cell.2012.07.032
PMCID:
PMC3517996
AbstractArticlePDF–4.9M
16.
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
Yasemin Sancak, Liron Bar-Peled, Roberto Zoncu, Andrew L. Markhard, Shigeyuki Nada, David M. Sabatini
Cell. Author manuscript; available in PMC 2011 Jan 21.
Published in final edited form as: Cell. 2010 Apr 16; 141(2): 290–303. Published online 2010 Apr 8. doi: 10.1016/j.cell.2010.02.024
PMCID:
PMC3024592
AbstractArticlePDF–5.5M
17.
AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor
Philipp Trepte, Christopher Secker, Simona Kostova, Sibusiso B. Maseko, Soon Gang Choi, Jeremy Blavier, Igor Minia, Eduardo Silva Ramos, Patricia Cassonnet, Sabrina Golusik, Martina Zenkner, Stephanie Beetz, Mara J. Liebich, Nadine Scharek, Anja Schütz, Marcel Sperling, Michael Lisurek, Yang Wang, Kerstin Spirohn, Tong Hao, Michael A. Calderwood, David E. Hill, Markus Landthaler, Julien Olivet, Jean-Claude Twizere, Marc Vidal, Erich E. Wanker
Version 1. bioRxiv. Preprint. 2023 Jun 14. doi: 10.1101/2023.06.14.544560
Published in:
Mol Syst Biol. 2024 Apr; 20(4): 428–457.
PMCID:
PMC10312674
AbstractArticlePDF–9.6M
18.
PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805
Yunpeng Bai, Guimei Yu, Hong-Ming Zhou, Ovini Amarasinghe, Yuan Zhou, Peipei Zhu, Qinglin Li, Lujuan Zhang, Frederick Nguele Meke, Yiming Miao, Eli Chapman, W. Andy Tao, Zhong-Yin Zhang
Autophagy. 2023; 19(5): 1562–1581. Published online 2022 Nov 7. doi: 10.1080/15548627.2022.2140558
PMCID:
PMC10240998
AbstractArticlePDF–4.4M
19.
Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC
Hao Zeng, Johnny Castillo-Cabrera, Mika Manser, Bo Lu, Zinger Yang, Vaik Strande, Damien Begue, Raffaella Zamponi, Shumei Qiu, Frederic Sigoillot, Qiong Wang, Alicia Lindeman, John S Reece-Hoyes, Carsten Russ, Debora Bonenfant, Xiaomo Jiang, Youzhen Wang, Feng Cong
eLife. 2019; 8: e50223. Published online 2019 Nov 19. doi: 10.7554/eLife.50223
PMCID:
PMC6927754
AbstractArticlePDF–5.1M
20.
Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells
Qing-Hua Zhang, Min Ye, Xin-Yan Wu, Shuang-Xi Ren, Meng Zhao, Chun-Jun Zhao, Gang Fu, Yu Shen, Hui-Yong Fan, Gang Lu, Ming Zhong, Xiang-Ru Xu, Ze-Guang Han, Ji-Wang Zhang, Jiong Tao, Qiu-Hua Huang, Jun Zhou, Geng-Xi Hu, Jian Gu, Sai-Juan Chen, Zhu Chen
Genome Res. 2000 Oct; 10(10): 1546–1560. doi: 10.1101/gr.140200
PMCID:
PMC310934
AbstractArticlePDF–1.3M

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