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Items: 18

Select item 86063971.

Omi inhibition ameliorates neuron apoptosis and neurological deficit after subarachnoid hemorrhage in rats

Yuanfeng Du, Dingbo Yang, Xiaoqiao Dong, Quan Du, Ding Wang, Yongfeng Shen, Wenhua Yu

Genes Genomics. 2021; 43(12): 1423–1432. Published online 2021 Oct 22. doi: 10.1007/s13258-021-01176-y

PMCID:: PMC8606397

Abstract Article PDF–2.3M

Select item 74535842.

Inhibition of HtrA2 alleviates inflammatory response and cell apoptosis in lipopolysaccharide-induced acute pneumonia in rats

Xin Wang

Mol Med Rep. 2020 Oct; 22(4): 3127–3134. Published online 2020 Aug 4. doi: 10.3892/mmr.2020.11410

PMCID:: PMC7453584

Abstract Article PDF–1023K

Select item 32283433.

Altered enzymatic activity and allele frequency of OMI/HTRA2 in Alzheimer's disease

Marie Westerlund, Homira Behbahani, Sandra Gellhaar, Charlotte Forsell, Andrea Carmine Belin, Anna Anvret, Anna Zettergren, Hans Nissbrandt, Charlotta Lind, Olof Sydow, Caroline Graff, Lars Olson, Maria Ankarcrona, Dagmar Galter

FASEB J. 2011 Apr; 25(4): 1345–1352. doi: 10.1096/fj.10-163402

PMCID:: PMC3228343

Abstract Article

Select item 32142654.

Novel variant Pro143Ala in HTRA2 contributes to Parkinson’s disease by inducing hyperphosphorylation of HTRA2 protein in mitochondria

Chin-Hsien Lin, Meng-Ling Chen, Grace Shiahuy Chen, Chun-Hwei Tai, Ruey-Meei Wu

Hum Genet. 2011; 130(6): 817–827. Published online 2011 Jun 24. doi: 10.1007/s00439-011-1041-6

PMCID:: PMC3214265

Abstract Article PDF–745K

Select item 35543385.

Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging

S Kang, J-P Louboutin, P Datta, C P Landel, D Martinez, A S Zervos, D S Strayer, T Fernandes-Alnemri, E S Alnemri

Cell Death Differ. 2013 Feb; 20(2): 259–269. Published online 2012 Sep 14. doi: 10.1038/cdd.2012.117

PMCID:: PMC3554338

Abstract Article PDF–3.1M

Select item 25748546.

Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls

Javier Simón-Sánchez, Andrew B. Singleton

Hum Mol Genet. 2008 Jul 1; 17(13): 1988–1993. Published online 2008 Mar 25. doi: 10.1093/hmg/ddn096

PMCID:: PMC2574854

Abstract Article PDF–75K

Select item 18551967.

Response of caspase-independent apoptotic factors to high salt diet-induced heart failure

Parco M. Siu, Soochan Bae, Natalya Bodyak, Debra L. Rigor, Peter M. Kang

J Mol Cell Cardiol. Author manuscript; available in PMC 2008 Mar 1.

Published in final edited form as: J Mol Cell Cardiol. 2007 Mar; 42(3): 678–686. Published online 2007 Jan 9. doi: 10.1016/j.yjmcc.2007.01.001

PMCID:: PMC1855196

Abstract Article PDF–362K

Select item 5254908.

Neuroprotective Role of the Reaper-Related Serine Protease HtrA2/Omi Revealed by Targeted Deletion in Mice

L. Miguel Martins, Alastair Morrison, Kristina Klupsch, Valentina Fedele, Nicoleta Moisoi, Peter Teismann, Alejandro Abuin, Evelyn Grau, Martin Geppert, George P. Livi, Caretha L. Creasy, Alison Martin, Iain Hargreaves, Simon J. Heales, Hitoshi Okada, Sebastian Brandner, Jörg B. Schulz, Tak Mak, Julian Downward

Mol Cell Biol. 2004 Nov; 24(22): 9848–9862. doi: 10.1128/MCB.24.22.9848-9862.2004

PMCID:: PMC525490

Abstract Article PDF–796K

Select item 5346559.

Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130

Jan-Hermen Dannenberg, Leontine Schuijff, Marleen Dekker, Martin van der Valk, Hein te Riele

Genes Dev. 2004 Dec 1; 18(23): 2952–2962. doi: 10.1101/gad.322004

PMCID:: PMC534655

Abstract Article PDF–630K

Select item 731251510.

Expression of HTRA Genes and Its Association with Microsatellite Instability and Survival of Patients with Colorectal Cancer

Dorota Zurawa-Janicka, Jarek Kobiela, Tomasz Slebioda, Rafal Peksa, Marcin Stanislawowski, Piotr Mieczyslaw Wierzbicki, Tomasz Wenta, Barbara Lipinska, Zbigniew Kmiec, Wojciech Biernat, Andrzej Jacek Lachinski, Zbigniew Sledzinski

Int J Mol Sci. 2020 Jun; 21(11): 3947. Published online 2020 May 31. doi: 10.3390/ijms21113947

PMCID:: PMC7312515

Abstract Article PDF–3.7M

Select item 363641511.

Variations in the protein level of Omi/HtrA2 in the heart of aged rats may contribute to the increased susceptibility of cardiomyocytes to ischemia/reperfusion injury and cell death: Omi/HtrA2 and aged heart injury

Ke Wang, Jie Zhang, Jingyi Liu, Jue Tian, Ye Wu, Xiaoliang Wang, Lin Quan, Haibo Xu, Wen Wang, Huirong Liu

Age (Dordr) 2013 Jun; 35(3): 733–746. Published online 2012 Apr 26. doi: 10.1007/s11357-012-9406-x

PMCID:: PMC3636415

Abstract Article PDF–690K

Select item 445430312.

The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway

R Xu, Q Hu, Q Ma, C Liu, G Wang

Cell Death Dis. 2014 Aug; 5(8): e1373. Published online 2014 Aug 14. doi: 10.1038/cddis.2014.328

PMCID:: PMC4454303

Abstract Article PDF–3.0M

Select item 289485613.

HOIL-1L Interacting Protein (HOIP) as an NF-κB Regulating Component of the CD40 Signaling Complex

Bruce S. Hostager, Daniel K. Fox, Douglas Whitten, Curtis G. Wilkerson, Betty A. Eipper, Victor P. Francone, Paul B. Rothman, John D. Colgan

PLoS One. 2010; 5(6): e11380. Published online 2010 Jun 30. doi: 10.1371/journal.pone.0011380

PMCID:: PMC2894856

Abstract Article PDF–739K

Select item 584108614.

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

Samuel A. Hasson, Lesley A. Kane, Koji Yamano, Chiu-Hui Huang, Danielle A. Sliter, Eugen Buehler, Chunxin Wang, Sabrina M. Heman-Ackah, Tara Hessa, Rajarshi Guha, Scott E. Martin, Richard J. Youle

Nature. Author manuscript; available in PMC 2018 Mar 7.

Published in final edited form as: Nature. 2013 Dec 12; 504(7479): 291–295. Published online 2013 Nov 24. doi: 10.1038/nature12748

PMCID:: PMC5841086

Abstract Article PDF–5.3M

Select item 458732715.

Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth

Joseph Mertz, Haiyan Tan, Vishwajeeth Pagala, Bing Bai, Ping-Chung Chen, Yuxin Li, Ji-Hoon Cho, Timothy Shaw, Xusheng Wang, Junmin Peng

Mol Cell Proteomics. 2015 Jul; 14(7): 1898–1910. Published online 2015 Apr 30. doi: 10.1074/mcp.M114.045898

PMCID:: PMC4587327

Abstract Article PDF–2.6M

Select item 277884416.

A mitochondrial protein compendium elucidates complex I disease biology

David J. Pagliarini, Sarah E. Calvo, Betty Chang, Sunil A. Sheth, Scott B. Vafai, Shao-En Ong, Geoffrey A. Walford, Canny Sugiana, Avihu Boneh, William K. Chen, David E. Hill, Marc Vidal, James G. Evans, David R. Thorburn, Steven A. Carr, Vamsi K. Mootha

Cell. Author manuscript; available in PMC 2009 Nov 18.

Published in final edited form as: Cell. 2008 Jul 11; 134(1): 112–123. doi: 10.1016/j.cell.2008.06.016