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Select item 104523551.

Phosphoserine Aminotransferase Pathogenetic Variants in Serine Deficiency Disorders: A Functional Characterization

Francesco Marchesani, Annalisa Michielon, Elisabetta Viale, Annalisa Bianchera, Davide Cavazzini, Loredano Pollegioni, Giulia Murtas, Andrea Mozzarelli, Stefano Bettati, Alessio Peracchi, Barbara Campanini, Stefano Bruno

Biomolecules. 2023 Aug; 13(8): 1219. Published online 2023 Aug 4. doi: 10.3390/biom13081219

PMCID:: PMC10452355

Abstract Article PDF–2.0M

Select item 100312352.

L‐serine biosynthesis in the human central nervous system: Structure and function of phosphoserine aminotransferase

Francesco Marchesani, Erika Zangelmi, Giulia Murtas, Elisa Costanzi, Raheem Ullah, Alessio Peracchi, Stefano Bruno, Loredano Pollegioni, Andrea Mozzarelli, Paola Storici, Barbara Campanini

Protein Sci. 2023 Apr; 32(4): e4609. Published online 2023 Apr 1. doi: 10.1002/pro.4609

PMCID:: PMC10031235

Abstract Article PDF–7.6M

Select item 100085653.

Downregulation of PSAT1 inhibits cell proliferation and migration in uterine corpus endometrial carcinoma

Min Wang, Song Yue, Zhu Yang

Sci Rep. 2023; 13: 4081. Published online 2023 Mar 11. doi: 10.1038/s41598-023-31325-0

PMCID:: PMC10008565

Abstract Article PDF–7.0M

Select item 88453024.

Lineage-specific silencing of PSAT1 induces serine auxotrophy and sensitivity to dietary serine starvation in luminal breast tumors

Bo-Hyun Choi, Vipin Rawat, Jenny Högström, Philippa A. Burns, Kelly O. Conger, Mete Emir Ozgurses, Jaymin M. Patel, Tejas S. Mehta, Angelica Warren, Laura M. Selfors, Taru Muranen, Jonathan L. Coloff

Cell Rep. Author manuscript; available in PMC 2022 Feb 15.

Published in final edited form as: Cell Rep. 2022 Jan 18; 38(3): 110278. doi: 10.1016/j.celrep.2021.110278

PMCID:: PMC8845302

Abstract Article PDF–2.9M

Select item 83304945.

Adult diagnosis of congenital serine biosynthesis defect: a treatable cause of progressive neuropathy

Sarah Debs, Carlos R. Ferreira, Catherine Groden, H. Jeffrey Kim, Kelly A. King, Monique C. King, Tanya Lehky, Edward W. Cowen, Laura H. Brown, Melissa Merideth, Carter M. Owen, Ellen Macnamara, Camilo Toro, William A. Gahl, Ariane Soldatos

Am J Med Genet A. Author manuscript; available in PMC 2022 Jul 1.

Published in final edited form as: Am J Med Genet A. 2021 Jul; 185(7): 2102–2107. Published online 2021 Jun 4. doi: 10.1002/ajmg.a.62245

PMCID:: PMC8330494

Abstract Article PDF–258K

Select item 74443166.

A yeast-based complementation assay elucidates the functional impact of 200 missense variants in human PSAT1

Amy Sirr, Russell S. Lo, Gareth A. Cromie, Adrian C. Scott, Julee Ashmead, Mirutse Heyesus, Aimée M. Dudley

J Inherit Metab Dis. Author manuscript; available in PMC 2021 Jul 1.

Published in final edited form as: J Inherit Metab Dis. 2020 Jul; 43(4): 758–769. Published online 2020 Feb 27. doi: 10.1002/jimd.12227

PMCID:: PMC7444316

Abstract Article PDF–1.0M

Select item 71629427.

Overexpression of PSAT1 regulated by G9A sustains cell proliferation in colorectal cancer

Huijuan Wang, Longzhen Cui, Dandan Li, Ming Fan, Zhangnan Liu, Chunqi Liu, Sijing Pan, Lei Zhang, Hailong Zhang, Yinglan Zhao

Signal Transduct Target Ther. 2020; 5: 47. Published online 2020 Apr 17. doi: 10.1038/s41392-020-0147-5

PMCID:: PMC7162942

Article PDF–1.1M

Select item 54370088.

Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer

Tommaso De Marchi, Mieke A. Timmermans, Anieta M. Sieuwerts, Marcel Smid, Maxime P. Look, Nicolai Grebenchtchikov, Fred C. G. J. Sweep, Jan G. Smits, Viktor Magdolen, Carolien H. M. van Deurzen, John A. Foekens, Arzu Umar, John W. Martens

Sci Rep. 2017; 7: 2099. Published online 2017 May 18. doi: 10.1038/s41598-017-02296-w

PMCID:: PMC5437008

Abstract Article PDF–3.1M

Select item 30495519.

A novel balanced chromosomal translocation found in subjects with schizophrenia and schizotypal personality disorder: altered L-serine level associated with disruption of PSAT1 gene expression

Yuji Ozeki, Benjamin S. Pickard, Shin-ichi Kano, Mary P. Malloy, Mariela Zeledon, Daniel Q. Sun, Kumiko Fujii, Keiko Wakui, Yukihiko Shirayama, Yoshimitsu Fukushima, Hiroshi Kunugi, Kenji Hashimoto, Walter J. Muir, Douglas H. Blackwood, Akira Sawa

Neurosci Res. Author manuscript; available in PMC 2012 Feb 1.

Published in final edited form as: Neurosci Res. 2011 Feb; 69(2): 154–160. Published online 2010 Oct 16. doi: 10.1016/j.neures.2010.10.003

PMCID:: PMC3049551

Abstract Article PDF–106K

Select item 224597810.

Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells

Nadia Vié, Virginie Copois, Caroline Bascoul-Mollevi, Vincent Denis, Nicole Bec, Bruno Robert, Caroline Fraslon, Emmanuel Conseiller, Franck Molina, Christian Larroque, Pierre Martineau, Maguy Del Rio, Céline Gongora

Mol Cancer. 2008; 7: 14. Published online 2008 Jan 25. doi: 10.1186/1476-4598-7-14

PMCID:: PMC2245978

Abstract Article PDF–633K

Select item 185273511.

Phosphoserine Aminotransferase Deficiency: A Novel Disorder of the Serine Biosynthesis Pathway

Claire E. Hart, Valerie Race, Younes Achouri, Elsa Wiame, Mark Sharrard, Simon E. Olpin, Jennifer Watkinson, James R. Bonham, Jaak Jaeken, Gert Matthijs, Emile Van Schaftingen

Am J Hum Genet. 2007 May; 80(5): 931–937. Published online 2007 Mar 30. doi: 10.1086/517888

PMCID:: PMC1852735

Abstract Article PDF–378K

Select item 122345612.

Characterization of human phosphoserine aminotransferase involved in the phosphorylated pathway of L-serine biosynthesis.

Joo Youn Baek, Do Youn Jun, Dennis Taub, Young Ho Kim

Biochem J. 2003 Jul 1; 373(Pt 1): 191–200. doi: 10.1042/BJ20030144

PMCID:: PMC1223456

Summary PDF–482K

Select item 1031760113.

Exosomal ERBB2IP contributes to tumor growth via elevating PSAT1 expression in non‐small cell lung carcinoma

Xijuan Peng, Lanfu Zhao, Linong Yao, Jingzhi Dong, Wei Wu, Tao Luo

Thorac Cancer. 2023 Jul; 14(19): 1812–1823. Published online 2023 May 16. doi: 10.1111/1759-7714.14926

PMCID:: PMC10317601

Abstract Article PDF–5.8M

Select item 992907114.

Targeting PSAT1 to mitigate metastasis in tumors with p53-72Pro variant

Jingwen Jiang, Hai-Ning Chen, Ping Jin, Li Zhou, Liyuan Peng, Zhao Huang, Siyuan Qin, Bowen Li, Hui Ming, Maochao Luo, Na Xie, Wei Gao, Edouard C. Nice, Qiang Yu, Canhua Huang

Signal Transduct Target Ther. 2023; 8: 65. Published online 2023 Feb 15. doi: 10.1038/s41392-022-01266-7

PMCID:: PMC9929071

Abstract Article PDF–7.3M

Select item 927594715.

Examination of the effects of microRNA-145-5p and phosphoserine aminotransferase 1 in colon cancer

Ruliang Ding, Weiwen Hong, Liang Huang, Jinfan Shao, Wenfeng Yu, Xijuan Xu

Bioengineered. 2022; 13(5): 12794–12806. Published online 2022 May 26. doi: 10.1080/21655979.2022.2071010

PMCID:: PMC9275947

Abstract Article PDF–2.6M

Select item 921632616.

Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression

Georgina D. Barnabas, Joo Sang Lee, Tamar Shami, Michal Harel, Lir Beck, Michael Selitrennik, Livnat Jerby-Arnon, Neta Erez, Eytan Ruppin, Tamar Geiger

Cancer Res. Author manuscript; available in PMC 2022 Jun 22.

Published in final edited form as: Cancer Res. 2021 Mar 15; 81(6): 1443–1456. Published online 2021 Jan 26. doi: 10.1158/0008-5472.CAN-19-3020

PMCID:: PMC9216326

Abstract Article PDF–2.6M

Select item 755098517.

Long non-coding RNA MEG3 suppresses epithelial-to-mesenchymal transition by inhibiting the PSAT1-dependent GSK-3β/Snail signaling pathway in esophageal squamous cell carcinoma

Ming-Kai Li, Li-Xuan Liu, Wei-Yi Zhang, Hao-Lian Zhan, Rui-Pei Chen, Jia-Lin Feng, Ling-Fei Wu

Oncol Rep. 2020 Nov; 44(5): 2130–2142. Published online 2020 Sep 7. doi: 10.3892/or.2020.7754

PMCID:: PMC7550985

Abstract Article PDF–790K

Select item 572148018.

PSAT1 is regulated by ATF4 and enhances cell proliferation via the GSK3β/β-catenin/cyclin D1 signaling pathway in ER-negative breast cancer

Song Gao, Anqi Ge, Shouping Xu, Zilong You, Shipeng Ning, Yashuang Zhao, Da Pang

J Exp Clin Cancer Res. 2017; 36: 179. Published online 2017 Dec 8. doi: 10.1186/s13046-017-0648-4

PMCID:: PMC5721480

Abstract Article PDF–1.9M

Select item 415714419.

Neu-Laxova Syndrome Is a Heterogeneous Metabolic Disorder Caused by Defects in Enzymes of the L-Serine Biosynthesis Pathway

Rocio Acuna-Hidalgo, Denny Schanze, Ariana Kariminejad, Ann Nordgren, Mohamad Hasan Kariminejad, Peter Conner, Giedre Grigelioniene, Daniel Nilsson, Magnus Nordenskjöld, Anna Wedell, Christoph Freyer, Anna Wredenberg, Dagmar Wieczorek, Gabriele Gillessen-Kaesbach, Hülya Kayserili, Nursel Elcioglu, Siavash Ghaderi-Sohi, Payman Goodarzi, Hamidreza Setayesh, Maartje van de Vorst, Marloes Steehouwer, Rolph Pfundt, Birgit Krabichler, Cynthia Curry, Malcolm G. MacKenzie, Kym M. Boycott, Christian Gilissen, Andreas R. Janecke, Alexander Hoischen, Martin Zenker

Am J Hum Genet. 2014 Sep 4; 95(3): 285–293. doi: 10.1016/j.ajhg.2014.07.012

PMCID:: PMC4157144

Abstract Article PDF–1.5M

Select item 655467120.

Nf1 loss promotes Kras‐driven lung adenocarcinoma and results in Psat1‐mediated glutamate dependence

Xiaojing Wang, Shengping Min, Hongli Liu, Nan Wu, Xincheng Liu, Tao Wang, Wei Li, Yuanbing Shen, Hongtao Wang, Zhongqing Qian, Huanbai Xu, Chengling Zhao, Yuqing Chen

EMBO Mol Med. 2019 Jun; 11(6): e9856. Published online 2019 Apr 29. doi: 10.15252/emmm.201809856

PMCID:: PMC6554671

Abstract Article PDF–2.5M

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