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Select item 108048101.

Distinct specificities of the HEMK2 protein methyltransferase in methylation of glutamine and lysine residues

Sara Weirich, Gizem T. Ulu, Thyagarajan T. Chandrasekaran, Jana Kehl, Jasmin Schmid, Franziska Dorscht, Margarita Kublanovsky, Dan Levy, Albert Jeltsch

Protein Sci. 2024 Feb; 33(2): e4897. Published online 2024 Jan 23. doi: 10.1002/pro.4897

PMCID:: PMC10804810

Abstract Article PDF–15M

Select item 89019052.

Reducing N6AMT1-mediated 6mA DNA modification promotes breast tumor progression via transcriptional repressing cell cycle inhibitors

Jiongyu Chen, Yixuan Zhuang, Ping Wang, Jinfeng Ning, Wei Liu, Yiteng Huang, Xueqiong Lin, Lin Peng, Donghong Zhang

Cell Death Dis. 2022 Mar; 13(3): 216. Published online 2022 Mar 7. doi: 10.1038/s41419-022-04661-8

PMCID:: PMC8901905

Abstract Article PDF–6.8M

Select item 67968633.

Structural insight into human N6amt1–Trm112 complex functioning as a protein methyltransferase

Wenjing Li, Yu Shi, Tianlong Zhang, Jie Ye, Jianping Ding

Cell Discov. 2019; 5: 51. Published online 2019 Sep 10. doi: 10.1038/s41421-019-0121-y

PMCID:: PMC6796863

Abstract Article PDF–3.9M

Select item 67968294.

Human HemK2/KMT9/N6AMT1 is an active protein methyltransferase, but does not act on DNA in vitro, in the presence of Trm112

Clayton B. Woodcock, Dan Yu, Xing Zhang, Xiaodong Cheng

Cell Discov. 2019; 5: 50. Published online 2019 Sep 10. doi: 10.1038/s41421-019-0119-5

PMCID:: PMC6796829

Article PDF–474K

Select item 67696525.

The Common Partner of Several Methyltransferases TRMT112 Regulates the Expression of N6AMT1 Isoforms in Mammalian Cells

Lilian Leetsi, Kadri Õunap, Aare Abroi, Reet Kurg

Biomolecules. 2019 Sep; 9(9): 422. Published online 2019 Aug 28. doi: 10.3390/biom9090422

PMCID:: PMC6769652

Abstract Article PDF–1.6M

Select item 64334696.

N⁶-methyladenine DNA Modification in Glioblastoma

Qi Xie, Tao P. Wu, Ryan C. Gimple, Zheng Li, Briana C. Prager, Qiulian Wu, Yang Yu, Pengcheng Wang, Yinsheng Wang, David U. Gorkin, Cheng Zhang, Alexis V. Dowiak, Kaixuan Lin, Chun Zeng, Yinghui Sui, Leo J. Y. Kim, Tyler E. Miller, Li Jiang, Christine Lee-Poturalski, Zhi Huang, Xiaoguang Fang, Kui Zhai, Stephen C. Mack, Maike Sander, Shideng Bao, Amber E. Kerstetter-Fogle, Andrew E. Sloan, Andrew Z. Xiao, Jeremy N. Rich

Cell. Author manuscript; available in PMC 2019 Nov 15.

Published in final edited form as: Cell. 2018 Nov 15; 175(5): 1228–1243.e20. Published online 2018 Nov 1. doi: 10.1016/j.cell.2018.10.006

PMCID:: PMC6433469

Abstract Article PDF–3.5M

Select item 55152507.

Associations between arsenic (+3 oxidation state) methyltransferase (AS3MT) and N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) polymorphisms, arsenic metabolism, and cancer risk in a Chilean population

Rosemarie de la Rosa, Craig Steinmaus, Nicholas K Akers, Lucia Conde, Catterina Ferreccio, David Kalman, Kevin R Zhang, Christine F Skibola, Allan H Smith, Luoping Zhang, Martyn T Smith

Environ Mol Mutagen. Author manuscript; available in PMC 2018 Jul 1.

Published in final edited form as: Environ Mol Mutagen. 2017 Jul; 58(6): 411–422. Published online 2017 Jun 22. doi: 10.1002/em.22104

PMCID:: PMC5515250

Abstract Article PDF–729K

Select item 52166488.

Interactive Influence of N6AMT1 and As3MT Genetic Variations on Arsenic Metabolism in the Population of Inner Mongolia, China

Xushen Chen, Xiaojuan Guo, Ping He, Jing Nie, Xiaoyan Yan, Jinqiu Zhu, Luoping Zhang, Guangyun Mao, Hongmei Wu, Zhiyue Liu, Diana Aga, Peilin Xu, Martyn Smith, Xuefeng Ren

Toxicol Sci. 2017 Jan; 155(1): 124–134. Published online 2016 Sep 16. doi: 10.1093/toxsci/kfw181

PMCID:: PMC5216648

Abstract Article PDF–270K

Select item 37020009.

N-6-Adenine-Specific DNA Methyltransferase 1 (N6AMT1) Polymorphisms and Arsenic Methylation in Andean Women

Florencia Harari, Karin Engström, Gabriela Concha, Graciela Colque, Marie Vahter, Karin Broberg

Environ Health Perspect. 2013 Jul; 121(7): 797–803. Published online 2013 May 10. doi: 10.1289/ehp.1206003

PMCID:: PMC3702000

Abstract Article PDF–255K

Select item 311481010.

Involvement of N-6 Adenine-Specific DNA Methyltransferase 1 (N6AMT1) in Arsenic Biomethylation and Its Role in Arsenic-Induced Toxicity

Xuefeng Ren, Maria Aleshin, William J. Jo, Russel Dills, David A. Kalman, Christopher D. Vulpe, Martyn T. Smith, Luoping Zhang

Environ Health Perspect. 2011 Jun; 119(6): 771–777. Published online 2010 Dec 30. doi: 10.1289/ehp.1002733

PMCID:: PMC3114810

Abstract Article PDF–493K

Select item 454282011.

Interactive Effects of N6AMT1 and As3MT in Arsenic Biomethylation

Hao Zhang, Yichen Ge, Ping He, Xushen Chen, Abreu Carina, Yulan Qiu, Diana S. Aga, Xuefeng Ren

Toxicol Sci. 2015 Aug; 146(2): 354–362. Published online 2015 May 20. doi: 10.1093/toxsci/kfv101

PMCID:: PMC4542820

Abstract Article PDF–505K

Select item 870861512.

Human TRMT112-Methyltransferase Network Consists of Seven Partners Interacting with a Common Co-Factor

Baiba Brūmele, Margit Mutso, Lilian Telanne, Kadri Õunap, Karīna Spunde, Aare Abroi, Reet Kurg

Int J Mol Sci. 2021 Dec; 22(24): 13593. Published online 2021 Dec 18. doi: 10.3390/ijms222413593

PMCID:: PMC8708615

Abstract Article PDF–2.7M

Select item 447201813.

The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis

Christiane Zorbas, Emilien Nicolas, Ludivine Wacheul, Emmeline Huvelle, Valérie Heurgué-Hamard, Denis L. J. Lafontaine

Mol Biol Cell. 2015 Jun 1; 26(11): 2080–2095. doi: 10.1091/mbc.E15-02-0073

PMCID:: PMC4472018

Abstract Article PDF–6.8M

Select item 607367014.

Preliminary RNA-Seq Analysis of Long Non-Coding RNAs Expressed in Human Term Placenta

Marta Majewska, Aleksandra Lipka, Lukasz Paukszto, Jan Pawel Jastrzebski, Marek Gowkielewicz, Marcin Jozwik, Mariusz Krzysztof Majewski

Int J Mol Sci. 2018 Jul; 19(7): 1894. Published online 2018 Jun 27. doi: 10.3390/ijms19071894

PMCID:: PMC6073670

Abstract Article PDF–3.6M

Select item 621963315.

ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas

Christopher G. Abraham, Michael P. Ludwig, Zdenek Andrysik, Ahwan Pandey, Molishree Joshi, Matthew D. Galbraith, Kelly D. Sullivan, Joaquin M. Espinosa

Cell Rep. Author manuscript; available in PMC 2018 Nov 6.

Published in final edited form as: Cell Rep. 2018 Sep 18; 24(12): 3224–3236. doi: 10.1016/j.celrep.2018.08.058

PMCID:: PMC6219633

Abstract Article PDF–1.1M

Select item 51531616.

Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions

Yutaka Suzuki, Riu Yamashita, Matsuyuki Shirota, Yuta Sakakibara, Joe Chiba, Junko Mizushima-Sugano, Kenta Nakai, Sumio Sugano

Genome Res. 2004 Sep; 14(9): 1711–1718. doi: 10.1101/gr.2435604

PMCID:: PMC515316

Abstract Article PDF–181K

Select item 835296417.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y