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Items: 1 to 20 of 61

1.
Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer’s disease: A [18F]PSS232 PET/MRI study
Jie Wang, Yingfang He, Xing Chen, Lin Huang, Junpeng Li, Zhiwen You, Qi Huang, Shuhua Ren, Kun He, Roger Schibli, Linjing Mu, Yihui Guan, Qihao Guo, Jun Zhao, Fang Xie
Alzheimers Res Ther. 2024; 16: 9. Published online 2024 Jan 12. doi: 10.1186/s13195-024-01385-z
PMCID:
PMC10785459
AbstractArticlePDF–2.9M
2.
Blockade of mGluR5 in astrocytes derived from human iPSCs modulates astrocytic function and increases phagocytosis
Izabella B. Q. de Lima, Pablo L. Cardozo, Julia S. Fahel, Juliana P. S. Lacerda, Aline S. Miranda, Antônio L. Teixeira, Fabiola M. Ribeiro
Front Immunol. 2023; 14: 1283331. Published online 2023 Dec 11. doi: 10.3389/fimmu.2023.1283331
PMCID:
PMC10749358
AbstractArticlePDF–5.8M
3.
mGluR5 binding changes during a mismatch negativity task in a multimodal protocol with [11C]ABP688 PET/MR-EEG
Cláudia Régio Brambilla, Tanja Veselinović, Ravichandran Rajkumar, Jörg Mauler, Andreas Matusch, Andrej Ruch, Linda Orth, Shukti Ramkiran, Hasan Sbaihat, Nicolas Kaulen, Nibal Yahya Khudeish, Christine Wyss, Karsten Heekeren, Wolfram Kawohl, Elena Rota Kops, Lutz Tellmann, Jürgen Scheins, Frank Boers, Bernd Neumaier, Johannes Ermert, Markus Lang, Stefan Stüsgen, Hans Herzog, Karl-Josef Langen, N. Jon Shah, Christoph W. Lerche, Irene Neuner
Transl Psychiatry. 2022; 12: 6. Published online 2022 Jan 10. doi: 10.1038/s41398-021-01763-3
PMCID:
PMC8748790
AbstractArticlePDF–2.4M
4.
Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations
Chady Nasrallah, Giuseppe Cannone, Julie Briot, Karine Rottier, Alice E. Berizzi, Chia-Ying Huang, Robert B. Quast, Francois Hoh, Jean-Louis Banères, Fanny Malhaire, Ludovic Berto, Anaëlle Dumazer, Joan Font-Ingles, Xavier Gómez-Santacana, Juanlo Catena, Julie Kniazeff, Cyril Goudet, Amadeu Llebaria, Jean-Philippe Pin, Kutti R. Vinothkumar, Guillaume Lebon
Cell Rep. 2021 Aug 31; 36(9): 109648. Published online 2021 Aug 31. doi: 10.1016/j.celrep.2021.109648
PMCID:
PMC8424648
AbstractArticle
5.
Effect of age on brain metabotropic glutamate receptor subtype 5 measured with [18F]FPEB PET
Adam P. Mecca, Kelly Rogers, Zachary Jacobs, Julia W. McDonald, Hannah R. Michalak, Nicole DellaGioia, Wenzhen Zhao, Ansel T Hillmer, Nabeel Nabulsi, Keunpoong Lim, Jim Ropchan, Yiyun Huang, David Matuskey, Irina Esterlis, Richard E. Carson, Christopher H. van Dyck
Neuroimage. Author manuscript; available in PMC 2021 Sep 1.
Published in final edited form as: Neuroimage. 2021 Sep; 238: 118217. Published online 2021 May 27. doi: 10.1016/j.neuroimage.2021.118217
PMCID:
PMC8378132
AbstractArticlePDF–849K
6.
In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker
Maria Mody, Yoann Petibon, Paul Han, Darshini Kuruppu, Chao Ma, Daniel Yokell, Ramesh Neelamegam, Marc D. Normandin, Georges El Fakhri, Anna-Liisa Brownell
Sci Rep. 2021; 11: 15897. Published online 2021 Aug 5. doi: 10.1038/s41598-021-94967-y
PMCID:
PMC8342610
AbstractArticlePDF–1.4M
7.
Cerebral Expression of Metabotropic Glutamate Receptor Subtype 5 in Idiopathic Autism Spectrum Disorder and Fragile X Syndrome: A Pilot Study
James Robert Brašić, Ayon Nandi, David S. Russell, Danna Jennings, Olivier Barret, Samuel D. Martin, Keith Slifer, Thomas Sedlak, John P. Seibyl, Dean F. Wong, Dejan B. Budimirovic
Int J Mol Sci. 2021 Mar; 22(6): 2863. Published online 2021 Mar 11. doi: 10.3390/ijms22062863
PMCID:
PMC7999711
AbstractArticlePDF–1.3M
8.
The selective blockade of metabotropic glutamate receptor-5 attenuates fat accumulation in an in vitro model of benign steatosis
Andrea Ferrigno, Clarissa Berardo, Laura Giuseppina Di Pasqua, Marta Cagna, Veronica Siciliano, Plinio Richelmi, Mariapia Vairetti
Eur J Histochem. 2020 Oct 19; 64(4): 3175. Published online 2020 Nov 10. doi: 10.4081/ejh.2020.3175
PMCID:
PMC7662107
AbstractArticlePDF–517K
9.
Metabotropic glutamate receptor 5 in bulimia nervosa
Yoan Mihov, Valerie Treyer, Funda Akkus, Erika Toman, Gabriella Milos, Simon M. Ametamey, Anass Johayem, Gregor Hasler
Sci Rep. 2020; 10: 6374. Published online 2020 Apr 14. doi: 10.1038/s41598-020-63389-7
PMCID:
PMC7156702
AbstractArticlePDF–1.2M
10.
The role of water and protein flexibility in the structure-based virtual screening of allosteric GPCR modulators: an mGlu5 receptor case study
Zoltán Orgován, György G. Ferenczy, György M. Keserű
J Comput Aided Mol Des. 2019; 33(9): 787–797. Published online 2019 Sep 21. doi: 10.1007/s10822-019-00224-w
PMCID:
PMC6825653
AbstractArticlePDF–1.2M
11.
In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation
Margaret T. Davis, Ansel Hillmer, Sophie E. Holmes, Robert H. Pietrzak, Nicole DellaGioia, Nabeel Nabulsi, David Matuskey, Gustavo Angarita-Africano, Richard E. Carson, John H. Krystal, Irina Esterlis
Proc Natl Acad Sci U S A. 2019 Jun 4; 116(23): 11490–11495. Published online 2019 May 13. doi: 10.1073/pnas.1818871116
Correction in:
Proc Natl Acad Sci U S A. 2019 Jul 2; 116(27): 13702.
PMCID:
PMC6561298
AbstractArticlePDF–807K
12.
Encephalitis with mGluR5 antibodies: Symptoms and antibody effects
Marianna Spatola, Lidia Sabater, Jesús Planagumà, Eugenia Martínez-Hernandez, Thaís Armangué, Harald Prüss, Takahiro Iizuka, Ruben L. Caparó Oblitas, Jean-Christophe Antoine, Richard Li, Nicholas Heaney, Niall Tubridy, Elvira Munteis Olivas, Myrna R. Rosenfeld, Francesc Graus, Josep Dalmau
Neurology. 2018 May 29; 90(22): e1964–e1972. doi: 10.1212/WNL.0000000000005614
PMCID:
PMC5980520
AbstractArticlePDF–989K
13.
mGluR5 mediates post-radiotherapy fatigue development in cancer patients
Li Rebekah Feng, Juan Luis Fernández-Martínez, Kristien J.M. Zaal, Enrique J deAndrés-Galiana, Brian S. Wolff, Leorey N. Saligan
Transl Psychiatry. 2018; 8: 110. Published online 2018 May 30. doi: 10.1038/s41398-018-0161-3
PMCID:
PMC5976668
AbstractArticlePDF–1.6M
14.
Metabotropic glutamate receptor 5 binding in male patients with alcohol use disorder
Funda Akkus, Yoan Mihov, Valerie Treyer, Simon M. Ametamey, Anass Johayem, Smeralda Senn, Susanne Rösner, Alfred Buck, Gregor Hasler
Transl Psychiatry. 2018; 8: 17. Published online 2018 Jan 10. doi: 10.1038/s41398-017-0066-6
PMCID:
PMC5802584
AbstractArticlePDF–503K
15.
Developmental distribution pattern of metabotropic glutamate receptor 5 in prenatal human hippocampus
Pengbo Yang, Junfeng Zhang, Lingyu Zhao, Qian Jian, Hui Jin, Xinli Xiao, Haixia Zhang, Ming Hu, Haixia Lu, Yong Liu
Neurosci Bull. 2012 Dec; 28(6): 704–714. Published online 2012 Dec 7. doi: 10.1007/s12264-012-1286-7
PMCID:
PMC5561823
AbstractArticlePDF–879K
16.
Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism
Simona D’Antoni, Michela Spatuzza, Carmela M. Bonaccorso, Sebastiano A. Musumeci, Lucia Ciranna, Ferdinando Nicoletti, Kimberly M. Huber, Maria Vincenza Catania
Neurosci Biobehav Rev. Author manuscript; available in PMC 2017 Jul 6.
Published in final edited form as: Neurosci Biobehav Rev. 2014 Oct; 46(Pt 2): 228–241. Published online 2014 Feb 15. doi: 10.1016/j.neubiorev.2014.02.003
PMCID:
PMC5499156
AbstractArticlePDF–562K
17.
Sequences within the C Terminus of the Metabotropic Glutamate Receptor 5 (mGluR5) Are Responsible for Inner Nuclear Membrane Localization
Ismail Sergin, Yuh-Jiin I. Jong, Steven K. Harmon, Vikas Kumar, Karen L. O'Malley
J Biol Chem. 2017 Mar 3; 292(9): 3637–3655. Published online 2017 Jan 17. doi: 10.1074/jbc.M116.757724
PMCID:
PMC5339749
AbstractArticlePDF–6.1M
18.
Characterization of brain mGluR5 binding in a pilot study of late-life major depressive disorder using positron emission tomography and [11C]ABP688
C DeLorenzo, J Sovago, J Gardus, J Xu, J Yang, R Behrje, J S D Kumar, D P Devanand, G H Pelton, C A Mathis, N S Mason, B Gomez-Mancilla, H Aizenstein, J J Mann, R V Parsey
Transl Psychiatry. 2015 Dec; 5(12): e693. Published online 2015 Dec 8. doi: 10.1038/tp.2015.189
PMCID:
PMC5068588
AbstractArticlePDF–436K
19.
Distinct Increased Metabotropic Glutamate Receptor Type 5 (mGluR5) in Temporal Lobe Epilepsy With and Without Hippocampal Sclerosis
Ludmyla Kandratavicius, Pedro Rosa-Neto, Mariana Raquel Monteiro, Marie-Christine Guiot, Joao Alberto Assirati, Carlos Gilberto Carlotti, Eliane Kobayashi, Joao Pereira Leite
Hippocampus. 2013 Dec; 23(12): 1212–1230. Published online 2013 Jul 23. doi: 10.1002/hipo.22160
PMCID:
PMC4165311
AbstractArticlePDF–1.5M
20.
Identification of Specific Ligand–Receptor Interactions That Govern Binding and Cooperativity of Diverse Modulators to a Common Metabotropic Glutamate Receptor 5 Allosteric Site
Karen J. Gregory, Elizabeth D. Nguyen, Chrysa Malosh, Jeffrey L. Mendenhall, Jessica Z. Zic, Brittney S. Bates, Meredith J. Noetzel, Emma F. Squire, Eric M. Turner, Jerri M. Rook, Kyle A. Emmitte, Shaun R. Stauffer, Craig W. Lindsley, Jens Meiler, P. Jeffrey Conn
ACS Chem Neurosci. 2014 Apr 16; 5(4): 282–295. Published online 2014 Feb 16. doi: 10.1021/cn400225x
PMCID:
PMC3990945
AbstractArticlePDF–6.4M

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