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Items: 1 to 20 of 59

1.
Selective Targeting of TGF-β Activation to Treat Fibroinflammatory Airway Disease
Shunsuke Minagawa, Jianlong Lou, Robert I. Seed, Anthony Cormier, Shenping Wu, Yifan Cheng, Lynne Murray, Ping Tsui, Jane Connor, Ronald Herbst, Cedric Govaerts, Tyren Barker, Stephanie Cambier, Haruhiko Yanagisawa, Amanda Goodsell, Mitsuo Hashimoto, Oliver J. Brand, Ran Cheng, Royce Ma, Kate J. McKnelly, Weihua Wen, Arthur Hill, David Jablons, Paul Wolters, Hideya Kitamura, Jun Araya, Andrea J. Barczak, David J. Erle, Louis F. Reichardt, James D. Marks, Jody L. Baron, Stephen L. Nishimura
Sci Transl Med. Author manuscript; available in PMC 2015 Feb 26.
Published in final edited form as: Sci Transl Med. 2014 Jun 18; 6(241): 241ra79. doi: 10.1126/scitranslmed.3008074
PMCID:
PMC4341974
AbstractArticlePDF–2.1M
2.
β8 integrin regulates neurogenesis and neurovascular homeostasis in the adult brain
Aaron K. Mobley, Jeremy H. Tchaicha, Jaekyung Shin, Mohammad G. Hossain, Joseph H. McCarty
J Cell Sci. 2009 Jun 1; 122(11): 1842–1851. Published online 2009 May 20. doi: 10.1242/jcs.043257
Correction in:
J Cell Sci. 2009 Jul 1; 122(13): 2322.
PMCID:
PMC2694619
AbstractArticle
3.
Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy
Eswari Dodagatta-Marri, Hsiao-Yen Ma, Benjia Liang, John Li, Dominique S. Meyer, Szu-Ying Chen, Kai-Hui Sun, Xin Ren, Bahar Zivak, Michael D. Rosenblum, Mark B. Headley, Lauren Pinzas, Nilgun I. Reed, Joselyn S. Del Cid, Byron C. Hann, Sharon Yang, Anand Giddabasappa, Kavon Noorbehesht, Bing Yang, Joseph Dal Porto, Tatsuya Tsukui, Kyle Niessen, Amha Atakilit, Rosemary J. Akhurst, Dean Sheppard
Cell Rep. Author manuscript; available in PMC 2021 Jul 29.
Published in final edited form as: Cell Rep. 2021 Jul 6; 36(1): 109309. doi: 10.1016/j.celrep.2021.109309
PMCID:
PMC8321414
AbstractArticlePDF–2.3M
4.
Migratory DCs activate TGF-β to precondition naive CD8+ T cells for tissue-resident memory fate
Vinidhra Mani, Shannon K. Bromley, Tarmo Äijö, Rut Mora-Buch, Esteban Carrizosa, Ross D. Warner, Moustafa Hamze, Debattama R. Sen, Alexandra Y. Chasse, Alina Lorant, Jason W. Griffith, Rod A. Rahimi, Craig P. McEntee, Kate L. Jeffrey, Francesco Marangoni, Mark A. Travis, Adam Lacy-Hulbert, Andrew D. Luster, Thorsten R. Mempel
Science. Author manuscript; available in PMC 2020 Apr 11.
Published in final edited form as: Science. 2019 Oct 11; 366(6462): eaav5728. doi: 10.1126/science.aav5728
PMCID:
PMC6939608
AbstractArticlePDF–2.7M
5.
Loss of Integrin αvβ8 in Murine Hepatocytes Accelerates Liver Regeneration
Stephen N. Greenhalgh, Kylie P. Matchett, Richard S. Taylor, Katherine Huang, John T. Li, Koy Saeteurn, Mhairi C. Donnelly, Eilidh E.M. Simpson, Joshua L. Pollack, Amha Atakilit, Kenneth J. Simpson, Jacquelyn J. Maher, John P. Iredale, Dean Sheppard, Neil C. Henderson
Am J Pathol. 2019 Feb; 189(2): 258–271. doi: 10.1016/j.ajpath.2018.10.007
PMCID:
PMC6360354
AbstractArticle
6.
Role of integrin alpha8 in murine model of lung fibrosis
Chi F. Hung, Carole L. Wilson, Yu-Hua Chow, Lynn M. Schnapp
PLoS One. 2018; 13(5): e0197937. Published online 2018 May 29. doi: 10.1371/journal.pone.0197937
PMCID:
PMC5973593
AbstractArticlePDF–8.8M
7.
Integrin β8 Deletion Enhances Vascular Dysplasia and Hemorrhage in the Brain of Adult Alk1 Heterozygous Mice
Li Ma, Fanxia Shen, Kristine Jun, Chen Bao, Robert Kuo, William L. Young, Stephen L. Nishimura, Hua Su
Transl Stroke Res. Author manuscript; available in PMC 2017 Dec 1.
Published in final edited form as: Transl Stroke Res. 2016 Dec; 7(6): 488–496. Published online 2016 Jun 29. doi: 10.1007/s12975-016-0478-2
PMCID:
PMC5065781
AbstractArticlePDF–1.0M
8.
An In Vivo Map of Bone Morphogenetic Protein 2 Post-transcriptional Repression in the Heart
Boudewijn P. T. Kruithof, Junwang Xu, David T. Fritz, Carolina S. Cabral, Vinciane Gaussin, Melissa B. Rogers
Genesis. Author manuscript; available in PMC 2012 Aug 7.
Published in final edited form as: Genesis. 2011 Nov; 49(11): 841–850. Published online 2011 Oct 14. doi: 10.1002/dvg.20757
PMCID:
PMC3413373
AbstractArticlePDF–3.4M
9.
Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice
Andrew C. Melton, Samantha L. Bailey-Bucktrout, Mark A. Travis, Brian T. Fife, Jeffrey A. Bluestone, Dean Sheppard
J Clin Invest. 2010 Dec 1; 120(12): 4436–4444. Published online 2010 Nov 22. doi: 10.1172/JCI43786
PMCID:
PMC2993595
AbstractArticlePDF–1.2M
10.
αVβ8 integrin targeting to prevent posterior capsular opacification
Mahbubul H. Shihan, Samuel G. Novo, Yan Wang, Dean Sheppard, Amha Atakilit, Thomas D. Arnold, Nicole M. Rossi, Adam P. Faranda, Melinda K. Duncan
JCI Insight. 2021 Nov 8; 6(21): e145715. Published online 2021 Nov 8. doi: 10.1172/jci.insight.145715
PMCID:
PMC8663568
AbstractArticlePDF–4.5M
11.
Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation
Alexandra Lainé, Ossama Labiad, Hector Hernandez-Vargas, Sébastien This, Amélien Sanlaville, Sophie Léon, Stéphane Dalle, Dean Sheppard, Mark A. Travis, Helena Paidassi, Julien C. Marie
Nat Commun. 2021; 12: 6228. Published online 2021 Oct 28. doi: 10.1038/s41467-021-26352-2
PMCID:
PMC8553942
AbstractArticlePDF–3.2M
12.
Pharmacologic Blockade of αvβ1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo
Yongen Chang, Wei Ling Lau, Hyunil Jo, Kazuyuki Tsujino, Leslie Gewin, Nilgun Isik Reed, Amha Atakilit, Ane Claudia Fernandes Nunes, William F. DeGrado, Dean Sheppard
J Am Soc Nephrol. 2017 Jul; 28(7): 1998–2005. Published online 2017 Feb 20. doi: 10.1681/ASN.2015050585
PMCID:
PMC5491273
AbstractArticle
13.
Protein Tyrosine Phosphatase-PEST and β8 Integrin Regulate Spatiotemporal Patterns of RhoGDI1 Activation in Migrating Cells
Hye Shin Lee, Mujeeburahiman Cheerathodi, Sankar P. Chaki, Steve B. Reyes, Yanhua Zheng, Zhimin Lu, Helena Paidassi, Celine DerMardirossian, Adam Lacy-Hulbert, Gonzalo M. Rivera, Joseph H. McCarty
Mol Cell Biol. 2015 Apr; 35(8): 1401–1413. Prepublished online 2015 Feb 9. Published online 2015 Mar 24. doi: 10.1128/MCB.00112-15
PMCID:
PMC4372704
AbstractArticlePDF–3.1M
14.
Mesangial cell αvβ8-integrin regulates glomerular capillary integrity and repair
Sujata Lakhe-Reddy, Vincent Li, Thomas D. Arnold, Shenaz Khan, Jeffrey R. Schelling
Am J Physiol Renal Physiol. 2014 Jun 15; 306(12): F1400–F1409. Published online 2014 Apr 16. doi: 10.1152/ajprenal.00624.2013
PMCID:
PMC4059974
AbstractArticle
15.
Production of Gastrointestinal Tumors in Mice by Modulating Latent Transforming Growth Factor Beta 1 Activation
Kotaro Shibahara, Mitsuhiko Ota, Masahito Horiguchi, Keiji Yoshinaga, Jonathan Melamed, Daniel B Rifkin
Cancer Res. Author manuscript; available in PMC 2014 Jan 1.
Published in final edited form as: Cancer Res. 2013 Jan 1; 73(1): 459–468. Published online 2012 Nov 1. doi: 10.1158/0008-5472.CAN-12-3141
PMCID:
PMC3537847
AbstractArticlePDF–2.1M
16.
The astrocyte-expressed integrin αvβ8 governs blood vessel sprouting in the developing retina
Shinya Hirota, Qian Liu, Hye Shin Lee, Mohammad G. Hossain, Adam Lacy-Hulbert, Joseph H. McCarty
Development. 2011 Dec 1; 138(23): 5157–5166. doi: 10.1242/dev.069153
PMCID:
PMC3253036
AbstractArticle
17.
A Mosaic Mouse Model of Astrocytoma Identifies avß8 Integrin as an Essential Regulator of Tumor-Induced Angiogenesis
Jeremy H. Tchaicha, Aaron K. Mobley, Mohammad G. Hossain, Kenneth D. Aldape, Joseph H. McCarty
Oncogene. Author manuscript; available in PMC 2011 Feb 11.
Published in final edited form as: Oncogene. 2010 Aug 5; 29(31): 4460–4472. Published online 2010 Jun 7. doi: 10.1038/onc.2010.199
PMCID:
PMC3037767
AbstractArticlePDF–1.8M
18.
β8 Integrin Binds Rho GDP Dissociation Inhibitor-1 and Activates Rac1 to Inhibit Mesangial Cell Myofibroblast Differentiation
Sujata Lakhe-Reddy, Shenaz Khan, Martha Konieczkowski, George Jarad, Karen L. Wu, Louis F. Reichardt, Yoshimi Takai, Leslie A. Bruggeman, Bingcheng Wang, John R. Sedor, Jeffrey R. Schelling
J Biol Chem. Author manuscript; available in PMC 2009 Jul 16.
Published in final edited form as: J Biol Chem. 2006 Jul 14; 281(28): 19688–19699. Published online 2006 May 11. doi: 10.1074/jbc.M601110200
PMCID:
PMC2711893
AbstractArticlePDF–991K
19.
miR-222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8
Yan-Yan Bai, Jun-Zhi Niu
Mol Med Rep. 2020 Mar; 21(3): 1145–1153. Published online 2019 Dec 23. doi: 10.3892/mmr.2019.10903
PMCID:
PMC7003054
AbstractArticlePDF–1.2M
20.
Keratinocyte-derived TGFβ is not required to maintain skin immune homeostasis
Yi Yang, Yukari Zenke, Toshiro Hirai, Daniel H. Kaplan
J Dermatol Sci. Author manuscript; available in PMC 2020 May 7.
Published in final edited form as: J Dermatol Sci. 2019 May; 94(2): 290–297. Published online 2019 May 7. doi: 10.1016/j.jdermsci.2019.04.008
Correction in:
J Dermatol Sci. 2019 Sep; 95(3): 134.
PMCID:
PMC6602918
AbstractArticlePDF–1.2M

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