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Select item 82808381.

Phosphoproteomic identification of ULK substrates reveals VPS15‐dependent ULK/VPS34 interplay in the regulation of autophagy

Thomas John Mercer, Yohei Ohashi, Stefan Boeing, Harold B J Jefferies, Stefano De Tito, Helen Flynn, Shirley Tremel, Wenxin Zhang, Martina Wirth, David Frith, Ambrosius P Snijders, Roger Lee Williams, Sharon A Tooze

EMBO J. 2021 Jul 15; 40(14): e105985. Published online 2021 Jun 14. doi: 10.15252/embj.2020105985

PMCID:: PMC8280838

Abstract Article PDF–9.2M

Select item 53863792.

Autophagy dysregulation in Danon disease

Anna Chiara Nascimbeni, Marina Fanin, Corrado Angelini, Marco Sandri

Cell Death Dis. 2017 Jan; 8(1): e2565. Published online 2017 Jan 19. doi: 10.1038/cddis.2016.475

PMCID:: PMC5386379

Abstract Article PDF–6.7M

Select item 51230563.

A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi

Corinne Stoetzel, Séverine Bär, Johan-Owen De Craene, Sophie Scheidecker, Christelle Etard, Johana Chicher, Jennifer R. Reck, Isabelle Perrault, Véronique Geoffroy, Kirsley Chennen, Uwe Strähle, Philippe Hammann, Sylvie Friant, Hélène Dollfus

Nat Commun. 2016; 7: 13586. Published online 2016 Nov 24. doi: 10.1038/ncomms13586

PMCID:: PMC5123056

Abstract Article PDF–2.3M

Select item 26528304.

hVps15, but not Ca²⁺/CaM, is required for the activity and regulation of hVps34 in mammalian cells

Ying Yan, Rory J. Flinn, Haiyan Wu, Rachel S. Schnur, Jonathan M. Backer

Biochem J. 2009 Feb 1; 417(Pt 3): 747–755. Prepublished online 2008 Oct 28. Published online 2009 Jan 16. doi: 10.1042/BJ20081865

PMCID:: PMC2652830

Abstract Article PDF–870K

Select item 1531105.

The Microtubule Plus-End Proteins EB1 and Dynactin Have Differential Effects on Microtubule Polymerization

Lee A. Ligon, Spencer S. Shelly, Mariko Tokito, Erika L.F. Holzbaur

Mol Biol Cell. 2003 Apr; 14(4): 1405–1417. doi: 10.1091/mbc.E02-03-0155

PMCID:: PMC153110

Abstract Article PDF–1.1M

Select item 21941706.

Tuberculosis Toxin Blocking Phagosome Maturation Inhibits a Novel Ca²⁺/Calmodulin-PI3K hVPS34 Cascade

Isabelle Vergne, Jennifer Chua, Vojo Deretic

J Exp Med. 2003 Aug 18; 198(4): 653–659. doi: 10.1084/jem.20030527

PMCID:: PMC2194170

Abstract Article PDF–381K

Select item 92885067.

Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance

Lidia Wrobel, Sandra M. Hill, Alvin Djajadikerta, Marian Fernandez-Estevez, Cansu Karabiyik, Avraham Ashkenazi, Victoria J. Barratt, Eleanna Stamatakou, Anders Gunnarsson, Timothy Rasmusson, Eric W. Miele, Nigel Beaton, Roland Bruderer, Yuehan Feng, Lukas Reiter, M. Paola Castaldi, Rebecca Jarvis, Keith Tan, Roland W. Bürli, David C. Rubinsztein

Nat Commun. 2022; 13: 4146. Published online 2022 Jul 16. doi: 10.1038/s41467-022-31905-0

PMCID:: PMC9288506

Abstract Article PDF–3.9M

Select item 71383998.

NEK2 induces autophagy‐mediated bortezomib resistance by stabilizing Beclin‐1 in multiple myeloma

Jiliang Xia, Yanjuan He, Bin Meng, Shilian Chen, Jingyu Zhang, Xuan Wu, Yinghong Zhu, Yi Shen, Xiangling Feng, Yongjun Guan, Chunmei Kuang, Jiaojiao Guo, Qian Lei, Yangbowen Wu, Gang An, Guancheng Li, Lugui Qiu, Fenghuang Zhan, Wen Zhou

Mol Oncol. 2020 Apr; 14(4): 763–778. Published online 2020 Jan 29. doi: 10.1002/1878-0261.12641

PMCID:: PMC7138399

Abstract Article PDF–6.8M

Select item 69373999.

Regulation of the autophagic PI3KC3 complex by laforin/malin E3-ubiquitin ligase, two proteins involved in Lafora disease

Pablo Sanchez-Martin, Marcos Lahuerta, Rosa Viana, Erwin Knecht, Pascual Sanz

Biochim Biophys Acta Mol Cell Res. Author manuscript; available in PMC 2021 Feb 1.

Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2020 Feb; 1867(2): 118613. Published online 2019 Nov 21. doi: 10.1016/j.bbamcr.2019.118613

PMCID:: PMC6937399

Abstract Article PDF–2.3M

Select item 652827610.

Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader

Hannah Tovell, Andrea Testa, Chiara Maniaci, Houjiang Zhou, Alan R Prescott, Thomas Macartney, Alessio Ciulli, Dario R Alessi

ACS Chem Biol. 2019 May 17; 14(5): 882–892. Published online 2019 Apr 12. doi: 10.1021/acschembio.8b01016

PMCID:: PMC6528276

Abstract Article PDF–7.6M

Select item 428188211.

Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex

Sulochanadevi Baskaran, Lars-Anders Carlson, Goran Stjepanovic, Lindsey N Young, Do Jin Kim, Patricia Grob, Robin E Stanley, Eva Nogales, James H Hurley

eLife. 2014; 3: e05115. Published online 2014 Dec 9. doi: 10.7554/eLife.05115

PMCID:: PMC4281882

Abstract Article PDF–11M

Select item 12997112.

Evidence That an Interaction between EB1 and p150^Glued Is Required for the Formation and Maintenance of a Radial Microtubule Array Anchored at the Centrosome

J. M. Askham, K. T. Vaughan, H. V. Goodson, E. E. Morrison

Mol Biol Cell. 2002 Oct; 13(10): 3627–3645. doi: 10.1091/mbc.E02-01-0061

PMCID:: PMC129971

Abstract Article PDF–4.9M

Select item 557319513.

Vps34 kinase domain dynamics regulate the autophagic PI 3-kinase complex

Goran Stjepanovic, Sulochanadevi Baskaran, Mary G. Lin, James H. Hurley

Mol Cell. Author manuscript; available in PMC 2018 Aug 3.

Published in final edited form as: Mol Cell. 2017 Aug 3; 67(3): 528–534.e3. Published online 2017 Jul 27. doi: 10.1016/j.molcel.2017.07.003

PMCID:: PMC5573195

Abstract Article PDF–1.0M

Select item 417622814.

Nrbf2 Protein Suppresses Autophagy by Modulating Atg14L Protein-containing Beclin 1-Vps34 Complex Architecture and Reducing Intracellular Phosphatidylinositol-3 Phosphate Levels

Yu Zhong, Deanna H. Morris, Lin Jin, Mittul S. Patel, Senthil K. Karunakaran, You-Jun Fu, Emily A. Matuszak, Heidi L. Weiss, Brian T. Chait, Qing Jun Wang

J Biol Chem. 2014 Sep 19; 289(38): 26021–26037. Published online 2014 Aug 1. doi: 10.1074/jbc.M114.561134

PMCID:: PMC4176228

Abstract Article PDF–4.6M

Select item 278970015.

Regulation of Beclin 1 in autophagy

Qiming Sun, Weiliang Fan, Qing Zhong

Autophagy. Author manuscript; available in PMC 2009 Dec 7.

Published in final edited form as: Autophagy. 2009 Jul; 5(5): 713–716. Published online 2009 Jul 24. doi: 10.4161/auto.5.5.8524

PMCID:: PMC2789700

Abstract Article PDF–429K

Select item 418010216.

NRBF2 regulates macroautophagy as a component of Vps34 Complex I

Yanyan Cao, Yichen Wang, Widian F. Abi Saab, Fajun Yang, Jeffrey E. Pessin, Jonathan M. Backer

Biochem J. Author manuscript; available in PMC 2015 Jul 15.

Published in final edited form as: Biochem J. 2014 Jul 15; 461(2): 315–322. doi: 10.1042/BJ20140515

PMCID:: PMC4180102

Abstract Article PDF–4.2M

Select item 854642017.

The deubiquitinase USP11 is a versatile and conserved regulator of autophagy

Mila Basic, Alexandra Hertel, Justyna Bajdzienko, Florian Bonn, Mariana Tellechea, Alexandra Stolz, Andreas Kern, Christian Behl, Anja Bremm

J Biol Chem. 2021 Nov; 297(5): 101263. Published online 2021 Sep 30. doi: 10.1016/j.jbc.2021.101263

PMCID:: PMC8546420

Abstract Article PDF–2.4M

Select item 375386018.

Role of Membrane Association and Atg14-Dependent Phosphorylation in Beclin-1-Mediated Autophagy

Adam I. Fogel, Brian J. Dlouhy, Chunxin Wang, Seung-Wook Ryu, Albert Neutzner, Samuel A. Hasson, Dionisia P. Sideris, Hagai Abeliovich, Richard J. Youle

Mol Cell Biol. 2013 Sep; 33(18): 3675–3688. doi: 10.1128/MCB.00079-13

PMCID:: PMC3753860

Abstract Article PDF–4.2M

Select item 259298619.

Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase

Qiming Sun, Weiliang Fan, Keling Chen, Xiaojun Ding, She Chen, Qing Zhong

Proc Natl Acad Sci U S A. 2008 Dec 9; 105(49): 19211–19216. Published online 2008 Dec 2. doi: 10.1073/pnas.0810452105

PMCID:: PMC2592986

Abstract Article PDF–1.2M

Select item 539321620.

ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer’s disease

Bo-Jeng Wang, Guor Mour Her, Ming-Kuan Hu, Yun-Wen Chen, Ying-Tsen Tung, Pei-Yi Wu, Wen-Ming Hsu, Hsinyu Lee, Lee-Way Jin, Sheng-Ping L. Hwang, Rita P.-Y. Chen, Chang-Jen Huang, Yung-Feng Liao

Proc Natl Acad Sci U S A. 2017 Apr 11; 114(15): E3129–E3138. Published online 2017 Mar 28. doi: 10.1073/pnas.1618804114